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$376+ Cheap flights from Missouri to Brussels

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 2/15. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BRU
Feb 20 — Feb 271
Fri 2/20
Fri 2/27
1 adult, Economy
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Cheap flight deals from Missouri to Brussels

Cheapest flights from Missouri to Brussels
Explore the most affordable flight options available from Missouri to Brussels. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 21, 2026.

This Flighttix deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/16:40 pm
STL
-
BRU
2 stops30h 10m
Air Canada
Tue 2/1010:00 am
BRU
-
STL
2 stops32h 02m
Air Canada
Deal found 1/21$430
This Flighttix deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/2410:00 am
STL
-
BRU
2 stops15h 50m
Multiple Airlines
Thu 4/210:15 am
BRU
-
STL
1 stop17h 53m
Multiple Airlines
Deal found 1/21$441
This Flighttix deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/11:15 pm
STL
-
BRU
1 stop12h 40m
Lufthansa
Tue 2/1010:10 am
BRU
-
STL
1 stop19h 48m
Lufthansa
Deal found 1/21$442
This United Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 2/16:30 am
STL
-
BRU
2 stops17h 45m
United Airlines
Tue 2/1010:10 am
BRU
-
STL
1 stop12h 53m
United Airlines
Deal found 1/21$453
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 2/278:00 am
MCI
-
BRU
2 stops22h 15m
United Airlines
Fri 3/610:00 am
BRU
-
MCI
2 stops31h 29m
United Airlines
Deal found 1/20$460
This United Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/188:30 am
STL
-
BRU
1 stop16h 45m
United Airlines
Wed 3/2510:00 am
BRU
-
STL
2 stops17h 42m
United Airlines
Deal found 1/21$462
This Flighttix deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/246:25 am
STL
-
BRU
2 stops19h 25m
Air Canada
Thu 4/29:25 am
BRU
-
STL
2 stops19h 32m
Air Canada
Deal found 1/21$466
This United Airlines deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/291:15 pm
STL
-
BRU
1 stop12h 40m
United Airlines
Tue 2/310:00 am
BRU
-
STL
2 stops35h 30m
United Airlines
Deal found 1/20$488
This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/48:54 am
JLN
-
BRU
2 stops21h 21m
United Airlines
Sun 3/810:10 am
BRU
-
JLN
1 stop13h 33m
United Airlines
Deal found 1/19$500
This United Airlines deal was found by Cheapflights users on 1/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/183:15 pm
SGF
-
BRU
2 stops15h 00m
United Airlines
Sun 2/2210:10 am
BRU
-
SGF
1 stop31h 31m
United Airlines
Deal found 1/19$505
This United Airlines deal was found by Cheapflights users on 1/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 1/308:00 am
MCI
-
BRU
1 stop17h 55m
United Airlines
Tue 2/311:55 am
BRU
-
MCI
1 stop15h 01m
United Airlines
Deal found 1/21$508
This FlightHub deal was found by Cheapflights users on 1/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 1/294:05 pm
STL
-
BRU
2 stops14h 10m
Air Canada
Tue 2/310:00 am
BRU
-
STL
2 stops35h 30m
Air Canada
Deal found 1/20$511

Find flight deals from Missouri to Brussels

Keep the following information in mind while searching for Missouri to Brussels flight deals. Data was last updated January 21, 2026.

Round-trip from

$430
(Flighttix)

One-way from

$376
(Kiwi.com)

Popular in

December

Cheapest in

February

Average price

$659
From Missouri to Brussels
Search Deals
One-way flight from Missouri to Brussels
Search Deals
Highest demand for flights based on searches. 24% potential increase in price ($304 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 14% potential price decrease ($115 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Brussels that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
Use the filters below to find and compare flights from Missouri to Brussels that are best for you.

Fly from

Missouri

Fly to

Brussels

Route

Depart

Return

Price

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Sun 2/1

1:15 pm-8:55 am

1 stop12h 40m

Brussels Bruxelles-National

Tue 2/10

10:10 am-10:58 pm

1 stop19h 48m

$442

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Sun 2/1

6:30 am-7:15 am

2 stops17h 45m

Brussels Bruxelles-National

Tue 2/10

10:10 am-4:03 pm

1 stop12h 53m

$453

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

Fri 2/27

11:32 am-1:15 pm

2 stops18h 43m

Brussels Bruxelles-National

Fri 3/6

10:00 am-12:19 pm

2 stops33h 19m

$460

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Wed 3/18

8:30 am-7:15 am

1 stop16h 45m

Brussels Bruxelles-National

Wed 3/25

10:00 am-9:42 pm

2 stops17h 42m

$462

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Tue 3/24

6:25 am-7:50 am

2 stops19h 25m

Brussels Bruxelles-National

Thu 4/2

9:25 am-9:57 pm

2 stops19h 32m

$466

JoplinBrussels

JLN - BRU

JLNBRU

Joplin

Wed 3/4

8:54 am-1:15 pm

2 stops21h 21m

Brussels Bruxelles-National

Sun 3/8

10:10 am-5:43 pm

1 stop13h 33m

$500

SpringfieldBrussels

SGF - BRU

SGFBRU

Springfield-Branson

Wed 2/18

3:15 pm-1:15 pm

2 stops15h 00m

Brussels Bruxelles-National

Sun 2/22

10:10 am-10:41 am

1 stop31h 31m

$505

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

Sat 3/7

6:34 pm-7:55 am

1 stop30h 21m

Brussels Bruxelles-National

Sat 3/14

2:25 pm-9:59 pm

2 stops37h 34m

$535

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

Sun 3/15

5:51 am-10:50 am

2 stops22h 59m

Brussels Bruxelles-National

Mon 3/23

8:45 pm-10:26 pm

2 stops31h 41m

$579

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

Wed 3/11

5:51 am-1:50 pm

2 stops25h 59m

Brussels Bruxelles-National

Sun 3/15

5:30 pm-11:54 pm

2 stops36h 24m

$589

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/19

Showing 1-10 of 23 results
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Best time to book a flight from Missouri to Brussels

Have a flexible travel schedule? Discover the best time to fly to Brussels from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Brussels

What is the cheapest month to book a flight from Missouri to Brussels?

Currently, April is the cheapest month in which you can book a flight from Missouri to Brussels (average of $443). Flying from Missouri to Brussels in June is currently the most expensive (average of $1,008). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Brussels. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Brussels?

    A quick flight from Missouri to Brussels can take about 12h 40m. Lufthansa provides one of the quickest options available for as low as $442. Missouri and Brussels are separated by a distance of 4393 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Missouri to Brussels?

    When deciding which route to take from Missouri to Brussels consider Lambert-St Louis - Brussels Bruxelles-National, Kansas City - Brussels Bruxelles-National or Springfield-Branson - Brussels Bruxelles-National as they are the most popular.

  • Can I find deals for flights from Missouri to Brussels that include hotel bookings?

    Yes. In addition to deals on Missouri to Brussels flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Brussels?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Brussels.

  • Can I find deals for business class flights from Missouri to Brussels?

    Yes. Cheapflights offers flight deals from Missouri to Brussels by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Brussels?

    Currently, April is the cheapest month in which you can book a flight from Missouri to Brussels (average of $443). Flying from Missouri to Brussels in June is currently the most expensive (average of $1,008). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to Brussels

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Bruxelles-National flights
Newark to Bruxelles-National flights
Dulles Intl to Bruxelles-National flights
LaGuardia to Bruxelles-National flights
O'Hare Intl to Bruxelles-National flights
Boston to Bruxelles-National flights
Reagan-National to Bruxelles-National flights
Baltimore to Bruxelles-National flights
Seattle to Bruxelles-National flights
Los Angeles to Bruxelles-National flights
Dallas/Fort Worth to Bruxelles-National flights
Atlanta to Bruxelles-National flights
Miami to Bruxelles-National flights
John F Kennedy Intl to Charleroi Brussels flights
San Francisco to Bruxelles-National flights
Newark to Charleroi Brussels flights
Charlotte to Bruxelles-National flights
Denver to Bruxelles-National flights
Santa Ana to Bruxelles-National flights
Hobby to Bruxelles-National flights
Boise to Bruxelles-National flights
Portland to Bruxelles-National flights
Philadelphia to Bruxelles-National flights
Orlando to Bruxelles-National flights
Ontario to Bruxelles-National flights
Love Field to Bruxelles-National flights
Sky Harbor Intl to Bruxelles-National flights
Cincinnati to Bruxelles-National flights
Boston to Charleroi Brussels flights
Dulles Intl to Charleroi Brussels flights
Midway to Bruxelles-National flights
Minneapolis to Bruxelles-National flights
George Bush Intcntl to Bruxelles-National flights
Raleigh to Bruxelles-National flights
Omaha to Bruxelles-National flights
Detroit to Bruxelles-National flights
Fort Lauderdale to Bruxelles-National flights
Austin to Bruxelles-National flights
O'Hare Intl to Charleroi Brussels flights
Tampa to Bruxelles-National flights
Columbus to Bruxelles-National flights
Los Angeles to Charleroi Brussels flights
Des Moines to Bruxelles-National flights
Cleveland to Bruxelles-National flights
Nashville to Bruxelles-National flights
Richmond to Bruxelles-National flights
San Diego to Bruxelles-National flights
Indianapolis to Bruxelles-National flights
St. Louis to Bruxelles-National flights

Top 2 airlines flying from Missouri to Brussels

Discover the top 2 airlines that operate flights from Missouri to Brussels. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 21, 2026.
AirlineCheapestAverageFlexibilityOn-time
LufthansaCheapest$441Average$2,205FlexibilityNo cancel feeOn-time76%
United AirlinesCheapest$506Average$772FlexibilityNo cancel feeOn-time69%

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