$309+ Cheap flights from Missouri to Santiago (SCL)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/20. Fares are subject to change and may not be available on all flights or dates of travel.
MCI — SCL
Jul 10 — Jul 171
Round-trip
1 adult, Economy
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Cheapest flights from Missouri to SantiagoExplore the most affordable flight options available from Missouri to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 10, 2026.
Explore the most affordable flight options available from Missouri to Santiago. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 10, 2026.
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/111:35 am
STL
- SCL
1 stop17h 50m
American Airlines
Sun 9/69:50 pm
SCL
- STL
1 stop14h 55m
American Airlines
Deal found 6/9![American Airlines logo]()
$947
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/281:27 pm
STL
- SCL
2 stops16h 23m
United Airlines
Mon 11/910:45 pm
SCL
- STL
2 stops16h 35m
United Airlines
Deal found 6/8![United Airlines logo]()
$948
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/91:22 pm
STL
- SCL
1 stop16h 53m
Delta
Thu 7/168:40 pm
SCL
- STL
1 stop16h 37m
Delta
Deal found 6/9![Delta logo]()
$957
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:51 am
STL
- SCL
2 stops16h 09m
Delta
Tue 11/1011:10 pm
SCL
- STL
1 stop14h 38m
Delta
Deal found 6/8![Delta logo]()
$958
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/53:25 pm
STL
- SCL
2 stops14h 40m
American Airlines
Wed 8/128:50 pm
SCL
- STL
2 stops17h 12m
American Airlines
Deal found 6/6![American Airlines logo]()
$981
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/1510:54 am
STL
- SCL
2 stops18h 56m
American Airlines
Sat 10/249:30 pm
SCL
- STL
2 stops16h 54m
American Airlines
Deal found 6/9![American Airlines logo]()
$982
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/153:42 pm
STL
- SCL
1 stop14h 33m
Delta
Sat 10/248:40 pm
SCL
- STL
1 stop13h 32m
Delta
Deal found 6/9![Delta logo]()
$987
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/304:17 pm
STL
- SCL
1 stop13h 33m
United Airlines
Tue 11/1010:45 pm
SCL
- STL
1 stop13h 57m
United Airlines
Deal found 6/8![United Airlines logo]()
$988
This Travelocity deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/231:30 pm
STL
- SCL
2 stops28h 15m
LATAM Airlines
Wed 12/301:40 am
SCL
- STL
2 stops19h 21m
LATAM Airlines
Deal found 6/7![LATAM Airlines logo]()
$993
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/95:10 pm
STL
- SCL
1 stop13h 40m
American Airlines
Fri 9/189:30 pm
SCL
- STL
1 stop20h 45m
American Airlines
Deal found 6/6![American Airlines logo]()
$997
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/46:35 am
SGF
- SCL
1 stop23h 15m
United Airlines
Tue 12/810:45 pm
SCL
- SGF
1 stop20h 18m
United Airlines
Deal found 6/9![United Airlines logo]()
$999
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/92:54 pm
MCI
- SCL
1 stop13h 51m
American Airlines
Wed 12/3011:45 pm
SCL
- MCI
1 stop13h 39m
American Airlines
Deal found 6/8![American Airlines logo]()
$1,025
Best flights from Missouri to SantiagoDiscover carefully curated flight deals from Missouri to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 10, 2026.
Discover carefully curated flight deals from Missouri to Santiago that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 10, 2026.
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/211:35 am
STL
- SCL
1 stop18h 30m
American Airlines
Mon 9/79:50 pm
SCL
- STL
1 stop14h 49m
American Airlines
Deal found 6/10![American Airlines logo]()
$947
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/284:17 pm
STL
- SCL
1 stop13h 33m
United Airlines
Tue 11/1010:45 pm
SCL
- STL
1 stop22h 53m
United Airlines
Deal found 6/8![United Airlines logo]()
$948
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:51 am
STL
- SCL
2 stops16h 09m
Delta
Tue 11/1011:10 pm
SCL
- STL
1 stop14h 38m
Delta
Deal found 6/8![Delta logo]()
$958
This KAYAK deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/26:00 am
STL
- SCL
3 stops27h 49m
LATAM Airlines
Mon 9/711:05 pm
SCL
- STL
2 stops26h 32m
LATAM Airlines
Deal found 6/10![LATAM Airlines logo]()
$967
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:00 am
STL
- SCL
2 stops21h 50m
United Airlines
Thu 11/1210:45 pm
SCL
- STL
1 stop13h 57m
United Airlines
Deal found 6/8![United Airlines logo]()
$948
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/110:16 am
STL
- SCL
2 stops19h 09m
American Airlines
Sun 9/69:50 pm
SCL
- STL
2 stops17h 12m
American Airlines
Deal found 6/10![American Airlines logo]()
$952
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:51 am
STL
- SCL
2 stops16h 09m
Delta
Mon 11/911:10 pm
SCL
- STL
1 stop14h 38m
Delta
Deal found 6/8![Delta logo]()
$958
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/511:35 am
STL
- SCL
1 stop18h 30m
American Airlines
Wed 8/128:50 pm
SCL
- STL
1 stop14h 55m
American Airlines
Deal found 6/6![American Airlines logo]()
$957
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2911:51 am
STL
- SCL
2 stops16h 09m
Delta
Wed 11/1111:10 pm
SCL
- STL
1 stop14h 38m
Delta
Deal found 6/8![Delta logo]()
$958
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/46:35 am
SGF
- SCL
1 stop23h 15m
United Airlines
Tue 12/810:45 pm
SCL
- SGF
1 stop20h 18m
United Airlines
Deal found 6/9![United Airlines logo]()
$999
This Orbitz deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/45:40 am
MCI
- SCL
1 stop22h 00m
LATAM Airlines
Fri 12/1812:10 am
SCL
- MCI
1 stop12h 25m
LATAM Airlines
Deal found 6/6![LATAM Airlines logo]()
$1,166
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/35:18 pm
MCI
- SCL
1 stop12h 57m
Delta
Mon 8/1010:55 pm
SCL
- MCI
1 stop23h 54m
Delta
Deal found 6/10![Delta logo]()
$1,065
This LATAM Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/231:23 pm
MCI
- SCL
1 stop16h 52m
LATAM Airlines
Thu 7/307:25 am
SCL
- MCI
2 stops17h 33m
LATAM Airlines
Deal found 6/8![LATAM Airlines logo]()
$1,215
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/411:15 am
MCI
- SCL
1 stop17h 30m
American Airlines
Fri 12/1811:45 pm
SCL
- MCI
1 stop20h 01m
American Airlines
Deal found 6/6![American Airlines logo]()
$1,125
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/67:07 am
MCI
- SCL
1 stop23h 08m
Delta
Thu 8/1310:55 pm
SCL
- MCI
1 stop20h 38m
Delta
Deal found 6/9![Delta logo]()
$1,065
This United Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/28:52 am
JLN
- SCL
2 stops20h 58m
United Airlines
Sun 12/610:45 pm
SCL
- JLN
2 stops27h 34m
United Airlines
Deal found 6/6![United Airlines logo]()
$1,290
This Delta deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1312:16 pm
MCI
- SCL
2 stops15h 24m
Delta
Wed 7/2211:05 pm
SCL
- MCI
2 stops20h 50m
Delta
Deal found 6/7![Delta logo]()
$1,215
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/73:58 pm
MCI
- SCL
1 stop14h 17m
Delta
Fri 8/148:40 pm
SCL
- MCI
1 stop14h 35m
Delta
Deal found 6/10![Delta logo]()
$1,395
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/2410:35 am
MCI
- SCL
1 stop18h 50m
Delta
Fri 7/3111:25 pm
SCL
- MCI
1 stop20h 47m
Delta
Deal found 6/8![Delta logo]()
$1,470
Last-minute flights from Missouri to SantiagoDiscover last-minute flight deals from Missouri to Santiago. Data last updated June 10, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Santiago. Data last updated June 10, 2026 and is based on user searches.
This KAYAK deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/136:41 pm
MCI
- SCL
2 stops27h 02m
Copa Airlines
Fri 7/311:22 am
SCL
- MCI
2 stops24h 07m
Copa Airlines
Deal found 6/6![Copa Airlines logo]()
$1,153
This Trip.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/208:00 am
MCI
- SCL
2 stops21h 00m
LATAM Airlines
Wed 6/248:40 pm
SCL
- MCI
1 stop13h 51m
LATAM Airlines
Deal found 6/10![LATAM Airlines logo]()
$1,466
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/311:00 am
STL
- SCL
1 stop19h 00m
American Airlines
Wed 7/229:00 pm
SCL
- STL
1 stop14h 24m
American Airlines
Deal found 6/7![American Airlines logo]()
$1,310
This Expedia deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/33:57 pm
STL
- SCL
3 stops20h 28m
LATAM Airlines
Wed 7/224:10 am
SCL
- STL
2 stops20h 43m
LATAM Airlines
Deal found 6/7![LATAM Airlines logo]()
$1,431
This LATAM Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/68:00 am
MCI
- SCL
2 stops21h 25m
LATAM Airlines
Sun 7/128:40 pm
SCL
- MCI
2 stops22h 27m
LATAM Airlines
Deal found 6/6![LATAM Airlines logo]()
$1,475
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/91:22 pm
STL
- SCL
1 stop16h 53m
Delta
Thu 7/168:40 pm
SCL
- STL
1 stop16h 37m
Delta
Deal found 6/9![Delta logo]()
$957
This KAYAK deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/93:58 pm
STL
- SCL
3 stops20h 27m
LATAM Airlines
Thu 7/168:40 pm
SCL
- STL
1 stop14h 03m
LATAM Airlines
Deal found 6/9![LATAM Airlines logo]()
$1,041
This Delta deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/135:40 pm
MCI
- SCL
1 stop12h 35m
Delta
Wed 7/228:40 pm
SCL
- MCI
1 stop15h 31m
Delta
Deal found 6/7![Delta logo]()
$1,215
This LATAM Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/238:00 am
MCI
- SCL
2 stops21h 00m
LATAM Airlines
Thu 7/307:25 am
SCL
- MCI
2 stops17h 33m
LATAM Airlines
Deal found 6/8![LATAM Airlines logo]()
$1,430
This Ovago deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/248:30 am
MCI
- SCL
2 stops19h 44m
Copa Airlines
Thu 7/302:14 am
SCL
- MCI
2 stops32h 49m
Copa Airlines
Deal found 6/8![Copa Airlines logo]()
$1,363
This Ovago deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/245:39 am
MCI
- SCL
2 stops32h 21m
LATAM Airlines
Fri 7/3110:55 pm
SCL
- MCI
1 stop20h 14m
LATAM Airlines
Deal found 6/8![LATAM Airlines logo]()
$1,372
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/2410:35 am
MCI
- SCL
1 stop18h 50m
Delta
Fri 7/3111:25 pm
SCL
- MCI
1 stop20h 47m
Delta
Deal found 6/8![Delta logo]()
$1,470
One-way flights from Missouri to SantiagoSearch for one-way flight options from Missouri to Santiago. Find affordable one-way fares based on user searches. Data last updated June 10, 2026.
Search for one-way flight options from Missouri to Santiago. Find affordable one-way fares based on user searches. Data last updated June 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/266:19 pm
MCI
- SCL
3 stops33h 55m
Multiple Airlines
Deal found 6/10![Multiple Airlines logo]()
$315
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/144:57 pm
STL
- SCL
3 stops49h 39m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$348
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:34 pm
STL
- SCL
3 stops30h 46m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$357
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1811:11 am
MCI
- SCL
2 stops31h 21m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$390
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/124:09 pm
STL
- SCL
2 stops26h 27m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$391
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/176:11 pm
MCI
- SCL
3 stops51h 28m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$420
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/181:45 pm
MCI
- SCL
3 stops55h 58m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$512
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/1211:35 am
STL
- SCL
1 stop18h 30m
American Airlines
Deal found 6/6![American Airlines logo]()
$624
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2410:16 am
STL
- SCL
2 stops19h 49m
American Airlines
Deal found 6/7![American Airlines logo]()
$628
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/189:14 am
MCI
- SCL
2 stops20h 11m
American Airlines
Deal found 6/8![American Airlines logo]()
$628
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/2411:00 am
STL
- SCL
1 stop19h 15m
Delta
Deal found 6/8![Delta logo]()
$633
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/265:01 am
MCI
- SCL
1 stop25h 04m
American Airlines
Deal found 6/10![American Airlines logo]()
$643
Find flight deals from Missouri to Santiago
Keep the following information in mind while searching for Missouri to Santiago flight deals. Data was last updated June 10, 2026.
Most accurate provider | Ovago 3 stars |
|---|---|
Most trusted provider | Ovago 3 stars |
Round-trip from | $947 (American Airlines) |
One-way from | $315 (Kiwi.com) |
Popular in | January |
Cheapest in | March |
Average price | $1,595 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Santiago that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 10, 2026.
Use the filters below to find and compare flights from Missouri to Santiago that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 9/2
11:35 am-7:05 am
1 stop18h 30m
Santiago Arturo Merino Benitez
Mon 9/7
9:50 pm-10:39 am
1 stop14h 49m
$947
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 10/28
4:17 pm-7:50 am
1 stop13h 33m
Santiago Arturo Merino Benitez
Tue 11/10
10:45 pm-6:38 pm
1 stop22h 53m
$948
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 10/28
8:00 am-7:50 am
2 stops21h 50m
Santiago Arturo Merino Benitez
Thu 11/12
10:45 pm-9:42 am
1 stop13h 57m
$948
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Tue 9/1
10:16 am-6:25 am
2 stops19h 09m
Santiago Arturo Merino Benitez
Sun 9/6
9:50 pm-1:02 pm
2 stops17h 12m
$952
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 8/5
11:35 am-7:05 am
1 stop18h 30m
Santiago Arturo Merino Benitez
Wed 8/12
8:50 pm-10:45 am
1 stop14h 55m
$957
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Thu 10/29
11:51 am-6:00 am
2 stops16h 09m
Santiago Arturo Merino Benitez
Tue 11/10
11:10 pm-10:48 am
1 stop14h 38m
$958
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Thu 10/29
11:51 am-6:00 am
2 stops16h 09m
Santiago Arturo Merino Benitez
Mon 11/9
11:10 pm-10:48 am
1 stop14h 38m
$958
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Thu 10/29
11:51 am-6:00 am
2 stops16h 09m
Santiago Arturo Merino Benitez
Wed 11/11
11:10 pm-10:48 am
1 stop14h 38m
$958
St. LouisSantiago
STL - SCL
STLSCL
Lambert-St Louis
Wed 9/2
6:00 am-10:49 am
3 stops27h 49m
Santiago Arturo Merino Benitez
Mon 9/7
11:05 pm-11:37 pm
2 stops26h 32m
$967
SpringfieldSantiago
SGF - SCL
SGFSCL
Springfield-Branson
Fri 12/4
6:35 am-8:50 am
1 stop23h 15m
Santiago Arturo Merino Benitez
Tue 12/8
10:45 pm-4:03 pm
1 stop20h 18m
$999
Showing 1-10 of 32 resultsSorted by cheapest first
Best time to book a flight from Missouri to Santiago
Have a flexible travel schedule? Discover the best time to fly to Santiago from Missouri with our price prediction graph.
STL-SCL
SGF-SCL
MCI-SCL
JLN-SCL
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Santiago
USMO-SCL
STL-SCL
SGF-SCL
MCI-SCL
JLN-SCL
What is the cheapest month to book a flight from Missouri to Santiago?
Currently, March is the cheapest month in which you can book a flight from Missouri to Santiago (average of $472). Flying from Missouri to Santiago in June is currently the most expensive (average of $1,122). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Missouri to Santiago. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
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Complete your trip
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Santiago flight routes
Top destinations
Alternative routes for Missouri to Santiago
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Santiago by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Santiago by cabin class
Find flights from Missouri to Santiago, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and Santiago flights
Browse other Missouri and Santiago flight options. Last updated on June 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to Santiago
Explore flights to Santiago departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 10, 2026.
Missouri to Santiago flights
Consider these flights traveling from Missouri to Santiago.
Top 3 airlines flying from Missouri to Santiago
Discover the top 3 airlines that operate flights from Missouri to Santiago. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$574 | Average$894 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$611 | Average$1,083 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$792 | Average$908 | FlexibilityNo cancel fee | On-time81% |