$105+ Cheap flights from Missouri to Panama City, FL (ECP)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/8. Fares are subject to change and may not be available on all flights or dates of travel.
MCI — ECP
Jul 11 — Jul 181
Round-trip
1 adult, Economy
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Cheapest flights from Missouri to Panama CityExplore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 11, 2026.
Explore the most affordable flight options available from Missouri to Panama City. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 11, 2026.
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/109:00 am
STL
- ECP
1 stop3h 39m
Delta
Tue 11/176:00 am
ECP
- STL
1 stop4h 48m
Delta
Deal found 6/8![Delta logo]()
$209
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/265:18 pm
MCI
- ECP
1 stop4h 22m
Delta
Tue 9/11:53 pm
ECP
- MCI
1 stop5h 08m
Delta
Deal found 6/10![Delta logo]()
$211
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/49:15 am
STL
- ECP
1 stop3h 33m
Delta
Mon 8/107:35 am
ECP
- STL
1 stop4h 11m
Delta
Deal found 6/8![Delta logo]()
$229
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/258:00 am
STL
- ECP
2 stops8h 38m
United Airlines
Thu 8/271:54 pm
ECP
- STL
1 stop8h 06m
United Airlines
Deal found 6/10![United Airlines logo]()
$234
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/88:25 am
STL
- ECP
1 stop6h 30m
Southwest
Tue 8/117:45 am
ECP
- STL
2 stops8h 40m
Southwest
Deal found 6/9![Southwest logo]()
$236
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/109:15 am
STL
- ECP
1 stop3h 33m
Delta
Mon 8/176:00 am
ECP
- STL
1 stop3h 54m
Delta
Deal found 6/8![Delta logo]()
$249
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/412:45 pm
STL
- ECP
2 stops7h 45m
Southwest
Mon 8/101:30 pm
ECP
- STL
1 stop5h 40m
Southwest
Deal found 6/10![Southwest logo]()
$251
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/273:58 pm
MCI
- ECP
1 stop4h 10m
Delta
Mon 8/317:35 am
ECP
- MCI
1 stop6h 17m
Delta
Deal found 6/9![Delta logo]()
$251
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2510:45 am
STL
- ECP
2 stops7h 25m
Southwest
Thu 8/271:30 pm
ECP
- STL
2 stops6h 25m
Southwest
Deal found 6/10![Southwest logo]()
$257
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:35 am
MCI
- ECP
2 stops8h 20m
Southwest
Sat 10/35:55 am
ECP
- MCI
1 stop3h 40m
Southwest
Deal found 6/8![Southwest logo]()
$257
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/261:30 pm
STL
- ECP
1 stop5h 29m
Delta
Tue 9/297:35 am
ECP
- STL
1 stop5h 48m
Delta
Deal found 6/10![Delta logo]()
$263
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/293:10 pm
STL
- ECP
1 stop4h 35m
Southwest
Tue 8/44:20 pm
ECP
- STL
1 stop5h 50m
Southwest
Deal found 6/8![Southwest logo]()
$264
Best flights from Missouri to Panama CityDiscover carefully curated flight deals from Missouri to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 11, 2026.
Discover carefully curated flight deals from Missouri to Panama City that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 11, 2026.
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/85:23 pm
STL
- ECP
1 stop4h 17m
Delta
Tue 8/116:00 am
ECP
- STL
1 stop5h 46m
Delta
Deal found 6/9![Delta logo]()
$229
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/88:25 am
STL
- ECP
2 stops9h 45m
Southwest
Tue 8/117:45 am
ECP
- STL
2 stops8h 40m
Southwest
Deal found 6/9![Southwest logo]()
$241
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/176:15 am
STL
- ECP
1 stop6h 22m
United Airlines
Wed 11/1811:10 am
ECP
- STL
1 stop5h 25m
United Airlines
Deal found 6/9![United Airlines logo]()
$289
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/113:01 pm
SGF
- ECP
1 stop7h 39m
American Airlines
Thu 8/206:03 pm
ECP
- SGF
1 stop5h 52m
American Airlines
Deal found 6/6![American Airlines logo]()
$305
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/246:30 am
STL
- ECP
2 stops8h 20m
Southwest
Tue 10/276:10 am
ECP
- STL
1 stop5h 05m
Southwest
Deal found 6/10![Southwest logo]()
$264
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/293:10 pm
STL
- ECP
1 stop4h 35m
Southwest
Tue 8/44:20 pm
ECP
- STL
1 stop5h 50m
Southwest
Deal found 6/8![Southwest logo]()
$264
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:53 pm
SGF
- ECP
1 stop4h 44m
Delta
Mon 7/275:03 pm
ECP
- SGF
1 stop5h 07m
Delta
Deal found 6/10![Delta logo]()
$305
This Delta deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/411:38 am
SGF
- ECP
1 stop7h 05m
Delta
Mon 7/137:50 am
ECP
- SGF
1 stop6h 50m
Delta
Deal found 6/7![Delta logo]()
$305
This United Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:25 am
SGF
- ECP
1 stop4h 39m
United Airlines
Wed 9/211:41 am
ECP
- SGF
1 stop7h 14m
United Airlines
Deal found 6/7![United Airlines logo]()
$371
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/227:08 am
STL
- ECP
1 stop5h 23m
Delta
Wed 7/299:12 am
ECP
- STL
1 stop5h 36m
Delta
Deal found 6/8![Delta logo]()
$317
This Southwest deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/292:50 pm
MCI
- ECP
1 stop7h 20m
Southwest
Tue 8/44:20 pm
ECP
- MCI
1 stop6h 15m
Southwest
Deal found 6/6![Southwest logo]()
$319
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/253:38 pm
MCI
- ECP
1 stop5h 09m
Delta
Mon 6/297:41 am
ECP
- MCI
1 stop4h 34m
Delta
Deal found 6/8![Delta logo]()
$319
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/242:30 pm
STL
- ECP
1 stop5h 45m
Southwest
Wed 7/297:00 am
ECP
- STL
2 stops8h 20m
Southwest
Deal found 6/9![Southwest logo]()
$322
This United Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:30 am
MCI
- ECP
2 stops9h 08m
United Airlines
Wed 8/266:30 am
ECP
- MCI
2 stops9h 41m
United Airlines
Deal found 6/6![United Airlines logo]()
$409
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/13:59 pm
SGF
- ECP
1 stop5h 40m
American Airlines
Fri 8/73:09 pm
ECP
- SGF
1 stop7h 34m
American Airlines
Deal found 6/7![American Airlines logo]()
$462
This Delta deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/45:40 pm
MCI
- ECP
1 stop4h 19m
Delta
Thu 7/99:12 am
ECP
- MCI
1 stop7h 18m
Delta
Deal found 6/7![Delta logo]()
$319
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/218:25 am
STL
- ECP
2 stops7h 15m
Southwest
Tue 7/287:00 am
ECP
- STL
2 stops8h 20m
Southwest
Deal found 6/7![Southwest logo]()
$327
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/203:38 pm
MCI
- ECP
1 stop5h 08m
Delta
Wed 7/221:36 pm
ECP
- MCI
1 stop7h 20m
Delta
Deal found 6/10![Delta logo]()
$319
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/166:40 am
STL
- ECP
1 stop3h 10m
Southwest
Thu 8/205:10 pm
ECP
- STL
Nonstop1h 45m
Southwest
Deal found 6/8![Southwest logo]()
$329
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/76:00 am
SGF
- ECP
1 stop4h 48m
Delta
Mon 7/1311:38 am
ECP
- SGF
1 stop6h 30m
Delta
Deal found 6/9![Delta logo]()
$319
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/145:45 am
SGF
- ECP
2 stops8h 08m
American Airlines
Tue 10/203:17 pm
ECP
- SGF
1 stop6h 54m
American Airlines
Deal found 6/8![American Airlines logo]()
$530
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/66:52 pm
SGF
- ECP
1 stop4h 52m
Delta
Mon 7/137:50 am
ECP
- SGF
1 stop6h 50m
Delta
Deal found 6/8![Delta logo]()
$319
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/22:05 pm
MCI
- ECP
2 stops6h 25m
Southwest
Mon 9/75:10 am
ECP
- MCI
2 stops8h 20m
Southwest
Deal found 6/8![Southwest logo]()
$360
This Delta deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/106:58 pm
STL
- ECP
1 stop4h 39m
Delta
Sun 7/196:48 pm
ECP
- STL
1 stop5h 05m
Delta
Deal found 6/6![Delta logo]()
$327
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/255:20 pm
MCI
- ECP
1 stop4h 40m
Southwest
Thu 7/306:10 am
ECP
- MCI
2 stops7h 00m
Southwest
Deal found 6/9![Southwest logo]()
$364
This Delta deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/265:46 pm
STL
- ECP
1 stop5h 10m
Delta
Tue 9/297:35 am
ECP
- STL
1 stop5h 48m
Delta
Deal found 6/6![Delta logo]()
$327
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/34:55 pm
MCI
- ECP
1 stop4h 45m
Southwest
Wed 7/87:40 am
ECP
- MCI
2 stops8h 35m
Southwest
Deal found 6/7![Southwest logo]()
$369
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/233:38 pm
MCI
- ECP
1 stop5h 08m
Delta
Mon 7/272:47 pm
ECP
- MCI
1 stop4h 08m
Delta
Deal found 6/10![Delta logo]()
$359
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/35:15 am
MCI
- ECP
1 stop5h 35m
Southwest
Fri 8/75:10 am
ECP
- MCI
2 stops8h 20m
Southwest
Deal found 6/8![Southwest logo]()
$396
This Southwest deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/2712:30 pm
MCI
- ECP
1 stop7h 50m
Southwest
Wed 7/15:25 pm
ECP
- MCI
2 stops6h 00m
Southwest
Deal found 6/6![Southwest logo]()
$399
Last-minute flights from Missouri to Panama CityDiscover last-minute flight deals from Missouri to Panama City. Data last updated June 11, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Panama City. Data last updated June 11, 2026 and is based on user searches.
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/34:55 pm
MCI
- ECP
1 stop4h 45m
Southwest
Wed 7/812:50 pm
ECP
- MCI
1 stop6h 30m
Southwest
Deal found 6/10![Southwest logo]()
$319
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/34:55 pm
MCI
- ECP
1 stop4h 45m
Southwest
Mon 7/206:20 pm
ECP
- MCI
1 stop5h 55m
Southwest
Deal found 6/7![Southwest logo]()
$324
This Delta deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/411:38 am
SGF
- ECP
1 stop7h 05m
Delta
Wed 7/87:50 am
ECP
- SGF
1 stop6h 50m
Delta
Deal found 6/7![Delta logo]()
$291
This Delta deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/411:38 am
SGF
- ECP
1 stop7h 05m
Delta
Fri 7/105:03 pm
ECP
- SGF
1 stop5h 07m
Delta
Deal found 6/7![Delta logo]()
$320
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/76:53 pm
SGF
- ECP
1 stop4h 44m
Delta
Mon 7/139:12 am
ECP
- SGF
1 stop5h 28m
Delta
Deal found 6/10![Delta logo]()
$319
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/89:40 am
STL
- ECP
2 stops6h 00m
Southwest
Tue 7/147:00 am
ECP
- STL
1 stop5h 05m
Southwest
Deal found 6/8![Southwest logo]()
$322
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/226:53 pm
SGF
- ECP
1 stop4h 44m
Delta
Mon 7/275:03 pm
ECP
- SGF
1 stop5h 07m
Delta
Deal found 6/10![Delta logo]()
$305
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/227:08 am
STL
- ECP
1 stop5h 23m
Delta
Wed 7/299:12 am
ECP
- STL
1 stop5h 36m
Delta
Deal found 6/8![Delta logo]()
$317
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/293:10 pm
STL
- ECP
1 stop4h 35m
Southwest
Tue 8/44:20 pm
ECP
- STL
1 stop5h 50m
Southwest
Deal found 6/8![Southwest logo]()
$264
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/306:58 pm
STL
- ECP
1 stop4h 39m
Delta
Tue 8/46:00 am
ECP
- STL
1 stop5h 46m
Delta
Deal found 6/11![Delta logo]()
$263
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/303:00 pm
MCI
- ECP
1 stop5h 15m
Southwest
Tue 8/44:20 pm
ECP
- MCI
1 stop6h 15m
Southwest
Deal found 6/11![Southwest logo]()
$265
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/301:50 pm
STL
- ECP
2 stops7h 55m
Southwest
Tue 8/44:20 pm
ECP
- STL
1 stop5h 50m
Southwest
Deal found 6/11![Southwest logo]()
$320
One-way flights from Missouri to Panama CitySearch for one-way flight options from Missouri to Panama City. Find affordable one-way fares based on user searches. Data last updated June 11, 2026.
Search for one-way flight options from Missouri to Panama City. Find affordable one-way fares based on user searches. Data last updated June 11, 2026.
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/46:00 am
STL
- ECP
1 stop4h 42m
Delta
Deal found 6/10![Delta logo]()
$105
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/42:05 pm
MCI
- ECP
1 stop4h 40m
Southwest
Deal found 6/8![Southwest logo]()
$106
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/512:45 pm
STL
- ECP
2 stops7h 45m
Southwest
Deal found 6/8![Southwest logo]()
$111
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/812:45 pm
STL
- ECP
2 stops7h 45m
Southwest
Deal found 6/11![Southwest logo]()
$123
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/85:23 pm
STL
- ECP
1 stop4h 17m
Delta
Deal found 6/11![Delta logo]()
$125
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/85:00 pm
MCI
- ECP
1 stop4h 40m
Delta
Deal found 6/9![Delta logo]()
$126
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/76:20 am
MCI
- ECP
1 stop4h 44m
United Airlines
Deal found 6/10![United Airlines logo]()
$143
This Delta deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/75:23 pm
STL
- ECP
1 stop6h 07m
Delta
Deal found 6/11![Delta logo]()
$145
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/158:25 am
STL
- ECP
2 stops8h 15m
Southwest
Deal found 6/10![Southwest logo]()
$146
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/73:58 pm
MCI
- ECP
1 stop4h 10m
Delta
Deal found 6/9![Delta logo]()
$146
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/125:10 am
STL
- ECP
1 stop5h 17m
American Airlines
Deal found 6/10![American Airlines logo]()
$159
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/75:40 pm
MCI
- ECP
1 stop5h 57m
Delta
Deal found 6/8![Delta logo]()
$160
Find flight deals from Missouri to Panama City
Keep the following information in mind while searching for Missouri to Panama City flight deals. Data was last updated June 11, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $209 (Delta) |
One-way from | $105 (Delta) |
Popular in | June |
Cheapest in | December |
Average price | $442 |
Good round-trip deal | $400 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Panama City that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 11, 2026.
Use the filters below to find and compare flights from Missouri to Panama City that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisPanama City
STL - ECP
STLECP
Lambert-St Louis
Sat 8/8
5:23 pm-9:40 pm
1 stop4h 17m
Panama City NW Florida Beaches
Tue 8/11
6:00 am-11:46 am
1 stop5h 46m
$229
St. LouisPanama City
STL - ECP
STLECP
Lambert-St Louis
Sat 8/8
8:25 am-6:10 pm
2 stops9h 45m
Panama City NW Florida Beaches
Tue 8/11
7:45 am-4:25 pm
2 stops8h 40m
$241
St. LouisPanama City
STL - ECP
STLECP
Lambert-St Louis
Sat 10/24
6:30 am-2:50 pm
2 stops8h 20m
Panama City NW Florida Beaches
Tue 10/27
6:10 am-11:15 am
1 stop5h 05m
$264
St. LouisPanama City
STL - ECP
STLECP
Lambert-St Louis
Wed 7/29
3:10 pm-7:45 pm
1 stop4h 35m
Panama City NW Florida Beaches
Tue 8/4
4:20 pm-10:10 pm
1 stop5h 50m
$264
St. LouisPanama City
STL - ECP
STLECP
Lambert-St Louis
Tue 11/17
6:15 am-12:37 pm
1 stop6h 22m
Panama City NW Florida Beaches
Wed 11/18
11:10 am-4:35 pm
1 stop5h 25m
$289
SpringfieldPanama City
SGF - ECP
SGFECP
Springfield-Branson
Tue 8/11
3:01 pm-10:40 pm
1 stop7h 39m
Panama City NW Florida Beaches
Thu 8/20
6:03 pm-11:55 pm
1 stop5h 52m
$305
SpringfieldPanama City
SGF - ECP
SGFECP
Springfield-Branson
Wed 7/22
6:53 pm-11:37 pm
1 stop4h 44m
Panama City NW Florida Beaches
Mon 7/27
5:03 pm-10:10 pm
1 stop5h 07m
$305
SpringfieldPanama City
SGF - ECP
SGFECP
Springfield-Branson
Sat 7/4
11:38 am-6:43 pm
1 stop7h 05m
Panama City NW Florida Beaches
Mon 7/13
7:50 am-2:40 pm
1 stop6h 50m
$305
St. LouisPanama City
STL - ECP
STLECP
Lambert-St Louis
Wed 7/22
7:08 am-12:31 pm
1 stop5h 23m
Panama City NW Florida Beaches
Wed 7/29
9:12 am-2:48 pm
1 stop5h 36m
$317
Kansas CityPanama City
MCI - ECP
MCIECP
Kansas City
Wed 7/29
2:50 pm-10:10 pm
1 stop7h 20m
Panama City NW Florida Beaches
Tue 8/4
4:20 pm-10:35 pm
1 stop6h 15m
$319
Showing 1-10 of 55 resultsSorted by cheapest first
Best time to book a flight from Missouri to Panama City
Have a flexible travel schedule? Discover the best time to fly to Panama City from Missouri with our price prediction graph.
STL-ECP
SGF-ECP
MCI-ECP
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Panama City
USMO-ECP
STL-ECP
SGF-ECP
MCI-ECP
What is the cheapest month to book a flight from Missouri to Panama City, Florida?
Currently, February is the cheapest month in which you can book a flight from Missouri to Panama City, Florida (average of $90). Flying from Missouri to Panama City, Florida in June is currently the most expensive (average of $241). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MO to ECP?
Find hourly flight availability from Missouri to Panama City. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 11, 2026.
When flying from Missouri to Panama City, Florida, the time of day you fly usually plays a role in the price. Save by searching for a flight in the evening, which can drop the price by up to 18% versus a flight in the afternoon.
How much does it cost to fly round-trip from Missouri to Panama City, Florida?
How far ahead should I book a flight from Missouri to Panama City, Florida?
To ensure you get the cheapest price possible for a flight from Missouri to Panama City, Florida, you should look to book at least 76 days in advance of your intended travel date. The price of your flight may increase if you delay and leave booking until a week or so before departure.
Related info for your journey
Find useful and relevant information for your journey from Missouri to Panama City. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Panama City?
Book flights to Panama City if you plan to visit one of these locationsMexico Beach
Browse thousands of different options on Cheapflights for your next trip
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Alternative routes for Missouri to Panama City
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Complete your trip
Complete your trip to Panama City by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Panama City by cabin class
Find flights from Missouri to Panama City, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and Panama City flights
Browse other Missouri and Panama City flight options. Last updated on June 11, 2026.
Other flights to Panama City
Explore flights to Panama City departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 11, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Missouri to Panama City flights
Consider these flights traveling from Missouri to Panama City.
Top 4 airlines flying from Missouri to Panama City
Discover the top 4 airlines that operate flights from Missouri to Panama City. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 11, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$176 | Average$349 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$186 | Average$397 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$195 | Average$412 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$266 | Average$372 | FlexibilityNo cancel fee | On-time69% |