South America

$133+ Cheap flights from Jacksonville (JAX) to South America

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/1. Fares are subject to change and may not be available on all flights or dates of travel.
JAX — BOG
Jul 5 — Jul 121
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Cheap flight deals from Jacksonville to South America

Cheapest flights from Jacksonville to South America
Explore the most affordable flight options available from Jacksonville to South America. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 5, 2026.

This KAYAK deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:05 am
JAX
-
MDE
1 stop15h 05m
Multiple Airlines
Mon 9/219:45 am
MDE
-
JAX
1 stop12h 35m
Multiple Airlines
Deal found 6/1$326
This United Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/147:05 am
JAX
-
MDE
1 stop15h 05m
United Airlines
Thu 9/179:45 am
MDE
-
JAX
1 stop12h 35m
United Airlines
Deal found 6/2$327
This United Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/214:45 pm
JAX
-
MDE
2 stops29h 25m
United Airlines
Mon 8/319:45 am
MDE
-
JAX
1 stop12h 35m
United Airlines
Deal found 6/3$332
This United Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/177:05 am
JAX
-
MDE
1 stop15h 05m
United Airlines
Mon 9/219:45 am
MDE
-
JAX
2 stops48h 06m
United Airlines
Deal found 6/1$345
This United Airlines deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/147:05 am
JAX
-
MDE
1 stop15h 05m
United Airlines
Sat 9/199:45 am
MDE
-
JAX
1 stop12h 35m
United Airlines
Deal found 6/2$366
This American Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/296:12 pm
JAX
-
CTG
2 stops18h 53m
American Airlines
Tue 11/32:34 pm
CTG
-
JAX
2 stops21h 08m
American Airlines
Deal found 6/4$378
This Trip.com deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/2111:20 am
JAX
-
MDE
2 stops27h 55m
Multiple Airlines
Wed 8/266:25 am
MDE
-
JAX
2 stops27h 00m
Multiple Airlines
Deal found 5/31$411
This JetBlue deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/187:10 am
JAX
-
CTG
1 stop5h 25m
JetBlue
Wed 7/2212:35 pm
CTG
-
JAX
1 stop6h 26m
JetBlue
Deal found 5/31$429
This KAYAK deal was found by Cheapflights users on 6/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/186:35 pm
JAX
-
MDE
2 stops27h 35m
Multiple Airlines
Wed 7/229:45 am
MDE
-
JAX
1 stop12h 35m
Multiple Airlines
Deal found 6/2$436
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/216:28 pm
JAX
-
CTG
1 stop20h 45m
American Airlines
Sat 7/41:35 pm
CTG
-
JAX
1 stop18h 52m
American Airlines
Deal found 6/3$439
This JetBlue deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure JetBlue is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/207:10 am
JAX
-
CTG
1 stop5h 25m
JetBlue
Mon 7/2712:35 pm
CTG
-
JAX
1 stop6h 26m
JetBlue
Deal found 6/5$443
This Avianca deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/217:00 pm
JAX
-
UIO
1 stop12h 35m
Multiple Airlines
Tue 9/295:25 pm
UIO
-
JAX
1 stop20h 01m
Multiple Airlines
Deal found 6/1$454

Find flight deals from Jacksonville to South America

Keep the following information in mind while searching for Jacksonville to South America flight deals. Data was last updated June 5, 2026.

Round-trip from

$326
(KAYAK)

One-way from

$133
(American Airlines)

Popular in

July

Cheapest in

April

Average price

$623
From Jacksonville to South America
One-way flight from Jacksonville to South America
Highest demand for flights based on searches. 1% potential increase in price ($10 potential increase over avg. RT price).
Cheapest flight prices on average. 1% potential price decrease ($9 potential savings vs. average RT price).
Average for round-trip flights in June 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Jacksonville to South America that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 5, 2026.
Use the filters below to find and compare flights from Jacksonville to South America that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

JacksonvilleMedellín

JAX - MDE

JAXMDE

Jacksonville

Mon 9/14

7:05 am-9:10 pm

1 stop15h 05m

Medellín Jose Maria Cordova Intl

Thu 9/17

9:45 am-11:20 pm

1 stop12h 35m

$327

JacksonvilleMedellín

JAX - MDE

JAXMDE

Jacksonville

Thu 9/17

7:05 am-9:10 pm

1 stop15h 05m

Medellín Jose Maria Cordova Intl

Mon 9/21

9:45 am-10:51 am

2 stops48h 06m

$345

JacksonvilleCartagena

JAX - CTG

JAXCTG

Jacksonville

Mon 10/19

8:26 pm-12:05 pm

2 stops16h 39m

Cartagena Rafael Nunez

Mon 10/26

2:05 pm-10:16 am

2 stops19h 11m

$378

JacksonvilleMedellín

JAX - MDE

JAXMDE

Jacksonville

Fri 8/21

11:20 am-2:15 pm

2 stops27h 55m

Medellín Jose Maria Cordova Intl

Wed 8/26

6:25 am-10:25 am

2 stops27h 00m

$411
Quickest round-trip

JacksonvilleCartagena

JAX - CTG

JAXCTG

Jacksonville

Sat 7/18

7:10 am-11:35 am

1 stop5h 25m

Cartagena Rafael Nunez

Wed 7/22

12:35 pm-8:01 pm

1 stop6h 26m

$429

JacksonvilleCartagena

JAX - CTG

JAXCTG

Jacksonville

Mon 7/20

7:10 am-11:35 am

1 stop5h 25m

Cartagena Rafael Nunez

Mon 7/27

12:35 pm-8:01 pm

1 stop6h 26m

$443

JacksonvilleCartagena

JAX - CTG

JAXCTG

Jacksonville

Fri 7/3

6:11 pm-12:35 pm

2 stops19h 24m

Cartagena Rafael Nunez

Fri 7/10

3:17 pm-12:50 pm

2 stops20h 33m

$459

JacksonvilleBarranquilla

JAX - BAQ

JAXBAQ

Jacksonville

Fri 7/17

7:37 pm-2:38 pm

1 stop20h 01m

Barranquilla E Cortissoz

Mon 7/20

1:34 pm-9:27 am

1 stop18h 53m

$472

JacksonvilleCartagena

JAX - CTG

JAXCTG

Jacksonville

Sun 6/21

8:20 am-11:35 pm

2 stops16h 15m

Cartagena Rafael Nunez

Sat 7/4

2:30 pm-11:59 pm

1 stop8h 29m

$475

JacksonvilleCartagena

JAX - CTG

JAXCTG

Jacksonville

Wed 7/29

7:37 pm-2:17 pm

1 stop19h 40m

Cartagena Rafael Nunez

Tue 8/4

3:17 pm-12:15 am

1 stop7h 58m

$479

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/2

Showing 1-10 of 60 resultsSorted by cheapest first
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6

Best time to book a flight from Jacksonville to South America

Have a flexible travel schedule? Discover the best time to fly to South America from Jacksonville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Jacksonville to South America

What is the cheapest month to book a flight from Jacksonville to South America?

Currently, February is the cheapest month in which you can book a flight from Jacksonville to South America (average of $154). Flying from Jacksonville to South America in September is currently the most expensive (average of $507). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How far ahead should I book a flight from Jacksonville to South America?

To ensure you get the cheapest price possible for a flight from Jacksonville to South America, you should look to book at least 70 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.

Reviews of airlines servicing South America

Get insights into the airlines that provide service to South America. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to South America. Reviews last updated June 5, 2026.
Get a feel of what it's like to fly with Delta,LATAM Airlines, andUnited Airlines from Jacksonville to South America by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.

Boarding

8.1

Overall

7.9

Food

7.2

Entertainment

7.8

Crew

8.5

Comfort

7.8

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Boarding

8.1

Overall

7.9

Food

7.2

Entertainment

7.8

Crew

8.5

Comfort

7.8

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Boarding

8.1

Overall

7.9

Food

7.2

Entertainment

7.8

Crew

8.5

Comfort

7.8

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Boarding

8.1

Overall

7.9

Food

7.2

Entertainment

7.8

Crew

8.5

Comfort

7.8

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Boarding

8.1

Overall

7.9

Food

7.2

Entertainment

7.8

Crew

8.5

Comfort

7.8

Reviews

1 / 20
6.0
Good

pilar,May 2025

RSW - ATL

The stewardess was not very nice because I requested two glasses of water. She didn’t even offer the snacks to me. She seemed angry and I felt very bad about her reaction. Also, the flight was full and you could not move. The airline should provide seats for obese people in consideration to the rest pf the passengers.

Related info for your journey

Find useful and relevant information for your journey from Jacksonville to South America. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • What airport do you fly from for flights from Jacksonville to South America?

    If you book a flight to South America from Jacksonville, you will be flying from Jacksonville, which is the city’s only airport. Jacksonville (JAX) is located 11.2 mi from the center of Jacksonville.

  • How long is the flight from Jacksonville to South America?

    Departing from Jacksonville to South America will take you 5h 25m. Jacksonville and South America are separated by a distance of 1440 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Jacksonville to South America one-way?

    The cheapest airlines for a one-way flight from Jacksonville to South America are American Airlines ($115), United Airlines ($148), and Delta ($326).

  • What are the most popular routes from Jacksonville to South America?

  • Can I find deals for flights from Jacksonville to South America that include hotel bookings?

    Yes. In addition to deals on Jacksonville to South America flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Jacksonville to South America?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Jacksonville to South America.

  • Can I find deals for business class flights from Jacksonville to South America?

    Yes. Cheapflights offers flight deals from Jacksonville to South America by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Jacksonville to South America?

    Currently, February is the cheapest month in which you can book a flight from Jacksonville to South America (average of $154). Flying from Jacksonville to South America in September is currently the most expensive (average of $507). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Jacksonville to South America

See prices for flight routes from nearby airports that may be better suited for you.

Top 4 airlines flying from Jacksonville to South America

Discover the top 4 airlines that operate flights from Jacksonville to South America. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 5, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$154Average$367FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$407Average$888FlexibilityNo cancel feeOn-time71%
DeltaCheapest$408Average$828FlexibilityNo cancel feeOn-timeN/A
LATAM AirlinesCheapest$590Average$687FlexibilityNo cancel feeOn-time81%

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