$384+ Cheap flights from St. Louis (STL) to Panama
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/14. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
Jul 9 — Jul 161
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Best
Last-minute
One-way
Cheapest flights from St. Louis to PanamaExplore the most affordable flight options available from St. Louis to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 9, 2026.
Explore the most affordable flight options available from St. Louis to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 9, 2026.
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:01 am
STL
- PTY
1 stop13h 30m
United Airlines
Wed 7/159:45 am
PTY
- STL
1 stop13h 59m
United Airlines
Deal found 6/8![United Airlines logo]()
$575
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:01 am
STL
- PTY
1 stop22h 03m
United Airlines
Wed 7/297:55 am
PTY
- STL
1 stop14h 50m
United Airlines
Deal found 6/8![United Airlines logo]()
$585
This United Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/206:01 am
STL
- PTY
1 stop13h 30m
United Airlines
Mon 7/2710:55 pm
PTY
- STL
2 stops16h 51m
United Airlines
Deal found 6/5![United Airlines logo]()
$589
This Kissandfly.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kissandfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:01 am
STL
- PTY
1 stop13h 30m
Lufthansa
Wed 7/157:55 am
PTY
- STL
1 stop14h 50m
Lufthansa
Deal found 6/5![Lufthansa logo]()
$591
This United Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/3111:10 am
STL
- PTY
1 stop7h 27m
United Airlines
Tue 8/49:45 am
PTY
- STL
1 stop13h 51m
United Airlines
Deal found 6/4![United Airlines logo]()
$592
This United Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/66:01 am
STL
- PTY
1 stop13h 30m
United Airlines
Mon 8/1010:55 pm
PTY
- STL
1 stop24h 43m
United Airlines
Deal found 6/4![United Airlines logo]()
$595
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/216:35 pm
STL
- PTY
2 stops20h 19m
American Airlines
Sun 1/314:46 pm
PTY
- STL
2 stops19h 45m
American Airlines
Deal found 6/8![American Airlines logo]()
$601
This Delta deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/26:00 am
STL
- PTY
1 stop7h 05m
Delta
Mon 8/102:20 pm
PTY
- STL
1 stop9h 38m
Delta
Deal found 6/5![Delta logo]()
$602
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/85:11 pm
STL
- PTY
2 stops19h 28m
American Airlines
Fri 8/141:39 pm
PTY
- STL
2 stops19h 45m
American Airlines
Deal found 6/8![American Airlines logo]()
$606
This United Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:00 am
STL
- PTY
1 stop12h 31m
United Airlines
Sat 9/2610:00 am
PTY
- STL
1 stop12h 30m
United Airlines
Deal found 6/4![United Airlines logo]()
$609
Best flights from St. Louis to PanamaDiscover carefully curated flight deals from St. Louis to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 9, 2026.
Discover carefully curated flight deals from St. Louis to Panama that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 9, 2026.
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/115:30 pm
STL
- PTY
2 stops20h 44m
United Airlines
Thu 8/133:30 pm
PTY
- STL
2 stops20h 32m
United Airlines
Deal found 6/8![United Airlines logo]()
$579
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:00 am
STL
- PTY
1 stop6h 55m
Delta
Fri 8/212:20 pm
PTY
- STL
1 stop9h 38m
Delta
Deal found 6/8![Delta logo]()
$592
This United Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:01 am
STL
- PTY
1 stop13h 30m
United Airlines
Wed 7/1510:55 pm
PTY
- STL
2 stops13h 16m
United Airlines
Deal found 6/7![United Airlines logo]()
$579
This United Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/25:59 pm
STL
- PTY
2 stops22h 13m
United Airlines
Mon 8/109:45 am
PTY
- STL
1 stop13h 59m
United Airlines
Deal found 6/4![United Airlines logo]()
$579
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/166:00 am
STL
- PTY
2 stops12h 37m
United Airlines
Mon 7/203:30 pm
PTY
- STL
2 stops24h 16m
United Airlines
Deal found 6/8![United Airlines logo]()
$579
This United Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/205:59 pm
STL
- PTY
2 stops22h 13m
United Airlines
Mon 7/2710:55 pm
PTY
- STL
2 stops16h 51m
United Airlines
Deal found 6/5![United Airlines logo]()
$589
This United Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/316:14 am
STL
- PTY
1 stop12h 23m
United Airlines
Tue 8/410:00 am
PTY
- STL
1 stop12h 45m
United Airlines
Deal found 6/6![United Airlines logo]()
$592
Last-minute flights from St. Louis to PanamaDiscover last-minute flight deals from St. Louis to Panama. Data last updated June 9, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Panama. Data last updated June 9, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/36:14 am
STL
- PTY
1 stop12h 23m
United Airlines
Fri 7/1010:55 pm
PTY
- STL
1 stop17h 12m
United Airlines
Deal found 6/4![United Airlines logo]()
$619
This United Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:14 am
STL
- PTY
1 stop12h 23m
United Airlines
Sat 7/117:55 am
PTY
- STL
1 stop14h 50m
United Airlines
Deal found 6/4![United Airlines logo]()
$609
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:01 am
STL
- PTY
1 stop13h 30m
United Airlines
Wed 7/159:45 am
PTY
- STL
1 stop13h 59m
United Airlines
Deal found 6/8![United Airlines logo]()
$575
This Kissandfly.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kissandfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:01 am
STL
- PTY
1 stop13h 30m
Lufthansa
Wed 7/157:55 am
PTY
- STL
1 stop14h 50m
Lufthansa
Deal found 6/5![Lufthansa logo]()
$591
This United Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/206:01 am
STL
- PTY
1 stop13h 30m
United Airlines
Mon 7/2710:55 pm
PTY
- STL
2 stops16h 51m
United Airlines
Deal found 6/5![United Airlines logo]()
$589
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:01 am
STL
- PTY
1 stop22h 03m
United Airlines
Wed 7/297:55 am
PTY
- STL
1 stop14h 50m
United Airlines
Deal found 6/8![United Airlines logo]()
$585
This United Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/3111:10 am
STL
- PTY
1 stop7h 27m
United Airlines
Tue 8/49:45 am
PTY
- STL
1 stop13h 51m
United Airlines
Deal found 6/4![United Airlines logo]()
$592
One-way flights from St. Louis to PanamaSearch for one-way flight options from St. Louis to Panama. Find affordable one-way fares based on user searches. Data last updated June 9, 2026.
Search for one-way flight options from St. Louis to Panama. Find affordable one-way fares based on user searches. Data last updated June 9, 2026.
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/147:05 pm
STL
- PTY
2 stops19h 09m
United Airlines
Deal found 6/8![United Airlines logo]()
$384
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/147:03 pm
STL
- PTY
3 stops29h 32m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$566
Find flight deals from St. Louis to Panama
Keep the following information in mind while searching for St. Louis to Panama flight deals. Data was last updated June 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $575 (United Airlines) |
One-way from | $384 (United Airlines) |
Popular in | December |
Cheapest in | April |
Average price | $631 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 9, 2026.
Use the filters below to find and compare flights from St. Louis to Panama that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Tue 8/11
5:30 pm-2:14 pm
2 stops20h 44m
Panama City Tocumen Intl
Thu 8/13
3:30 pm-12:02 pm
2 stops20h 32m
$579
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Thu 7/9
6:01 am-7:31 pm
1 stop13h 30m
Panama City Tocumen Intl
Wed 7/15
10:55 pm-12:11 pm
2 stops13h 16m
$579
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Sun 8/2
5:59 pm-4:12 pm
2 stops22h 13m
Panama City Tocumen Intl
Mon 8/10
9:45 am-11:44 pm
1 stop13h 59m
$579
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Thu 7/16
6:00 am-6:37 pm
2 stops12h 37m
Panama City Tocumen Intl
Mon 7/20
3:30 pm-3:46 pm
2 stops24h 16m
$579
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Mon 7/20
5:59 pm-4:12 pm
2 stops22h 13m
Panama City Tocumen Intl
Mon 7/27
10:55 pm-3:46 pm
2 stops16h 51m
$589
Quickest round-trip
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Tue 8/18
6:00 am-12:55 pm
1 stop6h 55m
Panama City Tocumen Intl
Fri 8/21
2:20 pm-11:58 pm
1 stop9h 38m
$592
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Fri 7/31
6:14 am-6:37 pm
1 stop12h 23m
Panama City Tocumen Intl
Tue 8/4
10:00 am-10:45 pm
1 stop12h 45m
$592
Cheapest one-way
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Sun 6/14
7:05 pm-2:14 pm
2 stops19h 09m
$384
Quickest one-way
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Sun 6/14
5:18 pm-12:13 pm
2 stops18h 55m
$409
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Sun 6/14
7:03 pm-12:35 am
3 stops29h 32m
$566
Sorted by cheapest first
Best time to book a flight from St. Louis to Panama
Have a flexible travel schedule? Discover the best time to fly to Panama from St. Louis with our price prediction graph.
STL-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Panama
STL-PA0
STL-PTY
What is the cheapest month to book a flight from St. Louis to Panama?
Currently, February is the cheapest month in which you can book a flight from St. Louis to Panama (average of $174). Flying from St. Louis to Panama in September is currently the most expensive (average of $513). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Reviews of airlines servicing Panama
Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated June 9, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from St. Louis to Panama. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Overall
7.9
Food
7.2
Crew
8.5
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Overall
7.9
Food
7.2
Crew
8.5
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Overall
7.9
Food
7.2
Crew
8.5
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Overall
7.9
Food
7.2
Crew
8.5
Entertainment
7.8
Boarding
8.1
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for St. Louis to Panama
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Complete your trip
Complete your trip to Panama by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from St. Louis to Panama by cabin class
Find flights from St. Louis to Panama, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Panama flights
Browse other St. Louis and Panama flight options. Last updated on June 9, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from St. Louis to Panama
Discover the top 3 airlines that operate flights from St. Louis to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$393 | Average$576 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$393 | Average$596 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$452 | Average$630 | FlexibilityNo cancel fee | On-timeN/A |