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$102+ Cheap flights from Key Largo, FL to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/23. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — PTY
Jun 21 — Jun 281
Sat 6/21
Sat 6/28
1 adult, Economy
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Cheap flight deals from Key Largo to Panama

Keep the following information in mind while searching for Key Largo to Panama flight deals. Data was last updated June 16, 2025.

Round-trip from

$267
(Flightnetwork)

One-way from

$102
(FlightHub)

Popular in

December

Cheapest in

May

Average price

$334
From Key Largo to Panama
Search Deals
One-way flight from Key Largo to Panama
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($44 potential increase over avg. RT price).
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Cheapest flight prices on average. 3% potential price decrease ($12 potential savings vs. average RT price).
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Average for round-trip flights in June 2025
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Find flight deals from Key Largo to Panama

Cheapest flights from Key Largo to Panama
Explore the most affordable flight options available from Key Largo to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 16, 2025.

This Flightnetwork deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flightnetwork is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/152:26 pmMIA - PTY
Nonstop3h 10mCopa Airlines
Tue 7/226:32 pmPTY - MIA
Nonstop3h 11mCopa Airlines
Deal found 6/15$267
This Gotogate deal was found by Cheapflights users on 6/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/98:15 amMIA - PTY
1 stop7h 25mAvianca
Tue 9/165:25 pmPTY - MIA
1 stop9h 40mAvianca
Deal found 6/15$271
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/84:53 pmMIA - PTY
1 stop26h 44mUnited Airlines
Fri 7/113:30 pmPTY - MIA
1 stop28h 15mUnited Airlines
Deal found 6/14$281
This Kiwi.com deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/66:05 amMIA - PTY
Nonstop3h 06mMultiple Airlines
Thu 8/1411:20 amPTY - MIA
1 stop16h 05mMultiple Airlines
Deal found 6/14$344
This American Airlines deal was found by Cheapflights users on 6/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/2010:30 amMIA - PTY
Nonstop3h 30mAmerican Airlines
Fri 6/273:20 pmPTY - MIA
Nonstop3h 05mAmerican Airlines
Deal found 6/13$366
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/226:01 amMIA - DAV
1 stop27h 59mCopa Airlines
Sun 6/296:20 pmDAV - MIA
1 stop27h 07mCopa Airlines
Deal found 6/16$578
This Kiwi.com deal was found by Cheapflights users on 6/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/186:25 pmMIA - DAV
2 stops40h 40mMultiple Airlines
Sun 6/299:44 amDAV - MIA
1 stop6h 15mMultiple Airlines
Deal found 6/16$709
This United Airlines deal was found by Cheapflights users on 6/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/175:23 pmMIA - DAV
1 stop25h 05mUnited Airlines
Thu 7/319:41 amDAV - MIA
2 stops24h 23mUnited Airlines
Deal found 6/14$1,059

Cheapflights Fare Finder

Customize your flight search to find flights from Key Largo to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2025.
Use the filters below to find and compare flights from Key Largo to Panama that are best for you.

Fly from

Key Largo

Fly to

Panama

Route

Depart

Return

Price

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Tue 7/15

2:26 pm-4:36 pm

Nonstop3h 10m

Panama City Tocumen Intl

Tue 7/22

6:32 pm-10:43 pm

Nonstop3h 11m

$267

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Tue 9/9

8:15 am-2:40 pm

1 stop7h 25m

Panama City Tocumen Intl

Tue 9/16

5:25 pm-4:05 am

1 stop9h 40m

$271

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Tue 7/8

4:53 pm-6:37 pm

1 stop26h 44m

Panama City Tocumen Intl

Fri 7/11

3:30 pm-8:45 pm

1 stop28h 15m

$281

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Wed 8/6

6:05 am-8:11 am

Nonstop3h 06m

Panama City Tocumen Intl

Thu 8/14

11:20 am-4:25 am

1 stop16h 05m

$344

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Sun 7/6

10:34 am-12:54 pm

Nonstop3h 20m

Panama City Tocumen Intl

Sat 7/12

1:55 pm-6:00 pm

Nonstop3h 05m

$393

MiamiDavid

MIA - DAV

MIADAV

Miami

Thu 7/17

5:23 pm-5:28 pm

1 stop25h 05m

David Enrique Malek

Thu 7/31

9:41 am-11:04 am

2 stops24h 23m

$1,059

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Wed 7/23

8:15 am-2:40 pm

1 stop7h 25m

$102

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Sat 10/11

6:04 am-8:11 am

Nonstop3h 07m

$160

MiamiDavid

MIA - DAV

MIADAV

Miami

Mon 10/27

6:29 pm-9:07 am

1 stop15h 38m

$168

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Fri 8/1

12:05 pm-2:15 pm

Nonstop3h 10m

$175

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/14

Showing 1-10 of 17 results
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Best time to book a flight from Key Largo to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Panama

What is the cheapest month to book a flight from Key Largo to Panama?

Currently, October is the cheapest month in which you can book a flight from Key Largo to Panama (average of $478). Flying from Key Largo to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to PA?

Find hourly flight availability from Key Largo to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 16, 2025.

When flying from Key Largo to Panama, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Key Largo to Panama?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to Panama. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Key Largo to Panama flight should consider departing on Sunday evenings when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Key Largo to Panama

Explore weekly flight availability from Key Largo to Panama. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated June 16, 2025.

The most flights from KE9 to PA0 are scheduled on a Saturday (17 on average). You will have fewer flight options on Tuesday, which is when the least amount of flights are scheduled (13 on average).

Rainfall in Panama by month

Plan your trip to Panama by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Panama ranges from 0.4 - 13.4 inches per month. October is typically the wettest month, when rainfall can reach 13.4 in. February is typically the driest time to visit Panama when rainfall is around 0.4 in.

Temperature in Panama by month

Plan your trip to Panama by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Panama, use this chart to help with planning. For those seeking warmer temperatures, February is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 78.8 F).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated June 16, 2025.
Read through reviews of airlines operating flights from Key Largo to Panama, such as Copa Airlines, Aeromexico and United Airlines. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,453 reviews

Crew

8.1

Comfort

7.4

Entertainment

6.8

Boarding

7.7

Food

6.8

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Anonymous,May 2025

LIM - PTY

This was my first tome flying with this airline and needless to say, I was not impressed! The seats were not comfortable at all. You could feel the metal digging into your skin. Also, there was a kid behind me that kept putting his knees up on the seat and usually this doesn’t bother me, but I was able to feel his knees dig into my back every single time. The food was mediocore at best. There were no phone chargers on an almost 5 hour flight! Horrible experience. Will never fly with Copa airlines again!
Copa Airlines
7.5
Good
1,453 reviews
Copa Airlines
7.5
Good
1,453 reviews

Crew

8.1

Comfort

7.4

Entertainment

6.8

Boarding

7.7

Food

6.8

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Anonymous,May 2025

LIM - PTY

This was my first tome flying with this airline and needless to say, I was not impressed! The seats were not comfortable at all. You could feel the metal digging into your skin. Also, there was a kid behind me that kept putting his knees up on the seat and usually this doesn’t bother me, but I was able to feel his knees dig into my back every single time. The food was mediocore at best. There were no phone chargers on an almost 5 hour flight! Horrible experience. Will never fly with Copa airlines again!
Aeromexico
7.5
Good
1,711 reviews
Copa Airlines
7.5
Good
1,453 reviews

Crew

8.1

Comfort

7.4

Entertainment

6.8

Boarding

7.7

Food

6.8

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Anonymous,May 2025

LIM - PTY

This was my first tome flying with this airline and needless to say, I was not impressed! The seats were not comfortable at all. You could feel the metal digging into your skin. Also, there was a kid behind me that kept putting his knees up on the seat and usually this doesn’t bother me, but I was able to feel his knees dig into my back every single time. The food was mediocore at best. There were no phone chargers on an almost 5 hour flight! Horrible experience. Will never fly with Copa airlines again!
United Airlines
7.4
Good
8,801 reviews
Copa Airlines
7.5
Good
1,453 reviews

Crew

8.1

Comfort

7.4

Entertainment

6.8

Boarding

7.7

Food

6.8

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Anonymous,May 2025

LIM - PTY

This was my first tome flying with this airline and needless to say, I was not impressed! The seats were not comfortable at all. You could feel the metal digging into your skin. Also, there was a kid behind me that kept putting his knees up on the seat and usually this doesn’t bother me, but I was able to feel his knees dig into my back every single time. The food was mediocore at best. There were no phone chargers on an almost 5 hour flight! Horrible experience. Will never fly with Copa airlines again!
American Airlines
7.2
Good
10,000 reviews
Copa Airlines
7.5
Good
1,453 reviews

Crew

8.1

Comfort

7.4

Entertainment

6.8

Boarding

7.7

Food

6.8

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Anonymous,May 2025

LIM - PTY

This was my first tome flying with this airline and needless to say, I was not impressed! The seats were not comfortable at all. You could feel the metal digging into your skin. Also, there was a kid behind me that kept putting his knees up on the seat and usually this doesn’t bother me, but I was able to feel his knees dig into my back every single time. The food was mediocore at best. There were no phone chargers on an almost 5 hour flight! Horrible experience. Will never fly with Copa airlines again!
Avianca
6.7
Okay
2,346 reviews
Copa Airlines
7.5
Good
1,453 reviews

Crew

8.1

Comfort

7.4

Entertainment

6.8

Boarding

7.7

Food

6.8

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Anonymous,May 2025

LIM - PTY

This was my first tome flying with this airline and needless to say, I was not impressed! The seats were not comfortable at all. You could feel the metal digging into your skin. Also, there was a kid behind me that kept putting his knees up on the seat and usually this doesn’t bother me, but I was able to feel his knees dig into my back every single time. The food was mediocore at best. There were no phone chargers on an almost 5 hour flight! Horrible experience. Will never fly with Copa airlines again!

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Key Largo to Panama flight route?

    This flight path from Key Largo to Panama was viewed by 239 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Key Largo to Panama one-way?

    The cheapest airlines for a one-way flight from Key Largo to Panama are Avianca ($102), Copa Airlines ($161), and American Airlines ($175).

  • What are the most popular routes from Key Largo to Panama?

    When deciding which route to take from Key Largo to Panama consider Miami - Panama City Tocumen Intl, Miami - Bocas Del Toro or Miami - David Enrique Malek as they are the most popular.

  • What are the most reliable airlines from Key Largo to Panama?

    The top 3 most reliable airlines when flying from Key Largo to Panama are Qatar Airways (100%), United Airlines (95%) and Copa Airlines (95%).

  • What are the cheapest flights from Key Largo to Panama?

    On average you can expect to pay $813 for a flight from Key Largo to Panama. The cheapest flight overall is $113 while the most popular route, (Miami - Panama City Tocumen Intl) is currently priced at $267.

  • Can I find deals for flights from Key Largo to Panama that include hotel bookings?

    Yes. In addition to deals on Key Largo to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Panama.

  • Can I find deals for business class flights from Key Largo to Panama?

    Yes. Cheapflights offers flight deals from Key Largo to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Panama?

    Currently, October is the cheapest month in which you can book a flight from Key Largo to Panama (average of $478). Flying from Key Largo to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Key Largo to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Key Largo to Panama

Discover the top 5 airlines that operate flights from Key Largo to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 16, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$127Average$390FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$265Average$361FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$279Average$410FlexibilityNo cancel feeOn-time69%
DeltaCheapest$283Average$401FlexibilityNo cancel feeOn-timeN/A
American AirlinesCheapest$290Average$402FlexibilityNo cancel feeOn-time71%

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