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$108+ Cheap flights from Key Largo, FL to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/16. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — PTY
Nov 19 — Nov 261
Wed 11/19
Wed 11/26
1 adult, Economy
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Find flight deals from Key Largo to Panama

Cheapest flights from Key Largo to Panama
Explore the most affordable flight options available from Key Largo to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 20, 2025.

This Copa Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/64:59 amMIA - PTY
Nonstop3h 07mCopa Airlines
Wed 12/176:11 pmPTY - MIA
Nonstop3h 11mCopa Airlines
Deal found 10/19$276
This Copa Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/117:31 amMIA - PTY
Nonstop3h 08mCopa Airlines
Fri 11/146:34 pmPTY - MIA
Nonstop3h 11mCopa Airlines
Deal found 10/19$286
This Cheapflightsfares deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/112:40 pmMIA - PTY
1 stop19h 50mAvianca
Tue 11/189:45 amPTY - MIA
1 stop17h 25mAvianca
Deal found 10/18$293
This Cheapflightsfares deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/318:00 amMIA - PTY
1 stop7h 00mAvianca
Tue 11/42:55 amPTY - MIA
1 stop8h 35mAvianca
Deal found 10/19$296
This Cheapflightsfares deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/316:10 amMIA - PTY
2 stops13h 45mAvianca
Sat 11/89:45 amPTY - MIA
1 stop7h 20mAvianca
Deal found 10/19$297
This Cheapflightsfares deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/245:35 amMIA - PTY
2 stops8h 00mAvianca
Sat 10/252:55 amPTY - MIA
1 stop14h 10mAvianca
Deal found 10/19$303
This Cheapflightsfares deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/268:00 amMIA - PTY
1 stop7h 00mAvianca
Tue 10/285:50 pmPTY - MIA
1 stop9h 20mAvianca
Deal found 10/19$305
This Copa Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/24:10 pmMIA - DAV
1 stop15h 40mCopa Airlines
Sat 11/89:53 amDAV - MIA
1 stop11h 52mCopa Airlines
Deal found 10/19$306
This Cheapflightsfares deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/15:50 pmMIA - PTY
2 stops17h 40mAvianca
Fri 11/72:55 amPTY - MIA
1 stop14h 10mAvianca
Deal found 10/19$306
This Kiwi.com deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/35:34 amMIA - PTY
Nonstop3h 06mCopa Airlines
Sat 12/69:33 pmPTY - MIA
Nonstop3h 12mCopa Airlines
Deal found 10/19$307
This Cheapflightsfares deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/215:00 pmMIA - PTY
1 stop8h 10mAvianca
Wed 10/223:20 amPTY - MIA
1 stop8h 10mAvianca
Deal found 10/20$309
This Mytrip deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/28:23 pmMIA - DAV
2 stops21h 01mMultiple Airlines
Sat 11/89:53 amDAV - MIA
1 stop8h 58mMultiple Airlines
Deal found 10/19$610

Cheap flight deals from Key Largo to Panama

Keep the following information in mind while searching for Key Largo to Panama flight deals. Data was last updated October 20, 2025.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$276
(Copa Airlines)

One-way from

$108
(Cheapflightsfares)

Popular in

December

Cheapest in

May

Average price

$303
Provider with most accurate pricing for Miami-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Miami-Panama City Tocumen Intl flights.
Search Deals
From Key Largo to Panama
Search Deals
One-way flight from Key Largo to Panama
Search Deals
Highest demand for flights based on searches. 14% potential increase in price ($51 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in October 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 20, 2025.
Use the filters below to find and compare flights from Key Largo to Panama that are best for you.

Fly from

Key Largo

Fly to

Panama

Route

Depart

Return

Price

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Wed 11/12

12:46 pm-3:54 pm

Nonstop3h 08m

Panama City Tocumen Intl

Wed 11/19

6:34 pm-9:45 pm

Nonstop3h 11m

$276

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Mon 11/3

4:59 am-8:06 am

Nonstop3h 07m

Panama City Tocumen Intl

Tue 11/18

10:47 am-1:58 pm

Nonstop3h 11m

$276

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Tue 12/2

4:59 am-8:06 am

Nonstop3h 07m

Panama City Tocumen Intl

Sat 12/6

8:25 am-11:36 am

Nonstop3h 11m

$276

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Thu 11/13

4:59 am-8:06 am

Nonstop3h 07m

Panama City Tocumen Intl

Tue 11/18

6:34 pm-9:45 pm

Nonstop3h 11m

$276

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Wed 12/10

4:59 am-8:06 am

Nonstop3h 07m

Panama City Tocumen Intl

Mon 12/15

6:34 pm-9:45 pm

Nonstop3h 11m

$276

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Fri 11/14

1:28 pm-4:36 pm

Nonstop3h 08m

Panama City Tocumen Intl

Fri 11/21

6:34 pm-9:45 pm

Nonstop3h 11m

$276

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Fri 11/7

12:46 pm-3:54 pm

Nonstop3h 08m

Panama City Tocumen Intl

Mon 12/8

9:33 pm-12:45 am

Nonstop3h 12m

$276

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Thu 11/27

1:28 pm-4:36 pm

Nonstop3h 08m

Panama City Tocumen Intl

Sat 12/6

3:39 pm-6:51 pm

Nonstop3h 12m

$276

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Sun 12/7

4:59 am-8:06 am

Nonstop3h 07m

Panama City Tocumen Intl

Tue 12/9

6:11 pm-9:22 pm

Nonstop3h 11m

$276

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Tue 11/18

4:10 pm-7:20 pm

Nonstop3h 10m

Panama City Tocumen Intl

Fri 11/21

9:33 pm-12:45 am

Nonstop3h 12m

$276

Flights are sorted by cheapest round-trip flights first.

Deals found on 10/20

Showing 1-10 of 41 results
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Best time to book a flight from Key Largo to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Panama

What is the cheapest month to book a flight from Key Largo to Panama?

Currently, July is the cheapest month in which you can book a flight from Key Largo to Panama (average of $132). Flying from Key Largo to Panama in March is currently the most expensive (average of $271). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to PA?

Find hourly flight availability from Key Largo to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated October 20, 2025.

A simple way to save on the total cost of your ticket is to fly from Key Largo to Panama in the evening. If you’re flexible enough to do this you can expect to save up to 54% on your trip compared to booking a flight in the morning.

What is the cheapest day to fly from Key Largo to Panama?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to Panama. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Key Largo to Panama flight should consider departing on Tuesday evenings when fares are most often at their lowest. Friday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Key Largo to Panama

Explore weekly flight availability from Key Largo to Panama. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated October 20, 2025.

The most flights from KE9 to PA0 are scheduled on a Saturday (14 on average). You will have fewer flight options on Wednesday, which is when the least amount of flights are scheduled (11 on average).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated October 20, 2025.
See what other customers who have flown with Copa Airlines, United Airlines, and American Airlines from Key Largo to Panama have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,557 reviews

Crew

8.1

Overall

7.6

Boarding

7.8

Food

6.8

Comfort

7.4

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
Copa Airlines
7.6
Good
1,557 reviews
Copa Airlines
7.6
Good
1,557 reviews

Crew

8.1

Overall

7.6

Boarding

7.8

Food

6.8

Comfort

7.4

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
United Airlines
7.4
Good
8,993 reviews
Copa Airlines
7.6
Good
1,557 reviews

Crew

8.1

Overall

7.6

Boarding

7.8

Food

6.8

Comfort

7.4

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
American Airlines
7.2
Good
11,026 reviews
Copa Airlines
7.6
Good
1,557 reviews

Crew

8.1

Overall

7.6

Boarding

7.8

Food

6.8

Comfort

7.4

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
Avianca
6.7
Okay
2,457 reviews
Copa Airlines
7.6
Good
1,557 reviews

Crew

8.1

Overall

7.6

Boarding

7.8

Food

6.8

Comfort

7.4

Entertainment

6.8

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Key Largo to Panama flight route?

    This flight path from Key Largo to Panama was viewed by 303 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Key Largo to Panama?

    A quick flight from Key Largo to Panama can take about 3h 08m. Copa Airlines provides one of the quickest options available for as low as $276. Key Largo and Panama are separated by a distance of 1156 mi. Most flights are nonstop.

  • What are the most popular routes from Key Largo to Panama?

    When deciding which route to take from Key Largo to Panama consider Miami - Panama City Tocumen Intl, Miami - David Enrique Malek or Miami - Bocas Del Toro as they are the most popular.

  • What are the most reliable airlines from Key Largo to Panama?

    The top 3 most reliable airlines when flying from Key Largo to Panama are Qatar Airways (96%), Copa Airlines (92%) and United Airlines (90%).

  • What are the cheapest flights from Key Largo to Panama?

    On average you can expect to pay $860 for a flight from Key Largo to Panama. The cheapest flight overall is $119 while the most popular route, (Miami - Panama City Tocumen Intl) is currently priced at $276.

  • Can I find deals for flights from Key Largo to Panama that include hotel bookings?

    Yes. In addition to deals on Key Largo to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Panama.

  • Can I find deals for business class flights from Key Largo to Panama?

    Yes. Cheapflights offers flight deals from Key Largo to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Panama?

    Currently, July is the cheapest month in which you can book a flight from Key Largo to Panama (average of $132). Flying from Key Largo to Panama in March is currently the most expensive (average of $271). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Key Largo to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Key Largo to Panama

Discover the top 4 airlines that operate flights from Key Largo to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 20, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$136Average$355FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$265Average$355FlexibilityNo cancel feeOn-time70%
American AirlinesCheapest$271Average$403FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$290Average$437FlexibilityNo cancel feeOn-time69%

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