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Santa Fe

$179+ Cheap flights from Missouri to Santa Fe (SAF)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/5. Fares are subject to change and may not be available on all flights or dates of travel.
STL — SAF
Feb 27 — Mar 61
Fri 2/27
Fri 3/6
1 adult, Economy
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Cheap flight deals from Missouri to Santa Fe

Cheapest flights from Missouri to Santa Fe
Explore the most affordable flight options available from Missouri to Santa Fe. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 28, 2026.

This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/186:38 am
STL
-
SAF
1 stop7h 35m
American Airlines
Mon 2/231:43 pm
SAF
-
STL
1 stop9h 16m
American Airlines
Deal found 1/27$264
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/247:41 am
STL
-
SAF
2 stops10h 27m
United Airlines
Tue 3/31:23 pm
SAF
-
STL
1 stop6h 03m
United Airlines
Deal found 1/27$270
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/1112:03 pm
STL
-
SAF
1 stop5h 32m
American Airlines
Sun 2/153:35 pm
SAF
-
STL
1 stop7h 24m
American Airlines
Deal found 1/27$274
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/36:04 am
MCI
-
SAF
1 stop4h 37m
United Airlines
Wed 6/106:00 pm
SAF
-
MCI
1 stop4h 27m
United Airlines
Deal found 1/26$290
This American Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/257:58 am
STL
-
SAF
1 stop8h 07m
American Airlines
Sat 2/283:35 pm
SAF
-
STL
1 stop7h 24m
American Airlines
Deal found 1/27$299
This American Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/155:20 am
STL
-
SAF
1 stop5h 47m
American Airlines
Sat 4/1812:19 pm
SAF
-
STL
2 stops9h 45m
American Airlines
Deal found 1/26$309
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/265:54 am
MCI
-
SAF
1 stop4h 30m
United Airlines
Mon 3/26:00 pm
SAF
-
MCI
1 stop4h 17m
United Airlines
Deal found 1/27$319
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/286:00 am
MCI
-
SAF
1 stop4h 09m
United Airlines
Sat 5/25:49 pm
SAF
-
MCI
1 stop5h 03m
United Airlines
Deal found 1/27$334
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/141:50 pm
MCI
-
SAF
1 stop4h 18m
United Airlines
Thu 2/196:00 pm
SAF
-
MCI
1 stop4h 17m
United Airlines
Deal found 1/26$340
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/105:45 am
MCI
-
SAF
1 stop4h 45m
United Airlines
Sat 2/1410:45 am
SAF
-
MCI
1 stop4h 34m
United Airlines
Deal found 1/26$345
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/292:45 pm
STL
-
SAF
1 stop7h 02m
United Airlines
Tue 2/33:30 pm
SAF
-
STL
1 stop4h 28m
United Airlines
Deal found 1/26$350
This United Airlines deal was found by Cheapflights users on 1/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/85:15 am
STL
-
SAF
1 stop5h 26m
United Airlines
Sat 6/136:00 pm
SAF
-
STL
1 stop4h 58m
United Airlines
Deal found 1/26$353

Find flight deals from Missouri to Santa Fe

Keep the following information in mind while searching for Missouri to Santa Fe flight deals. Data was last updated January 28, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$264
(American Airlines)

One-way from

$179
(United Airlines)

Popular in

October

Cheapest in

January

Average price

$289
Provider with most accurate pricing for Lambert-St Louis-Santa Fe flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Santa Fe flights.
Search Deals
From Missouri to Santa Fe
Search Deals
One-way flight from Missouri to Santa Fe
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($55 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($18 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Santa Fe that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
Use the filters below to find and compare flights from Missouri to Santa Fe that are best for you.

Fly from

Missouri

Fly to

Santa Fe

Route

Depart

Return

Price

St. LouisSanta Fe

STL - SAF

STLSAF

Lambert-St Louis

Tue 2/24

7:41 am-5:08 pm

2 stops10h 27m

Santa Fe

Tue 3/3

1:23 pm-8:26 pm

1 stop6h 03m

$270

St. LouisSanta Fe

STL - SAF

STLSAF

Lambert-St Louis

Wed 2/11

12:03 pm-4:35 pm

1 stop5h 32m

Santa Fe

Sun 2/15

3:35 pm-11:59 pm

1 stop7h 24m

$274

Kansas CitySanta Fe

MCI - SAF

MCISAF

Kansas City

Wed 6/3

6:04 am-9:41 am

1 stop4h 37m

Santa Fe

Wed 6/10

6:00 pm-11:27 pm

1 stop4h 27m

$290

St. LouisSanta Fe

STL - SAF

STLSAF

Lambert-St Louis

Wed 2/25

7:58 am-3:05 pm

1 stop8h 07m

Santa Fe

Sat 2/28

3:35 pm-11:59 pm

1 stop7h 24m

$299

Kansas CitySanta Fe

MCI - SAF

MCISAF

Kansas City

Thu 2/26

5:54 am-9:24 am

1 stop4h 30m

Santa Fe

Mon 3/2

6:00 pm-11:17 pm

1 stop4h 17m

$319

Kansas CitySanta Fe

MCI - SAF

MCISAF

Kansas City

Tue 4/28

6:00 am-9:09 am

1 stop4h 09m

Santa Fe

Sat 5/2

5:49 pm-11:52 pm

1 stop5h 03m

$334

St. LouisSanta Fe

STL - SAF

STLSAF

Lambert-St Louis

Wed 4/22

5:20 am-10:07 am

1 stop5h 47m

Santa Fe

Tue 4/28

3:29 pm-11:59 pm

1 stop7h 30m

$335

Kansas CitySanta Fe

MCI - SAF

MCISAF

Kansas City

Sat 2/14

1:50 pm-5:08 pm

1 stop4h 18m

Santa Fe

Thu 2/19

6:00 pm-11:17 pm

1 stop4h 17m

$340

Kansas CitySanta Fe

MCI - SAF

MCISAF

Kansas City

Tue 2/10

5:45 am-9:30 am

1 stop4h 45m

Santa Fe

Sat 2/14

10:45 am-4:19 pm

1 stop4h 34m

$345

St. LouisSanta Fe

STL - SAF

STLSAF

Lambert-St Louis

Mon 6/8

5:15 am-9:41 am

1 stop5h 26m

Santa Fe

Sat 6/13

6:00 pm-11:58 pm

1 stop4h 58m

$353

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 35 results
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Best time to book a flight from Missouri to Santa Fe

Have a flexible travel schedule? Discover the best time to fly to Santa Fe from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Santa Fe

What is the cheapest month to book a flight from Missouri to Santa Fe?

Currently, September is the cheapest month in which you can book a flight from Missouri to Santa Fe (average of $157). Flying from Missouri to Santa Fe in January is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Santa Fe. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Santa Fe from Missouri?

    Most people fly into Santa Fe (SAF) if they book a flight to Santa Fe from Missouri. Santa Fe is conveniently located just 9.8 mi from Santa Fe’s city center.

  • How long is the flight from Missouri to Santa Fe?

    United Airlines and American Airlines can get you from Missouri to Santa Fe in just under 5h 32m. Your travel time can differ by up to 4h 55m. The distance between Missouri and Santa Fe is about 890 mi. This flight may include one or multiple stops.

  • What are the most popular routes from Missouri to Santa Fe?

    When deciding which route to take from Missouri to Santa Fe consider Lambert-St Louis - Santa Fe, Kansas City - Santa Fe or Springfield-Branson - Santa Fe as they are the most popular.

  • Can I find deals for flights from Missouri to Santa Fe that include hotel bookings?

    Yes. In addition to deals on Missouri to Santa Fe flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Santa Fe?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Santa Fe.

  • Can I find deals for business class flights from Missouri to Santa Fe?

    Yes. Cheapflights offers flight deals from Missouri to Santa Fe by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Santa Fe?

    Currently, September is the cheapest month in which you can book a flight from Missouri to Santa Fe (average of $157). Flying from Missouri to Santa Fe in January is currently the most expensive (average of $268). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near Santa Fe?

Book flights to Santa Fe if you plan to visit one of these locations
Santa Rosa

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Top 2 airlines flying from Missouri to Santa Fe

Discover the top 2 airlines that operate flights from Missouri to Santa Fe. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$204Average$414FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$244Average$358FlexibilityNo cancel feeOn-time71%

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