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$357+ Cheap flights from Missouri to Brussels

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/14. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BRU
Feb 14 — Feb 211
Sat 2/14
Sat 2/21
1 adult, Economy
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Cheap flight deals from Missouri to Brussels

Keep the following information in mind while searching for Missouri to Brussels flight deals. Data was last updated January 15, 2026.

Round-trip from

$438
(United Airlines)

One-way from

$357
(Kiwi.com)

Popular in

December

Cheapest in

February

Average price

$659
From Missouri to Brussels
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One-way flight from Missouri to Brussels
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Highest demand for flights based on searches. 24% potential increase in price ($304 potential increase over avg. RT price).
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Cheapest flight prices on average. 14% potential price decrease ($115 potential savings vs. average RT price).
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Average for round-trip flights in January 2026
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Find flight deals from Missouri to Brussels

Cheapest flights from Missouri to Brussels
Explore the most affordable flight options available from Missouri to Brussels. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 15, 2026.

This United Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/188:30 am
STL
-
BRU
1 stop16h 45m
United Airlines
Wed 3/2510:00 am
BRU
-
STL
2 stops34h 42m
United Airlines
Deal found 1/13$438
This FlightHub deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/186:25 am
STL
-
BRU
2 stops19h 25m
Air Canada
Wed 3/2510:00 am
BRU
-
STL
2 stops34h 42m
Air Canada
Deal found 1/13$442
This oojo deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/2311:59 am
STL
-
BRU
2 stops16h 11m
British Airways
Mon 3/25:30 pm
BRU
-
STL
2 stops36h 52m
British Airways
Deal found 1/13$447
This United Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/2711:32 am
MCI
-
BRU
2 stops18h 43m
United Airlines
Fri 3/610:00 am
BRU
-
MCI
2 stops36h 09m
United Airlines
Deal found 1/13$460
This United Airlines deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/274:05 pm
STL
-
BRU
2 stops14h 10m
United Airlines
Fri 3/610:00 am
BRU
-
STL
2 stops35h 43m
United Airlines
Deal found 1/13$463
This United Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/159:15 am
MCI
-
BRU
1 stop16h 40m
United Airlines
Mon 3/2310:00 am
BRU
-
MCI
2 stops35h 09m
United Airlines
Deal found 1/14$463
This oojo deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/274:34 pm
SGF
-
BRU
2 stops17h 46m
British Airways
Fri 3/611:45 am
BRU
-
SGF
2 stops19h 10m
British Airways
Deal found 1/13$472
This oojo deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/129:37 am
STL
-
BRU
2 stops18h 13m
British Airways
Thu 2/193:00 pm
BRU
-
STL
2 stops38h 52m
British Airways
Deal found 1/13$472
This Ovago deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/129:55 am
STL
-
BRU
2 stops20h 20m
Multiple Airlines
Thu 2/1911:55 am
BRU
-
STL
1 stop15h 28m
Multiple Airlines
Deal found 1/13$479
This United Airlines deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 2/129:55 am
STL
-
BRU
2 stops20h 20m
United Airlines
Thu 2/1911:55 am
BRU
-
STL
1 stop15h 28m
United Airlines
Deal found 1/14$480
This Mytrip deal was found by Cheapflights users on 1/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/137:41 am
STL
-
BRU
2 stops17h 09m
Air Canada
Fri 2/2010:00 am
BRU
-
STL
2 stops31h 36m
Air Canada
Deal found 1/14$481
This KAYAK deal was found by Cheapflights users on 1/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 2/2312:15 pm
STL
-
BRU
1 stop12h 00m
Lufthansa
Mon 3/211:15 am
BRU
-
STL
1 stop19h 50m
Lufthansa
Deal found 1/13$482

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Brussels that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 15, 2026.
Use the filters below to find and compare flights from Missouri to Brussels that are best for you.

Fly from

Missouri

Fly to

Brussels

Route

Depart

Return

Price

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Wed 3/18

8:30 am-7:15 am

1 stop16h 45m

Brussels Bruxelles-National

Wed 3/25

10:00 am-2:42 pm

2 stops34h 42m

$438

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Mon 2/23

2:00 pm-4:40 pm

2 stops19h 40m

Brussels Bruxelles-National

Mon 3/2

8:45 pm-11:48 pm

2 stops34h 03m

$459

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

Fri 2/27

11:32 am-1:15 pm

2 stops18h 43m

Brussels Bruxelles-National

Fri 3/6

10:00 am-3:09 pm

2 stops36h 09m

$460

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Fri 2/27

4:05 pm-1:15 pm

2 stops14h 10m

Brussels Bruxelles-National

Fri 3/6

10:00 am-2:43 pm

2 stops35h 43m

$463

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

Sun 3/15

9:15 am-7:55 am

1 stop16h 40m

Brussels Bruxelles-National

Mon 3/23

10:00 am-3:09 pm

2 stops35h 09m

$463

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Thu 2/12

9:37 am-10:50 am

2 stops18h 13m

Brussels Bruxelles-National

Thu 2/19

3:00 pm-10:52 pm

2 stops38h 52m

$472

SpringfieldBrussels

SGF - BRU

SGFBRU

Springfield-Branson

Fri 2/27

4:34 pm-5:20 pm

2 stops17h 46m

Brussels Bruxelles-National

Fri 3/6

11:45 am-11:55 pm

2 stops19h 10m

$472

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Thu 2/12

9:55 am-1:15 pm

2 stops20h 20m

Brussels Bruxelles-National

Thu 2/19

11:55 am-8:23 pm

1 stop15h 28m

$479

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Thu 2/12

9:55 am-1:15 pm

2 stops20h 20m

Brussels Bruxelles-National

Thu 2/19

11:55 am-8:23 pm

1 stop15h 28m

$480

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Fri 2/13

7:41 am-7:50 am

2 stops17h 09m

Brussels Bruxelles-National

Fri 2/20

10:00 am-10:36 am

2 stops31h 36m

$481

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/15

Showing 1-10 of 35 results
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Best time to book a flight from Missouri to Brussels

Have a flexible travel schedule? Discover the best time to fly to Brussels from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Brussels

What is the cheapest month to book a flight from Missouri to Brussels?

Currently, April is the cheapest month in which you can book a flight from Missouri to Brussels (average of $443). Flying from Missouri to Brussels in June is currently the most expensive (average of $1,008). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Brussels. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Brussels?

    A quick flight from Missouri to Brussels can take about 16h 45m. United Airlines provides one of the quickest options available for as low as $438. Missouri and Brussels are separated by a distance of 4393 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Missouri to Brussels?

    When deciding which route to take from Missouri to Brussels consider Lambert-St Louis - Brussels Bruxelles-National, Kansas City - Brussels Bruxelles-National or Springfield-Branson - Brussels Bruxelles-National as they are the most popular.

  • Can I find deals for flights from Missouri to Brussels that include hotel bookings?

    Yes. In addition to deals on Missouri to Brussels flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Brussels?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Brussels.

  • Can I find deals for business class flights from Missouri to Brussels?

    Yes. Cheapflights offers flight deals from Missouri to Brussels by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Brussels?

    Currently, April is the cheapest month in which you can book a flight from Missouri to Brussels (average of $443). Flying from Missouri to Brussels in June is currently the most expensive (average of $1,008). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Brussels

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Bruxelles-National flights
Newark to Bruxelles-National flights
Dulles Intl to Bruxelles-National flights
LaGuardia to Bruxelles-National flights
O'Hare Intl to Bruxelles-National flights
Boston to Bruxelles-National flights
Reagan-National to Bruxelles-National flights
Baltimore to Bruxelles-National flights
Atlanta to Bruxelles-National flights
John F Kennedy Intl to Charleroi Brussels flights
Dallas/Fort Worth to Bruxelles-National flights
Seattle to Bruxelles-National flights
Miami to Bruxelles-National flights
Newark to Charleroi Brussels flights
San Francisco to Bruxelles-National flights
Los Angeles to Bruxelles-National flights
Hobby to Bruxelles-National flights
Charlotte to Bruxelles-National flights
Orlando to Bruxelles-National flights
Philadelphia to Bruxelles-National flights
Denver to Bruxelles-National flights
Boston to Charleroi Brussels flights
Cincinnati to Bruxelles-National flights
Minneapolis to Bruxelles-National flights
Love Field to Bruxelles-National flights
Fort Lauderdale to Bruxelles-National flights
George Bush Intcntl to Bruxelles-National flights
Dulles Intl to Charleroi Brussels flights
Tampa to Bruxelles-National flights
O'Hare Intl to Charleroi Brussels flights
Portland to Bruxelles-National flights
Midway to Bruxelles-National flights
Cleveland to Bruxelles-National flights
Omaha to Bruxelles-National flights
Raleigh to Bruxelles-National flights
Detroit to Bruxelles-National flights
San Jose to Bruxelles-National flights
Columbus to Bruxelles-National flights
Indianapolis to Bruxelles-National flights
Pittsburgh to Bruxelles-National flights
Santa Ana to Bruxelles-National flights
Austin to Bruxelles-National flights
Ontario to Bruxelles-National flights
St. Louis to Bruxelles-National flights
Sky Harbor Intl to Bruxelles-National flights
El Paso to Bruxelles-National flights
Miami to Charleroi Brussels flights
Salt Lake City to Bruxelles-National flights
West Palm Beach to Bruxelles-National flights
New Orleans to Bruxelles-National flights

Top 2 airlines flying from Missouri to Brussels

Discover the top 2 airlines that operate flights from Missouri to Brussels. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 15, 2026.
AirlineCheapestAverageFlexibilityOn-time
LufthansaCheapest$441Average$2,205FlexibilityNo cancel feeOn-time76%
United AirlinesCheapest$506Average$760FlexibilityNo cancel feeOn-time69%

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