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$359+ Cheap flights from Missouri to Brussels

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/6. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BRU
Feb 28 — Mar 71
Sat 2/28
Sat 3/7
1 adult, Economy
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Cheap flight deals from Missouri to Brussels

Cheapest flights from Missouri to Brussels
Explore the most affordable flight options available from Missouri to Brussels. Find the lowest fares from popular airlines and budget airlines, with prices last updated on January 29, 2026.

This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/2511:32 am
MCI
-
BRU
2 stops18h 43m
United Airlines
Sun 3/110:00 am
BRU
-
MCI
2 stops42h 59m
United Airlines
Deal found 1/28$486
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/17:41 am
STL
-
BRU
1 stop18h 14m
United Airlines
Wed 3/1110:00 am
BRU
-
STL
2 stops34h 42m
United Airlines
Deal found 1/28$489
This United Airlines deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/2412:37 pm
MCI
-
BRU
1 stop11h 38m
United Airlines
Tue 3/1010:00 am
BRU
-
MCI
2 stops34h 20m
United Airlines
Deal found 1/27$489
This Flighttix deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/96:00 am
MCI
-
BRU
2 stops19h 50m
Multiple Airlines
Tue 3/1710:10 am
BRU
-
MCI
1 stop17h 49m
Multiple Airlines
Deal found 1/28$491
This Flighttix deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/912:34 pm
MCI
-
BRU
1 stop12h 41m
Lufthansa
Tue 3/1711:55 am
BRU
-
MCI
1 stop14h 46m
Lufthansa
Deal found 1/28$492
This FlightHub deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/187:40 am
STL
-
BRU
2 stops18h 10m
Air Canada
Wed 3/2510:00 am
BRU
-
STL
2 stops34h 42m
Air Canada
Deal found 1/27$493
This Air Canada deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/248:00 am
MCI
-
BRU
3 stops16h 50m
Multiple Airlines
Tue 3/1010:00 am
BRU
-
MCI
2 stops30h 31m
Multiple Airlines
Deal found 1/27$493
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/38:00 am
MCI
-
BRU
1 stop18h 00m
United Airlines
Tue 5/1211:10 am
BRU
-
MCI
1 stop31h 15m
United Airlines
Deal found 1/28$502
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/48:54 am
JLN
-
BRU
2 stops21h 21m
United Airlines
Sun 3/810:10 am
BRU
-
JLN
1 stop13h 33m
United Airlines
Deal found 1/28$502
This United Airlines deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/259:55 am
STL
-
BRU
1 stop16h 00m
United Airlines
Sun 3/111:15 am
BRU
-
STL
1 stop12h 45m
United Airlines
Deal found 1/28$509
This oojo deal was found by Cheapflights users on 1/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/69:38 am
MCI
-
BRU
2 stops22h 27m
British Airways
Mon 5/119:55 pm
BRU
-
MCI
2 stops31h 55m
British Airways
Deal found 1/27$510
This Air Canada deal was found by Cheapflights users on 1/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 2/254:05 pm
STL
-
BRU
2 stops14h 10m
Air Canada
Sun 3/110:00 am
BRU
-
STL
2 stops18h 05m
Air Canada
Deal found 1/28$513

Find flight deals from Missouri to Brussels

Keep the following information in mind while searching for Missouri to Brussels flight deals. Data was last updated January 29, 2026.

Round-trip from

$486
(United Airlines)

One-way from

$359
(Kiwi.com)

Popular in

December

Cheapest in

February

Average price

$659
From Missouri to Brussels
Search Deals
One-way flight from Missouri to Brussels
Search Deals
Highest demand for flights based on searches. 24% potential increase in price ($304 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 14% potential price decrease ($116 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in January 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Brussels that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
Use the filters below to find and compare flights from Missouri to Brussels that are best for you.

Fly from

Missouri

Fly to

Brussels

Route

Depart

Return

Price

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

Wed 2/25

11:32 am-1:15 pm

2 stops18h 43m

Brussels Bruxelles-National

Sun 3/1

10:00 am-9:59 pm

2 stops42h 59m

$486

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Sun 3/1

7:41 am-8:55 am

1 stop18h 14m

Brussels Bruxelles-National

Wed 3/11

10:00 am-2:42 pm

2 stops34h 42m

$489

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

Tue 2/24

12:37 pm-7:15 am

1 stop11h 38m

Brussels Bruxelles-National

Tue 3/10

10:00 am-2:20 pm

2 stops34h 20m

$489

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Sun 3/1

6:55 pm-7:50 am

2 stops29h 55m

Brussels Bruxelles-National

Wed 3/11

10:00 am-2:42 pm

2 stops34h 42m

$493

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

Tue 2/24

8:00 am-7:50 am

3 stops16h 50m

Brussels Bruxelles-National

Tue 3/10

10:00 am-10:31 am

2 stops30h 31m

$493

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

Tue 2/24

9:12 am-7:50 am

2 stops15h 38m

Brussels Bruxelles-National

Tue 3/10

10:00 am-2:20 pm

2 stops34h 20m

$493

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

Mon 3/9

6:34 pm-7:50 am

2 stops31h 16m

Brussels Bruxelles-National

Tue 3/17

7:00 am-8:41 pm

2 stops19h 41m

$496

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

Sun 5/3

5:40 am-7:40 am

1 stop19h 00m

Brussels Bruxelles-National

Tue 5/12

9:45 am-5:31 pm

1 stop14h 46m

$502

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

Sun 5/3

8:00 am-9:00 am

1 stop18h 00m

Brussels Bruxelles-National

Tue 5/12

11:10 am-11:25 am

1 stop31h 15m

$502

JoplinBrussels

JLN - BRU

JLNBRU

Joplin

Wed 3/4

8:54 am-1:15 pm

2 stops21h 21m

Brussels Bruxelles-National

Sun 3/8

10:10 am-5:43 pm

1 stop13h 33m

$502

Flights are sorted by cheapest round-trip flights first.

Deals found on 1/27

Showing 1-10 of 22 results
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Best time to book a flight from Missouri to Brussels

Have a flexible travel schedule? Discover the best time to fly to Brussels from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Brussels

What is the cheapest month to book a flight from Missouri to Brussels?

Currently, April is the cheapest month in which you can book a flight from Missouri to Brussels (average of $443). Flying from Missouri to Brussels in June is currently the most expensive (average of $1,008). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Brussels. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Brussels?

    A quick flight from Missouri to Brussels can take about 12h 41m. United Airlines provides one of the quickest options available for as low as $492. Missouri and Brussels are separated by a distance of 4528 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the most popular routes from Missouri to Brussels?

    When deciding which route to take from Missouri to Brussels consider Lambert-St Louis - Brussels Bruxelles-National, Kansas City - Brussels Bruxelles-National or Springfield-Branson - Brussels Bruxelles-National as they are the most popular.

  • Can I find deals for flights from Missouri to Brussels that include hotel bookings?

    Yes. In addition to deals on Missouri to Brussels flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Brussels?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Brussels.

  • Can I find deals for business class flights from Missouri to Brussels?

    Yes. Cheapflights offers flight deals from Missouri to Brussels by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Brussels?

    Currently, April is the cheapest month in which you can book a flight from Missouri to Brussels (average of $443). Flying from Missouri to Brussels in June is currently the most expensive (average of $1,008). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to Brussels

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Bruxelles-National flights
Newark to Bruxelles-National flights
Dulles Intl to Bruxelles-National flights
O'Hare Intl to Bruxelles-National flights
LaGuardia to Bruxelles-National flights
Baltimore to Bruxelles-National flights
Reagan-National to Bruxelles-National flights
Dallas/Fort Worth to Bruxelles-National flights
Seattle to Bruxelles-National flights
Atlanta to Bruxelles-National flights
Boston to Bruxelles-National flights
Los Angeles to Bruxelles-National flights
John F Kennedy Intl to Charleroi Brussels flights
Miami to Bruxelles-National flights
Austin to Bruxelles-National flights
Hobby to Bruxelles-National flights
San Francisco to Bruxelles-National flights
Newark to Charleroi Brussels flights
Midway to Bruxelles-National flights
Charlotte to Bruxelles-National flights
Orlando to Bruxelles-National flights
Dulles Intl to Charleroi Brussels flights
Minneapolis to Bruxelles-National flights
Cincinnati to Bruxelles-National flights
Tampa to Bruxelles-National flights
San Diego to Bruxelles-National flights
Philadelphia to Bruxelles-National flights
Love Field to Bruxelles-National flights
Columbus to Bruxelles-National flights
Denver to Bruxelles-National flights
Sky Harbor Intl to Bruxelles-National flights
George Bush Intcntl to Bruxelles-National flights
O'Hare Intl to Charleroi Brussels flights
Fort Lauderdale to Bruxelles-National flights
Santa Ana to Bruxelles-National flights
Detroit to Bruxelles-National flights
Portland to Bruxelles-National flights
Tulsa to Bruxelles-National flights
Cleveland to Bruxelles-National flights
Raleigh to Bruxelles-National flights
Ontario to Bruxelles-National flights
Miami to Charleroi Brussels flights
Boston to Charleroi Brussels flights
San Antonio to Bruxelles-National flights
Omaha to Bruxelles-National flights
Nashville to Bruxelles-National flights
Los Angeles to Charleroi Brussels flights
Pittsburgh to Bruxelles-National flights
St. Louis to Bruxelles-National flights

Top 2 airlines flying from Missouri to Brussels

Discover the top 2 airlines that operate flights from Missouri to Brussels. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated January 29, 2026.
AirlineCheapestAverageFlexibilityOn-time
LufthansaCheapest$441Average$2,205FlexibilityNo cancel feeOn-time76%
United AirlinesCheapest$506Average$758FlexibilityNo cancel feeOn-time69%

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