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$244+ Cheap flights from Missouri to Santa Fe (SAF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SAF
Nov 12 — Nov 191
Wed 11/12
Wed 11/19
1 adult, Economy
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Cheap flight deals from Missouri to Santa Fe

Keep the following information in mind while searching for Missouri to Santa Fe flight deals. Data was last updated October 13, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$244
(American Airlines)

Popular in

October

Cheapest in

January

Average price

$619
Provider with most accurate pricing for Lambert-St Louis-Santa Fe flight deals.
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Provider most trusted by Cheapflights users for Lambert-St Louis-Santa Fe flights.
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From Missouri to Santa Fe
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Highest demand for flights based on searches. 1% potential increase in price ($6 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($19 potential savings vs. average RT price).
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Average for round-trip flights in October 2025
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Find flight deals from Missouri to Santa Fe

Cheapest flights from Missouri to Santa Fe
Explore the most affordable flight options available from Missouri to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 13, 2025.

This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/86:44 amMCI - SAF
1 stop7h 02mAmerican Airlines
Sat 12/139:58 amSAF - MCI
1 stop5h 50mAmerican Airlines
Deal found 10/12$244
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/289:00 amSTL - SAF
1 stop4h 41mUnited Airlines
Sat 11/17:00 amSAF - STL
1 stop4h 39mUnited Airlines
Deal found 10/13$254
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/146:00 amMCI - SAF
1 stop4h 25mUnited Airlines
Sat 11/221:26 pmSAF - MCI
1 stop6h 21mUnited Airlines
Deal found 10/12$290
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/145:34 amMCI - SAF
1 stop5h 16mAmerican Airlines
Wed 10/226:15 amSAF - MCI
1 stop7h 03mAmerican Airlines
Deal found 10/12$319
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/145:15 amMCI - SAF
1 stop5h 13mAmerican Airlines
Sat 11/224:56 pmSAF - MCI
1 stop4h 54mAmerican Airlines
Deal found 10/12$357
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/256:00 amSGF - SAF
1 stop4h 24mUnited Airlines
Fri 10/317:00 amSAF - SGF
1 stop4h 47mUnited Airlines
Deal found 10/12$375
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/105:10 pmMCI - SAF
1 stop5h 49mUnited Airlines
Fri 11/146:00 pmSAF - MCI
1 stop25h 47mUnited Airlines
Deal found 10/12$378
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/109:02 amMCI - SAF
1 stop4h 35mUnited Airlines
Wed 12/171:20 pmSAF - MCI
1 stop6h 27mUnited Airlines
Deal found 10/13$402
This United Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/274:43 pmSTL - SAF
1 stop6h 16mUnited Airlines
Fri 10/316:00 pmSAF - STL
1 stop17h 39mUnited Airlines
Deal found 10/12$463
This United Airlines deal was found by Cheapflights users on 10/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/283:20 pmSGF - SAF
2 stops31h 39mUnited Airlines
Sat 11/13:23 pmSAF - SGF
1 stop4h 28mUnited Airlines
Deal found 10/13$463
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/135:15 amMCI - SAF
1 stop5h 13mAmerican Airlines
Sun 11/163:25 pmSAF - MCI
1 stop7h 13mAmerican Airlines
Deal found 10/12$470
This American Airlines deal was found by Cheapflights users on 10/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/208:25 amSGF - SAF
1 stop5h 17mAmerican Airlines
Wed 11/264:56 pmSAF - SGF
1 stop4h 32mAmerican Airlines
Deal found 10/12$476

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 13, 2025.
Use the filters below to find and compare flights from Missouri to Santa Fe that are best for you.

Fly from

Missouri

Fly to

Santa Fe

Route

Depart

Return

Price

Kansas CitySanta Fe

MCI - SAF

MCISAF

Kansas City

Mon 12/8

6:44 am-12:46 pm

1 stop7h 02m

Santa Fe

Sat 12/13

9:58 am-4:48 pm

1 stop5h 50m

$244

St. LouisSanta Fe

STL - SAF

STLSAF

Lambert-St Louis

Tue 10/28

9:00 am-12:41 pm

1 stop4h 41m

Santa Fe

Sat 11/1

7:00 am-12:39 pm

1 stop4h 39m

$254

Kansas CitySanta Fe

MCI - SAF

MCISAF

Kansas City

Fri 11/14

6:00 am-9:25 am

1 stop4h 25m

Santa Fe

Sat 11/22

1:26 pm-8:47 pm

1 stop6h 21m

$290

Kansas CitySanta Fe

MCI - SAF

MCISAF

Kansas City

Sat 2/28

5:39 am-9:26 am

1 stop4h 47m

Santa Fe

Tue 3/3

3:36 pm-11:16 pm

1 stop6h 40m

$314

St. LouisSanta Fe

STL - SAF

STLSAF

Lambert-St Louis

Sat 2/21

5:27 am-9:26 am

1 stop4h 59m

Santa Fe

Wed 2/25

10:52 am-4:06 pm

1 stop4h 14m

$314

Kansas CitySanta Fe

MCI - SAF

MCISAF

Kansas City

Thu 10/30

1:47 pm-4:57 pm

1 stop4h 10m

Santa Fe

Mon 11/3

6:00 pm-11:42 pm

1 stop4h 42m

$319

Kansas CitySanta Fe

MCI - SAF

MCISAF

Kansas City

Fri 11/14

5:15 am-9:28 am

1 stop5h 13m

Santa Fe

Sat 11/22

4:56 pm-10:50 pm

1 stop4h 54m

$357

SpringfieldSanta Fe

SGF - SAF

SGFSAF

Springfield-Branson

Sat 10/25

6:00 am-9:24 am

1 stop4h 24m

Santa Fe

Fri 10/31

7:00 am-12:47 pm

1 stop4h 47m

$375

Kansas CitySanta Fe

MCI - SAF

MCISAF

Kansas City

Mon 11/10

5:10 pm-9:59 pm

1 stop5h 49m

Santa Fe

Fri 11/14

6:00 pm-8:47 pm

1 stop25h 47m

$378

St. LouisSanta Fe

STL - SAF

STLSAF

Lambert-St Louis

Sun 4/5

5:28 am-11:07 am

1 stop6h 39m

Santa Fe

Wed 4/8

2:55 pm-10:29 pm

1 stop6h 34m

$417

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/11

Showing 1-10 of 18 results
1
2

Best time to book a flight from Missouri to Santa Fe

Have a flexible travel schedule? Discover the best time to fly to Santa Fe from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Santa Fe

What is the cheapest month to book a flight from Missouri to Santa Fe?

Currently, September is the cheapest month in which you can book a flight from Missouri to Santa Fe (average of $157). Flying from Missouri to Santa Fe in December is currently the most expensive (average of $331). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Missouri to Santa Fe?

Related info for your journey

Find useful and relevant information for your journey from Missouri to Santa Fe. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santa Fe from Missouri?

    Most people fly into Santa Fe (SAF) if they book a flight to Santa Fe from Missouri. Santa Fe is conveniently located just 9.8 mi from Santa Fe’s city center.

  • How long is the flight from Missouri to Santa Fe?

    American Airlines and United Airlines can get you from Missouri to Santa Fe in just under 4h 41m. Your travel time can differ by up to 2h 21m. The distance between Missouri and Santa Fe is about 890 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Missouri to Santa Fe?

    When deciding which route to take from Missouri to Santa Fe consider Kansas City - Santa Fe, Springfield-Branson - Santa Fe or Lambert-St Louis - Santa Fe as they are the most popular.

  • Can I find deals for flights from Missouri to Santa Fe that include hotel bookings?

    Yes. In addition to deals on Missouri to Santa Fe flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Santa Fe?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Santa Fe.

  • Can I find deals for business class flights from Missouri to Santa Fe?

    Yes. Cheapflights offers flight deals from Missouri to Santa Fe by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Santa Fe?

    Currently, September is the cheapest month in which you can book a flight from Missouri to Santa Fe (average of $157). Flying from Missouri to Santa Fe in December is currently the most expensive (average of $331). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Santa Rosa

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Top 2 airlines flying from Missouri to Santa Fe

Discover the top 2 airlines that operate flights from Missouri to Santa Fe. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$243Average$450FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$243Average$339FlexibilityNo cancel feeOn-time71%

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