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Grand Cayman

$569+ Cheap flights from Knoxville (TYS) to Grand Cayman

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/28. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — GCM
May 10 — May 171
Sun 5/10
Sun 5/17
1 adult, Economy
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Cheap flight deals from Knoxville to Grand Cayman

Cheapest flights from Knoxville to Grand Cayman
Explore the most affordable flight options available from Knoxville to Grand Cayman. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 10, 2026.

This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/288:15 am
TYS
-
GCM
1 stop10h 05m
Multiple Airlines
Sun 5/314:45 pm
GCM
-
TYS
2 stops28h 57m
Multiple Airlines
Deal found 4/7$569
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/207:59 pm
TYS
-
GCM
1 stop16h 31m
American Airlines
Fri 6/262:42 pm
GCM
-
TYS
1 stop8h 14m
American Airlines
Deal found 4/6$626
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/287:59 pm
TYS
-
GCM
1 stop16h 31m
American Airlines
Sun 7/512:02 pm
GCM
-
TYS
1 stop10h 57m
American Airlines
Deal found 4/5$639
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/166:00 am
TYS
-
GCM
1 stop6h 01m
American Airlines
Mon 7/275:12 pm
GCM
-
TYS
1 stop5h 47m
American Airlines
Deal found 4/5$641
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/165:03 am
TYS
-
GCM
1 stop7h 22m
American Airlines
Sun 7/265:12 pm
GCM
-
TYS
1 stop5h 47m
American Airlines
Deal found 4/6$646
This American Airlines deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/57:32 am
TYS
-
GCM
2 stops9h 39m
American Airlines
Tue 6/95:12 pm
GCM
-
TYS
1 stop5h 47m
American Airlines
Deal found 4/7$656
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:38 pm
TYS
-
GCM
2 stops17h 53m
American Airlines
Fri 5/82:10 pm
GCM
-
TYS
2 stops20h 05m
American Airlines
Deal found 4/5$666

Find flight deals from Knoxville to Grand Cayman

Keep the following information in mind while searching for Knoxville to Grand Cayman flight deals. Data was last updated April 10, 2026.

Round-trip from

$569
(Kiwi.com)

Popular in

April

Cheapest in

February

Average price

$754
From Knoxville McGhee Tyson to Grand Cayman
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($54 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in April 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Grand Cayman that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 10, 2026.
Use the filters below to find and compare flights from Knoxville to Grand Cayman that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Thu 5/28

8:15 am-5:20 pm

1 stop10h 05m

George Town Owen Roberts Intl

Sun 5/31

4:45 pm-10:42 pm

2 stops28h 57m

$569

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sun 6/28

6:00 am-4:11 pm

1 stop11h 11m

George Town Owen Roberts Intl

Sun 7/5

5:12 pm-12:34 pm

2 stops18h 22m

$644

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Thu 7/16

6:00 am-11:01 am

1 stop6h 01m

George Town Owen Roberts Intl

Mon 7/27

5:12 pm-10:38 am

2 stops16h 26m

$646
Quickest round-trip

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Thu 7/16

7:01 am-1:36 pm

1 stop7h 35m

George Town Owen Roberts Intl

Sun 7/26

5:12 pm-11:59 pm

1 stop5h 47m

$646

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Fri 6/5

6:55 am-11:30 am

1 stop5h 35m

George Town Owen Roberts Intl

Tue 6/9

12:01 pm-11:59 pm

1 stop10h 58m

$651

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sat 6/20

7:59 pm-11:30 am

1 stop16h 31m

George Town Owen Roberts Intl

Fri 6/26

12:01 pm-8:34 am

2 stops19h 33m

$651

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/7

Sorted by cheapest first

Best time to book a flight from Knoxville to Grand Cayman

Have a flexible travel schedule? Discover the best time to fly to Grand Cayman from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Grand Cayman
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Grand Cayman

Get insights into the airlines that provide service to Grand Cayman. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Grand Cayman. Reviews last updated April 10, 2026.
Get a feel of what it's like to fly with American Airlines from Knoxville to Grand Cayman by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.1
Good
11,564 reviews

Boarding

7.5

Entertainment

6.8

Food

6.4

Crew

7.9

Comfort

7.2

Overall

7.1

Reviews

1 / 20
4.0
Okay

Elizabeth,Mar 2026

ORD - MIA

Staff was rude and flight attendants 2 out of 3 looked like they had just been thru a hurricane.
American Airlines
7.1
Good
11,564 reviews
American Airlines
7.1
Good
11,564 reviews

Boarding

7.5

Entertainment

6.8

Food

6.4

Crew

7.9

Comfort

7.2

Overall

7.1

Reviews

1 / 20
4.0
Okay

Elizabeth,Mar 2026

ORD - MIA

Staff was rude and flight attendants 2 out of 3 looked like they had just been thru a hurricane.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Grand Cayman. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Grand Cayman?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Grand Cayman. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Knoxville to Grand Cayman?

    Airlines like American Airlines fly from Knoxville to Grand Cayman in about 11h 11m. The time it takes to get you to your destination can typically vary by up to . There are 1151 mi between Knoxville and Grand Cayman.

  • Can I find deals for flights from Knoxville to Grand Cayman that include hotel bookings?

    Yes. In addition to deals on Knoxville to Grand Cayman flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Grand Cayman?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Grand Cayman.

  • Can I find deals for business class flights from Knoxville to Grand Cayman?

    Yes. Cheapflights offers flight deals from Knoxville to Grand Cayman by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Complete your trip

Complete your trip to Grand Cayman by adding a car rental and/or hotel reservation to your travel itinerary.
George Town Owen Roberts Intl Airport car rentals
George Town car rentals

Top airline flying from Knoxville to Grand Cayman

Discover the top airline that operate flights from Knoxville to Grand Cayman. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 10, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$540Average$650FlexibilityNo cancel feeOn-time71%

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