$157+ Cheap flights from Missouri to Grand Cayman
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/27. Fares are subject to change and may not be available on all flights or dates of travel.
STL — GCM
Aug 24 — Aug 311
Round-trip
1 adult, Economy
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Cheapest flights from Missouri to Grand CaymanExplore the most affordable flight options available from Missouri to Grand Cayman. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 25, 2026.
Explore the most affordable flight options available from Missouri to Grand Cayman. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 25, 2026.
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/215:01 am
MCI
- GCM
1 stop8h 09m
American Airlines
Fri 8/2812:00 pm
GCM
- MCI
1 stop11h 59m
American Airlines
Deal found 7/22![American Airlines logo]()
$419
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:28 am
STL
- GCM
1 stop6h 02m
American Airlines
Tue 10/1312:00 pm
GCM
- STL
1 stop9h 56m
American Airlines
Deal found 7/23![American Airlines logo]()
$419
This American Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/12:54 pm
MCI
- GCM
2 stops20h 06m
American Airlines
Thu 10/1512:35 pm
GCM
- MCI
1 stop11h 22m
American Airlines
Deal found 7/21![American Airlines logo]()
$424
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:10 pm
STL
- GCM
2 stops18h 20m
American Airlines
Sat 10/103:15 pm
GCM
- STL
1 stop8h 27m
American Airlines
Deal found 7/22![American Airlines logo]()
$424
This American Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:01 am
MCI
- GCM
1 stop8h 09m
American Airlines
Tue 8/1812:30 pm
GCM
- MCI
2 stops11h 07m
American Airlines
Deal found 7/20![American Airlines logo]()
$429
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:07 pm
STL
- GCM
2 stops15h 20m
American Airlines
Tue 8/252:10 pm
GCM
- STL
1 stop8h 30m
American Airlines
Deal found 7/22![American Airlines logo]()
$429
This American Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/227:44 am
MCI
- GCM
1 stop27h 43m
American Airlines
Tue 9/2912:00 pm
GCM
- MCI
2 stops20h 58m
American Airlines
Deal found 7/20![American Airlines logo]()
$433
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/156:00 am
MCI
- GCM
1 stop5h 39m
Delta
Thu 8/201:04 pm
GCM
- MCI
1 stop10h 54m
Delta
Deal found 7/20![Delta logo]()
$435
This United Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/275:00 am
STL
- GCM
2 stops10h 30m
United Airlines
Sun 11/12:25 pm
GCM
- STL
1 stop8h 26m
United Airlines
Deal found 7/22![United Airlines logo]()
$435
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:00 am
MCI
- GCM
2 stops9h 35m
United Airlines
Tue 11/35:45 pm
GCM
- MCI
2 stops19h 38m
United Airlines
Deal found 7/20![United Airlines logo]()
$440
This American Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/188:07 pm
STL
- GCM
2 stops15h 20m
American Airlines
Mon 8/2412:00 pm
GCM
- STL
2 stops10h 40m
American Airlines
Deal found 7/20![American Airlines logo]()
$440
This Expedia deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/2612:10 pm
STL
- GCM
2 stops47h 15m
Air Canada
Sat 10/1012:25 pm
GCM
- STL
1 stop7h 35m
Air Canada
Deal found 7/19![Air Canada logo]()
$447
Best flights from Missouri to Grand CaymanDiscover carefully curated flight deals from Missouri to Grand Cayman that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 25, 2026.
Discover carefully curated flight deals from Missouri to Grand Cayman that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated July 25, 2026.
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/215:01 am
MCI
- GCM
1 stop8h 09m
American Airlines
Fri 8/2812:00 pm
GCM
- MCI
1 stop11h 59m
American Airlines
Deal found 7/22![American Airlines logo]()
$419
This Delta deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/206:00 am
STL
- GCM
1 stop5h 40m
Delta
Wed 1/272:05 pm
GCM
- STL
1 stop10h 34m
Delta
Deal found 7/21![Delta logo]()
$419
This United Airlines deal was found by Cheapflights users on 7/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:15 am
STL
- GCM
1 stop6h 10m
United Airlines
Sat 10/101:35 pm
GCM
- STL
1 stop8h 55m
United Airlines
Deal found 7/19![United Airlines logo]()
$451
This Southwest deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/107:00 pm
MCI
- GCM
2 stops16h 55m
Southwest
Fri 1/151:50 pm
GCM
- MCI
2 stops9h 10m
Southwest
Deal found 7/24![Southwest logo]()
$524
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:28 am
STL
- GCM
1 stop6h 02m
American Airlines
Tue 10/1312:00 pm
GCM
- STL
1 stop9h 56m
American Airlines
Deal found 7/23![American Airlines logo]()
$419
This Delta deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/206:00 am
STL
- GCM
1 stop5h 40m
Delta
Tue 2/22:05 pm
GCM
- STL
1 stop10h 34m
Delta
Deal found 7/21![Delta logo]()
$419
This United Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/136:20 am
MCI
- GCM
1 stop9h 10m
United Airlines
Sun 11/155:45 pm
GCM
- MCI
1 stop24h 07m
United Airlines
Deal found 7/20![United Airlines logo]()
$460
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:00 am
STL
- GCM
2 stops13h 00m
American Airlines
Fri 11/63:45 pm
GCM
- STL
1 stop7h 02m
American Airlines
Deal found 7/23![American Airlines logo]()
$424
This Delta deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/206:00 am
STL
- GCM
1 stop5h 40m
Delta
Mon 2/12:05 pm
GCM
- STL
1 stop10h 34m
Delta
Deal found 7/21![Delta logo]()
$435
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/268:43 am
STL
- GCM
1 stop26h 47m
American Airlines
Sat 10/1012:25 pm
GCM
- STL
1 stop11h 34m
American Airlines
Deal found 7/23![American Airlines logo]()
$428
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/315:40 am
MCI
- GCM
1 stop6h 00m
Delta
Mon 11/21:55 pm
GCM
- MCI
1 stop8h 10m
Delta
Deal found 7/20![Delta logo]()
$451
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/198:07 pm
STL
- GCM
2 stops15h 20m
American Airlines
Tue 8/252:10 pm
GCM
- STL
1 stop8h 30m
American Airlines
Deal found 7/23![American Airlines logo]()
$429
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/286:00 am
STL
- GCM
1 stop5h 39m
Delta
Mon 8/311:04 pm
GCM
- STL
1 stop10h 54m
Delta
Deal found 7/20![Delta logo]()
$451
This United Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/314:54 pm
MCI
- GCM
2 stops23h 36m
United Airlines
Tue 11/35:45 pm
GCM
- MCI
2 stops17h 41m
United Airlines
Deal found 7/22![United Airlines logo]()
$560
This American Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/1311:40 am
MCI
- GCM
1 stop7h 43m
American Airlines
Sun 1/173:25 pm
GCM
- MCI
1 stop9h 53m
American Airlines
Deal found 7/21![American Airlines logo]()
$454
This Delta deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/206:00 am
STL
- GCM
1 stop5h 40m
Delta
Thu 1/282:05 pm
GCM
- STL
1 stop7h 44m
Delta
Deal found 7/22![Delta logo]()
$499
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/48:07 pm
STL
- GCM
2 stops17h 03m
American Airlines
Fri 9/1112:00 pm
GCM
- STL
1 stop11h 59m
American Airlines
Deal found 7/23![American Airlines logo]()
$504
This Delta deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/315:40 am
MCI
- GCM
1 stop6h 00m
Delta
Sat 1/912:59 pm
GCM
- MCI
1 stop9h 19m
Delta
Deal found 7/24![Delta logo]()
$515
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/295:40 am
MCI
- GCM
1 stop6h 00m
Delta
Sun 11/11:55 pm
GCM
- MCI
1 stop8h 10m
Delta
Deal found 7/20![Delta logo]()
$535
This American Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 1/107:46 pm
MCI
- GCM
2 stops15h 19m
American Airlines
Fri 1/153:25 pm
GCM
- MCI
1 stop9h 53m
American Airlines
Deal found 7/24![American Airlines logo]()
$544
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2210:59 am
MCI
- GCM
1 stop24h 28m
American Airlines
Tue 9/2912:00 pm
GCM
- MCI
1 stop10h 59m
American Airlines
Deal found 7/23![American Airlines logo]()
$550
Last-minute flights from Missouri to Grand CaymanDiscover last-minute flight deals from Missouri to Grand Cayman. Data last updated July 25, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Grand Cayman. Data last updated July 25, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/105:43 am
MCI
- GCM
1 stop5h 56m
Delta
Thu 8/201:04 pm
GCM
- MCI
1 stop10h 54m
Delta
Deal found 7/20![Delta logo]()
$499
This American Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/117:04 am
MCI
- GCM
1 stop6h 06m
American Airlines
Thu 8/2012:00 pm
GCM
- MCI
1 stop11h 59m
American Airlines
Deal found 7/20![American Airlines logo]()
$509
This American Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/117:39 pm
MCI
- GCM
2 stops17h 31m
American Airlines
Wed 8/1912:30 pm
GCM
- MCI
2 stops12h 05m
American Airlines
Deal found 7/20![American Airlines logo]()
$514
This American Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:01 am
MCI
- GCM
1 stop8h 09m
American Airlines
Tue 8/1812:30 pm
GCM
- MCI
2 stops11h 07m
American Airlines
Deal found 7/20![American Airlines logo]()
$429
This American Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:01 am
MCI
- GCM
1 stop8h 09m
American Airlines
Wed 8/1912:30 pm
GCM
- MCI
2 stops20h 29m
American Airlines
Deal found 7/20![American Airlines logo]()
$519
This American Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:01 am
MCI
- GCM
1 stop8h 09m
American Airlines
Tue 8/182:10 pm
GCM
- MCI
1 stop8h 35m
American Airlines
Deal found 7/20![American Airlines logo]()
$531
This Delta deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/156:00 am
MCI
- GCM
1 stop5h 39m
Delta
Thu 8/201:04 pm
GCM
- MCI
1 stop10h 54m
Delta
Deal found 7/20![Delta logo]()
$435
This American Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/177:39 pm
MCI
- GCM
2 stops17h 31m
American Airlines
Fri 8/2112:00 pm
GCM
- MCI
2 stops11h 37m
American Airlines
Deal found 7/21![American Airlines logo]()
$440
This American Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/185:00 am
STL
- GCM
1 stop6h 00m
American Airlines
Mon 8/2412:30 pm
GCM
- STL
1 stop10h 10m
American Airlines
Deal found 7/20![American Airlines logo]()
$435
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/195:00 am
STL
- GCM
1 stop8h 10m
American Airlines
Tue 8/2512:30 pm
GCM
- STL
1 stop10h 25m
American Airlines
Deal found 7/22![American Airlines logo]()
$424
This American Airlines deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/215:01 am
MCI
- GCM
1 stop8h 09m
American Airlines
Fri 8/2812:00 pm
GCM
- MCI
1 stop11h 59m
American Airlines
Deal found 7/22![American Airlines logo]()
$419
This American Airlines deal was found by Cheapflights users on 7/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/275:00 am
STL
- GCM
1 stop8h 10m
American Airlines
Mon 8/3112:00 pm
GCM
- STL
1 stop10h 40m
American Airlines
Deal found 7/20![American Airlines logo]()
$451
One-way flights from Missouri to Grand CaymanSearch for one-way flight options from Missouri to Grand Cayman. Find affordable one-way fares based on user searches. Data last updated July 25, 2026.
Search for one-way flight options from Missouri to Grand Cayman. Find affordable one-way fares based on user searches. Data last updated July 25, 2026.
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/275:00 am
MCI
- GCM
1 stop5h 58m
American Airlines
Deal found 7/23![American Airlines logo]()
$157
This Southwest deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/157:20 pm
STL
- GCM
2 stops16h 15m
Southwest
Deal found 7/22![Southwest logo]()
$157
This American Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/144:37 pm
STL
- GCM
2 stops18h 23m
American Airlines
Deal found 7/21![American Airlines logo]()
$163
This American Airlines deal was found by Cheapflights users on 7/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/95:01 am
MCI
- GCM
1 stop13h 59m
American Airlines
Deal found 7/21![American Airlines logo]()
$173
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/266:36 pm
MCI
- GCM
1 stop16h 29m
American Airlines
Deal found 7/23![American Airlines logo]()
$202
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/265:59 am
STL
- GCM
2 stops12h 59m
American Airlines
Deal found 7/23![American Airlines logo]()
$202
This Orbitz deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/234:05 pm
STL
- GCM
1 stop19h 05m
Air Canada
Deal found 7/23![Air Canada logo]()
$209
This Southwest deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:20 pm
STL
- GCM
2 stops16h 15m
Southwest
Deal found 7/23![Southwest logo]()
$251
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/236:36 pm
MCI
- GCM
1 stop16h 29m
American Airlines
Deal found 7/23![American Airlines logo]()
$287
This Kiwi.com deal was found by Cheapflights users on 7/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/158:10 pm
STL
- GCM
3 stops24h 05m
Multiple Airlines
Deal found 7/22![Multiple Airlines logo]()
$311
This American Airlines deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/226:36 pm
MCI
- GCM
1 stop16h 29m
American Airlines
Deal found 7/23![American Airlines logo]()
$447
This Kiwi.com deal was found by Cheapflights users on 7/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/277:05 pm
STL
- GCM
3 stops18h 45m
Multiple Airlines
Deal found 7/23![Multiple Airlines logo]()
$451
Find flight deals from Missouri to Grand Cayman
Keep the following information in mind while searching for Missouri to Grand Cayman flight deals. Data was last updated July 25, 2026.
Round-trip from | $419 (American Airlines) |
|---|---|
One-way from | $157 (American Airlines) |
Popular in | June |
Cheapest in | April |
Average price | $579 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Grand Cayman that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 25, 2026.
Use the filters below to find and compare flights from Missouri to Grand Cayman that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Kansas CityGeorge Town
MCI - GCM
MCIGCM
Kansas City
Fri 8/21
5:01 am-1:10 pm
1 stop8h 09m
George Town Owen Roberts Intl
Fri 8/28
12:00 pm-11:59 pm
1 stop11h 59m
$419
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Wed 1/20
6:00 am-12:40 pm
1 stop5h 40m
George Town Owen Roberts Intl
Wed 1/27
2:05 pm-11:39 pm
1 stop10h 34m
$419
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Fri 10/9
5:28 am-11:30 am
1 stop6h 02m
George Town Owen Roberts Intl
Tue 10/13
12:00 pm-9:56 pm
1 stop9h 56m
$419
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Wed 1/20
6:00 am-12:40 pm
1 stop5h 40m
George Town Owen Roberts Intl
Tue 2/2
2:05 pm-11:39 pm
1 stop10h 34m
$419
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sat 10/31
6:00 am-7:00 pm
2 stops13h 00m
George Town Owen Roberts Intl
Fri 11/6
3:45 pm-9:47 pm
1 stop7h 02m
$424
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sat 9/26
8:43 am-11:30 am
1 stop26h 47m
George Town Owen Roberts Intl
Sat 10/10
12:25 pm-11:59 pm
1 stop11h 34m
$428
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Wed 8/19
8:07 pm-11:27 am
2 stops15h 20m
George Town Owen Roberts Intl
Tue 8/25
2:10 pm-10:40 pm
1 stop8h 30m
$429
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Wed 1/20
6:00 am-12:40 pm
1 stop5h 40m
George Town Owen Roberts Intl
Mon 2/1
2:05 pm-11:39 pm
1 stop10h 34m
$435
St. LouisGeorge Town
STL - GCM
STLGCM
Lambert-St Louis
Sat 9/26
6:15 am-12:25 pm
1 stop6h 10m
George Town Owen Roberts Intl
Sat 10/10
1:35 pm-10:30 pm
1 stop8h 55m
$451
Kansas CityGeorge Town
MCI - GCM
MCIGCM
Kansas City
Sat 10/31
5:40 am-11:40 am
1 stop6h 00m
George Town Owen Roberts Intl
Mon 11/2
1:55 pm-9:05 pm
1 stop8h 10m
$451
Showing 1-10 of 35 resultsSorted by cheapest first
Best time to book a flight from Missouri to Grand Cayman
Have a flexible travel schedule? Discover the best time to fly to Grand Cayman from Missouri with our price prediction graph.
MCI-GCM
STL-GCM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Grand Cayman
USMO-zzLAW
MCI-GCM
STL-GCM
What is the cheapest month to book a flight from Missouri to Grand Cayman?
Currently, August is the cheapest month in which you can book a flight from Missouri to Grand Cayman (average of $510). Flying from Missouri to Grand Cayman in June is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Missouri to Grand Cayman. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
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Popular flights
Alternative routes for Missouri to Grand Cayman
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Grand Cayman by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Grand Cayman by cabin class
Find flights from Missouri to Grand Cayman, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and Grand Cayman flights
Browse other Missouri and Grand Cayman flight options. Last updated on July 25, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 4 airlines flying from Missouri to Grand Cayman
Discover the top 4 airlines that operate flights from Missouri to Grand Cayman. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 25, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$237 | Average$560 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$364 | Average$631 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$429 | Average$578 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$464 | Average$653 | FlexibilityNo cancel fee | On-time71% |