$172+ Cheap flights from Missouri to Grand Cayman
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/27. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GCM
Mai 24 — Mai 311
Round-trip
1 adult, Economy
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Cheapest flights from Missouri to Grand CaymanExplore the most affordable flight options available from Missouri to Grand Cayman. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2026.
Explore the most affordable flight options available from Missouri to Grand Cayman. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 24, 2026.
This Air Canada deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 6/61:05 pm
STL
- GCM
2 stops46h 20m
Air Canada
Sa 6/1310:55 am
GCM
- STL
1 stop25h 11m
Air Canada
Deal found 4/21![Air Canada logo]()
$419
This Air Canada deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
So 8/238:55 am
STL
- GCM
1 stop26h 30m
Air Canada
Do 8/2712:25 pm
GCM
- STL
1 stop7h 42m
Air Canada
Deal found 4/20![Air Canada logo]()
$445
This Air Canada deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 8/112:10 pm
STL
- GCM
2 stops47h 15m
Air Canada
Sa 8/810:40 am
GCM
- STL
1 stop9h 27m
Air Canada
Deal found 4/19![Air Canada logo]()
$448
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Di 8/45:39 am
MCI
- GCM
1 stop5h 52m
Delta
Di 8/1812:56 pm
GCM
- MCI
1 stop10h 56m
Delta
Deal found 4/24![Delta logo]()
$457
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Di 7/286:15 pm
MCI
- GCM
2 stops16h 46m
American Airlines
Di 8/112:10 pm
GCM
- MCI
2 stops20h 21m
American Airlines
Deal found 4/24![American Airlines logo]()
$462
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 7/256:12 pm
STL
- GCM
2 stops16h 49m
American Airlines
Mi 7/2912:02 pm
GCM
- STL
2 stops11h 30m
American Airlines
Deal found 4/23![American Airlines logo]()
$462
This Air Canada deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 9/98:55 am
STL
- GCM
1 stop26h 35m
Air Canada
Do 9/1712:25 pm
GCM
- STL
1 stop25h 35m
Air Canada
Deal found 4/19![Air Canada logo]()
$463
This Air Canada deal was found by Cheapflights users on 4/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 9/98:55 am
STL
- GCM
1 stop26h 35m
Air Canada
Mo 9/1412:25 pm
GCM
- STL
2 stops54h 16m
Air Canada
Deal found 4/19![Air Canada logo]()
$466
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Di 6/235:14 am
STL
- GCM
1 stop6h 16m
American Airlines
Di 6/3012:01 pm
GCM
- STL
1 stop22h 34m
American Airlines
Deal found 4/22![American Airlines logo]()
$470
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 10/316:08 pm
STL
- GCM
1 stop20h 09m
American Airlines
Fr 11/64:10 pm
GCM
- STL
1 stop22h 07m
American Airlines
Deal found 4/22![American Airlines logo]()
$479
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 9/45:14 pm
MCI
- GCM
2 stops18h 10m
American Airlines
Fr 9/111:20 pm
GCM
- MCI
2 stops21h 22m
American Airlines
Deal found 4/24![American Airlines logo]()
$497
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 12/116:40 am
MCI
- GCM
1 stop6h 44m
American Airlines
Fr 12/183:35 pm
GCM
- MCI
1 stop22h 42m
American Airlines
Deal found 4/22![American Airlines logo]()
$500
Best flights from Missouri to Grand CaymanDiscover carefully curated flight deals from Missouri to Grand Cayman that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 24, 2026.
Discover carefully curated flight deals from Missouri to Grand Cayman that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 24, 2026.
This Air Canada deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
So 8/238:55 am
STL
- GCM
1 stop26h 30m
Air Canada
Do 8/2712:25 pm
GCM
- STL
1 stop7h 42m
Air Canada
Deal found 4/20![Air Canada logo]()
$445
This Delta deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Di 8/45:39 am
MCI
- GCM
1 stop5h 52m
Delta
Di 8/1812:56 pm
GCM
- MCI
1 stop10h 56m
Delta
Deal found 4/24![Delta logo]()
$457
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Di 8/45:20 pm
MCI
- GCM
2 stops17h 40m
American Airlines
Di 8/1812:00 pm
GCM
- MCI
2 stops9h 53m
American Airlines
Deal found 4/24![American Airlines logo]()
$462
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 7/256:12 pm
STL
- GCM
2 stops16h 49m
American Airlines
Mi 7/292:45 pm
GCM
- STL
1 stop9h 11m
American Airlines
Deal found 4/22![American Airlines logo]()
$462
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Do 7/235:39 am
MCI
- GCM
1 stop5h 52m
Delta
Di 7/2812:56 pm
GCM
- MCI
1 stop11h 01m
Delta
Deal found 4/23![Delta logo]()
$492
This American Airlines deal was found by Cheapflights users on 4/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 9/45:14 pm
MCI
- GCM
2 stops18h 10m
American Airlines
Fr 9/111:20 pm
GCM
- MCI
1 stop10h 18m
American Airlines
Deal found 4/24![American Airlines logo]()
$497
This Delta deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 9/45:40 am
MCI
- GCM
1 stop6h 01m
Delta
Fr 9/1112:55 pm
GCM
- MCI
1 stop10h 57m
Delta
Deal found 4/22![Delta logo]()
$518
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
So 7/266:12 pm
STL
- GCM
1 stop17h 13m
American Airlines
Mi 7/292:45 pm
GCM
- STL
1 stop9h 11m
American Airlines
Deal found 4/23![American Airlines logo]()
$502
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Di 8/116:00 am
STL
- GCM
1 stop5h 41m
Delta
Fr 8/1412:56 pm
GCM
- STL
1 stop10h 41m
Delta
Deal found 4/21![Delta logo]()
$518
This Delta deal was found by Cheapflights users on 4/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Di 6/236:00 am
STL
- GCM
1 stop5h 34m
Delta
Di 6/3012:59 pm
GCM
- STL
1 stop10h 57m
Delta
Deal found 4/21![Delta logo]()
$518
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 5/155:00 am
MCI
- GCM
1 stop6h 00m
American Airlines
Fr 5/292:42 pm
GCM
- MCI
1 stop18h 16m
American Airlines
Deal found 4/23![American Airlines logo]()
$536
This Delta deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 6/66:00 am
STL
- GCM
1 stop5h 54m
Delta
Sa 6/1312:59 pm
GCM
- STL
1 stop8h 41m
Delta
Deal found 4/23![Delta logo]()
$553
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 5/206:00 am
STL
- GCM
1 stop5h 54m
Delta
Mi 5/271:19 pm
GCM
- STL
1 stop10h 40m
Delta
Deal found 4/20![Delta logo]()
$579
Last-minute flights from Missouri to Grand CaymanDiscover last-minute flight deals from Missouri to Grand Cayman. Data last updated April 24, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Grand Cayman. Data last updated April 24, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 5/156:28 pm
MCI
- GCM
1 stop17h 03m
American Airlines
Fr 5/295:11 pm
GCM
- MCI
2 stops15h 24m
American Airlines
Deal found 4/23![American Airlines logo]()
$497
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fr 5/155:00 am
MCI
- GCM
1 stop6h 00m
American Airlines
Sa 5/2312:31 pm
GCM
- MCI
1 stop10h 36m
American Airlines
Deal found 4/23![American Airlines logo]()
$527
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
So 5/176:54 pm
STL
- GCM
2 stops16h 06m
American Airlines
Fr 5/2212:33 pm
GCM
- STL
1 stop11h 11m
American Airlines
Deal found 4/22![American Airlines logo]()
$567
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 5/206:28 pm
MCI
- GCM
2 stops16h 33m
American Airlines
Mi 5/272:42 pm
GCM
- MCI
1 stop9h 44m
American Airlines
Deal found 4/23![American Airlines logo]()
$592
This United Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 5/206:10 am
MCI
- GCM
1 stop6h 20m
United Airlines
Mi 5/271:35 pm
GCM
- MCI
1 stop20h 28m
United Airlines
Deal found 4/23![United Airlines logo]()
$598
This Southwest deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mi 5/208:45 pm
STL
- GCM
2 stops15h 25m
Southwest
Mi 5/271:05 pm
GCM
- STL
1 stop9h 30m
Southwest
Deal found 4/20![Southwest logo]()
$598
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 5/235:12 pm
MCI
- GCM
2 stops17h 49m
American Airlines
Mi 5/275:12 pm
GCM
- MCI
2 stops18h 14m
American Airlines
Deal found 4/22![American Airlines logo]()
$559
This American Airlines deal was found by Cheapflights users on 4/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 5/235:12 pm
MCI
- GCM
2 stops17h 49m
American Airlines
Sa 5/3012:31 pm
GCM
- MCI
1 stop22h 55m
American Airlines
Deal found 4/23![American Airlines logo]()
$599
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Di 5/267:00 am
STL
- GCM
2 stops9h 11m
American Airlines
So 5/315:11 pm
GCM
- STL
2 stops17h 26m
American Airlines
Deal found 4/20![American Airlines logo]()
$589
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 5/307:20 pm
STL
- GCM
2 stops16h 10m
American Airlines
Sa 6/612:40 pm
GCM
- STL
1 stop11h 19m
American Airlines
Deal found 4/22![American Airlines logo]()
$497
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 5/306:00 am
STL
- GCM
1 stop5h 54m
Delta
Sa 6/61:19 pm
GCM
- STL
1 stop10h 40m
Delta
Deal found 4/20![Delta logo]()
$579
This Air Canada deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 5/301:05 pm
STL
- GCM
2 stops46h 20m
Air Canada
Sa 6/610:55 am
GCM
- STL
1 stop25h 11m
Air Canada
Deal found 4/20![Air Canada logo]()
$580
One-way flights from Missouri to Grand CaymanSearch for one-way flight options from Missouri to Grand Cayman. Find affordable one-way fares based on user searches. Data last updated April 24, 2026.
Search for one-way flight options from Missouri to Grand Cayman. Find affordable one-way fares based on user searches. Data last updated April 24, 2026.
This Expedia deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 6/271:20 pm
STL
- GCM
2 stops46h 05m
Air Canada
Deal found 4/22![Air Canada logo]()
$172
This American Airlines deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 6/276:24 pm
STL
- GCM
1 stop21h 47m
American Airlines
Deal found 4/22![American Airlines logo]()
$195
This Delta deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 6/275:39 am
MCI
- GCM
1 stop5h 55m
Delta
Deal found 4/20![Delta logo]()
$237
This American Airlines deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 6/275:21 pm
MCI
- GCM
2 stops18h 09m
American Airlines
Deal found 4/20![American Airlines logo]()
$243
This Kiwi.com deal was found by Cheapflights users on 4/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 6/278:08 pm
STL
- GCM
3 stops15h 27m
Multiple Airlines
Deal found 4/22![Multiple Airlines logo]()
$299
This Kiwi.com deal was found by Cheapflights users on 4/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sa 6/271:45 pm
MCI
- GCM
3 stops21h 50m
Multiple Airlines
Deal found 4/20![Multiple Airlines logo]()
$360
Find flight deals from Missouri to Grand Cayman
Keep the following information in mind while searching for Missouri to Grand Cayman flight deals. Data was last updated April 24, 2026.
Round-trip from | $419 (Air Canada) |
|---|---|
One-way from | $172 (Expedia) |
Popular in | December |
Cheapest in | September |
Average price | $497 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Grand Cayman that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2026.
Use the filters below to find and compare flights from Missouri to Grand Cayman that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
So 8/23
8:55 am-11:25 am
1 stop26h 30m
George Town Owen Roberts Intl
Do 8/27
12:25 pm-8:07 pm
1 stop7h 42m
$445
Kansas CityGeorge Town
MCI - GCM
MCIGCM
Kansas City
Di 8/4
5:39 am-11:31 am
1 stop5h 52m
George Town Owen Roberts Intl
Di 8/18
12:56 pm-11:52 pm
1 stop10h 56m
$457
Kansas CityGeorge Town
MCI - GCM
MCIGCM
Kansas City
Di 8/4
5:20 pm-11:00 am
2 stops17h 40m
George Town Owen Roberts Intl
Di 8/18
12:00 pm-9:53 pm
2 stops9h 53m
$462
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sa 7/25
6:12 pm-11:01 am
2 stops16h 49m
George Town Owen Roberts Intl
Mi 7/29
2:45 pm-11:56 pm
1 stop9h 11m
$462
Kansas CityGeorge Town
MCI - GCM
MCIGCM
Kansas City
Do 7/23
5:39 am-11:31 am
1 stop5h 52m
George Town Owen Roberts Intl
Di 7/28
12:56 pm-11:57 pm
1 stop11h 01m
$492
Kansas CityGeorge Town
MCI - GCM
MCIGCM
Kansas City
Fr 9/4
5:14 pm-11:24 am
2 stops18h 10m
George Town Owen Roberts Intl
Fr 9/11
1:20 pm-11:38 pm
1 stop10h 18m
$497
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
So 7/26
6:12 pm-11:25 am
1 stop17h 13m
George Town Owen Roberts Intl
Mi 7/29
2:45 pm-11:56 pm
1 stop9h 11m
$502
Kansas CityGeorge Town
MCI - GCM
MCIGCM
Kansas City
Fr 9/4
5:40 am-11:41 am
1 stop6h 01m
George Town Owen Roberts Intl
Fr 9/11
12:55 pm-11:52 pm
1 stop10h 57m
$518
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Di 8/11
6:00 am-11:41 am
1 stop5h 41m
George Town Owen Roberts Intl
Fr 8/14
12:56 pm-11:37 pm
1 stop10h 41m
$518
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Di 6/23
6:00 am-11:34 am
1 stop5h 34m
George Town Owen Roberts Intl
Di 6/30
12:59 pm-11:56 pm
1 stop10h 57m
$518
Showing 1-10 of 21 resultsSorted by cheapest first
Best time to book a flight from Missouri to Grand Cayman
Have a flexible travel schedule? Discover the best time to fly to Grand Cayman from Missouri with our price prediction graph.
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MCI-GCM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Grand Cayman
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STL-GCM
MCI-GCM
How far ahead should I book a flight from Missouri to Grand Cayman?
To ensure you get the cheapest price possible for a flight from Missouri to Grand Cayman, you should look to book at least 87 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
What is the cheapest month to book a flight from Missouri to Grand Cayman?
Currently, February is the cheapest month in which you can book a flight from Missouri to Grand Cayman (average of $108). Flying from Missouri to Grand Cayman in October is currently the most expensive (average of $458). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Missouri to Grand Cayman. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Missouri to Grand Cayman
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Grand Cayman by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Grand Cayman by cabin class
Find flights from Missouri to Grand Cayman, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and Grand Cayman flights
Browse other Missouri and Grand Cayman flight options. Last updated on April 24, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from Missouri to Grand Cayman
Discover the top 4 airlines that operate flights from Missouri to Grand Cayman. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 24, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$190 | Average$523 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$364 | Average$628 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$421 | Average$588 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$429 | Average$585 | FlexibilityNo cancel fee | On-time63% |