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$500+ Cheap flights from Missouri to Brussels

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/9. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BRU
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
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Cheap flight deals from Missouri to Brussels

Keep the following information in mind while searching for Missouri to Brussels flight deals. Data was last updated September 15, 2025.

Round-trip from

$526
(FlightHub)

One-way from

$500
(TravelUp)

Popular in

December

Cheapest in

October

Average price

$763
From Missouri to Brussels
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One-way flight from Missouri to Brussels
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Highest demand for flights based on searches. 11% potential increase in price ($130 potential increase over avg. RT price).
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Cheapest flight prices on average. 6% potential price decrease ($60 potential savings vs. average RT price).
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Average for round-trip flights in September 2025
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Find flight deals from Missouri to Brussels

Cheapest flights from Missouri to Brussels
Explore the most affordable flight options available from Missouri to Brussels. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/127:00 amSTL - BRU
2 stops17h 50mUnited Airlines
Thu 11/2710:00 amBRU - STL
2 stops35h 25mUnited Airlines
Deal found 9/14$534
This SmartFares deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/293:59 pmSTL - BRU
2 stops16h 31mScandinavian Airlines
Wed 11/53:10 pmBRU - STL
2 stops37h 28mScandinavian Airlines
Deal found 9/14$537
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/296:00 amMCI - BRU
2 stops19h 50mUnited Airlines
Tue 11/1110:00 amBRU - MCI
2 stops35h 21mUnited Airlines
Deal found 9/14$554
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/298:25 amSTL - BRU
1 stop16h 50mUnited Airlines
Wed 11/510:10 amBRU - STL
1 stop19h 35mUnited Airlines
Deal found 9/14$556
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/153:19 pmSTL - BRU
1 stop10h 36mUnited Airlines
Thu 12/2510:00 amBRU - STL
2 stops35h 26mUnited Airlines
Deal found 9/13$579
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/141:30 pmSTL - BRU
1 stop11h 35mUnited Airlines
Wed 10/2910:10 amBRU - STL
1 stop15h 29mUnited Airlines
Deal found 9/13$594
This Air Canada deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/149:15 amSTL - BRU
2 stops15h 50mAir Canada
Wed 10/2910:00 amBRU - STL
2 stops35h 29mAir Canada
Deal found 9/14$602
This Air Canada deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/155:27 pmSTL - BRU
2 stops31h 23mAir Canada
Thu 12/2510:00 amBRU - STL
2 stops36h 29mAir Canada
Deal found 9/14$609
This United Airlines deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/2812:31 pmSTL - BRU
1 stop13h 24mUnited Airlines
Tue 11/410:10 amBRU - STL
1 stop12h 37mUnited Airlines
Deal found 9/13$613
This Air Canada deal was found by Cheapflights users on 9/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/246:35 amSTL - BRU
2 stops18h 30mAir Canada
Wed 10/810:00 amBRU - STL
1 stop16h 57mAir Canada
Deal found 9/13$633
This Air Canada deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/298:00 amMCI - BRU
3 stops17h 50mMultiple Airlines
Tue 11/1110:00 amBRU - MCI
2 stops18h 10mMultiple Airlines
Deal found 9/14$648
This United Airlines deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/296:15 amMCI - BRU
2 stops28h 15mUnited Airlines
Mon 1/54:55 pmBRU - MCI
2 stops36h 45mUnited Airlines
Deal found 9/14$665

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Brussels that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Missouri to Brussels that are best for you.

Fly from

Missouri

Fly to

Brussels

Route

Depart

Return

Price

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Wed 11/12

11:05 am-8:55 am

1 stop14h 50m

Brussels Bruxelles-National

Thu 11/27

10:00 am-5:39 pm

2 stops38h 39m

$534

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

Wed 10/29

12:45 pm-7:15 am

1 stop12h 30m

Brussels Bruxelles-National

Tue 11/11

10:00 am-2:21 pm

2 stops35h 21m

$554

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Mon 1/12

1:00 pm-7:15 am

1 stop11h 15m

Brussels Bruxelles-National

Fri 1/23

10:10 am-5:43 pm

1 stop14h 33m

$556

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Wed 10/29

8:25 am-7:15 am

1 stop16h 50m

Brussels Bruxelles-National

Wed 11/5

10:10 am-10:45 pm

1 stop19h 35m

$556

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Tue 10/28

10:00 am-7:50 am

2 stops15h 50m

Brussels Bruxelles-National

Tue 11/4

10:10 am-9:40 pm

1 stop18h 30m

$556

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Mon 12/15

8:00 am-7:50 am

2 stops16h 50m

Brussels Bruxelles-National

Thu 12/25

10:00 am-2:26 pm

2 stops35h 26m

$579

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Tue 3/3

7:41 am-7:50 am

2 stops17h 09m

Brussels Bruxelles-National

Mon 3/9

10:00 am-2:18 pm

2 stops34h 18m

$584

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Tue 3/3

1:11 pm-8:55 am

1 stop12h 44m

Brussels Bruxelles-National

Mon 3/9

2:25 pm-5:14 pm

2 stops32h 49m

$589

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

Mon 12/29

6:15 am-5:30 pm

2 stops28h 15m

Brussels Bruxelles-National

Mon 1/5

4:55 pm-10:40 pm

2 stops36h 45m

$665

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

Sun 10/12

5:47 pm-8:05 am

2 stops31h 18m

Brussels Bruxelles-National

Sun 10/19

6:45 am-5:26 pm

2 stops17h 41m

$695

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/14

Showing 1-10 of 19 results
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Best time to book a flight from Missouri to Brussels

Have a flexible travel schedule? Discover the best time to fly to Brussels from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Brussels

What is the cheapest month to book a flight from Missouri to Brussels?

Currently, November is the cheapest month in which you can book a flight from Missouri to Brussels (average of $614). Flying from Missouri to Brussels in June is currently the most expensive (average of $1,077). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to BRU?

Find hourly flight availability from Missouri to Brussels. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Brussels as you normally would.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Brussels. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Brussels?

    A quick flight from Missouri to Brussels can take about 10h 34m. United Airlines provides one of the quickest options available for as low as $1,051. Missouri and Brussels are separated by a distance of 4582 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Missouri to Brussels?

    When deciding which route to take from Missouri to Brussels consider Lambert-St Louis - Brussels Bruxelles-National, Kansas City - Brussels Bruxelles-National or Springfield-Branson - Brussels Bruxelles-National as they are the most popular.

  • Can I find deals for flights from Missouri to Brussels that include hotel bookings?

    Yes. In addition to deals on Missouri to Brussels flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Brussels?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Brussels.

  • Can I find deals for business class flights from Missouri to Brussels?

    Yes. Cheapflights offers flight deals from Missouri to Brussels by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Brussels?

    Currently, November is the cheapest month in which you can book a flight from Missouri to Brussels (average of $614). Flying from Missouri to Brussels in June is currently the most expensive (average of $1,077). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to Brussels

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Bruxelles-National flights
Newark to Bruxelles-National flights
Dulles Intl to Bruxelles-National flights
O'Hare Intl to Bruxelles-National flights
LaGuardia to Bruxelles-National flights
Reagan-National to Bruxelles-National flights
Baltimore to Bruxelles-National flights
Boston to Bruxelles-National flights
John F Kennedy Intl to Charleroi Brussels flights
Atlanta to Bruxelles-National flights
Newark to Charleroi Brussels flights
Los Angeles to Bruxelles-National flights
Seattle to Bruxelles-National flights
Midway to Bruxelles-National flights
Dallas/Fort Worth to Bruxelles-National flights
Miami to Bruxelles-National flights
San Francisco to Bruxelles-National flights
Hobby to Bruxelles-National flights
Charlotte to Bruxelles-National flights
Denver to Bruxelles-National flights
Sky Harbor Intl to Bruxelles-National flights
Philadelphia to Bruxelles-National flights
Orlando to Bruxelles-National flights
Boston to Charleroi Brussels flights
Portland to Bruxelles-National flights
Detroit to Bruxelles-National flights
Minneapolis to Bruxelles-National flights
San Diego to Bruxelles-National flights
Dulles Intl to Charleroi Brussels flights
O'Hare Intl to Charleroi Brussels flights
Fort Lauderdale to Bruxelles-National flights
George Bush Intcntl to Bruxelles-National flights
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Raleigh to Bruxelles-National flights
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Ontario to Bruxelles-National flights
Cleveland to Bruxelles-National flights
Los Angeles to Charleroi Brussels flights
Pittsburgh to Bruxelles-National flights
Tampa to Bruxelles-National flights
Providence to Bruxelles-National flights
Miami to Charleroi Brussels flights
Seattle to Charleroi Brussels flights
Pensacola to Bruxelles-National flights
Madison to Bruxelles-National flights
Salt Lake City to Bruxelles-National flights
Hartford to Bruxelles-National flights
Cincinnati to Bruxelles-National flights
West Palm Beach to Bruxelles-National flights

Top airline flying from Missouri to Brussels

Discover the top airline that operate flights from Missouri to Brussels. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$640Average$1,033FlexibilityNo cancel feeOn-time69%

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