$575+ Cheap flights from St. Louis (STL) to Panama City (PTY)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/9. Fares are subject to change and may not be available on all flights or dates of travel.
STL — PTY
Jul 12 — Jul 191
Round-trip
1 adult, Economy
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Find cheap flights from St. Louis to Panama City with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from St. Louis to Panama City
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Best
Last-minute
Cheapest flights from St. Louis to Panama CityExplore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2026.
Explore the most affordable flight options available from St. Louis to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2026.
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:01 am
STL
- PTY
1 stop13h 30m
United Airlines
Wed 7/159:45 am
PTY
- STL
1 stop13h 59m
United Airlines
Deal found 6/8![United Airlines logo]()
$575
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/25:59 pm
STL
- PTY
2 stops20h 15m
United Airlines
Mon 8/103:30 pm
PTY
- STL
2 stops20h 32m
United Airlines
Deal found 6/12![United Airlines logo]()
$579
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:00 am
STL
- PTY
1 stop12h 31m
United Airlines
Wed 8/2610:55 pm
PTY
- STL
1 stop24h 43m
United Airlines
Deal found 6/9![United Airlines logo]()
$585
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/3111:10 am
STL
- PTY
1 stop7h 27m
United Airlines
Tue 8/43:30 pm
PTY
- STL
1 stop18h 37m
United Airlines
Deal found 6/8![United Airlines logo]()
$592
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/216:35 pm
STL
- PTY
2 stops20h 19m
American Airlines
Sun 1/314:46 pm
PTY
- STL
2 stops19h 19m
American Airlines
Deal found 6/11![American Airlines logo]()
$601
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/85:11 pm
STL
- PTY
2 stops19h 28m
American Airlines
Fri 8/141:39 pm
PTY
- STL
2 stops19h 45m
American Airlines
Deal found 6/8![American Airlines logo]()
$606
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:00 am
STL
- PTY
1 stop12h 31m
United Airlines
Sat 9/2610:00 am
PTY
- STL
1 stop10h 16m
United Airlines
Deal found 6/12![United Airlines logo]()
$609
Best flights from St. Louis to Panama CityDiscover carefully curated flight deals from St. Louis to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 12, 2026.
Discover carefully curated flight deals from St. Louis to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 12, 2026.
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/811:10 am
STL
- PTY
1 stop7h 27m
United Airlines
Wed 7/157:55 am
PTY
- STL
1 stop14h 50m
United Airlines
Deal found 6/9![United Airlines logo]()
$575
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/186:00 am
STL
- PTY
1 stop6h 55m
Delta
Fri 8/212:20 pm
PTY
- STL
1 stop9h 38m
Delta
Deal found 6/8![Delta logo]()
$592
This United Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:14 am
STL
- PTY
1 stop12h 23m
United Airlines
Wed 7/293:30 pm
PTY
- STL
1 stop18h 37m
United Airlines
Deal found 6/7![United Airlines logo]()
$575
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/116:15 am
STL
- PTY
1 stop7h 59m
United Airlines
Thu 8/133:30 pm
PTY
- STL
2 stops20h 32m
United Airlines
Deal found 6/8![United Airlines logo]()
$579
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/236:00 am
STL
- PTY
2 stops22h 04m
United Airlines
Wed 7/2910:00 am
PTY
- STL
2 stops22h 39m
United Airlines
Deal found 6/8![United Airlines logo]()
$579
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/258:00 am
STL
- PTY
2 stops11h 31m
United Airlines
Wed 8/2610:55 pm
PTY
- STL
2 stops13h 07m
United Airlines
Deal found 6/11![United Airlines logo]()
$579
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/25:59 pm
STL
- PTY
2 stops22h 13m
United Airlines
Mon 8/103:30 pm
PTY
- STL
2 stops20h 32m
United Airlines
Deal found 6/8![United Airlines logo]()
$579
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1611:15 am
STL
- PTY
1 stop7h 22m
United Airlines
Sat 9/199:45 am
PTY
- STL
1 stop13h 53m
United Airlines
Deal found 6/11![United Airlines logo]()
$592
Last-minute flights from St. Louis to Panama CityDiscover last-minute flight deals from St. Louis to Panama City. Data last updated June 12, 2026 and is based on user searches.
Discover last-minute flight deals from St. Louis to Panama City. Data last updated June 12, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:01 am
STL
- PTY
1 stop13h 30m
United Airlines
Wed 7/159:45 am
PTY
- STL
1 stop13h 59m
United Airlines
Deal found 6/8![United Airlines logo]()
$575
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/95:58 pm
STL
- PTY
2 stops18h 16m
American Airlines
Wed 7/151:14 pm
PTY
- STL
2 stops22h 41m
American Airlines
Deal found 6/8![American Airlines logo]()
$585
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/126:14 am
STL
- PTY
1 stop12h 23m
United Airlines
Sat 7/189:45 am
PTY
- STL
1 stop13h 59m
United Airlines
Deal found 6/9![United Airlines logo]()
$609
This American Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/155:48 pm
STL
- PTY
2 stops18h 26m
American Airlines
Sun 7/191:14 pm
PTY
- STL
2 stops19h 19m
American Airlines
Deal found 6/12![American Airlines logo]()
$614
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/168:35 am
STL
- PTY
1 stop7h 37m
United Airlines
Mon 7/209:45 am
PTY
- STL
1 stop13h 59m
United Airlines
Deal found 6/12![United Airlines logo]()
$626
This Ovago deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/206:14 am
STL
- PTY
1 stop8h 00m
Copa Airlines
Mon 7/279:45 am
PTY
- STL
1 stop13h 59m
Copa Airlines
Deal found 6/8![Copa Airlines logo]()
$625
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/245:59 pm
STL
- PTY
2 stops22h 13m
United Airlines
Fri 7/313:30 pm
PTY
- STL
1 stop18h 37m
United Airlines
Deal found 6/9![United Airlines logo]()
$613
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/3111:10 am
STL
- PTY
1 stop7h 27m
United Airlines
Tue 8/43:30 pm
PTY
- STL
1 stop18h 37m
United Airlines
Deal found 6/8![United Airlines logo]()
$592
Find flight deals from St. Louis to Panama City
Discover tips and strategies to find the most affordable flight options for your journey from St. Louis (STL) to Panama City (PTY). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $575 (United Airlines) |
Popular in | December |
Cheapest in | April |
Average price | $631 |
Cheapflights Fare Finder
Customize your flight search to find flights from St. Louis to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2026.
Use the filters below to find and compare flights from St. Louis to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Wed 7/8
11:10 am-6:37 pm
1 stop7h 27m
Panama City Tocumen Intl
Wed 7/15
7:55 am-10:45 pm
1 stop14h 50m
$575
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Wed 7/22
6:14 am-6:37 pm
1 stop12h 23m
Panama City Tocumen Intl
Wed 7/29
3:30 pm-10:07 am
1 stop18h 37m
$575
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Tue 8/11
6:15 am-2:14 pm
1 stop7h 59m
Panama City Tocumen Intl
Thu 8/13
3:30 pm-12:02 pm
2 stops20h 32m
$579
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Thu 7/23
6:00 am-4:04 am
2 stops22h 04m
Panama City Tocumen Intl
Wed 7/29
10:00 am-8:39 am
2 stops22h 39m
$579
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Tue 8/25
8:00 am-7:31 pm
2 stops11h 31m
Panama City Tocumen Intl
Wed 8/26
10:55 pm-12:02 pm
2 stops13h 07m
$579
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Sun 8/2
5:59 pm-4:12 pm
2 stops22h 13m
Panama City Tocumen Intl
Mon 8/10
3:30 pm-12:02 pm
2 stops20h 32m
$579
Quickest round-trip
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Tue 8/18
6:00 am-12:55 pm
1 stop6h 55m
Panama City Tocumen Intl
Fri 8/21
2:20 pm-11:58 pm
1 stop9h 38m
$592
St. LouisPanama City
STL - PTY
STLPTY
Lambert-St Louis
Wed 9/16
11:15 am-6:37 pm
1 stop7h 22m
Panama City Tocumen Intl
Sat 9/19
9:45 am-11:38 pm
1 stop13h 53m
$592
Sorted by cheapest first
Compare providers for flights from St. Louis to Panama City
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from St. Louis to Panama City in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on St. Louis-Panama City flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on St. Louis-Panama City flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from St. Louis-Panama City flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on St. Louis-Panama City flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for St. Louis-Panama City flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from St. Louis to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from St. Louis with our price prediction graph.
STL-PTY
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from St. Louis to Panama City
What is the cheapest month to book a flight from St. Louis to Panama City?
Currently, April is the cheapest month in which you can book a flight from St. Louis to Panama City (average of $495). Flying from St. Louis to Panama City in December is currently the most expensive (average of $719). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from St. Louis to Panama City?
Reviews of airlines servicing Panama City
Get insights into the airlines that provide service to Panama City. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama City. Reviews last updated June 12, 2026.
Read reviews from past customers who have flown Delta,United Airlines, andAmerican Airlines from St. Louis to Panama City. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.5
Overall
7.9
Comfort
7.8
Food
7.2
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Crew
8.5
Overall
7.9
Comfort
7.8
Food
7.2
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Crew
8.5
Overall
7.9
Comfort
7.8
Food
7.2
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Boarding
8.1
Crew
8.5
Overall
7.9
Comfort
7.8
Food
7.2
Entertainment
7.8
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from St. Louis to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from St. Louis to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
St. Louis and Panama City flights
Browse other St. Louis and Panama City flight options. Last updated on June 12, 2026.
Other flights from St. Louis
Browse through other flights departing from St. Louis. Flights are based on user searches made on Cheapflights and were last updated on June 12, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 12, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 3 airlines flying from St. Louis to Panama City
Discover the top 3 airlines that operate flights from St. Louis to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$393 | Average$576 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$393 | Average$596 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$452 | Average$630 | FlexibilityNo cancel fee | On-timeN/A |