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$280+ Cheap flights from Guatemala City (GUA) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/24. Fares are subject to change and may not be available on all flights or dates of travel.
GUA — SCL
Jan 13 — Jan 201
Tue 1/13
Tue 1/20
1 adult, Economy
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Find cheap flights from Guatemala City to Santiago with Cheapflights

1. Tell us where you want to go

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3. Compare prices and book

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Cheapflights Tip: The best prices from Guatemala City La Aurora to Santiago Arturo Merino Benitez are usually found in May or August, booked 86 days in advance, depart on a Saturday or Sunday and return on a Friday

Cheap flight deals from Guatemala City to Santiago

Cheapest flights from Guatemala City to Santiago
Explore the most affordable flight options available from Guatemala City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 14, 2025.

This Copa Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/2810:34 amGUA - SCL
1 stop10h 07mCopa Airlines
Tue 2/101:46 amSCL - GUA
1 stop10h 48mCopa Airlines
Deal found 12/14$558
This Kiwi.com deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/249:30 amGUA - SCL
1 stop12h 00mMultiple Airlines
Sun 12/281:08 amSCL - GUA
1 stop10h 48mMultiple Airlines
Deal found 12/13$573
This Copa Airlines deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/227:15 amGUA - SCL
1 stop10h 06mCopa Airlines
Sun 12/281:08 amSCL - GUA
1 stop11h 26mCopa Airlines
Deal found 12/12$575
This Kiwi.com deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 12/276:24 amGUA - SCL
2 stops14h 17mCopa Airlines
Sun 12/281:08 amSCL - GUA
1 stop10h 48mCopa Airlines
Deal found 12/13$579
This Copa Airlines deal was found by Cheapflights users on 12/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/286:24 amGUA - SCL
2 stops15h 00mCopa Airlines
Sun 2/81:46 amSCL - GUA
1 stop10h 48mCopa Airlines
Deal found 12/14$582
This Kiwi.com deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/254:28 pmGUA - SCL
1 stop10h 33mCopa Airlines
Sun 12/281:08 amSCL - GUA
1 stop10h 48mCopa Airlines
Deal found 12/13$590
This Kiwi.com deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/216:24 amGUA - SCL
2 stops10h 57mCopa Airlines
Sun 12/281:08 amSCL - GUA
1 stop10h 48mCopa Airlines
Deal found 12/13$597
This Kiwi.com deal was found by Cheapflights users on 12/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/229:30 amGUA - SCL
1 stop12h 00mMultiple Airlines
Sun 12/281:08 amSCL - GUA
1 stop10h 48mMultiple Airlines
Deal found 12/13$624
This Copa Airlines deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/241:12 pmGUA - SCL
1 stop13h 49mCopa Airlines
Wed 12/315:44 amSCL - GUA
1 stop20h 27mCopa Airlines
Deal found 12/12$635
This FlightHub deal was found by Cheapflights users on 12/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/156:20 amGUA - SCL
1 stop15h 10mAvianca
Wed 1/141:35 amSCL - GUA
1 stop14h 25mAvianca
Deal found 12/12$647

Find flight deals from Guatemala City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Guatemala City (GUA) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 14, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$531
(Copa Airlines)

One-way from

$280
(Copa Airlines)

Popular in

January

Cheapest in

May

Average price

$592
Provider with most accurate pricing for Guatemala City La Aurora-Santiago Arturo Merino Benitez flight deals.
Search Deals
Provider most trusted by Cheapflights users for Guatemala City La Aurora-Santiago Arturo Merino Benitez flights.
Search Deals
From Guatemala City La Aurora to Santiago Arturo Merino Benitez
Search Deals
One-way flight from Guatemala City La Aurora to Santiago Arturo Merino Benitez
Search Deals
Highest demand for flights based on searches. 8% potential increase in price ($53 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Guatemala City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 14, 2025.
Use the filters below to find and compare flights from Guatemala City to Santiago that are best for you.

Fly from

Guatemala City

Fly to

Santiago

Route

Depart

Return

Price

Guatemala CitySantiago

GUA - SCL

GUASCL

Guatemala City La Aurora

Wed 12/31

2:26 am-12:32 am

1 stop19h 06m

Santiago Arturo Merino Benitez

Wed 3/4

1:38 am-8:55 am

1 stop10h 17m

$531

Guatemala CitySantiago

GUA - SCL

GUASCL

Guatemala City La Aurora

Fri 3/13

6:24 am-12:34 am

2 stops15h 10m

Santiago Arturo Merino Benitez

Sat 3/21

5:21 am-9:40 pm

2 stops19h 19m

$531

Guatemala CitySantiago

GUA - SCL

GUASCL

Guatemala City La Aurora

Thu 3/26

6:24 am-11:49 pm

2 stops14h 25m

Santiago Arturo Merino Benitez

Tue 4/7

11:25 am-11:10 pm

1 stop13h 45m

$541

Guatemala CitySantiago

GUA - SCL

GUASCL

Guatemala City La Aurora

Mon 1/12

4:24 am-11:43 pm

1 stop16h 19m

Santiago Arturo Merino Benitez

Mon 4/20

2:30 am-11:50 am

1 stop11h 20m

$541

Guatemala CitySantiago

GUA - SCL

GUASCL

Guatemala City La Aurora

Mon 1/12

4:24 am-11:43 pm

1 stop16h 19m

Santiago Arturo Merino Benitez

Mon 3/16

3:32 am-11:36 am

1 stop11h 04m

$541

Guatemala CitySantiago

GUA - SCL

GUASCL

Guatemala City La Aurora

Tue 3/10

10:34 am-11:49 pm

1 stop10h 15m

Santiago Arturo Merino Benitez

Sat 3/14

5:44 am-9:40 pm

2 stops18h 56m

$541

Guatemala CitySantiago

GUA - SCL

GUASCL

Guatemala City La Aurora

Tue 3/17

10:34 am-12:34 am

1 stop11h 00m

Santiago Arturo Merino Benitez

Thu 3/26

12:28 pm-11:11 pm

1 stop13h 43m

$548

Guatemala CitySantiago

GUA - SCL

GUASCL

Guatemala City La Aurora

Thu 3/12

6:24 am-11:49 pm

2 stops14h 25m

Santiago Arturo Merino Benitez

Mon 3/16

3:32 am-9:40 pm

2 stops21h 08m

$549

Guatemala CitySantiago

GUA - SCL

GUASCL

Guatemala City La Aurora

Mon 4/27

10:37 am-10:43 pm

1 stop10h 06m

Santiago Arturo Merino Benitez

Tue 4/28

12:09 am-9:36 am

1 stop11h 27m

$551

Guatemala CitySantiago

GUA - SCL

GUASCL

Guatemala City La Aurora

Wed 12/24

2:26 am-8:21 pm

1 stop14h 55m

$280

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/12

Showing 1-10 of 16 results
1
2

Compare providers for flights from Guatemala City to Santiago

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Guatemala City to Santiago in December.
ProviderPrice AccuracyTrust Score*
eDreamsPrice Accuracy3 starsTrust Score*3 stars
FlightHubPrice Accuracy3 starsTrust Score*1 star

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Guatemala City-Santiago flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Guatemala City-Santiago flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Guatemala City-Santiago flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Guatemala City-Santiago flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Guatemala City-Santiago flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Guatemala City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Guatemala City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Guatemala City to Santiago

What is the cheapest month to book a flight from Guatemala City to Santiago?

Currently, June is the cheapest month in which you can book a flight from Guatemala City to Santiago (average of $230). Flying from Guatemala City to Santiago in February is currently the most expensive (average of $495). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GUA to SCL?

Find hourly flight availability from Guatemala City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 14, 2025.

One of the essential ways to save on airfare from Guatemala City to Santiago is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 32% on airfare.

How much does it cost to fly round-trip from Guatemala City to Santiago?

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated December 14, 2025.
Read through reviews of airlines operating flights from Guatemala City to Santiago, such as Copa Airlines and Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,557 reviews

Boarding

7.8

Overall

7.6

Crew

8.1

Comfort

7.4

Entertainment

6.8

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,557 reviews
Copa Airlines
7.6
Good
1,557 reviews

Boarding

7.8

Overall

7.6

Crew

8.1

Comfort

7.4

Entertainment

6.8

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Avianca
6.6
Okay
2,485 reviews
Copa Airlines
7.6
Good
1,557 reviews

Boarding

7.8

Overall

7.6

Crew

8.1

Comfort

7.4

Entertainment

6.8

Food

6.8

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Guatemala City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Guatemala City to Santiago?

    For as low as $531, Copa Airlines can have you in Santiago from Guatemala City in 19h 06m. Guatemala City and Santiago are separated by a distance of 3559 mi.

  • What are the cheapest airlines flying from Guatemala City to Santiago round-trip?

    Currently priced at $279, Copa Airlines will fly you from Guatemala City to Santiago and back. In addition to Copa Airlines, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on Avianca for as low as $407. Users have found that Copa Airlines is 49% cheaper than the other options available to this destination.

  • Can I find deals for flights from Guatemala City to Santiago that include hotel bookings?

    Yes. In addition to deals on Guatemala City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Guatemala City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Guatemala City to Santiago.

  • Can I find deals for business class flights from Guatemala City to Santiago?

    Yes. Cheapflights offers flight deals from Guatemala City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Guatemala City to Santiago?

    Currently, June is the cheapest month in which you can book a flight from Guatemala City to Santiago (average of $230). Flying from Guatemala City to Santiago in February is currently the most expensive (average of $495). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Complete your trip

Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Santiago car rentals
Santiago Arturo Merino Benitez Airport car rentals
Lastarria car rentals

Top 2 airlines flying from Guatemala City to Santiago

Discover the top 2 airlines that operate flights from Guatemala City to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$407Average$537FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$410Average$571FlexibilityNo cancel feeOn-time70%

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