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$244+ Cheap flights from Missouri to Santa Fe (SAF)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SAF
ago. 22 — ago. 291
vie. 8/22
vie. 8/29
1 adult, Economy
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Cheap flight deals from Missouri to Santa Fe

Keep the following information in mind while searching for Missouri to Santa Fe flight deals. Data was last updated agosto 17, 2025.

Round-trip from

$244
(American Airlines)

Popular in

March

Cheapest in

September

Average price

$426
From Missouri to Santa Fe
Search Deals
Highest demand for flights based on searches. 6% potential increase in price ($27 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($24 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Missouri to Santa Fe

Cheapest flights from Missouri to Santa Fe
Explore the most affordable flight options available from Missouri to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on agosto 17, 2025.

This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/85:23 amMCI - SAF
1 stop5h 08mAmerican Airlines
sáb. 12/134:50 pmSAF - MCI
1 stop4h 35mAmerican Airlines
Deal found 8/17$244
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/165:18 amSTL - SAF
1 stop5h 15mAmerican Airlines
sáb. 9/2011:47 amSAF - STL
1 stop7h 28mAmerican Airlines
Deal found 8/17$244
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/175:15 amSTL - SAF
1 stop5h 08mUnited Airlines
sáb. 9/2010:45 amSAF - STL
2 stops9h 47mUnited Airlines
Deal found 8/16$254
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 10/85:15 amSTL - SAF
1 stop5h 09mUnited Airlines
sáb. 10/115:59 pmSAF - STL
1 stop4h 59mUnited Airlines
Deal found 8/16$269
This United Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/65:15 pmMCI - SAF
1 stop5h 45mUnited Airlines
sáb. 9/135:59 pmSAF - MCI
1 stop4h 28mUnited Airlines
Deal found 8/15$314
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 8/285:15 amSTL - SAF
1 stop5h 08mUnited Airlines
dom. 8/3110:45 amSAF - STL
1 stop4h 48mUnited Airlines
Deal found 8/16$316
This United Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar. 9/164:40 pmSTL - SAF
1 stop6h 20mUnited Airlines
sáb. 9/2010:45 amSAF - STL
2 stops9h 47mUnited Airlines
Deal found 8/17$324
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 9/255:18 amSTL - SAF
1 stop5h 15mAmerican Airlines
lun. 9/295:18 pmSAF - STL
1 stop4h 32mAmerican Airlines
Deal found 8/17$325
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/196:00 amMCI - SAF
1 stop4h 23mUnited Airlines
mar. 9/237:00 amSAF - MCI
1 stop4h 40mUnited Airlines
Deal found 8/16$328
This American Airlines deal was found by Cheapflights users on 8/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 9/177:16 amSTL - SAF
2 stops8h 35mAmerican Airlines
mié. 9/2411:47 amSAF - STL
1 stop5h 35mAmerican Airlines
Deal found 8/17$333
This American Airlines deal was found by Cheapflights users on 8/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 9/67:00 amMCI - SAF
2 stops8h 51mAmerican Airlines
sáb. 9/137:15 amSAF - MCI
1 stop5h 58mAmerican Airlines
Deal found 8/15$345
This United Airlines deal was found by Cheapflights users on 8/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
vie. 9/125:15 amSTL - SAF
1 stop5h 08mUnited Airlines
lun. 9/155:59 pmSAF - STL
2 stops20h 45mUnited Airlines
Deal found 8/16$387

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 17, 2025.
Use the filters below to find and compare flights from Missouri to Santa Fe that are best for you.

Fly from

Missouri

Fly to

Santa Fe

Route

Depart

Return

Price

Kansas CitySanta Fe

MCI - SAF

MCISAF

Kansas City

lun. 12/8

5:23 am-9:31 am

1 stop5h 08m

Santa Fe

sáb. 12/13

3:26 pm-11:24 pm

1 stop6h 58m

$244

St. LouisSanta Fe

STL - SAF

STLSAF

Lambert-St Louis

lun. 1/19

4:30 pm-9:54 pm

1 stop6h 24m

Santa Fe

sáb. 1/24

7:00 am-12:43 pm

1 stop4h 43m

$244

St. LouisSanta Fe

STL - SAF

STLSAF

Lambert-St Louis

mié. 9/17

5:18 am-9:33 am

1 stop5h 15m

Santa Fe

sáb. 9/20

11:47 am-8:15 pm

1 stop7h 28m

$244

St. LouisSanta Fe

STL - SAF

STLSAF

Lambert-St Louis

mié. 9/17

5:15 am-9:23 am

1 stop5h 08m

Santa Fe

mié. 9/24

5:59 pm-11:53 pm

1 stop4h 54m

$244

St. LouisSanta Fe

STL - SAF

STLSAF

Lambert-St Louis

mar. 9/16

5:18 am-9:33 am

1 stop5h 15m

Santa Fe

sáb. 9/20

11:47 am-8:15 pm

1 stop7h 28m

$244

St. LouisSanta Fe

STL - SAF

STLSAF

Lambert-St Louis

dom. 1/18

8:14 am-2:39 pm

1 stop7h 25m

Santa Fe

sáb. 1/24

4:19 pm-11:59 pm

1 stop6h 40m

$244

St. LouisSanta Fe

STL - SAF

STLSAF

Lambert-St Louis

sáb. 1/31

1:48 pm-7:55 pm

1 stop7h 07m

Santa Fe

sáb. 2/7

10:43 am-6:23 pm

1 stop6h 40m

$244

St. LouisSanta Fe

STL - SAF

STLSAF

Lambert-St Louis

jue. 1/15

5:14 am-9:21 am

1 stop5h 07m

Santa Fe

mar. 1/20

4:19 pm-11:59 pm

1 stop6h 40m

$244

Kansas CitySanta Fe

MCI - SAF

MCISAF

Kansas City

sáb. 9/6

5:15 pm-10:00 pm

1 stop5h 45m

Santa Fe

sáb. 9/13

5:59 pm-11:27 pm

1 stop4h 28m

$314

SpringfieldSanta Fe

SGF - SAF

SGFSAF

Springfield-Branson

sáb. 8/30

6:00 am-9:23 am

1 stop4h 23m

Santa Fe

mié. 9/3

5:59 pm-11:39 pm

1 stop4h 40m

$324

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/16

Showing 1-10 of 22 results
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Best time to book a flight from Missouri to Santa Fe

Have a flexible travel schedule? Discover the best time to fly to Santa Fe from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Santa Fe

What is the cheapest month to book a flight from Missouri to Santa Fe?

Currently, January is the cheapest month in which you can book a flight from Missouri to Santa Fe (average of $372). Flying from Missouri to Santa Fe in March is currently the most expensive (average of $536). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Missouri to Santa Fe?

Related info for your journey

Find useful and relevant information for your journey from Missouri to Santa Fe. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santa Fe from Missouri?

    Most people fly into Santa Fe (SAF) if they book a flight to Santa Fe from Missouri. Santa Fe is conveniently located just 9.8 mi from Santa Fe’s city center.

  • What are the most popular routes from Missouri to Santa Fe?

    When deciding which route to take from Missouri to Santa Fe consider Lambert-St Louis - Santa Fe, Kansas City - Santa Fe or Springfield-Branson - Santa Fe as they are the most popular.

  • Can I find deals for flights from Missouri to Santa Fe that include hotel bookings?

    Yes. In addition to deals on Missouri to Santa Fe flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Santa Fe?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Santa Fe.

  • Can I find deals for business class flights from Missouri to Santa Fe?

    Yes. Cheapflights offers flight deals from Missouri to Santa Fe by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Santa Fe?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Santa Fe (average of $372). Flying from Missouri to Santa Fe in March is currently the most expensive (average of $536). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Santa Rosa

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Alternative routes for Missouri to Santa Fe

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Top 2 airlines flying from Missouri to Santa Fe

Discover the top 2 airlines that operate flights from Missouri to Santa Fe. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated agosto 17, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$243Average$452FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$243Average$346FlexibilityNo cancel feeOn-time71%

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