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$541+ Cheap flights from Florence, SC to Detroit (FLO - DTT)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/16. Fares are subject to change and may not be available on all flights or dates of travel.
FLO — DTT
Jul 4 — Jul 111
Sat 7/4
Sat 7/11
1 adult, Economy
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Cheap flight deals from Florence to Detroit

Cheapest flights from Florence to Detroit
Explore the most affordable flight options available from Florence to Detroit. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 4, 2026.

This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/162:35 pm
FLO
-
DTW
1 stop4h 43m
American Airlines
Sat 6/204:32 pm
DTW
-
FLO
1 stop5h 28m
American Airlines
Deal found 6/1$541
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/275:05 am
FLO
-
DTW
1 stop4h 12m
American Airlines
Mon 7/67:58 pm
DTW
-
FLO
1 stop3h 39m
American Airlines
Deal found 6/1$548
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/22:35 pm
FLO
-
DTW
1 stop4h 43m
American Airlines
Wed 7/81:36 pm
DTW
-
FLO
1 stop6h 31m
American Airlines
Deal found 6/1$557
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/45:17 am
FLO
-
DTW
2 stops7h 58m
American Airlines
Mon 7/67:58 pm
DTW
-
FLO
1 stop3h 39m
American Airlines
Deal found 6/1$626
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/45:17 am
FLO
-
DTW
2 stops7h 58m
American Airlines
Tue 7/71:34 pm
DTW
-
FLO
2 stops10h 03m
American Airlines
Deal found 6/1$630
This American Airlines deal was found by Cheapflights users on 6/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/182:35 pm
FLO
-
DTW
1 stop4h 43m
American Airlines
Mon 6/2210:01 am
DTW
-
FLO
1 stop4h 09m
American Airlines
Deal found 6/3$639

Find flight deals from Florence to Detroit

Discover tips and strategies to find the most affordable flight options for your journey from Florence (FLO) to Detroit (DTT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 4, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$541
(American Airlines)
Provider with most accurate pricing for Florence-Detroit (DTT) flight deals.
Search Deals
Provider most trusted by Cheapflights users for Florence-Detroit (DTT) flights.
Search Deals
From Florence to Detroit (DTT)
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Florence to Detroit that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 4, 2026.
Use the filters below to find and compare flights from Florence to Detroit that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

FlorenceDetroit

FLO - DTW

FLODTW

Florence

Tue 6/16

2:35 pm-7:18 pm

1 stop4h 43m

Detroit Metropolitan Wayne County

Sat 6/20

4:32 pm-10:00 pm

1 stop5h 28m

$541
Quickest round-trip

FlorenceDetroit

FLO - DTW

FLODTW

Florence

Sat 7/4

5:17 am-9:49 am

1 stop4h 32m

Detroit Metropolitan Wayne County

Mon 7/6

10:00 am-2:10 pm

1 stop4h 10m

$557

FlorenceDetroit

FLO - DTW

FLODTW

Florence

Thu 7/2

5:17 am-9:17 am

1 stop4h 00m

Detroit Metropolitan Wayne County

Tue 7/7

10:25 am-11:37 pm

2 stops13h 12m

$561

FlorenceDetroit

FLO - DTW

FLODTW

Florence

Sat 6/27

5:05 am-5:06 pm

2 stops12h 01m

Detroit Metropolitan Wayne County

Mon 7/6

10:00 am-2:10 pm

1 stop4h 10m

$598

FlorenceDetroit

FLO - DTW

FLODTW

Florence

Thu 6/18

2:35 pm-7:18 pm

1 stop4h 43m

Detroit Metropolitan Wayne County

Mon 6/22

10:01 am-2:10 pm

1 stop4h 09m

$639

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/1

Sorted by cheapest first
  • Most accurate provider: When it comes to deals on Florence, South Carolina-Detroit flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Florence, South Carolina-Detroit flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Florence, South Carolina-Detroit flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Florence, South Carolina-Detroit flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Florence, South Carolina-Detroit flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Florence to Detroit

Have a flexible travel schedule? Discover the best time to fly to Detroit from Florence with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Florence to Detroit
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Florence to Detroit. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Florence, South Carolina to Detroit?

    Departing from Florence, South Carolina to Detroit will take you 4h 43m. Florence, South Carolina and Detroit are separated by a distance of 589 mi.

  • Can I find deals for flights from Florence to Detroit that include hotel bookings?

    Yes. In addition to deals on Florence to Detroit flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Florence to Detroit?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Florence to Detroit.

  • Can I find deals for business class flights from Florence to Detroit?

    Yes. Cheapflights offers flight deals from Florence to Detroit by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Detroit?

Book flights to Detroit if you plan to visit one of these locations
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Port Huron

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