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$244+ Cheap flights from Missouri to Santa Fe (SAF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/18. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SAF
ene. 2 — ene. 91
vie. 1/2
vie. 1/9
1 adult, Economy
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Cheap flight deals from Missouri to Santa Fe

Cheapest flights from Missouri to Santa Fe
Explore the most affordable flight options available from Missouri to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 3, 2025.

This United Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/164:37 pmSTL - SAF
1 stop6h 22mUnited Airlines
sáb. 12/204:40 pmSAF - STL
1 stop4h 42mUnited Airlines
Deal found 12/1$274
This United Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/179:02 amMCI - SAF
1 stop6h 37mUnited Airlines
dom. 12/216:02 pmSAF - MCI
1 stop4h 13mUnited Airlines
Deal found 12/2$344
This United Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/169:02 amMCI - SAF
1 stop6h 37mUnited Airlines
sáb. 12/201:22 pmSAF - MCI
1 stop5h 47mUnited Airlines
Deal found 11/30$374
This United Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/245:45 amMCI - SAF
1 stop4h 54mUnited Airlines
dom. 12/286:02 pmSAF - MCI
1 stop4h 13mUnited Airlines
Deal found 11/30$385
This United Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/179:00 amSTL - SAF
1 stop6h 39mUnited Airlines
dom. 12/214:40 pmSAF - STL
1 stop4h 42mUnited Airlines
Deal found 12/2$425
This American Airlines deal was found by Cheapflights users on 12/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/185:17 amSTL - SAF
1 stop5h 18mAmerican Airlines
lun. 12/221:30 pmSAF - STL
1 stop5h 01mAmerican Airlines
Deal found 12/2$449
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/235:16 amSTL - SAF
1 stop5h 19mAmerican Airlines
mar. 12/303:27 pmSAF - STL
1 stop7h 24mAmerican Airlines
Deal found 12/1$512
This United Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/85:10 pmMCI - SAF
1 stop5h 49mUnited Airlines
sáb. 12/131:20 pmSAF - MCI
1 stop6h 27mUnited Airlines
Deal found 12/3$545
This United Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/295:45 amMCI - SAF
1 stop4h 54mUnited Airlines
lun. 1/56:02 pmSAF - MCI
1 stop4h 13mUnited Airlines
Deal found 12/1$591
This United Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 12/235:02 pmSTL - SAF
2 stops20h 42mUnited Airlines
mar. 12/304:40 pmSAF - STL
1 stop4h 49mUnited Airlines
Deal found 12/1$607
This American Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/242:00 pmMCI - SAF
2 stops24h 00mAmerican Airlines
dom. 12/283:27 pmSAF - MCI
1 stop7h 31mAmerican Airlines
Deal found 11/30$622
This American Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/810:45 amMCI - SAF
2 stops7h 55mAmerican Airlines
sáb. 12/136:15 amSAF - MCI
1 stop6h 35mAmerican Airlines
Deal found 12/1$727

Find flight deals from Missouri to Santa Fe

Keep the following information in mind while searching for Missouri to Santa Fe flight deals. Data was last updated diciembre 3, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$244
(American Airlines)

Popular in

October

Cheapest in

January

Average price

$446
Provider with most accurate pricing for Lambert-St Louis-Santa Fe flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Santa Fe flights.
Search Deals
From Missouri to Santa Fe
Search Deals
Highest demand for flights based on searches. 2% potential increase in price ($11 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($19 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 3, 2025.
Use the filters below to find and compare flights from Missouri to Santa Fe that are best for you.

Fly from

Missouri

Fly to

Santa Fe

Route

Depart

Return

Price

St. LouisSanta Fe

STL - SAF

STLSAF

Lambert-St Louis

mié. 2/18

5:14 am-9:39 am

1 stop5h 25m

Santa Fe

lun. 2/23

3:32 pm-12:05 am

1 stop7h 33m

$244

Kansas CitySanta Fe

MCI - SAF

MCISAF

Kansas City

dom. 1/18

9:05 am-12:39 pm

1 stop4h 34m

Santa Fe

jue. 1/22

3:30 pm-8:33 pm

1 stop4h 03m

$268

St. LouisSanta Fe

STL - SAF

STLSAF

Lambert-St Louis

mar. 12/16

4:37 pm-9:59 pm

1 stop6h 22m

Santa Fe

sáb. 12/20

4:40 pm-10:22 pm

1 stop4h 42m

$274

Kansas CitySanta Fe

MCI - SAF

MCISAF

Kansas City

dom. 1/18

7:19 am-5:57 pm

2 stops11h 38m

Santa Fe

jue. 1/22

3:23 pm-11:59 pm

1 stop7h 36m

$278

Kansas CitySanta Fe

MCI - SAF

MCISAF

Kansas City

lun. 3/2

5:54 am-9:24 am

1 stop4h 30m

Santa Fe

vie. 3/6

5:53 pm-11:15 pm

1 stop4h 22m

$292

Kansas CitySanta Fe

MCI - SAF

MCISAF

Kansas City

dom. 1/11

5:48 am-12:29 pm

1 stop7h 41m

Santa Fe

jue. 1/15

5:05 pm-11:12 pm

1 stop5h 07m

$292

Kansas CitySanta Fe

MCI - SAF

MCISAF

Kansas City

mar. 1/27

8:00 am-2:53 pm

1 stop7h 53m

Santa Fe

jue. 1/29

3:23 pm-11:59 pm

1 stop7h 36m

$292

St. LouisSanta Fe

STL - SAF

STLSAF

Lambert-St Louis

sáb. 1/24

8:45 am-2:54 pm

1 stop7h 09m

Santa Fe

mié. 1/28

3:30 pm-8:58 pm

1 stop4h 28m

$314

Kansas CitySanta Fe

MCI - SAF

MCISAF

Kansas City

sáb. 1/10

11:34 am-4:48 pm

1 stop6h 14m

Santa Fe

mié. 1/14

5:05 pm-11:12 pm

1 stop5h 07m

$314

St. LouisSanta Fe

STL - SAF

STLSAF

Lambert-St Louis

sáb. 1/24

7:43 am-2:53 pm

1 stop8h 10m

Santa Fe

mié. 1/28

3:23 pm-11:59 pm

1 stop7h 36m

$314

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/1

Showing 1-10 of 18 results
1
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Best time to book a flight from Missouri to Santa Fe

Have a flexible travel schedule? Discover the best time to fly to Santa Fe from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Santa Fe

What is the cheapest month to book a flight from Missouri to Santa Fe?

Currently, September is the cheapest month in which you can book a flight from Missouri to Santa Fe (average of $157). Flying from Missouri to Santa Fe in February is currently the most expensive (average of $255). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Missouri to Santa Fe?

Related info for your journey

Find useful and relevant information for your journey from Missouri to Santa Fe. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santa Fe from Missouri?

    Most people fly into Santa Fe (SAF) if they book a flight to Santa Fe from Missouri. Santa Fe is conveniently located just 9.8 mi from Santa Fe’s city center.

  • How long is the flight from Missouri to Santa Fe?

    American Airlines and United Airlines can get you from Missouri to Santa Fe in just under 4h 34m. Your travel time can differ by up to 51m. The distance between Missouri and Santa Fe is about 672 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Missouri to Santa Fe?

    When deciding which route to take from Missouri to Santa Fe consider Kansas City - Santa Fe, Lambert-St Louis - Santa Fe or Springfield-Branson - Santa Fe as they are the most popular.

  • Can I find deals for flights from Missouri to Santa Fe that include hotel bookings?

    Yes. In addition to deals on Missouri to Santa Fe flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Santa Fe?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Santa Fe.

  • Can I find deals for business class flights from Missouri to Santa Fe?

    Yes. Cheapflights offers flight deals from Missouri to Santa Fe by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Santa Fe?

    Currently, September is the cheapest month in which you can book a flight from Missouri to Santa Fe (average of $157). Flying from Missouri to Santa Fe in February is currently the most expensive (average of $255). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Santa Rosa

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Alternative routes for Missouri to Santa Fe

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Top 2 airlines flying from Missouri to Santa Fe

Discover the top 2 airlines that operate flights from Missouri to Santa Fe. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 3, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$204Average$459FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$244Average$361FlexibilityNo cancel feeOn-time71%

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