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$161+ Cheap flights from Key Largo, FL to Panama

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/8. Fares are subject to change and may not be available on all flights or dates of travel.
MIA — PTY
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Key Largo to Panama

Cheapest flights from Key Largo to Panama
Explore the most affordable flight options available from Key Largo to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This Gotogate deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/314:50 pm
MIA
-
PTY
2 stops17h 40m
Avianca
Tue 2/39:45 am
PTY
-
MIA
1 stop7h 20m
Avianca
Deal found 1/27$330
This Avianca deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/32:05 am
MIA
-
PTY
1 stop6h 45m
Avianca
Mon 3/99:45 am
PTY
-
MIA
2 stops11h 30m
Avianca
Deal found 1/27$331
This Mytrip deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/154:50 pm
MIA
-
PTY
3 stops16h 00m
Avianca
Sat 2/212:55 pm
PTY
-
MIA
1 stop12h 15m
Avianca
Deal found 1/27$332
This Gotogate deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/184:50 pm
MIA
-
PTY
3 stops16h 00m
Avianca
Sun 2/229:45 am
PTY
-
MIA
1 stop7h 20m
Avianca
Deal found 1/28$333
This Gotogate deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/83:50 pm
MIA
-
PTY
1 stop11h 05m
Avianca
Sun 7/125:30 am
PTY
-
MIA
1 stop5h 40m
Avianca
Deal found 1/27$334
This Priceline deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/307:00 am
MIA
-
PTY
1 stop17h 40m
Avianca
Sun 2/12:55 pm
PTY
-
MIA
1 stop12h 15m
Avianca
Deal found 1/28$336
This Aviatur deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Aviatur is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/24:35 pm
MIA
-
PTY
1 stop8h 05m
Avianca
Sun 3/295:55 pm
PTY
-
MIA
1 stop23h 10m
Avianca
Deal found 1/28$337
This Priceline deal was found by Cheapflights users on 1/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/124:50 pm
MIA
-
PTY
2 stops17h 40m
Avianca
Mon 2/169:45 am
PTY
-
MIA
1 stop7h 20m
Avianca
Deal found 1/29$338
This Avianca deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/56:00 pm
MIA
-
PTY
2 stops8h 55m
Avianca
Wed 7/155:30 am
PTY
-
MIA
1 stop5h 40m
Avianca
Deal found 1/27$339
This Priceline deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/204:50 pm
MIA
-
PTY
3 stops16h 00m
Avianca
Sun 2/225:50 pm
PTY
-
MIA
1 stop9h 20m
Avianca
Deal found 1/27$340
This Priceline deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/252:40 pm
MIA
-
PTY
2 stops18h 10m
Avianca
Wed 3/49:45 am
PTY
-
MIA
2 stops11h 30m
Avianca
Deal found 1/28$341
This Kiwi.com deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/12:05 am
MIA
-
PTY
1 stop6h 45m
Avianca
Thu 3/122:55 am
PTY
-
MIA
1 stop8h 35m
Avianca
Deal found 1/28$342

Find flight deals from Key Largo to Panama

Keep the following information in mind while searching for Key Largo to Panama flight deals. Data was last updated January 29, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$330
(TravelUp)

One-way from

$161
(Copa Airlines)

Popular in

December

Cheapest in

May

Average price

$377
Provider with most accurate pricing for Miami-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Miami-Panama City Tocumen Intl flights.
Search Deals
From Key Largo to Panama
Search Deals
One-way flight from Key Largo to Panama
Search Deals
Highest demand for flights based on searches. 18% potential increase in price ($69 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Key Largo to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Key Largo to Panama that are best for you.

Fly from

Key Largo

Fly to

Panama

Route

Depart

Return

Price

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Thu 2/26

4:50 pm-10:30 am

2 stops17h 40m

Panama City Tocumen Intl

Sun 3/1

5:50 pm-3:10 am

1 stop9h 20m

$338

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Sat 3/28

5:35 pm-2:15 pm

1 stop21h 40m

Panama City Tocumen Intl

Wed 4/15

5:30 am-2:00 pm

2 stops7h 30m

$345

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Fri 3/20

5:50 pm-10:30 am

2 stops17h 40m

Panama City Tocumen Intl

Tue 3/24

7:50 pm-1:55 pm

2 stops17h 05m

$349

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Fri 3/20

6:01 am-8:06 am

Nonstop3h 05m

Panama City Tocumen Intl

Mon 3/23

6:34 pm-10:42 pm

Nonstop3h 08m

$350

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Tue 4/7

5:14 pm-7:20 pm

Nonstop3h 06m

Panama City Tocumen Intl

Thu 4/23

6:15 pm-10:23 pm

Nonstop3h 08m

$350

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Fri 3/20

6:27 pm-8:37 pm

Nonstop3h 10m

Panama City Tocumen Intl

Tue 3/24

3:39 pm-7:55 pm

Nonstop3h 16m

$350

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Tue 4/7

5:14 pm-7:20 pm

Nonstop3h 06m

Panama City Tocumen Intl

Wed 4/15

6:34 pm-10:42 pm

Nonstop3h 08m

$350

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Sat 4/18

5:14 pm-7:20 pm

Nonstop3h 06m

Panama City Tocumen Intl

Sat 4/25

6:15 pm-10:23 pm

Nonstop3h 08m

$350

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Thu 3/19

5:10 pm-7:20 pm

Nonstop3h 10m

Panama City Tocumen Intl

Sun 3/29

6:34 pm-10:42 pm

Nonstop3h 08m

$350

MiamiPanama City

MIA - PTY

MIAPTY

Miami

Wed 4/8

6:31 pm-8:37 pm

Nonstop3h 06m

Panama City Tocumen Intl

Sat 4/11

6:15 pm-10:23 pm

Nonstop3h 08m

$350

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/26

Showing 1-10 of 43 results
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Best time to book a flight from Key Largo to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Key Largo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Key Largo to Panama

What is the cheapest month to book a flight from Key Largo to Panama?

Currently, July is the cheapest month in which you can book a flight from Key Largo to Panama (average of $166). Flying from Key Largo to Panama in March is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from KE9 to PA?

Find hourly flight availability from Key Largo to Panama. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated January 29, 2026.

A simple way to save on the total cost of your ticket is to fly from Key Largo to Panama at noon. If you’re flexible enough to do this you can expect to save up to 18% on your trip compared to booking a flight in the evening.

What is the cheapest day to fly from Key Largo to Panama?

Use this chart to determine the cheapest time to fly round-trip from Key Largo to Panama. Price data was last updated on January 24, 2026.

Travelers seeking maximum savings on their Key Largo to Panama flight should consider departing on Tuesday at noon when fares are most often at their lowest. Tuesday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Weekly flight availability from Key Largo to Panama

Explore weekly flight availability from Key Largo to Panama. Discover flights operating on different days of the week, giving you the flexibility to choose a travel day that best fits your plans. Compare info to find the most convenient option for your journey. Data last updated January 29, 2026.

The most flights from KE9 to PA0 are scheduled on a Thursday (16 on average). You will have fewer flight options on Monday, which is when the least amount of flights are scheduled (10 on average).

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated January 29, 2026.
See what other customers who have flown with Copa Airlines, United Airlines, and American Airlines from Key Largo to Panama have to say. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.5
Good
1,560 reviews

Comfort

7.4

Crew

8.1

Boarding

7.8

Food

6.8

Entertainment

6.8

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Copa Airlines
7.5
Good
1,560 reviews
Copa Airlines
7.5
Good
1,560 reviews

Comfort

7.4

Crew

8.1

Boarding

7.8

Food

6.8

Entertainment

6.8

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
United Airlines
7.4
Good
9,215 reviews
Copa Airlines
7.5
Good
1,560 reviews

Comfort

7.4

Crew

8.1

Boarding

7.8

Food

6.8

Entertainment

6.8

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
American Airlines
7.2
Good
11,206 reviews
Copa Airlines
7.5
Good
1,560 reviews

Comfort

7.4

Crew

8.1

Boarding

7.8

Food

6.8

Entertainment

6.8

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.
Avianca
6.6
Okay
2,492 reviews
Copa Airlines
7.5
Good
1,560 reviews

Comfort

7.4

Crew

8.1

Boarding

7.8

Food

6.8

Entertainment

6.8

Overall

7.5

Reviews

1 / 20
2.0
Mediocre

Juan,Dec 2025

EZE - PTY

The outbound flight from Boston was awful. The handicapped services were the worst i have ever seen. NEVER AGAIN. THIS WAS NOT WORTH ANYWHERE NEAR $4K.

Related info for your journey

Find useful and relevant information for your journey from Key Largo to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How popular is this Key Largo to Panama flight route?

    This flight path from Key Largo to Panama was viewed by 317 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Key Largo to Panama?

    A quick flight from Key Largo to Panama can take about 3h 05m. Avianca provides one of the quickest options available for as low as $350. Key Largo and Panama are separated by a distance of 1156 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • What are the cheapest airlines to fly from Key Largo to Panama one-way?

    The cheapest airlines for a one-way flight from Key Largo to Panama are Avianca ($92), Copa Airlines ($123), and American Airlines ($145).

  • What are the most popular routes from Key Largo to Panama?

    When deciding which route to take from Key Largo to Panama consider Miami - Panama City Tocumen Intl, Miami - David Enrique Malek or Miami - Bocas Del Toro as they are the most popular.

  • What are the most reliable airlines from Key Largo to Panama?

    The top 3 most reliable airlines when flying from Key Largo to Panama are Qatar Airways (96%), United Airlines (95%) and Copa Airlines (92%).

  • What are the cheapest flights from Key Largo to Panama?

    On average you can expect to pay $830 for a flight from Key Largo to Panama. The cheapest flight overall is $150 while the most popular route, (Miami - Panama City Tocumen Intl) is currently priced at $333.

  • Can I find deals for flights from Key Largo to Panama that include hotel bookings?

    Yes. In addition to deals on Key Largo to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Key Largo to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Key Largo to Panama.

  • Can I find deals for business class flights from Key Largo to Panama?

    Yes. Cheapflights offers flight deals from Key Largo to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Key Largo to Panama?

    Currently, July is the cheapest month in which you can book a flight from Key Largo to Panama (average of $166). Flying from Key Largo to Panama in March is currently the most expensive (average of $278). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Key Largo to Panama

See prices for flight routes from nearby airports that may be better suited for you.
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West Palm Beach to Liberia flights
Tampa to Managua flights
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Jacksonville to Guatemala City flights
Jacksonville to Philip S.W.Goldson flights
Pensacola to San José flights
Sarasota to Panama City flights
Jacksonville to San Salvador flights
Fort Myers to Philip S.W.Goldson flights
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Top 4 airlines flying from Key Largo to Panama

Discover the top 4 airlines that operate flights from Key Largo to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$127Average$348FlexibilityNo cancel feeOn-time71%
Copa AirlinesCheapest$265Average$365FlexibilityNo cancel feeOn-time70%
American AirlinesCheapest$275Average$429FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$290Average$661FlexibilityNo cancel feeOn-time69%

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