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$280+ Cheap flights from Guatemala City (GUA) to Santiago (SCL)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/15. Fares are subject to change and may not be available on all flights or dates of travel.
GUA — SCL
Oct 11 — Oct 181
Sat 10/11
Sat 10/18
1 adult, Economy
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Cheapflights Tip: The best prices from Guatemala City La Aurora to Santiago Arturo Merino Benitez are usually found in May or August, booked 86 days in advance, depart on a Saturday or Sunday and return on a Friday

Cheap flight deals from Guatemala City to Santiago

Discover tips and strategies to find the most affordable flight options for your journey from Guatemala City (GUA) to Santiago (SCL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 11, 2025.

Round-trip from

$529
(Mytrip)

One-way from

$280
(Copa Airlines)

Popular in

December

Cheapest in

May

Average price

$540
From Guatemala City La Aurora to Santiago Arturo Merino Benitez
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One-way flight from Guatemala City La Aurora to Santiago Arturo Merino Benitez
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Highest demand for flights based on searches. 10% potential increase in price ($64 potential increase over avg. RT price).
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Cheapest flight prices on average. 1% potential price decrease ($11 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Guatemala City to Santiago

Cheapest flights from Guatemala City to Santiago
Explore the most affordable flight options available from Guatemala City to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 11, 2025.

This Mytrip deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/79:40 amGUA - SCL
1 stop16h 35mAvianca
Wed 10/157:10 amSCL - GUA
1 stop11h 30mAvianca
Deal found 9/9$529
This Priceline deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/299:40 amGUA - SCL
1 stop16h 35mAvianca
Fri 10/37:10 amSCL - GUA
1 stop11h 30mAvianca
Deal found 9/11$534
This Trip.com deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/11:55 pmGUA - SCL
1 stop12h 35mMultiple Airlines
Thu 11/131:35 amSCL - GUA
2 stops17h 38mMultiple Airlines
Deal found 9/10$540
This Priceline deal was found by Cheapflights users on 9/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/106:10 amGUA - SCL
2 stops14h 20mAvianca
Sun 11/24:25 pmSCL - GUA
1 stop12h 15mAvianca
Deal found 9/9$542
This Avianca deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/49:30 amGUA - SCL
1 stop12h 00mAvianca
Thu 11/131:35 amSCL - GUA
1 stop14h 25mAvianca
Deal found 9/10$546
This Avianca deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/149:45 amGUA - SCL
1 stop16h 30mAvianca
Sat 9/277:10 amSCL - GUA
1 stop11h 04mAvianca
Deal found 9/10$547
This Copa Airlines deal was found by Cheapflights users on 9/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/32:41 amGUA - SCL
1 stop18h 25mCopa Airlines
Thu 11/131:29 amSCL - GUA
1 stop13h 06mCopa Airlines
Deal found 9/11$551
This Avianca deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/46:10 amGUA - SCL
2 stops15h 20mAvianca
Mon 11/101:35 amSCL - GUA
1 stop14h 25mAvianca
Deal found 9/10$554
This Copa Airlines deal was found by Cheapflights users on 9/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/135:39 amGUA - SCL
2 stops15h 01mCopa Airlines
Thu 10/303:35 amSCL - GUA
2 stops21h 03mCopa Airlines
Deal found 9/10$559

Cheapflights Fare Finder

 
Customize your flight search to find flights from Guatemala City to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
Use the filters below to find and compare flights from Guatemala City to Santiago that are best for you.

Fly from

Guatemala City

Fly to

Santiago

Route

Depart

Return

Price

Guatemala CitySantiago

GUA - SCL

GUASCL

Guatemala City La Aurora

Mon 11/3

2:41 am-12:06 am

1 stop18h 25m

Santiago Arturo Merino Benitez

Thu 11/13

3:23 am-9:38 pm

2 stops21h 15m

$551

Guatemala CitySantiago

GUA - SCL

GUASCL

Guatemala City La Aurora

Thu 11/6

2:41 am-8:21 pm

1 stop14h 40m

Santiago Arturo Merino Benitez

Tue 11/18

12:20 pm-11:11 pm

1 stop13h 51m

$551

Guatemala CitySantiago

GUA - SCL

GUASCL

Guatemala City La Aurora

Thu 11/6

5:39 am-12:06 am

2 stops15h 27m

Santiago Arturo Merino Benitez

Tue 11/11

3:23 am-9:38 pm

2 stops21h 15m

$551

Guatemala CitySantiago

GUA - SCL

GUASCL

Guatemala City La Aurora

Mon 10/6

5:39 am-12:04 am

2 stops15h 25m

Santiago Arturo Merino Benitez

Thu 10/16

1:24 am-9:18 am

1 stop10h 54m

$551

Guatemala CitySantiago

GUA - SCL

GUASCL

Guatemala City La Aurora

Sun 10/19

3:59 am-11:40 pm

1 stop16h 41m

Santiago Arturo Merino Benitez

Tue 10/28

12:20 pm-11:11 pm

1 stop13h 51m

$551

Guatemala CitySantiago

GUA - SCL

GUASCL

Guatemala City La Aurora

Tue 11/4

5:39 am-8:21 pm

2 stops11h 42m

Santiago Arturo Merino Benitez

Tue 11/11

5:12 am-9:38 pm

2 stops19h 26m

$551

Guatemala CitySantiago

GUA - SCL

GUASCL

Guatemala City La Aurora

Fri 9/26

5:39 am-12:04 am

2 stops15h 25m

Santiago Arturo Merino Benitez

Thu 10/2

3:35 am-9:36 pm

2 stops21h 01m

$551

Guatemala CitySantiago

GUA - SCL

GUASCL

Guatemala City La Aurora

Thu 11/6

4:28 pm-6:01 am

1 stop10h 33m

Santiago Arturo Merino Benitez

Mon 11/17

5:12 am-9:38 pm

2 stops19h 26m

$551

Guatemala CitySantiago

GUA - SCL

GUASCL

Guatemala City La Aurora

Thu 10/30

4:29 pm-5:58 am

1 stop10h 29m

Santiago Arturo Merino Benitez

Wed 11/5

12:20 pm-9:38 pm

2 stops12h 18m

$551

Guatemala CitySantiago

GUA - SCL

GUASCL

Guatemala City La Aurora

Sun 11/9

4:21 am-12:06 am

1 stop16h 45m

Santiago Arturo Merino Benitez

Fri 11/14

3:23 am-7:55 pm

1 stop19h 32m

$551

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/8

Showing 1-10 of 14 results
1
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Best time to book a flight from Guatemala City to Santiago

Have a flexible travel schedule? Discover the best time to fly to Santiago from Guatemala City with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Guatemala City to Santiago

What is the cheapest month to book a flight from Guatemala City to Santiago?

Currently, April is the cheapest month in which you can book a flight from Guatemala City to Santiago (average of $752). Flying from Guatemala City to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from GUA to SCL?

Find hourly flight availability from Guatemala City to Santiago. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 11, 2025.

One of the essential ways to save on airfare from Guatemala City to Santiago is to remain as flexible as possible. Flights that are in the afternoon tend to be the most expensive. A flight in the evening could potentially save you up to 33% on airfare.

Reviews of airlines servicing Santiago

Get insights into the airlines that provide service to Santiago. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santiago. Reviews last updated September 11, 2025.
Read through reviews of airlines operating flights from Guatemala City to Santiago, such as Copa Airlines and Avianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,531 reviews

Comfort

7.4

Overall

7.6

Boarding

7.8

Food

6.8

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
Copa Airlines
7.6
Good
1,531 reviews
Copa Airlines
7.6
Good
1,531 reviews

Comfort

7.4

Overall

7.6

Boarding

7.8

Food

6.8

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
Avianca
6.7
Okay
2,436 reviews
Copa Airlines
7.6
Good
1,531 reviews

Comfort

7.4

Overall

7.6

Boarding

7.8

Food

6.8

Crew

8.1

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring

Related info for your journey

Find useful and relevant information for your journey from Guatemala City to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Guatemala City to Santiago?

    For as low as $551, Copa Airlines can have you in Santiago from Guatemala City in 18h 25m. Guatemala City and Santiago are separated by a distance of 3559 mi.

  • What are the cheapest airlines flying from Guatemala City to Santiago round-trip?

    Currently priced at $384, Avianca will fly you from Guatemala City to Santiago and back. In addition to Avianca, many other airlines offer competitively priced options for your trip. Check Cheapflights for deals on Copa Airlines for as low as $410. Users have found that Avianca is 30% cheaper than the other options available to this destination.

  • Can I find deals for flights from Guatemala City to Santiago that include hotel bookings?

    Yes. In addition to deals on Guatemala City to Santiago flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Guatemala City to Santiago?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Guatemala City to Santiago.

  • Can I find deals for business class flights from Guatemala City to Santiago?

    Yes. Cheapflights offers flight deals from Guatemala City to Santiago by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Guatemala City to Santiago?

    Currently, April is the cheapest month in which you can book a flight from Guatemala City to Santiago (average of $752). Flying from Guatemala City to Santiago in December is currently the most expensive (average of $1,098). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
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Top 2 airlines flying from Guatemala City to Santiago

Discover the top 2 airlines that operate flights from Guatemala City to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 11, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$384Average$562FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$410Average$635FlexibilityNo cancel feeOn-time70%

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