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$274+ Cheap flights from Missouri to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 12/6. Fares are subject to change and may not be available on all flights or dates of travel.
STL — MAD
Dec 6 — Dec 131
Sat 12/6
Sat 12/13
1 adult, Economy
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Find flight deals from Missouri to Spain

Cheapest flights from Missouri to Spain
Explore the most affordable flight options available from Missouri to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 6, 2025.

This KLM deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/317:05 amMCI - BCN
1 stop18h 35mKLM
Wed 1/1410:55 amBCN - MCI
1 stop16h 07mKLM
Deal found 11/5$434
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/15:50 amMCI - MAD
1 stop20h 25mDelta
Wed 12/1010:00 amMAD - MCI
1 stop19h 59mDelta
Deal found 11/5$438
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/316:00 amMCI - BCN
2 stops19h 00mDelta
Wed 1/1410:55 amBCN - MCI
1 stop16h 07mDelta
Deal found 11/5$438
This Virgin Atlantic deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Virgin Atlantic is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/210:24 amMCI - MAD
1 stop15h 51mVirgin Atlantic
Fri 12/1210:00 amMAD - MCI
2 stops18h 13mVirgin Atlantic
Deal found 11/5$442
This Virgin Atlantic deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Virgin Atlantic is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/13:25 pmMCI - MAD
1 stop10h 50mVirgin Atlantic
Fri 12/1210:00 amMAD - MCI
2 stops18h 13mVirgin Atlantic
Deal found 11/4$443
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/16:38 pmMCI - MAD
2 stops17h 32mDelta
Thu 12/1111:15 amMAD - MCI
1 stop16h 53mDelta
Deal found 11/5$457
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/41:35 pmSTL - BCN
2 stops37h 00mUnited Airlines
Thu 12/111:35 pmBCN - STL
2 stops34h 28mUnited Airlines
Deal found 11/5$461
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/306:38 pmMCI - MAD
1 stop31h 37mDelta
Tue 12/96:00 amMAD - MCI
2 stops23h 59mDelta
Deal found 11/5$462
This Delta deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/46:38 pmMCI - MAD
1 stop31h 37mDelta
Wed 12/1010:00 amMAD - MCI
1 stop13h 50mDelta
Deal found 11/5$463
This KLM deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/45:12 pmSTL - BCN
1 stop32h 28mKLM
Thu 12/1110:55 amBCN - STL
1 stop17h 07mKLM
Deal found 11/4$464
This United Airlines deal was found by Cheapflights users on 11/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/26:27 pmMCI - MAD
2 stops30h 33mUnited Airlines
Sat 12/131:35 pmMAD - MCI
2 stops31h 46mUnited Airlines
Deal found 11/4$465
This United Airlines deal was found by Cheapflights users on 11/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 12/36:42 pmSTL - MAD
2 stops30h 18mUnited Airlines
Wed 12/101:35 pmMAD - STL
2 stops33h 05mUnited Airlines
Deal found 11/5$465

Cheap flight deals from Missouri to Spain

Keep the following information in mind while searching for Missouri to Spain flight deals. Data was last updated November 6, 2025.

Round-trip from

$434
(KLM)

One-way from

$274
(Kiwi.com)

Popular in

June

Cheapest in

February

Average price

$669
From Missouri to Spain
Search Deals
One-way flight from Missouri to Spain
Search Deals
Highest demand for flights based on searches. 24% potential increase in price ($295 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($37 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
Use the filters below to find and compare flights from Missouri to Spain that are best for you.

Fly from

Missouri

Fly to

Spain

Route

Depart

Return

Price

Kansas CityBarcelona

MCI - BCN

MCIBCN

Kansas City

Tue 2/24

6:23 am-8:00 am

2 stops18h 37m

Barcelona-El Prat

Tue 3/3

10:15 am-9:00 pm

2 stops17h 45m

$411

Kansas CityBarcelona

MCI - BCN

MCIBCN

Kansas City

Tue 2/24

10:44 am-8:40 am

1 stop14h 56m

Barcelona-El Prat

Tue 3/3

10:15 am-7:19 pm

1 stop16h 04m

$424

Kansas CityBarcelona

MCI - BCN

MCIBCN

Kansas City

Wed 12/31

12:38 pm-8:40 am

1 stop13h 02m

Barcelona-El Prat

Wed 1/14

10:55 am-8:02 pm

1 stop16h 07m

$434

Kansas CityBarcelona

MCI - BCN

MCIBCN

Kansas City

Wed 12/31

7:05 am-8:40 am

1 stop18h 35m

Barcelona-El Prat

Wed 1/14

10:55 am-8:02 pm

1 stop16h 07m

$434

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Sun 11/30

6:38 pm-9:15 am

1 stop31h 37m

Madrid Barajas

Wed 12/10

11:15 am-2:21 pm

1 stop34h 06m

$438

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Sun 11/30

6:38 pm-9:15 am

1 stop31h 37m

Madrid Barajas

Thu 12/11

11:15 am-9:08 pm

1 stop16h 53m

$438

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Sun 11/30

6:38 pm-9:15 am

1 stop31h 37m

Madrid Barajas

Fri 12/12

11:15 am-10:09 am

1 stop29h 54m

$438

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Tue 12/2

10:24 am-9:15 am

1 stop15h 51m

Madrid Barajas

Wed 12/10

11:15 am-11:47 pm

1 stop19h 32m

$438

Kansas CityBarcelona

MCI - BCN

MCIBCN

Kansas City

Wed 12/31

10:42 am-8:00 am

2 stops14h 18m

Barcelona-El Prat

Wed 1/14

10:55 am-8:02 pm

1 stop16h 07m

$438

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Mon 12/1

3:25 pm-9:15 am

1 stop10h 50m

Madrid Barajas

Fri 12/12

10:00 am-9:13 pm

2 stops18h 13m

$443

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/6

Showing 1-10 of 60 results
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Best time to book a flight from Missouri to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Spain

What is the cheapest month to book a flight from Missouri to Spain?

Currently, January is the cheapest month in which you can book a flight from Missouri to Spain (average of $452). Flying from Missouri to Spain in May is currently the most expensive (average of $811). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to ES?

Find hourly flight availability from Missouri to Spain. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 6, 2025.

It’s optimal to fly from Missouri to Spain at noon. By choosing this option you can save up to 14% on the cost of your flight, compared to a flight in the evening.

What is the cheapest day to fly from Missouri to Spain?

Use this chart to determine the cheapest time to fly round-trip from Missouri to Spain. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Missouri to Spain flight should consider departing on Wednesday mornings when fares are most often at their lowest. Monday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Spain?

    Virgin Atlantic, KLM, and Delta can get you from Missouri to Spain in just under 14h 56m. Your travel time can differ by up to 16h 41m. There are 4803 mi between Missouri and Spain. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Missouri to Spain one-way?

    The cheapest airline one-way is Lufthansa, with whom users have recently found tickets for as low as $371. However, be on the lookout for offers from Air Canada and United Airlines, as they are both options that can get you from Missouri to Spain for a low price.

  • Can I find deals for flights from Missouri to Spain that include hotel bookings?

    Yes. In addition to deals on Missouri to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Spain.

  • Can I find deals for business class flights from Missouri to Spain?

    Yes. Cheapflights offers flight deals from Missouri to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Spain?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Spain (average of $452). Flying from Missouri to Spain in May is currently the most expensive (average of $811). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Spain

See prices for flight routes from nearby airports that may be better suited for you.
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Top 10 airlines flying from Missouri to Spain

Discover the top 10 airlines that operate flights from Missouri to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 6, 2025.
AirlineCheapestAverageFlexibilityOn-time
KLMCheapest$483Average$751FlexibilityNo cancel feeOn-time75%
DeltaCheapest$488Average$880FlexibilityNo cancel feeOn-timeN/A
LufthansaCheapest$524Average$1,155FlexibilityNo cancel feeOn-time76%
United AirlinesCheapest$531Average$986FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$532Average$1,136FlexibilityNo cancel feeOn-time71%
Air FranceCheapest$533Average$752FlexibilityNo cancel feeOn-time77%
British AirwaysCheapest$546Average$945FlexibilityNo cancel feeOn-time70%
IberiaCheapest$578Average$1,021FlexibilityNo cancel feeOn-time77%
Virgin AtlanticCheapest$582Average$707FlexibilityNo cancel feeOn-time72%
Air CanadaCheapest$624Average$1,093FlexibilityNo cancel feeOn-time67%

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