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$462+ Cheap flights from Missouri to Brussels

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/12. Fares are subject to change and may not be available on all flights or dates of travel.
STL — BRU
Aug 19 — Aug 261
Tue 8/19
Tue 8/26
1 adult, Economy
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Cheap flight deals from Missouri to Brussels

Keep the following information in mind while searching for Missouri to Brussels flight deals. Data was last updated August 14, 2025.

Round-trip from

$462
(KLM)

Popular in

December

Cheapest in

October

Average price

$1,139
From Missouri to Brussels
Search Deals
Highest demand for flights based on searches. 11% potential increase in price ($135 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 7% potential price decrease ($72 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in August 2025
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Find flight deals from Missouri to Brussels

Cheapest flights from Missouri to Brussels
Explore the most affordable flight options available from Missouri to Brussels. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 14, 2025.

This KLM deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1211:51 amSTL - BRU
2 stops14h 09mKLM
Thu 11/2711:00 amBRU - STL
2 stops16h 29mKLM
Deal found 8/14$462
This Delta deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/146:30 amSTL - BRU
2 stops19h 30mDelta
Mon 11/2411:00 amBRU - STL
2 stops19h 02mDelta
Deal found 8/14$562
This Delta deal was found by Cheapflights users on 8/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/126:00 amSTL - BRU
2 stops20h 00mDelta
Thu 11/2711:00 amBRU - STL
2 stops16h 29mDelta
Deal found 8/13$571
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/128:00 amSTL - BRU
1 stop17h 55mUnited Airlines
Thu 11/2710:00 amBRU - STL
2 stops35h 25mUnited Airlines
Deal found 8/14$583
This Air Canada deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/94:05 pmSTL - BRU
2 stops32h 45mAir Canada
Wed 11/2610:00 amBRU - STL
2 stops31h 51mAir Canada
Deal found 8/14$585
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/155:24 pmSTL - BRU
1 stop32h 31mUnited Airlines
Thu 11/2710:00 amBRU - STL
2 stops35h 25mUnited Airlines
Deal found 8/14$589
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/93:14 pmSTL - BRU
1 stop10h 41mUnited Airlines
Wed 11/2610:10 amBRU - STL
1 stop16h 29mUnited Airlines
Deal found 8/14$606
This United Airlines deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/156:43 pmSTL - BRU
1 stop31h 12mUnited Airlines
Wed 11/2610:10 amBRU - STL
1 stop14h 29mUnited Airlines
Deal found 8/14$611
This lastminute.com deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lastminute.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/176:49 pmSTL - BRU
2 stops30h 51mVirgin Atlantic
Tue 8/2610:45 amBRU - STL
2 stops18h 17mVirgin Atlantic
Deal found 8/14$618
This Gotogate deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/174:00 pmSTL - BRU
1 stop32h 50mAir Canada
Tue 8/2610:00 amBRU - STL
1 stop17h 00mAir Canada
Deal found 8/14$621
This United deal was found by Cheapflights users on 8/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/176:00 amSTL - BRU
1 stop18h 45mMultiple Airlines
Tue 8/2610:00 amBRU - STL
1 stop17h 00mMultiple Airlines
Deal found 8/14$645
This FlightHub deal was found by Cheapflights users on 8/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/86:29 pmMCI - BRU
2 stops30h 36mAir Canada
Wed 9/2410:00 amBRU - MCI
2 stops35h 20mAir Canada
Deal found 8/11$653

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Brussels that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
Use the filters below to find and compare flights from Missouri to Brussels that are best for you.

Fly from

Missouri

Fly to

Brussels

Route

Depart

Return

Price

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Wed 11/12

11:51 am-9:00 am

2 stops14h 09m

Brussels Bruxelles-National

Thu 11/27

11:00 am-8:29 pm

2 stops16h 29m

$462

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Fri 11/14

6:30 am-9:00 am

2 stops19h 30m

Brussels Bruxelles-National

Mon 11/24

11:00 am-11:02 pm

2 stops19h 02m

$562

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Wed 11/12

6:00 am-9:00 am

2 stops20h 00m

Brussels Bruxelles-National

Thu 11/27

11:00 am-8:29 pm

2 stops16h 29m

$571

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Wed 11/12

6:30 am-7:50 am

2 stops18h 20m

Brussels Bruxelles-National

Tue 11/25

10:00 am-2:25 pm

2 stops35h 25m

$583

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Mon 11/10

8:00 am-8:55 am

1 stop17h 55m

Brussels Bruxelles-National

Thu 11/27

10:00 am-2:25 pm

2 stops35h 25m

$583

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Wed 11/12

6:30 am-7:50 am

2 stops18h 20m

Brussels Bruxelles-National

Thu 11/27

10:00 am-2:25 pm

2 stops35h 25m

$583

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Wed 11/12

8:20 am-7:50 am

2 stops16h 30m

Brussels Bruxelles-National

Thu 11/27

10:00 am-2:25 pm

2 stops35h 25m

$583

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Wed 11/12

6:30 am-7:50 am

2 stops18h 20m

Brussels Bruxelles-National

Wed 11/26

10:00 am-12:28 pm

2 stops33h 28m

$583

St. LouisBrussels

STL - BRU

STLBRU

Lambert-St Louis

Mon 11/10

6:30 am-7:50 am

2 stops18h 20m

Brussels Bruxelles-National

Thu 11/27

10:00 am-2:25 pm

2 stops35h 25m

$583

Kansas CityBrussels

MCI - BRU

MCIBRU

Kansas City

Thu 1/8

3:22 pm-8:55 am

1 stop10h 33m

Brussels Bruxelles-National

Fri 1/23

10:00 am-7:32 pm

2 stops40h 32m

$633

Flights are sorted by cheapest round-trip flights first.

Deals found on 8/14

Showing 1-10 of 20 results
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Best time to book a flight from Missouri to Brussels

Have a flexible travel schedule? Discover the best time to fly to Brussels from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Brussels

What is the cheapest month to book a flight from Missouri to Brussels?

Currently, November is the cheapest month in which you can book a flight from Missouri to Brussels (average of $614). Flying from Missouri to Brussels in June is currently the most expensive (average of $1,079). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to BRU?

Find hourly flight availability from Missouri to Brussels. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated August 14, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Brussels as you normally would.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Brussels. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the most popular routes from Missouri to Brussels?

    When deciding which route to take from Missouri to Brussels consider Lambert-St Louis - Brussels Bruxelles-National, Kansas City - Brussels Bruxelles-National or Joplin - Brussels Bruxelles-National as they are the most popular.

  • Can I find deals for flights from Missouri to Brussels that include hotel bookings?

    Yes. In addition to deals on Missouri to Brussels flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Brussels?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Brussels.

  • Can I find deals for business class flights from Missouri to Brussels?

    Yes. Cheapflights offers flight deals from Missouri to Brussels by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Brussels?

    Currently, November is the cheapest month in which you can book a flight from Missouri to Brussels (average of $614). Flying from Missouri to Brussels in June is currently the most expensive (average of $1,079). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Brussels

See prices for flight routes from nearby airports that may be better suited for you.
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Top airline flying from Missouri to Brussels

Discover the top airline that operate flights from Missouri to Brussels. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated August 14, 2025.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$640Average$1,050FlexibilityNo cancel feeOn-time69%

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