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$121+ Cheap flights from Key Largo, FL to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/28. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — PTY
Aug 7 — Aug 141
Thu 8/7
Thu 8/14
1 adult, Economy
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Cheap flight deals from Key Largo to Panama

Keep the following information in mind while searching for Key Largo to Panama flight deals. Data was last updated August 2, 2025.

Round-trip from

$271
(Mytrip)

One-way from

$121
(Kiwi.com)

Popular in

December

Cheapest in

May

Average price

$347
From Key Largo to Panama
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One-way flight from Key Largo to Panama
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Highest demand for flights based on searches. 12% potential increase in price ($45 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($13 potential savings vs. average RT price).
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Average for round-trip flights in August 2025
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Find flight deals from Key Largo to Panama

Cheapest flights from Key Largo to Panama
Explore the most affordable flight options available from Key Largo to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 2, 2025.

This Mytrip deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/47:55 amMIA - PTY
1 stop9h 35mAvianca
Sun 9/1410:05 pmPTY - MIA
1 stop10h 45mAvianca
Deal found 8/1$271
This American Airlines deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/812:23 pmMIA - PTY
Nonstop3h 08mAmerican Airlines
Fri 9/123:31 pmPTY - MIA
Nonstop3h 08mAmerican Airlines
Deal found 8/2$276
This Delta deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/56:00 amMIA - PTY
1 stop7h 50mDelta
Wed 9/102:05 pmPTY - MIA
1 stop9h 19mDelta
Deal found 8/2$290
This Copa Airlines deal was found by Cheapflights users on 7/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/176:29 pmMIA - DAV
1 stop15h 29mCopa Airlines
Sun 10/198:18 amDAV - MIA
1 stop5h 17mCopa Airlines
Deal found 7/31$359
This Kiwi.com deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/315:00 pmMIA - DAV
2 stops16h 58mMultiple Airlines
Sun 9/76:18 pmDAV - MIA
1 stop6h 18mMultiple Airlines
Deal found 8/1$596
This United Airlines deal was found by Cheapflights users on 8/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/158:40 amMIA - DAV
2 stops49h 18mUnited Airlines
Mon 9/229:42 amDAV - MIA
2 stops35h 33mUnited Airlines
Deal found 8/1$832
This Kiwi.com deal was found by Cheapflights users on 8/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/82:05 amMIA - BOC
2 stops15h 55mMultiple Airlines
Fri 1/29:15 amBOC - MIA
1 stop12h 09mMultiple Airlines
Deal found 8/2$899

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 2, 2025.
Use the filters below to find and compare flights from Key Largo to Panama that are best for you.

Fly from

Key Largo

Fly to

Panama

Route

Depart

Return

Price

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Thu 9/4

7:55 am-4:30 pm

1 stop9h 35m

Panama City Tocumen Intl

Sun 9/14

10:05 pm-9:50 am

1 stop10h 45m

$271

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Mon 9/8

12:23 pm-2:31 pm

Nonstop3h 08m

Panama City Tocumen Intl

Fri 9/12

3:31 pm-7:39 pm

Nonstop3h 08m

$276

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Fri 9/5

6:00 am-12:50 pm

1 stop7h 50m

Panama City Tocumen Intl

Tue 9/16

2:10 pm-12:23 am

1 stop9h 13m

$290

MiamiDavid

MIA - DAV

MIADAV

Miami

Fri 10/17

6:29 pm-8:58 am

1 stop15h 29m

David Enrique Malek

Sun 10/19

8:18 am-2:35 pm

1 stop5h 17m

$359

MiamiDavid

MIA - DAV

MIADAV

Miami

Sun 8/31

5:00 pm-8:58 am

2 stops16h 58m

David Enrique Malek

Sun 9/7

6:18 pm-1:36 am

1 stop6h 18m

$596

MiamiDavid

MIA - DAV

MIADAV

Miami

Mon 9/15

8:40 am-8:58 am

2 stops49h 18m

David Enrique Malek

Mon 9/22

9:42 am-10:15 pm

2 stops35h 33m

$832

MiamiBocas del Toro

MIA - BOC

MIABOC

Miami

Sat 11/8

2:05 am-6:00 pm

2 stops15h 55m

Bocas Del Toro

Fri 1/2

9:15 am-9:24 pm

1 stop12h 09m

$899

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Thu 8/28

5:35 am-12:35 pm

2 stops8h 00m

$121

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Thu 10/23

6:27 am-8:30 am

Nonstop3h 03m

$159

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Wed 9/24

10:45 am-12:55 pm

Nonstop3h 10m

$160

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/2

Showing 1-10 of 12 results
1
2

Best time to book a flight from Key Largo to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Panama

What is the cheapest month to book a flight from Key Largo to Panama?

Currently, October is the cheapest month in which you can book a flight from Key Largo to Panama (average of $478). Flying from Key Largo to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to PA?

Find hourly flight availability from Key Largo to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 2, 2025.

When flying from Key Largo to Panama, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.

What is the cheapest day to fly from Key Largo to Panama?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to Panama. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Key Largo to Panama flight should consider departing on Sunday evenings when fares are most often at their lowest. Sunday afternoons flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Key Largo to Panama

Explore weekly flight availability from Key Largo to Panama. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated August 2, 2025.

The most flights from KE9 to PA0 are scheduled on a Friday (16 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (12 on average).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated August 2, 2025.
See what other customers who have flown with Delta, Copa Airlines, and United Airlines from Key Largo to Panama have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,983 reviews

Entertainment

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Comfort

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Delta
8.0
Very good
7,983 reviews
Delta
8.0
Very good
7,983 reviews

Entertainment

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Comfort

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Copa Airlines
7.5
Good
1,493 reviews
Delta
8.0
Very good
7,983 reviews

Entertainment

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Comfort

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
United Airlines
7.4
Good
8,904 reviews
Delta
8.0
Very good
7,983 reviews

Entertainment

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Comfort

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
American Airlines
7.2
Good
10,000 reviews
Delta
8.0
Very good
7,983 reviews

Entertainment

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Comfort

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.
Avianca
6.7
Okay
2,388 reviews
Delta
8.0
Very good
7,983 reviews

Entertainment

7.9

Overall

8.0

Crew

8.5

Boarding

8.2

Comfort

7.9

Food

7.3

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Key Largo to Panama flight route?

    This flight path from Key Largo to Panama was viewed by 314 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • What are the cheapest airlines to fly from Key Largo to Panama one-way?

    The cheapest airlines for a one-way flight from Key Largo to Panama are Avianca ($121), Copa Airlines ($159), and American Airlines ($160).

  • What are the most popular routes from Key Largo to Panama?

    When deciding which route to take from Key Largo to Panama consider Miami - Panama City Tocumen Intl, Miami - David Enrique Malek or Miami - Bocas Del Toro as they are the most popular.

  • What are the most reliable airlines from Key Largo to Panama?

    The top 3 most reliable airlines when flying from Key Largo to Panama are Qatar Airways (100%), Copa Airlines (92%) and United Airlines (91%).

  • What are the cheapest flights from Key Largo to Panama?

    On average you can expect to pay $1,020 for a flight from Key Largo to Panama. The cheapest flight overall is $124 while the most popular route, (Miami - Panama City Tocumen Intl) is currently priced at $281.

  • Can I find deals for flights from Key Largo to Panama that include hotel bookings?

    Yes. In addition to deals on Key Largo to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Panama.

  • Can I find deals for business class flights from Key Largo to Panama?

    Yes. Cheapflights offers flight deals from Key Largo to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Panama?

    Currently, October is the cheapest month in which you can book a flight from Key Largo to Panama (average of $478). Flying from Key Largo to Panama in December is currently the most expensive (average of $634). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Key Largo to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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Top 5 airlines flying from Key Largo to Panama

Discover the top 5 airlines that operate flights from Key Largo to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$130Average$381FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$265Average$363FlexibilityNo cancel feeOn-time70%
American AirlinesCheapest$283Average$402FlexibilityNo cancel feeOn-time71%
DeltaCheapest$283Average$462FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$290Average$412FlexibilityNo cancel feeOn-time69%

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