HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Grand Cayman

$251+ Cheap flights from Knoxville (TYS) to Grand Cayman

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/19. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — GCM
Mar 5 — Mar 121
Thu 3/5
Thu 3/12
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Knoxville to Grand Cayman with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Knoxville to Grand Cayman

Cheapest flights from Knoxville to Grand Cayman
Explore the most affordable flight options available from Knoxville to Grand Cayman. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 3, 2026.

This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:00 am
TYS
-
GCM
1 stop6h 00m
American Airlines
Tue 6/1612:00 pm
GCM
-
TYS
1 stop10h 59m
American Airlines
Deal found 2/1$526
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 12/135:03 pm
TYS
-
GCM
1 stop19h 07m
American Airlines
Sun 12/204:30 pm
GCM
-
TYS
1 stop7h 15m
American Airlines
Deal found 2/3$544
This American Airlines deal was found by Cheapflights users on 2/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/308:09 pm
TYS
-
GCM
1 stop18h 23m
American Airlines
Sat 6/612:50 pm
GCM
-
TYS
1 stop23h 28m
American Airlines
Deal found 2/1$545
This American Airlines deal was found by Cheapflights users on 1/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/186:00 am
TYS
-
GCM
1 stop6h 05m
American Airlines
Wed 3/253:30 pm
GCM
-
TYS
1 stop17h 40m
American Airlines
Deal found 1/31$564
This American Airlines deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/208:11 pm
TYS
-
GCM
2 stops15h 49m
American Airlines
Thu 6/252:40 pm
GCM
-
TYS
1 stop8h 05m
American Airlines
Deal found 2/2$579
This American Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 3/285:00 pm
TYS
-
GCM
1 stop18h 40m
American Airlines
Sat 4/47:45 am
GCM
-
TYS
1 stop15h 14m
American Airlines
Deal found 2/3$588

Find flight deals from Knoxville to Grand Cayman

Keep the following information in mind while searching for Knoxville to Grand Cayman flight deals. Data was last updated February 3, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$564
(American Airlines)

One-way from

$251
(Kiwi.com)

Popular in

June

Cheapest in

February

Average price

$519
Provider with most accurate pricing for Knoxville McGhee Tyson-George Town Owen Roberts Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Knoxville McGhee Tyson-George Town Owen Roberts Intl flights.
Search Deals
From Knoxville McGhee Tyson to Grand Cayman
Search Deals
One-way flight from Knoxville McGhee Tyson to Grand Cayman
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($80 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($13 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Knoxville to Grand Cayman that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
Use the filters below to find and compare flights from Knoxville to Grand Cayman that are best for you.

Fly from

Knoxville

Fly to

Grand Cayman

Route

Depart

Return

Price

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Thu 6/11

6:41 pm-11:00 am

2 stops17h 19m

George Town Owen Roberts Intl

Tue 6/16

2:10 pm-11:59 pm

1 stop8h 49m

$531

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sat 5/30

8:09 pm-1:32 pm

1 stop18h 23m

George Town Owen Roberts Intl

Sat 6/6

12:50 pm-1:18 pm

1 stop23h 28m

$545

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Wed 3/18

6:00 am-11:05 am

1 stop6h 05m

George Town Owen Roberts Intl

Wed 3/25

3:30 pm-10:10 am

1 stop17h 40m

$564

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Fri 3/20

7:05 am-3:30 pm

1 stop9h 25m

George Town Owen Roberts Intl

Fri 3/27

4:45 pm-6:10 pm

1 stop24h 25m

$607

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sat 3/28

5:00 pm-10:40 am

1 stop18h 40m

George Town Owen Roberts Intl

Sat 4/4

7:45 am-11:59 pm

1 stop15h 14m

$624

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Fri 3/20

7:02 am-7:15 pm

2 stops13h 13m

George Town Owen Roberts Intl

Fri 3/27

7:45 am-11:59 pm

1 stop15h 14m

$629

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Sat 6/20

8:09 pm-1:32 pm

1 stop18h 23m

George Town Owen Roberts Intl

Thu 6/25

2:40 pm-11:45 pm

1 stop8h 05m

$639

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Thu 2/19

6:30 am-11:35 am

2 stops29h 05m

$251

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Fri 2/20

7:22 pm-1:43 pm

3 stops42h 21m

$288

KnoxvilleGeorge Town

TYS - GCM

TYSGCM

Knoxville McGhee Tyson

Thu 2/19

6:45 am-1:45 pm

1 stop7h 00m

$321

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/2

Showing 1-10 of 12 results
1
2

Best time to book a flight from Knoxville to Grand Cayman

Have a flexible travel schedule? Discover the best time to fly to Grand Cayman from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Knoxville to Grand Cayman
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Grand Cayman

Get insights into the airlines that provide service to Grand Cayman. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Grand Cayman. Reviews last updated February 3, 2026.
Get a feel of what it's like to fly with American Airlines from Knoxville to Grand Cayman by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
American Airlines
7.2
Good
11,216 reviews

Entertainment

6.9

Comfort

7.2

Overall

7.2

Food

6.4

Boarding

7.5

Crew

8.0

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.
American Airlines
7.2
Good
11,216 reviews
American Airlines
7.2
Good
11,216 reviews

Entertainment

6.9

Comfort

7.2

Overall

7.2

Food

6.4

Boarding

7.5

Crew

8.0

Reviews

1 / 20
2.0
Mediocre

Susie,Jan 2026

CLT - TPA

This flight was delayed 3 or 4 times. We had boarded the plane, sat on plane for a good 30 minutes, then we had to board the aircraft, walk to a different gate, wait and then board another aircraft. We arrived in Tampa 4 hours later than the original booking. I feel there should have been some sort of compensation especially for the advantage members.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to Grand Cayman. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Knoxville to Grand Cayman?

    Most people fly from Knoxville McGhee Tyson (TYS) if they book a flight from Knoxville to Grand Cayman. Knoxville McGhee Tyson is conveniently located just 11.3 mi from Knoxville’s city center.

  • How long is the flight from Knoxville to Grand Cayman?

    Airlines like American Airlines fly from Knoxville to Grand Cayman in about 17h 19m. The time it takes to get you to your destination can typically vary by up to . There are 1151 mi between Knoxville and Grand Cayman.

  • Can I find deals for flights from Knoxville to Grand Cayman that include hotel bookings?

    Yes. In addition to deals on Knoxville to Grand Cayman flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to Grand Cayman?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to Grand Cayman.

  • Can I find deals for business class flights from Knoxville to Grand Cayman?

    Yes. Cheapflights offers flight deals from Knoxville to Grand Cayman by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to Grand Cayman

See prices for flight routes from nearby airports that may be better suited for you.
Knoxville to George Town flights
Nashville to George Town flights
Memphis to George Town flights
Blountville to George Town flights

Top airline flying from Knoxville to Grand Cayman

Discover the top airline that operate flights from Knoxville to Grand Cayman. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 3, 2026.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$540Average$684FlexibilityNo cancel feeOn-time71%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.