$105+ Cheap flights from Missouri to South Carolina
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/5. Fares are subject to change and may not be available on all flights or dates of travel.
MCI — CHS
Jul 11 — Jul 181
Round-trip
1 adult, Economy
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Cheapest flights from Missouri to South CarolinaExplore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 11, 2026.
Explore the most affordable flight options available from Missouri to South Carolina. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 11, 2026.
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:54 am
STL
- CLT
Nonstop1h 55m
American Airlines
Wed 8/269:45 pm
CLT
- STL
Nonstop1h 55m
American Airlines
Deal found 6/10![American Airlines logo]()
$189
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:53 am
STL
- CLT
Nonstop1h 57m
American Airlines
Tue 9/229:50 pm
CLT
- STL
Nonstop1h 52m
American Airlines
Deal found 6/8![American Airlines logo]()
$193
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/286:05 am
STL
- CLT
1 stop7h 15m
Southwest
Wed 11/46:20 pm
CLT
- STL
Nonstop2h 10m
Southwest
Deal found 6/10![Southwest logo]()
$199
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:00 am
STL
- CLT
1 stop7h 18m
United Airlines
Wed 8/268:05 am
CLT
- STL
1 stop4h 57m
United Airlines
Deal found 6/8![United Airlines logo]()
$209
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1810:15 am
STL
- CLT
2 stops9h 55m
Southwest
Wed 8/268:05 am
CLT
- STL
1 stop4h 15m
Southwest
Deal found 6/10![Southwest logo]()
$214
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:13 pm
STL
- CLT
Nonstop2h 02m
American Airlines
Wed 7/157:37 am
CLT
- STL
Nonstop1h 56m
American Airlines
Deal found 6/10![American Airlines logo]()
$217
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2210:45 am
STL
- CLT
2 stops7h 15m
Southwest
Tue 9/291:30 pm
CLT
- STL
2 stops9h 10m
Southwest
Deal found 6/9![Southwest logo]()
$219
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/72:55 pm
STL
- CHS
1 stop5h 55m
Southwest
Wed 10/148:00 am
CHS
- STL
1 stop6h 50m
Southwest
Deal found 6/9![Southwest logo]()
$221
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1610:45 am
STL
- CLT
2 stops9h 40m
Southwest
Tue 9/221:30 pm
CLT
- STL
2 stops9h 10m
Southwest
Deal found 6/8![Southwest logo]()
$225
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/14:00 pm
STL
- CLT
1 stop4h 10m
Southwest
Wed 7/81:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Deal found 6/9![Southwest logo]()
$227
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/164:15 pm
MCI
- CLT
1 stop4h 10m
Southwest
Wed 9/2312:35 pm
CLT
- MCI
1 stop6h 00m
Southwest
Deal found 6/10![Southwest logo]()
$230
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/73:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Tue 7/141:50 pm
CHS
- STL
Nonstop2h 10m
Southwest
Deal found 6/9![Southwest logo]()
$237
Best flights from Missouri to South CarolinaDiscover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 11, 2026.
Discover carefully curated flight deals from Missouri to South Carolina that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 11, 2026.
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:35 am
STL
- CLT
1 stop6h 15m
Southwest
Wed 10/72:55 pm
CLT
- STL
Nonstop1h 55m
Southwest
Deal found 6/10![Southwest logo]()
$237
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/216:45 pm
STL
- MYR
1 stop3h 45m
Delta
Sat 9/266:00 am
MYR
- STL
1 stop4h 34m
Delta
Deal found 6/8![Delta logo]()
$271
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/258:00 am
STL
- CLT
1 stop5h 54m
United Airlines
Sat 8/295:36 pm
CLT
- STL
1 stop5h 24m
United Airlines
Deal found 6/8![United Airlines logo]()
$289
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/174:24 pm
MCI
- MYR
1 stop6h 03m
American Airlines
Sat 10/2411:09 am
MYR
- MCI
1 stop4h 18m
American Airlines
Deal found 6/6![American Airlines logo]()
$369
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/14:00 pm
STL
- CLT
1 stop4h 10m
Southwest
Wed 7/87:05 pm
CLT
- STL
1 stop4h 25m
Southwest
Deal found 6/9![Southwest logo]()
$237
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/196:00 am
STL
- MYR
1 stop6h 33m
Delta
Sat 8/226:00 am
MYR
- STL
1 stop4h 20m
Delta
Deal found 6/9![Delta logo]()
$271
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/119:30 am
STL
- CLT
1 stop11h 40m
Southwest
Wed 7/157:50 am
CLT
- STL
2 stops8h 00m
Southwest
Deal found 6/10![Southwest logo]()
$248
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1812:59 pm
STL
- CHS
1 stop7h 35m
United Airlines
Wed 8/1911:40 am
CHS
- STL
1 stop4h 58m
United Airlines
Deal found 6/9![United Airlines logo]()
$301
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1811:55 am
MCI
- MYR
2 stops6h 25m
Southwest
Tue 8/252:25 pm
MYR
- MCI
2 stops8h 40m
Southwest
Deal found 6/10![Southwest logo]()
$251
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/27:00 am
STL
- CHS
1 stop5h 11m
Delta
Sun 9/67:13 am
CHS
- STL
1 stop5h 43m
Delta
Deal found 6/9![Delta logo]()
$279
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/56:00 am
MCI
- CHS
2 stops7h 35m
United Airlines
Wed 9/98:14 am
CHS
- MCI
1 stop7h 04m
United Airlines
Deal found 6/11![United Airlines logo]()
$303
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2211:20 am
MCI
- SAV
1 stop6h 55m
Southwest
Tue 9/291:10 pm
SAV
- MCI
1 stop5h 30m
Southwest
Deal found 6/10![Southwest logo]()
$252
This Delta deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/141:22 pm
STL
- MYR
1 stop4h 45m
Delta
Wed 7/227:59 pm
MYR
- STL
1 stop4h 54m
Delta
Deal found 6/6![Delta logo]()
$297
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:00 am
STL
- SAV
1 stop6h 16m
United Airlines
Wed 8/194:59 pm
SAV
- STL
1 stop6h 01m
United Airlines
Deal found 6/10![United Airlines logo]()
$305
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1611:20 am
MCI
- SAV
2 stops7h 15m
Southwest
Wed 9/236:45 am
SAV
- MCI
2 stops7h 45m
Southwest
Deal found 6/10![Southwest logo]()
$263
This Delta deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/43:39 pm
STL
- MYR
1 stop5h 11m
Delta
Tue 7/76:00 am
MYR
- STL
1 stop4h 43m
Delta
Deal found 6/6![Delta logo]()
$317
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/241:13 pm
STL
- CLT
1 stop7h 16m
United Airlines
Sat 8/18:05 am
CLT
- STL
1 stop5h 06m
United Airlines
Deal found 6/10![United Airlines logo]()
$319
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/62:20 pm
STL
- CHS
1 stop6h 05m
Southwest
Mon 8/107:15 pm
CHS
- STL
1 stop3h 50m
Southwest
Deal found 6/10![Southwest logo]()
$265
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/276:00 am
COU
- CLT
1 stop5h 38m
American Airlines
Tue 7/72:35 pm
CLT
- COU
1 stop7h 26m
American Airlines
Deal found 6/10![American Airlines logo]()
$442
This Delta deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/1510:51 am
STL
- SAV
1 stop4h 23m
Delta
Sun 7/265:39 am
SAV
- STL
1 stop3h 40m
Delta
Deal found 6/6![Delta logo]()
$319
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/153:14 pm
MCI
- CHS
1 stop5h 20m
United Airlines
Sat 8/222:54 pm
CHS
- MCI
2 stops7h 50m
United Airlines
Deal found 6/10![United Airlines logo]()
$330
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/226:50 am
STL
- SAV
2 stops10h 05m
Southwest
Sat 8/298:15 am
SAV
- STL
2 stops6h 10m
Southwest
Deal found 6/10![Southwest logo]()
$279
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/227:15 am
SGF
- CLT
1 stop6h 53m
American Airlines
Sat 7/257:46 am
CLT
- SGF
1 stop6h 54m
American Airlines
Deal found 6/6![American Airlines logo]()
$475
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1812:10 pm
MCI
- SAV
1 stop6h 25m
United Airlines
Wed 8/1912:59 pm
SAV
- MCI
1 stop5h 31m
United Airlines
Deal found 6/10![United Airlines logo]()
$333
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/176:58 pm
STL
- CHS
1 stop4h 28m
Delta
Wed 7/225:10 am
CHS
- STL
1 stop5h 33m
Delta
Deal found 6/8![Delta logo]()
$337
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/165:40 am
STL
- CLT
1 stop4h 15m
Southwest
Mon 10/191:20 pm
CLT
- STL
Nonstop2h 00m
Southwest
Deal found 6/9![Southwest logo]()
$280
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/1110:00 am
MCI
- SAV
2 stops8h 35m
United Airlines
Wed 8/124:59 pm
SAV
- MCI
1 stop5h 45m
United Airlines
Deal found 6/8![United Airlines logo]()
$338
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/298:00 am
STL
- SAV
1 stop5h 48m
Delta
Fri 7/31:57 pm
SAV
- STL
1 stop5h 10m
Delta
Deal found 6/10![Delta logo]()
$339
This Southwest deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/247:05 pm
STL
- CLT
1 stop3h 15m
Southwest
Wed 7/291:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Deal found 6/6![Southwest logo]()
$294
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/246:12 pm
SGF
- CLT
Nonstop2h 22m
American Airlines
Sun 7/265:45 am
CLT
- SGF
1 stop5h 27m
American Airlines
Deal found 6/10![American Airlines logo]()
$535
Last-minute flights from Missouri to South CarolinaDiscover last-minute flight deals from Missouri to South Carolina. Data last updated June 11, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to South Carolina. Data last updated June 11, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/16:13 pm
STL
- CLT
Nonstop2h 02m
American Airlines
Wed 7/157:37 am
CLT
- STL
Nonstop1h 56m
American Airlines
Deal found 6/10![American Airlines logo]()
$217
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/14:00 pm
STL
- CLT
1 stop4h 10m
Southwest
Wed 7/151:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Deal found 6/10![Southwest logo]()
$227
This CheapOair deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/11:45 pm
MCI
- CLT
1 stop27h 34m
Frontier
Wed 7/810:04 pm
CLT
- MCI
1 stop15h 56m
Frontier
Deal found 6/10![Frontier logo]()
$240
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/76:00 am
STL
- CLT
1 stop6h 31m
Delta
Sat 7/116:00 am
CLT
- STL
1 stop4h 06m
Delta
Deal found 6/9![Delta logo]()
$237
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/73:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Tue 7/141:50 pm
CHS
- STL
Nonstop2h 10m
Southwest
Deal found 6/9![Southwest logo]()
$237
This CheapOair deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/74:09 pm
STL
- CLT
1 stop23h 49m
Frontier
Wed 7/810:04 pm
CLT
- STL
1 stop22h 19m
Frontier
Deal found 6/8![Frontier logo]()
$240
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/76:00 am
STL
- CHS
1 stop7h 06m
United Airlines
Tue 7/1411:31 am
CHS
- STL
1 stop5h 15m
United Airlines
Deal found 6/9![United Airlines logo]()
$247
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/73:10 pm
STL
- CLT
1 stop6h 00m
Southwest
Tue 7/147:50 am
CLT
- STL
2 stops11h 35m
Southwest
Deal found 6/9![Southwest logo]()
$248
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/84:50 pm
STL
- CLT
Nonstop1h 50m
Southwest
Wed 7/157:50 am
CLT
- STL
2 stops8h 00m
Southwest
Deal found 6/9![Southwest logo]()
$232
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/119:30 am
STL
- CLT
1 stop11h 40m
Southwest
Wed 7/151:25 pm
CLT
- STL
Nonstop2h 00m
Southwest
Deal found 6/10![Southwest logo]()
$233
This CheapOair deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/254:09 pm
STL
- CLT
1 stop18h 20m
Frontier
Wed 7/2912:24 pm
CLT
- STL
1 stop12h 35m
Frontier
Deal found 6/9![Frontier logo]()
$254
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/294:45 pm
STL
- SAV
Nonstop1h 55m
Southwest
Tue 8/410:50 am
SAV
- STL
1 stop8h 05m
Southwest
Deal found 6/9![Southwest logo]()
$251
One-way flights from Missouri to South CarolinaSearch for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated June 11, 2026.
Search for one-way flight options from Missouri to South Carolina. Find affordable one-way fares based on user searches. Data last updated June 11, 2026.
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/43:45 pm
STL
- CLT
1 stop4h 25m
Southwest
Deal found 6/7![Southwest logo]()
$105
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/411:00 am
STL
- CLT
1 stop4h 12m
Delta
Deal found 6/9![Delta logo]()
$111
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/42:45 pm
STL
- CHS
1 stop4h 00m
Southwest
Deal found 6/8![Southwest logo]()
$111
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/49:15 am
STL
- SAV
1 stop3h 49m
Delta
Deal found 6/8![Delta logo]()
$113
This Priceline deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Priceline is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/11:45 pm
MCI
- CLT
1 stop6h 40m
Frontier
Deal found 6/10![Frontier logo]()
$115
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/58:10 am
STL
- CHS
1 stop10h 05m
Southwest
Deal found 6/8![Southwest logo]()
$117
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/510:45 am
STL
- SAV
2 stops7h 30m
Southwest
Deal found 6/8![Southwest logo]()
$118
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/72:45 pm
STL
- CLT
Nonstop1h 50m
Southwest
Deal found 6/10![Southwest logo]()
$118
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/11:13 pm
STL
- CLT
1 stop7h 16m
United Airlines
Deal found 6/10![United Airlines logo]()
$119
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/73:15 pm
STL
- CHS
Nonstop2h 00m
Southwest
Deal found 6/10![Southwest logo]()
$119
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/411:55 am
MCI
- CLT
2 stops8h 15m
Southwest
Deal found 6/8![Southwest logo]()
$120
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/41:25 pm
MCI
- MYR
1 stop4h 55m
Southwest
Deal found 6/8![Southwest logo]()
$121
Find flight deals from Missouri to South Carolina
Keep the following information in mind while searching for Missouri to South Carolina flight deals. Data was last updated June 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $189 (American Airlines) |
One-way from | $105 (Southwest) |
Popular in | April |
Cheapest in | February |
Average price | $426 |
Good round-trip deal | $336 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to South Carolina that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 11, 2026.
Use the filters below to find and compare flights from Missouri to South Carolina that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Mon 10/5
6:35 am-1:50 pm
1 stop6h 15m
Charlotte Douglas
Wed 10/7
2:55 pm-3:50 pm
Nonstop1h 55m
$237
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Wed 7/1
4:00 pm-9:10 pm
1 stop4h 10m
Charlotte Douglas
Wed 7/8
7:05 pm-10:30 pm
1 stop4h 25m
$237
St. LouisCharlotte
STL - CLT
STLCLT
Lambert-St Louis
Sat 7/11
9:30 am-10:10 pm
1 stop11h 40m
Charlotte Douglas
Wed 7/15
7:50 am-2:50 pm
2 stops8h 00m
$248
Kansas CityMyrtle Beach
MCI - MYR
MCIMYR
Kansas City
Tue 8/18
11:55 am-7:20 pm
2 stops6h 25m
Myrtle Beach Intl
Tue 8/25
2:25 pm-10:05 pm
2 stops8h 40m
$251
Kansas CitySavannah
MCI - SAV
MCISAV
Kansas City
Tue 9/22
11:20 am-7:15 pm
1 stop6h 55m
Savannah/Hilton Head
Tue 9/29
1:10 pm-5:40 pm
1 stop5h 30m
$252
Kansas CitySavannah
MCI - SAV
MCISAV
Kansas City
Wed 9/16
11:20 am-7:35 pm
2 stops7h 15m
Savannah/Hilton Head
Wed 9/23
6:45 am-1:30 pm
2 stops7h 45m
$263
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Thu 8/6
2:20 pm-9:25 pm
1 stop6h 05m
Charleston
Mon 8/10
7:15 pm-10:05 pm
1 stop3h 50m
$265
St. LouisMyrtle Beach
STL - MYR
STLMYR
Lambert-St Louis
Mon 9/21
6:45 pm-11:30 pm
1 stop3h 45m
Myrtle Beach Intl
Sat 9/26
6:00 am-9:34 am
1 stop4h 34m
$271
St. LouisMyrtle Beach
STL - MYR
STLMYR
Lambert-St Louis
Wed 8/19
6:00 am-1:33 pm
1 stop6h 33m
Myrtle Beach Intl
Sat 8/22
6:00 am-9:20 am
1 stop4h 20m
$271
St. LouisCharleston
STL - CHS
STLCHS
Lambert-St Louis
Wed 9/2
7:00 am-1:11 pm
1 stop5h 11m
Charleston
Sun 9/6
7:13 am-11:56 am
1 stop5h 43m
$279
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Missouri to South Carolina
Have a flexible travel schedule? Discover the best time to fly to South Carolina from Missouri with our price prediction graph.
STL-CLT
MCI-CHS
STL-MYR
STL-SAV
STL-CHS
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to South Carolina
USMO-USSC
STL-CLT
MCI-CHS
STL-MYR
STL-SAV
What is the cheapest month to book a flight from Missouri to South Carolina?
Currently, July is the cheapest month in which you can book a flight from Missouri to South Carolina (average of $89). Flying from Missouri to South Carolina in January is currently the most expensive (average of $228). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MO to SC?
Find hourly flight availability from Missouri to South Carolina. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 11, 2026.
When flying from Missouri to South Carolina, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How much does it cost to fly round-trip from Missouri to South Carolina?
How far ahead should I book a flight from Missouri to South Carolina?
The price you pay for your flight from Missouri to South Carolina may vary depending on when you book. For the best chance of a lower fare, look to book 87 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Reviews of airlines servicing South Carolina
Get insights into the airlines that provide service to South Carolina. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South Carolina. Reviews last updated June 11, 2026.
See what other customers who have flown with Southwest,Delta, andUnited Airlines from Missouri to South Carolina have to say. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
7.5
Food
7.0
Overall
7.9
Crew
8.6
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Entertainment
7.5
Food
7.0
Overall
7.9
Crew
8.6
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Entertainment
7.5
Food
7.0
Overall
7.9
Crew
8.6
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Entertainment
7.5
Food
7.0
Overall
7.9
Crew
8.6
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Entertainment
7.5
Food
7.0
Overall
7.9
Crew
8.6
Boarding
8.1
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from Missouri to South Carolina. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Missouri to South Carolina
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to South Carolina by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to South Carolina by cabin class
Find flights from Missouri to South Carolina, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and South Carolina flights
Browse other Missouri and South Carolina flight options. Last updated on June 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from South Carolina
Find the right flight back to Missouri after your stay in South Carolina
Missouri to South Carolina flights
Consider these flights traveling from Missouri to South Carolina.
Top 4 airlines flying from Missouri to South Carolina
Discover the top 4 airlines that operate flights from Missouri to South Carolina. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$146 | Average$375 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$193 | Average$416 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$196 | Average$391 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$237 | Average$418 | FlexibilityNo cancel fee | On-time63% |