$386+ Cheap flights from Madrid, Spain (MAD) to Santa Cruz de la Sierra (VVI)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/6. Fares are subject to change and may not be available on all flights or dates of travel.
MAD — VVI
Sep 10 — Sep 171
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Madrid to Santa Cruz de la Sierra with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl are usually found in September or April, booked 56 days in advance, depart on a Wednesday or Tuesday and return on a Friday
Cheap flight deals from Madrid to Santa Cruz de la Sierra
Cheapest
Best
Last-minute
One-way
Cheapest flights from Madrid to Santa Cruz de la SierraExplore the most affordable flight options available from Madrid to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 11, 2026.
Explore the most affordable flight options available from Madrid to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 11, 2026.
This Avianca deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:20 am -
1 stop24h 15m
Mon 11/233:40 am -
1 stop20h 40m
Deal found 8/10![Avianca logo]()
$865
This Avianca deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1211:05 am -
1 stop21h 25m
Tue 10/133:35 am -
1 stop14h 45m
Deal found 8/7![Avianca logo]()
$868
This CheapOair deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1111:35 pm -
Nonstop11h 20m
Tue 11/241:30 pm -
Nonstop10h 40m
Deal found 8/7![Air Europa logo]()
$871
This Avianca deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/117:20 am -
1 stop24h 15m
Tue 11/173:40 am -
1 stop14h 40m
Deal found 8/10![Avianca logo]()
$936
This Avianca deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1111:05 am -
1 stop21h 25m
Tue 10/133:35 am -
1 stop14h 45m
Deal found 8/11![Avianca logo]()
$956
This Kiwi.com deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/1911:35 pm -
Nonstop11h 15m
Tue 11/241:30 pm -
Nonstop10h 40m
Deal found 8/8![Air Europa logo]()
$974
This Avianca deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/3110:25 am -
2 stops21h 10m
Mon 2/13:40 am -
1 stop14h 40m
Deal found 8/7![Avianca logo]()
$982
Best flights from Madrid to Santa Cruz de la SierraDiscover carefully curated flight deals from Madrid to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 11, 2026.
Discover carefully curated flight deals from Madrid to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 11, 2026.
This United Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2110:50 am -
2 stops22h 48m
Sat 10/1011:47 am -
2 stops38h 18m
Deal found 8/9![United Airlines logo]()
$1,336
This Turkish Airlines deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/812:00 pm -
3 stops45h 38m
Wed 9/2312:15 pm -
2 stops46h 45m
Deal found 8/10![Multiple Airlines logo]()
$2,017
This United Airlines deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/1311:00 am -
2 stops40h 38m
Tue 1/2611:53 am -
2 stops40h 22m
Deal found 8/7![United Airlines logo]()
$1,486
This Turkish Airlines deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/302:55 pm -
3 stops42h 40m
Wed 9/2312:15 pm -
2 stops43h 20m
Deal found 8/8![Multiple Airlines logo]()
$2,086
This Turkish Airlines deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Turkish Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:30 pm -
3 stops58h 14m
Mon 11/2311:55 am -
2 stops44h 20m
Deal found 8/9![Multiple Airlines logo]()
$2,476
Last-minute flights from Madrid to Santa Cruz de la SierraDiscover last-minute flight deals from Madrid to Santa Cruz de la Sierra. Data last updated August 11, 2026 and is based on user searches.
Discover last-minute flight deals from Madrid to Santa Cruz de la Sierra. Data last updated August 11, 2026 and is based on user searches.
This Avianca deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1111:05 am -
1 stop21h 25m
Tue 10/133:35 am -
1 stop14h 45m
Deal found 8/11![Avianca logo]()
$956
This Avianca deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1211:05 am -
1 stop21h 25m
Tue 10/133:35 am -
1 stop14h 45m
Deal found 8/7![Avianca logo]()
$868
This Avianca deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/185:20 pm -
1 stop15h 10m
Thu 10/223:35 am -
1 stop14h 45m
Deal found 8/11![Avianca logo]()
$987
This FlightHub deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/2111:35 pm -
Nonstop11h 15m
Sat 10/1012:15 pm -
Nonstop10h 50m
Deal found 8/10![Air Europa logo]()
$1,072
One-way flights from Madrid to Santa Cruz de la SierraSearch for one-way flight options from Madrid to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated August 11, 2026.
Search for one-way flight options from Madrid to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated August 11, 2026.
This Avianca deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/68:05 pm -
2 stops36h 25m
Deal found 8/7![Avianca logo]()
$386
This SmartFares deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/2311:35 pm -
Nonstop11h 15m
Deal found 8/9![Air Europa logo]()
$464
This Travelocity deal was found by Cheapflights users on 8/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/221:45 am -
1 stop32h 50m
Deal found 8/9![LATAM Airlines logo]()
$485
This Orbitz deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/71:20 pm -
2 stops48h 36m
Deal found 8/10![LATAM Airlines logo]()
$490
This Avianca deal was found by Cheapflights users on 8/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/28:10 am -
1 stop24h 20m
Deal found 8/8![Avianca logo]()
$502
This Avianca deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/111:25 am -
2 stops20h 10m
Deal found 8/11![Multiple Airlines logo]()
$508
This Avianca deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/110:25 am -
2 stops21h 10m
Deal found 8/10![Avianca logo]()
$511
This Avianca deal was found by Cheapflights users on 8/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/711:05 am -
1 stop21h 25m
Deal found 8/10![Avianca logo]()
$517
This Expedia deal was found by Cheapflights users on 8/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/151:45 am -
1 stop32h 50m
Deal found 8/7![LATAM Airlines logo]()
$520
Find flight deals from Madrid to Santa Cruz de la Sierra
Discover tips and strategies to find the most affordable flight options for your journey from Madrid (MAD) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated August 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $828 (Avianca) |
One-way from | $386 (Avianca) |
Popular in | July |
Cheapest in | September |
Average price | $1,232 |
Cheapflights Fare Finder
Customize your flight search to find flights from Madrid to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 11, 2026.
Use the filters below to find and compare flights from Madrid to Santa Cruz de la Sierra that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Mon 9/21
10:50 am-3:38 am
2 stops22h 48m
Santa Cruz de la Sierra Viru Viru Intl
Sat 10/10
11:47 am-8:05 am
2 stops38h 18m
$1,336
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Fri 11/13
11:00 am-10:38 pm
2 stops40h 38m
Santa Cruz de la Sierra Viru Viru Intl
Tue 1/26
11:53 am-9:15 am
2 stops40h 22m
$1,486
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Tue 9/8
12:00 pm-3:38 am
3 stops45h 38m
Santa Cruz de la Sierra Viru Viru Intl
Wed 9/23
12:15 pm-5:00 pm
2 stops46h 45m
$2,017
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Sun 8/30
2:55 pm-3:35 am
3 stops42h 40m
Santa Cruz de la Sierra Viru Viru Intl
Wed 9/23
12:15 pm-1:35 pm
2 stops43h 20m
$2,086
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Fri 10/23
6:30 pm-10:44 pm
3 stops58h 14m
Santa Cruz de la Sierra Viru Viru Intl
Mon 11/23
11:55 am-1:15 pm
2 stops44h 20m
$2,476
Cheapest one-way
Quickest one-way
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Sun 9/6
11:05 am-2:30 am
1 stop21h 25m
$421
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Tue 8/18
1:15 pm-7:56 am
1 stop24h 41m
$613
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Sun 11/1
11:00 am-10:38 pm
2 stops40h 38m
$784
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Wed 9/2
11:15 am-10:44 pm
2 stops41h 29m
$784
MadridSanta Cruz de la Sierra
MAD Madrid Barajas - VVI Santa Cruz de la Sierra Viru Viru Intl
MADVVI
Madrid Barajas
Wed 10/7
11:15 am-10:44 pm
2 stops41h 29m
$784
Showing 1-10 of 16 resultsSorted by cheapest first
- Most accurate provider: When it comes to deals on Madrid-Santa Cruz de la Sierra flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Madrid-Santa Cruz de la Sierra flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Madrid-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Madrid-Santa Cruz de la Sierra flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Madrid-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Madrid to Santa Cruz de la Sierra
Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Madrid with our price prediction graph.
MAD-VVI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Madrid to Santa Cruz de la Sierra
Prices
Delays
How far ahead should I book a flight from Madrid to Santa Cruz de la Sierra?
The best time to book flights from Madrid to Santa Cruz de la Sierra is 55 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Madrid to Santa Cruz de la Sierra?
Currently, September is the cheapest month in which you can book a flight from Madrid to Santa Cruz de la Sierra (average of $840). Flying from Madrid to Santa Cruz de la Sierra in July is currently the most expensive (average of $1,465). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MAD to VVI?
Find hourly flight availability from Madrid to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 11, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Madrid to Santa Cruz de la Sierra as you normally would.
How often are flights from Madrid to Santa Cruz de la Sierra delayed?
About 46% of weekly flights between Madrid and Santa Cruz de la Sierra have experienced delays in the past year, with the average delay time being 131 minutes.
What is the most punctual flight time for Madrid to Santa Cruz de la Sierra flights?
Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Saturday tends to have the lowest number of delays on this route, whereas Thursday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Madrid to Santa Cruz de la Sierra flights?
Over the last year, Air Europa have had the lowest number of delays on this route, with just 39% of flights being delayed.
Reviews of airlines servicing Santa Cruz de la Sierra
Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated August 11, 2026.
Read through reviews of airlines operating flights from Madrid to Santa Cruz de la Sierra, such as Air Europa,Iberia, andBoA. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Comfort
6.9
Food
6.3
Crew
7.5
Overall
7.0
Entertainment
6.5
Boarding
7.1
Reviews
1 / 18
6.0
GoodDaniel Alan,Jul 2026
MAD - MIA
Comfort
6.9
Food
6.3
Crew
7.5
Overall
7.0
Entertainment
6.5
Boarding
7.1
Reviews
1 / 18
6.0
GoodDaniel Alan,Jul 2026
MAD - MIA
Comfort
6.9
Food
6.3
Crew
7.5
Overall
7.0
Entertainment
6.5
Boarding
7.1
Reviews
1 / 18
6.0
GoodDaniel Alan,Jul 2026
MAD - MIA
Comfort
6.9
Food
6.3
Crew
7.5
Overall
7.0
Entertainment
6.5
Boarding
7.1
Reviews
1 / 18
6.0
GoodDaniel Alan,Jul 2026
MAD - MIA
Comfort
6.9
Food
6.3
Crew
7.5
Overall
7.0
Entertainment
6.5
Boarding
7.1
Reviews
1 / 18
6.0
GoodDaniel Alan,Jul 2026
MAD - MIA
Related info for your journey
Find useful and relevant information for your journey from Madrid to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Madrid
Popular flights
Alternative routes for Madrid to Santa Cruz de la Sierra
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Madrid to Santa Cruz de la Sierra by cabin class
Find flights from Madrid to Santa Cruz de la Sierra, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Madrid and Santa Cruz de la Sierra flights
Browse other Madrid and Santa Cruz de la Sierra flight options. Last updated on August 11, 2026.
Other flights from Madrid
Browse through other flights departing from Madrid. Flights are based on user searches made on Cheapflights and were last updated on August 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from Madrid to Santa Cruz de la Sierra
Discover the top 4 airlines that operate flights from Madrid to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$677 | Average$1,383 | FlexibilityNo cancel fee | On-time83% | |
| Cheapest$696 | Average$810 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$744 | Average$1,774 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$837 | Average$1,201 | FlexibilityNo cancel fee | On-time77% |