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$419+ Cheap flights from Missouri to Brussels

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/13. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BRU
ene. 1 — ene. 81
jue. 1/1
jue. 1/8
1 adult, Economy
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Cheap flight deals from Missouri to Brussels

Cheapest flights from Missouri to Brussels
Explore the most affordable flight options available from Missouri to Brussels. Find the lowest fares from popular airlines and budget airlines, with prices last updated on diciembre 2, 2025.

This Delta deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/89:50 amSTL - BRU
1 stop16h 10mDelta
lun. 12/1511:00 amBRU - STL
1 stop16h 17mDelta
Deal found 12/1$499
This United Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/153:19 pmSTL - BRU
1 stop10h 36mUnited Airlines
jue. 12/2510:00 amBRU - STL
2 stops43h 43mUnited Airlines
Deal found 12/1$730
This Cheapflightsfares deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/151:00 pmSTL - BRU
1 stop12h 55mLufthansa
jue. 12/2510:10 amBRU - STL
1 stop13h 17mLufthansa
Deal found 11/30$872
This Air Canada deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/158:00 amSTL - BRU
2 stops16h 50mMultiple Airlines
jue. 12/2510:00 amBRU - STL
2 stops36h 29mMultiple Airlines
Deal found 11/30$898
This Mytrip deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
sáb. 12/64:05 pmSTL - BRU
3 stops19h 30mMultiple Airlines
sáb. 12/138:45 pmBRU - STL
2 stops24h 10mMultiple Airlines
Deal found 12/1$899
This Mytrip deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/46:00 amMCI - BRU
2 stops28h 55mMultiple Airlines
mar. 12/99:50 amBRU - MCI
2 stops18h 35mMultiple Airlines
Deal found 12/1$907
This United Airlines deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/246:30 amSTL - BRU
1 stop19h 25mUnited Airlines
mié. 12/317:00 amBRU - STL
1 stop13h 55mUnited Airlines
Deal found 11/30$944
This Mytrip deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/296:35 pmMCI - BRU
2 stops39h 55mMultiple Airlines
lun. 1/510:00 amBRU - MCI
2 stops41h 33mMultiple Airlines
Deal found 12/1$952
This Gotogate deal was found by Cheapflights users on 11/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
mié. 12/244:05 pmSTL - BRU
2 stops14h 30mMultiple Airlines
mié. 12/317:00 amBRU - STL
1 stop13h 55mMultiple Airlines
Deal found 11/30$953
This United Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/296:00 amMCI - BRU
1 stop19h 55mUnited Airlines
lun. 1/510:00 amBRU - MCI
2 stops37h 08mUnited Airlines
Deal found 12/1$1,130
This Cheapflightsfares deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
jue. 12/411:36 amMCI - BRU
1 stop14h 19mLufthansa
mar. 12/911:55 amBRU - MCI
1 stop14h 59mLufthansa
Deal found 12/1$1,564
This Cheapflightsfares deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
lun. 12/2911:24 amMCI - BRU
1 stop14h 31mLufthansa
lun. 1/511:55 amBRU - MCI
1 stop15h 36mLufthansa
Deal found 12/1$1,568

Find flight deals from Missouri to Brussels

Keep the following information in mind while searching for Missouri to Brussels flight deals. Data was last updated diciembre 2, 2025.

Round-trip from

$419
(Kiwi.com)

Popular in

December

Cheapest in

February

Average price

$2,205
From Missouri to Brussels
Search Deals
Highest demand for flights based on searches. 25% potential increase in price ($350 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 12% potential price decrease ($110 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in December 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Brussels that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 2, 2025.
Use the filters below to find and compare flights from Missouri to Brussels that are best for you.

Fly from

Missouri

Fly to

Brussels

Route

Depart

Return

Price

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

mar. 1/13

12:44 pm-7:15 am

1 stop11h 31m

Brussels Bruxelles-National

mar. 1/20

11:35 am-7:27 pm

2 stops38h 52m

$419

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

mar. 1/13

12:44 pm-7:15 am

1 stop11h 31m

Brussels Bruxelles-National

mar. 1/20

6:30 am-11:59 pm

2 stops24h 29m

$421

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

mar. 1/13

8:05 am-7:50 am

2 stops16h 45m

Brussels Bruxelles-National

mar. 1/20

10:00 am-2:30 pm

2 stops35h 30m

$441

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

mié. 1/14

7:00 am-7:50 am

2 stops17h 50m

Brussels Bruxelles-National

mié. 1/21

11:55 am-7:27 pm

1 stop14h 32m

$457

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

vie. 1/30

11:29 am-10:10 am

2 stops15h 41m

Brussels Bruxelles-National

sáb. 2/7

10:10 am-9:59 pm

1 stop18h 49m

$459

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

vie. 1/30

3:24 pm-8:55 am

1 stop10h 31m

Brussels Bruxelles-National

vie. 2/6

10:00 am-10:32 am

2 stops31h 32m

$459

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

vie. 1/30

11:29 am-8:55 am

1 stop14h 26m

Brussels Bruxelles-National

mar. 2/3

10:00 am-2:27 pm

2 stops35h 27m

$459

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

lun. 1/12

6:44 pm-4:40 pm

2 stops14h 56m

Brussels Bruxelles-National

lun. 1/19

3:00 pm-10:44 pm

2 stops38h 44m

$460

SpringfieldBrussels

SGF - BRU

SGFBRU

Springfield-Branson

mié. 1/14

4:29 pm-4:20 pm

2 stops16h 51m

Brussels Bruxelles-National

mié. 1/21

11:50 am-10:47 pm

2 stops17h 57m

$460

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

lun. 1/19

10:50 am-4:40 pm

2 stops22h 50m

Brussels Bruxelles-National

lun. 2/2

5:30 pm-10:39 pm

2 stops36h 09m

$460

Flights are sorted by cheapest round-trip flights first.

Deals found on 12/1

Showing 1-10 of 30 results
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Best time to book a flight from Missouri to Brussels

Have a flexible travel schedule? Discover the best time to fly to Brussels from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Brussels

What is the cheapest month to book a flight from Missouri to Brussels?

Currently, April is the cheapest month in which you can book a flight from Missouri to Brussels (average of $453). Flying from Missouri to Brussels in June is currently the most expensive (average of $1,008). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to BRU?

Find hourly flight availability from Missouri to Brussels. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated diciembre 2, 2025.

It’s optimal to fly from Missouri to Brussels in the afternoon. By choosing this option you can save up to 25% on the cost of your flight, compared to a flight in the morning.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Brussels. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Brussels?

    A quick flight from Missouri to Brussels can take about 11h 31m. Brussels Airlines provides one of the quickest options available for as low as $419. Missouri and Brussels are separated by a distance of 4393 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Missouri to Brussels?

    When deciding which route to take from Missouri to Brussels consider Lambert-St Louis - Brussels Bruxelles-National, Kansas City - Brussels Bruxelles-National or Springfield-Branson - Brussels Bruxelles-National as they are the most popular.

  • Can I find deals for flights from Missouri to Brussels that include hotel bookings?

    Yes. In addition to deals on Missouri to Brussels flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Brussels?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Brussels.

  • Can I find deals for business class flights from Missouri to Brussels?

    Yes. Cheapflights offers flight deals from Missouri to Brussels by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Brussels?

    Currently, April is the cheapest month in which you can book a flight from Missouri to Brussels (average of $453). Flying from Missouri to Brussels in June is currently the most expensive (average of $1,008). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to Brussels

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Bruxelles-National flights
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Madison to Bruxelles-National flights

Top 2 airlines flying from Missouri to Brussels

Discover the top 2 airlines that operate flights from Missouri to Brussels. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated diciembre 2, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$640Average$1,029FlexibilityNo cancel feeOn-time69%
LufthansaCheapest$829Average$2,205FlexibilityNo cancel feeOn-time76%

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