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$379+ Cheap flights from Missouri to Brussels

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/17. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BRU
Feb 1 — Feb 81
Sun 2/1
Sun 2/8
1 adult, Economy
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Cheap flight deals from Missouri to Brussels

Best flights from Missouri to Brussels
Discover carefully curated flight deals from Missouri to Brussels that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated January 2, 2026.

This United Airlines deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/184:05 pmSTL - BRU
2 stops15h 10mUnited Airlines
Wed 3/2510:00 amBRU - STL
2 stops34h 42mUnited Airlines
Deal found 12/31$487
This FlightHub deal was found by Cheapflights users on 1/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 1/314:05 pmSTL - BRU
2 stops33h 50mAir Canada
Sat 2/710:00 amBRU - STL
2 stops35h 30mAir Canada
Deal found 1/1$489
This oojo deal was found by Cheapflights users on 1/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/152:19 pmSGF - BRU
2 stops19h 21mBritish Airways
Sun 2/2211:20 amBRU - SGF
2 stops18h 09mBritish Airways
Deal found 1/1$510
This Cheapflightsfares deal was found by Cheapflights users on 1/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/201:15 pmSTL - BRU
1 stop12h 40mLufthansa
Tue 1/279:00 amBRU - STL
2 stops20h 58mLufthansa
Deal found 1/1$679
This United Airlines deal was found by Cheapflights users on 1/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/298:05 amSTL - BRU
1 stop17h 50mUnited Airlines
Tue 2/310:00 amBRU - STL
2 stops35h 30mUnited Airlines
Deal found 1/1$489
This FlightHub deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/294:05 pmSTL - BRU
2 stops14h 10mAir Canada
Tue 2/310:00 amBRU - STL
2 stops36h 15mAir Canada
Deal found 12/31$507
This United Airlines deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/46:19 pmJLN - BRU
2 stops35h 56mUnited Airlines
Sun 3/810:10 amBRU - JLN
1 stop13h 33mUnited Airlines
Deal found 12/30$500
This Mytrip deal was found by Cheapflights users on 1/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/157:41 amSTL - BRU
2 stops17h 09mAir Canada
Sun 2/2210:00 amBRU - STL
2 stops18h 05mAir Canada
Deal found 1/1$507
This United Airlines deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/146:15 amSGF - BRU
2 stops43h 40mUnited Airlines
Sat 2/2110:10 amBRU - SGF
1 stop31h 31mUnited Airlines
Deal found 12/31$505
This United Airlines deal was found by Cheapflights users on 1/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/151:11 pmSTL - BRU
2 stops17h 04mUnited Airlines
Sun 2/2210:10 amBRU - STL
1 stop12h 52mUnited Airlines
Deal found 1/1$506
This United Airlines deal was found by Cheapflights users on 1/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/1511:20 amSGF - BRU
2 stops18h 55mUnited Airlines
Sun 2/2210:10 amBRU - SGF
1 stop18h 49mUnited Airlines
Deal found 1/1$506
This United Airlines deal was found by Cheapflights users on 1/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/1511:32 amMCI - BRU
2 stops18h 43mUnited Airlines
Sun 2/2210:10 amBRU - MCI
1 stop14h 23mUnited Airlines
Deal found 1/1$506
This United Airlines deal was found by Cheapflights users on 12/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 2/143:22 pmMCI - BRU
2 stops14h 53mUnited Airlines
Sat 2/2110:00 amBRU - MCI
2 stops18h 59mUnited Airlines
Deal found 12/31$508
This United Airlines deal was found by Cheapflights users on 12/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/236:15 amSGF - BRU
2 stops24h 00mUnited Airlines
Tue 1/2710:00 amBRU - SGF
2 stops35h 38mUnited Airlines
Deal found 12/30$666
This United Airlines deal was found by Cheapflights users on 12/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/2312:35 pmMCI - BRU
2 stops17h 40mUnited Airlines
Tue 1/2710:00 amBRU - MCI
2 stops35h 27mUnited Airlines
Deal found 12/29$666

Find flight deals from Missouri to Brussels

Keep the following information in mind while searching for Missouri to Brussels flight deals. Data was last updated January 2, 2026.

Round-trip from

$487
(United Airlines)

One-way from

$379
(Kiwi.com)

Popular in

December

Cheapest in

February

Average price

$990
From Missouri to Brussels
Search Deals
One-way flight from Missouri to Brussels
Search Deals
Highest demand for flights based on searches. 27% potential increase in price ($368 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 12% potential price decrease ($112 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Brussels that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 2, 2026.
Use the filters below to find and compare flights from Missouri to Brussels that are best for you.

Fly from

Missouri

Fly to

Brussels

Route

Depart

Return

Price

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Wed 3/18

4:05 pm-1:15 pm

2 stops15h 10m

Brussels Bruxelles-National

Wed 3/25

10:00 am-2:42 pm

2 stops34h 42m

$487

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Sat 1/31

4:05 pm-8:55 am

2 stops33h 50m

Brussels Bruxelles-National

Sat 2/7

10:00 am-2:30 pm

2 stops35h 30m

$489

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Thu 1/29

8:05 am-8:55 am

1 stop17h 50m

Brussels Bruxelles-National

Tue 2/3

10:00 am-2:30 pm

2 stops35h 30m

$489

JoplinBrussels

JLN - BRU

JLNBRU

Joplin

Wed 3/4

6:19 pm-1:15 pm

2 stops35h 56m

Brussels Bruxelles-National

Sun 3/8

10:10 am-5:43 pm

1 stop13h 33m

$500

SpringfieldBrussels

SGF - BRU

SGFBRU

Springfield-Branson

Sat 2/14

6:15 am-8:55 am

2 stops43h 40m

Brussels Bruxelles-National

Sat 2/21

10:10 am-10:41 am

1 stop31h 31m

$505

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Sun 2/15

1:11 pm-1:15 pm

2 stops17h 04m

Brussels Bruxelles-National

Sun 2/22

10:10 am-4:02 pm

1 stop12h 52m

$506

SpringfieldBrussels

SGF - BRU

SGFBRU

Springfield-Branson

Sun 2/15

11:20 am-1:15 pm

2 stops18h 55m

Brussels Bruxelles-National

Sun 2/22

10:10 am-9:59 pm

1 stop18h 49m

$506

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

Sun 2/15

11:32 am-1:15 pm

2 stops18h 43m

Brussels Bruxelles-National

Sun 2/22

10:10 am-5:33 pm

1 stop14h 23m

$506

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Thu 1/29

4:05 pm-1:15 pm

2 stops14h 10m

Brussels Bruxelles-National

Tue 2/3

10:00 am-3:15 pm

2 stops36h 15m

$507

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Sun 2/15

7:41 am-7:50 am

2 stops17h 09m

Brussels Bruxelles-National

Sun 2/22

10:00 am-9:05 pm

2 stops18h 05m

$507

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/1

Showing 1-10 of 19 results
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Best time to book a flight from Missouri to Brussels

Have a flexible travel schedule? Discover the best time to fly to Brussels from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Brussels

What is the cheapest month to book a flight from Missouri to Brussels?

Currently, April is the cheapest month in which you can book a flight from Missouri to Brussels (average of $453). Flying from Missouri to Brussels in June is currently the most expensive (average of $1,008). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Missouri to Brussels?

Related info for your journey

Find useful and relevant information for your journey from Missouri to Brussels. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Brussels?

    A quick flight from Missouri to Brussels can take about 15h 10m. United Airlines provides one of the quickest options available for as low as $487. Missouri and Brussels are separated by a distance of 4393 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Missouri to Brussels?

    When deciding which route to take from Missouri to Brussels consider Lambert-St Louis - Brussels Bruxelles-National, Kansas City - Brussels Bruxelles-National or Springfield-Branson - Brussels Bruxelles-National as they are the most popular.

  • Can I find deals for flights from Missouri to Brussels that include hotel bookings?

    Yes. In addition to deals on Missouri to Brussels flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Brussels?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Brussels.

  • Can I find deals for business class flights from Missouri to Brussels?

    Yes. Cheapflights offers flight deals from Missouri to Brussels by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Brussels?

    Currently, April is the cheapest month in which you can book a flight from Missouri to Brussels (average of $453). Flying from Missouri to Brussels in June is currently the most expensive (average of $1,008). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to Brussels

See prices for flight routes from nearby airports that may be better suited for you.
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Top 2 airlines flying from Missouri to Brussels

Discover the top 2 airlines that operate flights from Missouri to Brussels. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 2, 2026.
AirlineCheapestAverageFlexibilityOn-time
LufthansaCheapest$441Average$2,205FlexibilityNo cancel feeOn-time76%
United AirlinesCheapest$506Average$762FlexibilityNo cancel feeOn-time69%

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