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$343+ Cheap flights from Missouri to Brussels

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/17. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BRU
dic 19 — dic 261
ven 12/19
ven 12/26
1 adult, Economy
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Cheap flight deals from Missouri to Brussels

Keep the following information in mind while searching for Missouri to Brussels flight deals. Data was last updated novembre 19, 2025.

Round-trip from

$457
(Kiwi.com)

Popular in

December

Cheapest in

February

Average price

$705
From Missouri to Brussels
Search Deals
Highest demand for flights based on searches. 24% potential increase in price ($312 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 12% potential price decrease ($111 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Find flight deals from Missouri to Brussels

Cheapest flights from Missouri to Brussels
Explore the most affordable flight options available from Missouri to Brussels. Find the lowest fares from popular airlines and budget airlines, with prices last updated on novembre 19, 2025.

This United Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer 12/3111:24 amMCI - BRU
2 stops18h 51mUnited Airlines
lun 1/127:00 amBRU - MCI
2 stops19h 56mUnited Airlines
Deal found 11/16$509
This United Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun 12/153:19 pmSTL - BRU
2 stops14h 56mUnited Airlines
gio 12/2510:00 amBRU - STL
2 stops35h 26mUnited Airlines
Deal found 11/17$601
This United Airlines deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
ven 12/57:50 amJLN - BRU
2 stops17h 00mUnited Airlines
mar 12/910:00 amBRU - JLN
2 stops44h 27mUnited Airlines
Deal found 11/16$680
This United Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
gio 12/41:35 pmSTL - BRU
2 stops35h 15mUnited Airlines
mer 12/174:55 pmBRU - STL
2 stops30h 32mUnited Airlines
Deal found 11/17$732
This Cheapflightsfares deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer 12/3111:24 amMCI - BRU
2 stops18h 46mLufthansa
lun 1/1210:10 amBRU - MCI
1 stop18h 49mLufthansa
Deal found 11/16$790
This Air Canada deal was found by Cheapflights users on 11/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer 12/317:40 amMCI - BRU
3 stops17h 10mMultiple Airlines
lun 1/1210:00 amBRU - MCI
2 stops31h 32mMultiple Airlines
Deal found 11/16$820
This Ovago deal was found by Cheapflights users on 11/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun 12/1512:55 pmSTL - BRU
1 stop11h 20mLufthansa
gio 12/2510:10 amBRU - STL
1 stop13h 17mLufthansa
Deal found 11/19$832
This Ovago deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer 11/196:00 amSTL - BRU
2 stops20h 35mAer Lingus
mer 11/2610:15 amBRU - STL
2 stops20h 41mAer Lingus
Deal found 11/17$894
This Ovago deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer 11/196:00 amSTL - BRU
2 stops20h 35mAer Lingus
mar 11/2510:15 amBRU - STL
2 stops20h 41mAer Lingus
Deal found 11/17$901
This Trip.com deal was found by Cheapflights users on 11/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mar 12/236:35 pmSTL - BRU
1 stop31h 20mLufthansa
mar 12/307:30 pmBRU - STL
1 stop25h 25mLufthansa
Deal found 11/18$911
This Ovago deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer 11/196:05 amMCI - BRU
2 stops20h 30mAer Lingus
dom 11/2310:15 amBRU - MCI
2 stops18h 08mAer Lingus
Deal found 11/17$994
This United Airlines deal was found by Cheapflights users on 11/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mer 12/1711:36 amMCI - BRU
2 stops18h 39mUnited Airlines
gio 1/110:10 amBRU - MCI
1 stop16h 32mUnited Airlines
Deal found 11/17$1,086

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Brussels that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated novembre 19, 2025.
Use the filters below to find and compare flights from Missouri to Brussels that are best for you.

Fly from

Missouri

Fly to

Brussels

Route

Depart

Return

Price

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

ven 1/30

3:24 pm-1:15 pm

2 stops14h 51m

Brussels Bruxelles-National

mar 2/3

10:00 am-10:32 am

2 stops31h 32m

$480

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

dom 1/11

4:05 pm-1:15 pm

2 stops38h 10m

Brussels Bruxelles-National

dom 1/25

7:00 am-1:55 pm

1 stop13h 55m

$496

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

ven 1/30

12:35 pm-7:15 am

1 stop11h 40m

Brussels Bruxelles-National

mar 2/3

10:10 am-5:41 pm

1 stop14h 31m

$500

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

mer 1/28

4:05 pm-1:15 pm

2 stops14h 10m

Brussels Bruxelles-National

dom 2/1

10:00 am-3:29 pm

2 stops36h 29m

$502

SpringfieldBrussels

SGF - BRU

SGFBRU

Springfield-Branson

ven 2/13

1:25 pm-1:15 pm

2 stops16h 50m

Brussels Bruxelles-National

mar 2/17

10:00 am-2:45 pm

2 stops35h 45m

$503

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

gio 1/29

4:05 pm-1:15 pm

2 stops14h 10m

Brussels Bruxelles-National

mar 2/3

11:55 am-7:27 pm

1 stop14h 32m

$505

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

ven 1/30

12:35 pm-7:15 am

1 stop11h 40m

Brussels Bruxelles-National

mar 2/3

11:55 am-7:56 pm

1 stop15h 01m

$507

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

mer 12/31

11:24 am-1:15 pm

2 stops18h 51m

Brussels Bruxelles-National

lun 1/12

7:00 am-7:56 pm

2 stops19h 56m

$509

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

ven 1/30

11:29 am-1:15 pm

3 stops18h 46m

Brussels Bruxelles-National

mar 2/3

10:00 am-7:57 pm

2 stops16h 57m

$510

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

mer 1/28

11:20 am-8:55 am

1 stop14h 35m

Brussels Bruxelles-National

dom 2/1

11:55 am-10:58 pm

2 stops18h 03m

$512

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/19

Showing 1-10 of 25 results
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Best time to book a flight from Missouri to Brussels

Have a flexible travel schedule? Discover the best time to fly to Brussels from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Brussels

What is the cheapest month to book a flight from Missouri to Brussels?

Currently, November is the cheapest month in which you can book a flight from Missouri to Brussels (average of $592). Flying from Missouri to Brussels in June is currently the most expensive (average of $1,008). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to BRU?

Find hourly flight availability from Missouri to Brussels. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated novembre 19, 2025.

It’s optimal to fly from Missouri to Brussels in the afternoon. By choosing this option you can save up to 25% on the cost of your flight, compared to a flight in the morning.

How much does it cost to fly round-trip from Missouri to Brussels?

Related info for your journey

Find useful and relevant information for your journey from Missouri to Brussels. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Brussels?

    A quick flight from Missouri to Brussels can take about 11h 40m. United Airlines provides one of the quickest options available for as low as $500. Missouri and Brussels are separated by a distance of 4528 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Missouri to Brussels?

    When deciding which route to take from Missouri to Brussels consider Lambert-St Louis - Brussels Bruxelles-National, Kansas City - Brussels Bruxelles-National or Joplin - Brussels Bruxelles-National as they are the most popular.

  • Can I find deals for flights from Missouri to Brussels that include hotel bookings?

    Yes. In addition to deals on Missouri to Brussels flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Brussels?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Brussels.

  • Can I find deals for business class flights from Missouri to Brussels?

    Yes. Cheapflights offers flight deals from Missouri to Brussels by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Brussels?

    Currently, November is the cheapest month in which you can book a flight from Missouri to Brussels (average of $592). Flying from Missouri to Brussels in June is currently the most expensive (average of $1,008). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to Brussels

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Missouri to Brussels

Discover the top 2 airlines that operate flights from Missouri to Brussels. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated novembre 19, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$640Average$1,021FlexibilityNo cancel feeOn-time69%
LufthansaCheapest$829Average$2,205FlexibilityNo cancel feeOn-time76%

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