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Panama City

$236+ Cheap flights from Missouri to Panama City (PTY)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/25. Fares are subject to change and may not be available on all flights or dates of travel.
MCI — PTY
Jul 12 — Jul 191
Sun 7/12
Sun 7/19
1 adult, Economy
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Cheap flight deals from Missouri to Panama City

Cheapest flights from Missouri to Panama City
Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2026.

This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/206:20 am
MCI
-
PTY
1 stop12h 17m
United Airlines
Mon 8/2410:00 am
PTY
-
MCI
1 stop12h 35m
United Airlines
Deal found 6/8$527
This United Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/168:30 am
MCI
-
PTY
1 stop29h 44m
United Airlines
Wed 8/1910:55 pm
PTY
-
MCI
2 stops17h 12m
United Airlines
Deal found 6/7$540
This American Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:02 am
MCI
-
PTY
1 stop7h 14m
American Airlines
Tue 9/151:16 pm
PTY
-
MCI
1 stop9h 43m
American Airlines
Deal found 6/11$557
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/96:00 am
MCI
-
PTY
2 stops12h 37m
United Airlines
Wed 7/297:55 am
PTY
-
MCI
2 stops15h 22m
United Airlines
Deal found 6/8$561
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:30 am
MCI
-
PTY
2 stops11h 07m
United Airlines
Fri 8/283:30 pm
PTY
-
MCI
2 stops18h 55m
United Airlines
Deal found 6/11$565
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/46:16 am
MCI
-
PTY
1 stop7h 58m
United Airlines
Sat 8/810:55 pm
PTY
-
MCI
1 stop25h 04m
United Airlines
Deal found 6/10$572
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:01 am
STL
-
PTY
1 stop13h 30m
United Airlines
Wed 7/159:45 am
PTY
-
STL
1 stop13h 59m
United Airlines
Deal found 6/8$575
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/25:59 pm
STL
-
PTY
2 stops20h 15m
United Airlines
Mon 8/103:30 pm
PTY
-
STL
2 stops20h 32m
United Airlines
Deal found 6/12$579
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:00 am
STL
-
PTY
1 stop12h 31m
United Airlines
Wed 8/2610:55 pm
PTY
-
STL
1 stop24h 43m
United Airlines
Deal found 6/9$585
This KAYAK deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/178:30 am
MCI
-
PTY
1 stop10h 07m
Copa Airlines
Wed 8/193:30 pm
PTY
-
MCI
1 stop18h 36m
Copa Airlines
Deal found 6/10$585
This United Airlines deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/96:16 am
MCI
-
PTY
1 stop9h 56m
United Airlines
Mon 7/137:55 am
PTY
-
MCI
1 stop8h 52m
United Airlines
Deal found 6/12$587
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/3111:10 am
STL
-
PTY
1 stop7h 27m
United Airlines
Tue 8/43:30 pm
PTY
-
STL
1 stop18h 37m
United Airlines
Deal found 6/8$592

Find flight deals from Missouri to Panama City

Keep the following information in mind while searching for Missouri to Panama City flight deals. Data was last updated June 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$527
(United Airlines)

One-way from

$236
(United Airlines)

Popular in

December

Cheapest in

April

Average price

$631
Provider with most accurate pricing for Lambert-St Louis-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Lambert-St Louis-Panama City Tocumen Intl flights.
Search Deals
From Missouri to Panama City Tocumen Intl
Search Deals
One-way flight from Missouri to Panama City Tocumen Intl
Search Deals
Highest demand for flights based on searches. 0% potential increase in price ($5 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 1% potential price decrease ($10 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2026.
Use the filters below to find and compare flights from Missouri to Panama City that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Sun 8/16

6:36 pm-2:14 pm

2 stops19h 38m

Panama City Tocumen Intl

Wed 8/19

3:30 pm-8:58 am

2 stops17h 28m

$531

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Mon 8/17

6:20 am-6:37 pm

1 stop12h 17m

Panama City Tocumen Intl

Wed 8/19

3:30 pm-2:18 pm

2 stops22h 48m

$531

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Thu 8/20

7:30 am-6:37 pm

2 stops11h 07m

Panama City Tocumen Intl

Mon 8/24

3:30 pm-8:58 am

2 stops17h 28m

$531

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Thu 7/30

8:30 am-4:12 pm

1 stop7h 42m

Panama City Tocumen Intl

Tue 8/4

7:55 am-10:31 pm

1 stop14h 36m

$557

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Fri 8/21

6:20 am-6:37 pm

1 stop12h 17m

Panama City Tocumen Intl

Mon 8/24

10:00 am-10:35 pm

1 stop12h 35m

$561

Kansas CityPanama City

MCI - PTY

MCIPTY

Kansas City

Mon 8/24

6:07 am-7:31 pm

1 stop13h 24m

Panama City Tocumen Intl

Fri 8/28

10:55 pm-4:40 pm

1 stop17h 45m

$561

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 7/8

11:10 am-6:37 pm

1 stop7h 27m

Panama City Tocumen Intl

Wed 7/15

7:55 am-10:45 pm

1 stop14h 50m

$575

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Wed 7/22

6:14 am-6:37 pm

1 stop12h 23m

Panama City Tocumen Intl

Wed 7/29

3:30 pm-10:07 am

1 stop18h 37m

$575

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Tue 8/11

6:15 am-2:14 pm

1 stop7h 59m

Panama City Tocumen Intl

Thu 8/13

3:30 pm-12:02 pm

2 stops20h 32m

$579

St. LouisPanama City

STL - PTY

STLPTY

Lambert-St Louis

Thu 7/23

6:00 am-4:04 am

2 stops22h 04m

Panama City Tocumen Intl

Wed 7/29

10:00 am-8:39 am

2 stops22h 39m

$579

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/12

Showing 1-10 of 30 resultsSorted by cheapest first
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Best time to book a flight from Missouri to Panama City

Have a flexible travel schedule? Discover the best time to fly to Panama City from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Panama City

What is the cheapest month to book a flight from Missouri to Panama City?

Currently, February is the cheapest month in which you can book a flight from Missouri to Panama City (average of $174). Flying from Missouri to Panama City in September is currently the most expensive (average of $513). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from Missouri to Panama City?

Related info for your journey

Find useful and relevant information for your journey from Missouri to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to Panama City from Missouri?

    If you book a flight to Panama City from Missouri, you will be flying to Tocumen Intl, which is the city’s only airport. Panama City Tocumen Intl (PTY) is located 11.4 mi from the center of Panama City.

  • How long is the flight from Missouri to Panama City?

    Departing from Missouri to Panama City will take you 19h 38m. Missouri and Panama City are separated by a distance of 2292 mi.

  • What are the most popular routes from Missouri to Panama City?

    While some choose either Kansas City - Panama City Tocumen Intl or Springfield-Branson - Panama City Tocumen Intl, Lambert-St Louis - Panama City Tocumen Intl is the most popular route from Missouri to Panama City.

  • Can I find deals for flights from Missouri to Panama City that include hotel bookings?

    Yes. In addition to deals on Missouri to Panama City flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Panama City?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Panama City.

  • Can I find deals for business class flights from Missouri to Panama City?

    Yes. Cheapflights offers flight deals from Missouri to Panama City by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Panama City?

    Currently, February is the cheapest month in which you can book a flight from Missouri to Panama City (average of $174). Flying from Missouri to Panama City in September is currently the most expensive (average of $513). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Panama City

See prices for flight routes from nearby airports that may be better suited for you.
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Top 3 airlines flying from Missouri to Panama City

Discover the top 3 airlines that operate flights from Missouri to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$393Average$607FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$393Average$642FlexibilityNo cancel feeOn-time71%
DeltaCheapest$408Average$568FlexibilityNo cancel feeOn-timeN/A

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