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$127+ Cheap flights from Key Largo, FL to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/28. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — PTY
Jan 8 — Jan 151
Thu 1/8
Thu 1/15
1 adult, Economy
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Cheap flight deals from Key Largo to Panama

Cheapest flights from Key Largo to Panama
Explore the most affordable flight options available from Key Largo to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on December 9, 2025.

This Cheapflightsfares deal was found by Cheapflights users on 12/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/101:00 pmMIA - PTY
1 stop11h 40mAvianca
Wed 12/172:55 pmPTY - MIA
1 stop12h 15mAvianca
Deal found 12/6$385
This Cheapflightsfares deal was found by Cheapflights users on 12/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/124:50 pmMIA - PTY
2 stops17h 40mAvianca
Thu 1/295:50 pmPTY - MIA
1 stop9h 20mAvianca
Deal found 12/7$396
This Avianca deal was found by Cheapflights users on 12/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/97:00 amMIA - PTY
1 stop9h 55mAvianca
Sat 12/139:45 amPTY - MIA
2 stops11h 30mAvianca
Deal found 12/6$407
This Cheapflightsfares deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/111:00 pmMIA - PTY
1 stop12h 00mAvianca
Thu 1/292:55 pmPTY - MIA
1 stop12h 15mAvianca
Deal found 12/8$418
This Cheapflightsfares deal was found by Cheapflights users on 12/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/117:05 amMIA - PTY
1 stop11h 50mAvianca
Sat 12/139:45 amPTY - MIA
1 stop7h 20mAvianca
Deal found 12/7$420
This Gotogate deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/124:50 pmMIA - PTY
2 stops17h 40mAvianca
Mon 12/159:45 amPTY - MIA
2 stops11h 30mAvianca
Deal found 12/8$423
This flugladen.de deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure flugladen.de is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/147:05 amMIA - PTY
1 stop11h 50mAvianca
Tue 12/165:50 pmPTY - MIA
1 stop9h 20mAvianca
Deal found 12/9$431
This Cheapflightsfares deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/117:05 amMIA - PTY
1 stop11h 50mAvianca
Thu 12/182:55 pmPTY - MIA
1 stop7h 35mAvianca
Deal found 12/8$442
This Kiwi.com deal was found by Cheapflights users on 12/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/97:00 amMIA - PTY
1 stop9h 55mMultiple Airlines
Sat 12/136:34 pmPTY - MIA
Nonstop3h 11mMultiple Airlines
Deal found 12/6$449
This Copa Airlines deal was found by Cheapflights users on 12/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/185:27 pmMIA - DAV
1 stop14h 23mCopa Airlines
Mon 1/128:32 amDAV - MIA
1 stop13h 11mCopa Airlines
Deal found 12/9$588
This Copa Airlines deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/184:59 amMIA - DAV
1 stop12h 25mCopa Airlines
Tue 12/239:50 amDAV - MIA
1 stop9h 01mCopa Airlines
Deal found 12/8$603
This Kiwi.com deal was found by Cheapflights users on 12/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/192:03 pmMIA - DAV
1 stop17h 47mMultiple Airlines
Tue 12/239:50 amDAV - MIA
2 stops17h 20mMultiple Airlines
Deal found 12/8$811

Find flight deals from Key Largo to Panama

Keep the following information in mind while searching for Key Largo to Panama flight deals. Data was last updated December 9, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$289
(Kiwi.com)

One-way from

$127
(FlightHub)

Popular in

December

Cheapest in

May

Average price

$461
Provider with most accurate pricing for Miami-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Miami-Panama City Tocumen Intl flights.
Search Deals
From Key Largo to Panama
Search Deals
One-way flight from Key Largo to Panama
Search Deals
Highest demand for flights based on searches. 16% potential increase in price ($62 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($14 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 9, 2025.
Use the filters below to find and compare flights from Key Largo to Panama that are best for you.

Fly from

Key Largo

Fly to

Panama

Route

Depart

Return

Price

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Tue 5/5

6:24 am-8:30 am

Nonstop3h 06m

Panama City Tocumen Intl

Tue 5/12

9:33 pm-1:41 am

Nonstop3h 08m

$349

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Sat 3/14

6:27 pm-8:37 pm

Nonstop3h 10m

Panama City Tocumen Intl

Sun 3/22

9:33 pm-1:40 am

Nonstop3h 07m

$349

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Sun 3/15

6:26 am-8:30 am

Nonstop3h 04m

Panama City Tocumen Intl

Tue 3/24

6:16 pm-10:24 pm

Nonstop3h 08m

$349

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Fri 3/13

6:01 am-8:06 am

Nonstop3h 05m

Panama City Tocumen Intl

Mon 3/16

6:16 pm-10:24 pm

Nonstop3h 08m

$349

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Thu 2/5

5:29 pm-8:37 pm

Nonstop3h 08m

Panama City Tocumen Intl

Sun 2/8

6:15 pm-9:24 pm

Nonstop3h 09m

$349

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Sun 2/8

5:36 am-8:40 am

Nonstop3h 04m

Panama City Tocumen Intl

Sun 2/22

6:15 pm-9:24 pm

Nonstop3h 09m

$349

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Fri 3/13

5:10 pm-7:20 pm

Nonstop3h 10m

Panama City Tocumen Intl

Sat 3/21

6:34 pm-10:42 pm

Nonstop3h 08m

$349

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Wed 2/4

5:01 am-8:06 am

Nonstop3h 05m

Panama City Tocumen Intl

Sun 2/8

9:33 pm-12:37 am

Nonstop3h 04m

$349

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Thu 3/5

4:10 pm-7:20 pm

Nonstop3h 10m

Panama City Tocumen Intl

Thu 3/12

6:16 pm-10:24 pm

Nonstop3h 08m

$349

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Mon 2/9

4:12 pm-7:20 pm

Nonstop3h 08m

Panama City Tocumen Intl

Mon 2/23

3:39 pm-6:56 pm

Nonstop3h 17m

$349

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/8

Showing 1-10 of 39 results
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Best time to book a flight from Key Largo to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Panama

What is the cheapest month to book a flight from Key Largo to Panama?

Currently, July is the cheapest month in which you can book a flight from Key Largo to Panama (average of $152). Flying from Key Largo to Panama in December is currently the most expensive (average of $276). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to PA?

Find hourly flight availability from Key Largo to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated December 9, 2025.

A simple way to save on the total cost of your ticket is to fly from Key Largo to Panama in the evening. If you’re flexible enough to do this you can expect to save up to 54% on your trip compared to booking a flight in the morning.

What is the cheapest day to fly from Key Largo to Panama?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to Panama. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Key Largo to Panama flight should consider departing on Tuesday evenings when fares are most often at their lowest. Saturday mornings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Key Largo to Panama

Explore weekly flight availability from Key Largo to Panama. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated December 9, 2025.

The most flights from KE9 to PA0 are scheduled on a Tuesday (16 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (15 on average).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated December 9, 2025.
See what other customers who have flown with Copa Airlines, United Airlines, and American Airlines from Key Largo to Panama have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,555 reviews

Crew

8.1

Food

6.9

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Overall

7.6

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
Copa Airlines
7.6
Good
1,555 reviews
Copa Airlines
7.6
Good
1,555 reviews

Crew

8.1

Food

6.9

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Overall

7.6

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
United Airlines
7.4
Good
9,090 reviews
Copa Airlines
7.6
Good
1,555 reviews

Crew

8.1

Food

6.9

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Overall

7.6

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
American Airlines
7.2
Good
11,045 reviews
Copa Airlines
7.6
Good
1,555 reviews

Crew

8.1

Food

6.9

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Overall

7.6

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring
Avianca
6.6
Okay
2,478 reviews
Copa Airlines
7.6
Good
1,555 reviews

Crew

8.1

Food

6.9

Boarding

7.8

Comfort

7.4

Entertainment

6.8

Overall

7.6

Reviews

1 / 20
10.0
Excellent

Juan Pablo,Sep 2025

MEX - PTY

never better, had a very plesent trip to panama, cant say the same thing of my trip, from panama to santa cruz... it was very poor, unconftrable and boring

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Key Largo to Panama flight route?

    This flight path from Key Largo to Panama was viewed by 307 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Key Largo to Panama?

    A quick flight from Key Largo to Panama can take about 3h 06m. Copa Airlines provides one of the quickest options available for as low as $349. Key Largo and Panama are separated by a distance of 1156 mi. Most flights are nonstop.

  • What are the cheapest airlines to fly from Key Largo to Panama one-way?

    The cheapest airlines for a one-way flight from Key Largo to Panama are Avianca ($93), Copa Airlines ($116), and American Airlines ($140).

  • What are the most popular routes from Key Largo to Panama?

    When deciding which route to take from Key Largo to Panama consider Miami - Panama City Tocumen Intl, Miami - David Enrique Malek or Miami - Bocas Del Toro as they are the most popular.

  • What are the most reliable airlines from Key Largo to Panama?

    The top 3 most reliable airlines when flying from Key Largo to Panama are Qatar Airways (100%), United Airlines (92%) and Copa Airlines (91%).

  • What are the cheapest flights from Key Largo to Panama?

    On average you can expect to pay $845 for a flight from Key Largo to Panama. The cheapest flight overall is $136 while the most popular route, (Miami - Panama City Tocumen Intl) is currently priced at $333.

  • Can I find deals for flights from Key Largo to Panama that include hotel bookings?

    Yes. In addition to deals on Key Largo to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Panama.

  • Can I find deals for business class flights from Key Largo to Panama?

    Yes. Cheapflights offers flight deals from Key Largo to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Panama?

    Currently, July is the cheapest month in which you can book a flight from Key Largo to Panama (average of $152). Flying from Key Largo to Panama in December is currently the most expensive (average of $276). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Key Largo to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 4 airlines flying from Key Largo to Panama

Discover the top 4 airlines that operate flights from Key Largo to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 9, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$148Average$354FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$265Average$360FlexibilityNo cancel feeOn-time70%
American AirlinesCheapest$275Average$412FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$290Average$449FlexibilityNo cancel feeOn-time69%

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