HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Spain

$229+ Cheap flights from Missouri to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/24. Fares are subject to change and may not be available on all flights or dates of travel.
STL — MAD
Dec 13 — Dec 201
Sat 12/13
Sat 12/20
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Missouri to Spain with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Find flight deals from Missouri to Spain

Cheapest flights from Missouri to Spain
Explore the most affordable flight options available from Missouri to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 13, 2025.

This Ticket deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ticket is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/246:43 pmMCI - MAD
2 stops22h 07mLufthansa
Tue 12/96:00 amMAD - MCI
2 stops22h 58mLufthansa
Deal found 11/11$417
This Flighttix deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/81:57 pmSTL - MAD
1 stop12h 18mVirgin Atlantic
Wed 12/2411:15 amMAD - STL
1 stop14h 49mVirgin Atlantic
Deal found 11/11$426
This Delta deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/89:30 amSTL - MAD
1 stop16h 45mDelta
Wed 12/2411:15 amMAD - STL
1 stop19h 23mDelta
Deal found 11/11$429
This Delta deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/307:02 pmSTL - BCN
1 stop30h 38mDelta
Fri 1/3010:55 amBCN - STL
1 stop19h 44mDelta
Deal found 11/12$434
This Delta deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/16:00 amSGF - MAD
1 stop20h 15mDelta
Thu 12/1111:15 amMAD - SGF
1 stop35h 08mDelta
Deal found 11/12$438
This Delta deal was found by Cheapflights users on 11/13. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/266:40 amSTL - BCN
2 stops18h 20mDelta
Thu 12/410:55 amBCN - STL
1 stop17h 07mDelta
Deal found 11/13$438
This KLM deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/112:18 pmMCI - MAD
1 stop13h 57mKLM
Fri 12/1211:15 amMAD - MCI
1 stop19h 32mKLM
Deal found 11/12$438
This Virgin Atlantic deal was found by Cheapflights users on 11/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Virgin Atlantic is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/912:47 pmMCI - BCN
1 stop12h 53mVirgin Atlantic
Tue 12/1610:15 amBCN - MCI
2 stops17h 58mVirgin Atlantic
Deal found 11/10$438
This KLM deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/89:30 amSTL - MAD
1 stop16h 45mKLM
Wed 12/2411:15 amMAD - STL
1 stop14h 49mKLM
Deal found 11/12$438
This KLM deal was found by Cheapflights users on 11/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/85:12 pmSTL - BCN
1 stop32h 28mKLM
Wed 12/249:30 amBCN - STL
1 stop13h 58mKLM
Deal found 11/11$439
This Delta deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/16:58 pmSGF - MAD
1 stop31h 17mDelta
Tue 12/910:00 amMAD - SGF
2 stops36h 23mDelta
Deal found 11/12$443
This Delta deal was found by Cheapflights users on 11/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/112:18 pmMCI - MAD
1 stop13h 57mDelta
Fri 12/1210:00 amMAD - MCI
2 stops18h 13mDelta
Deal found 11/12$443

Cheap flight deals from Missouri to Spain

Keep the following information in mind while searching for Missouri to Spain flight deals. Data was last updated November 13, 2025.

Round-trip from

$417
(Ticket)

One-way from

$229
(Kiwi.com)

Popular in

June

Cheapest in

February

Average price

$666
From Missouri to Spain
Search Deals
One-way flight from Missouri to Spain
Search Deals
Highest demand for flights based on searches. 23% potential increase in price ($288 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($35 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in November 2025
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
Use the filters below to find and compare flights from Missouri to Spain that are best for you.

Fly from

Missouri

Fly to

Spain

Route

Depart

Return

Price

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Mon 12/8

9:30 am-9:15 am

1 stop16h 45m

Madrid Barajas

Wed 12/24

11:15 am-11:38 pm

1 stop19h 23m

$429

St. LouisBarcelona

STL - BCN

STLBCN

Lambert-St Louis

Tue 12/2

9:30 am-8:40 am

1 stop16h 10m

Barcelona-El Prat

Fri 1/30

10:55 am-8:39 pm

1 stop16h 44m

$434

SpringfieldMadrid

SGF - MAD

SGFMAD

Springfield-Branson

Mon 12/1

11:53 am-9:15 am

1 stop14h 22m

Madrid Barajas

Wed 12/10

11:15 am-10:15 pm

1 stop18h 00m

$438

SpringfieldMadrid

SGF - MAD

SGFMAD

Springfield-Branson

Mon 12/1

6:00 am-9:15 am

1 stop20h 15m

Madrid Barajas

Wed 12/10

11:15 am-10:15 pm

1 stop18h 00m

$438

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Mon 12/1

12:18 pm-9:15 am

1 stop13h 57m

Madrid Barajas

Fri 12/12

11:15 am-11:47 pm

1 stop19h 32m

$438

Kansas CityBarcelona

MCI - BCN

MCIBCN

Kansas City

Tue 12/9

12:47 pm-8:40 am

1 stop12h 53m

Barcelona-El Prat

Tue 12/16

10:15 am-9:13 pm

2 stops17h 58m

$438

SpringfieldMadrid

SGF - MAD

SGFMAD

Springfield-Branson

Sun 11/30

6:58 pm-9:15 am

1 stop31h 17m

Madrid Barajas

Thu 12/11

11:15 am-10:15 pm

1 stop18h 00m

$438

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Tue 12/2

10:24 am-9:15 am

1 stop15h 51m

Madrid Barajas

Fri 12/12

10:00 am-4:50 pm

1 stop13h 50m

$438

SpringfieldMadrid

SGF - MAD

SGFMAD

Springfield-Branson

Tue 11/25

6:58 pm-9:15 am

1 stop31h 17m

Madrid Barajas

Thu 12/11

11:15 am-3:23 pm

1 stop35h 08m

$438

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Mon 12/8

9:30 am-9:15 am

1 stop16h 45m

Madrid Barajas

Wed 12/24

11:15 am-11:38 pm

1 stop19h 23m

$438

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/11

Showing 1-10 of 60 results
1
2
3
...
6

Best time to book a flight from Missouri to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Spain

What is the cheapest month to book a flight from Missouri to Spain?

Currently, January is the cheapest month in which you can book a flight from Missouri to Spain (average of $448). Flying from Missouri to Spain in May is currently the most expensive (average of $841). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to ES?

Find hourly flight availability from Missouri to Spain. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated November 13, 2025.

It’s optimal to fly from Missouri to Spain at noon. By choosing this option you can save up to 14% on the cost of your flight, compared to a flight in the evening.

What is the cheapest day to fly from Missouri to Spain?

Use this chart to determine the cheapest time to fly round-trip from Missouri to Spain. Price data was last updated on December 16, 2024.

Travelers seeking maximum savings on their Missouri to Spain flight should consider departing on Wednesday mornings when fares are most often at their lowest. Monday evenings flights should be avoided if possible as fares are typically the most expensive at this time.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Spain?

    Delta, Virgin Atlantic, and KLM can get you from Missouri to Spain in just under 13h 57m. Your travel time can differ by up to 2h 48m. There are 4589 mi between Missouri and Spain. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Missouri to Spain one-way?

    The cheapest airline one-way is British Airways, with whom users have recently found tickets for as low as $234. However, be on the lookout for offers from Iberia and Lufthansa, as they are both options that can get you from Missouri to Spain for a low price.

  • Can I find deals for flights from Missouri to Spain that include hotel bookings?

    Yes. In addition to deals on Missouri to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Spain.

  • Can I find deals for business class flights from Missouri to Spain?

    Yes. Cheapflights offers flight deals from Missouri to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Spain?

    Currently, January is the cheapest month in which you can book a flight from Missouri to Spain (average of $448). Flying from Missouri to Spain in May is currently the most expensive (average of $841). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to Spain

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Heathrow flights
Newark to Heathrow flights
John F Kennedy Intl to Charles de Gaulle flights
Newark to Charles de Gaulle flights
John F Kennedy Intl to Istanbul flights
John F Kennedy Intl to Leonardo da Vinci/Fiumicino flights
Newark to Orly flights
LaGuardia to Heathrow flights
John F Kennedy Intl to London City flights
John F Kennedy Intl to Orly flights
Newark to Leonardo da Vinci/Fiumicino flights
Newark to Gatwick flights
Boston to Heathrow flights
John F Kennedy Intl to Gatwick flights
John F Kennedy Intl to Madrid flights
Dulles Intl to Heathrow flights
Los Angeles to Heathrow flights
Miami to Madrid flights
LaGuardia to Gatwick flights
John F Kennedy Intl to Stansted flights
LaGuardia to Charles de Gaulle flights
Newark to Madrid flights
Los Angeles to Charles de Gaulle flights
John F Kennedy Intl to Malpensa flights
San Francisco to Heathrow flights
John F Kennedy Intl to Lisbon flights
John F Kennedy Intl to Barcelona-El Prat flights
John F Kennedy Intl to Luton flights
Boston to Charles de Gaulle flights
Newark to London City flights
O'Hare Intl to Heathrow flights
Newark to Barcelona-El Prat flights
Newark to Lisbon flights
Newark to Malpensa flights
Baltimore to Heathrow flights
John F Kennedy Intl to Dublin flights
Dallas/Fort Worth to Heathrow flights
Dulles Intl to Charles de Gaulle flights
Newark to Dublin flights
O'Hare Intl to Charles de Gaulle flights
John F Kennedy Intl to Amsterdam flights
San Francisco to Charles de Gaulle flights
Newark to Frankfurt flights
Newark to Athens flights
Dallas/Fort Worth to Charles de Gaulle flights
Newark to Istanbul flights
Newark to Stansted flights
Seattle to Heathrow flights
Newark to Luton flights
Dulles Intl to Madrid flights

Top 10 airlines flying from Missouri to Spain

Discover the top 10 airlines that operate flights from Missouri to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 13, 2025.
AirlineCheapestAverageFlexibilityOn-time
KLMCheapest$483Average$751FlexibilityNo cancel feeOn-time75%
DeltaCheapest$488Average$880FlexibilityNo cancel feeOn-timeN/A
LufthansaCheapest$524Average$1,155FlexibilityNo cancel feeOn-time76%
United AirlinesCheapest$531Average$986FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$532Average$1,136FlexibilityNo cancel feeOn-time71%
Air FranceCheapest$533Average$752FlexibilityNo cancel feeOn-time77%
British AirwaysCheapest$546Average$945FlexibilityNo cancel feeOn-time70%
IberiaCheapest$578Average$1,021FlexibilityNo cancel feeOn-time77%
Virgin AtlanticCheapest$582Average$707FlexibilityNo cancel feeOn-time72%
Air CanadaCheapest$624Average$1,093FlexibilityNo cancel feeOn-time67%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.