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$341+ Cheap flights from Missouri to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/8. Fares are subject to change and may not be available on all flights or dates of travel.
STL — MAD
May 6 — May 131
Tue 5/6
Tue 5/13
1 adult, Economy
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Cheap flight deals from Missouri to Spain

Keep the following information in mind while searching for Missouri to Spain flight deals. Data was last updated May 1, 2025.

Round-trip from

$456
(Lufthansa)

One-way from

$341
(Kiwi.com)

Popular in

May

Cheapest in

February

Average price

$1,411
From Missouri to Spain
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One-way flight from Missouri to Spain
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Highest demand for flights based on searches. 21% potential increase in price ($272 potential increase over avg. RT price).
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Cheapest flight prices on average. 4% potential price decrease ($41 potential savings vs. average RT price).
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Average for round-trip flights in May 2025
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Find flight deals from Missouri to Spain

Cheapest flights from Missouri to Spain
Explore the most affordable flight options available from Missouri to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 1, 2025.

This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/279:00 amSTL - BCN
1 stop16h 00mDelta
Wed 11/1210:15 amBCN - STL
1 stop17h 35mDelta
Deal found 4/30$542
This American Airlines deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/214:13 pmSGF - MAD
1 stop15h 07mAmerican Airlines
Mon 11/1712:55 amMAD - SGF
1 stop14h 42mAmerican Airlines
Deal found 4/29$546
This Finnair deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1211:46 amSTL - MAD
1 stop10h 54mMultiple Airlines
Wed 10/2211:35 amMAD - STL
1 stop15h 48mMultiple Airlines
Deal found 4/30$546
This Finnair deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/41:06 pmSTL - BCN
1 stop17h 14mMultiple Airlines
Tue 11/1111:00 amBCN - STL
2 stops18h 29mMultiple Airlines
Deal found 4/30$550
This British Airways deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/128:01 pmSTL - MAD
2 stops14h 34mBritish Airways
Wed 10/221:45 pmMAD - STL
1 stop13h 34mBritish Airways
Deal found 5/1$550
This Delta deal was found by Cheapflights users on 4/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/223:30 pmSGF - MAD
1 stop11h 05mDelta
Wed 11/1910:00 amMAD - SGF
2 stops19h 32mDelta
Deal found 4/29$551
This Delta deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/63:30 pmSTL - MAD
1 stop11h 05mDelta
Tue 10/2112:40 pmMAD - STL
2 stops26h 30mDelta
Deal found 4/30$551
This United Airlines deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/1212:28 pmSTL - MAD
2 stops35h 12mUnited Airlines
Wed 10/2212:45 pmMAD - STL
2 stops33h 53mUnited Airlines
Deal found 4/30$563
This Justfly.com deal was found by Cheapflights users on 5/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/124:05 pmSTL - MAD
2 stops31h 35mAir Canada
Wed 10/2212:45 pmMAD - STL
2 stops32h 34mAir Canada
Deal found 5/1$565
This Finnair deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/54:17 pmSTL - BIO
2 stops22h 38mMultiple Airlines
Wed 10/156:45 amBIO - STL
2 stops24h 04mMultiple Airlines
Deal found 4/30$568
This oojo deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/148:00 pmMCI - MAD
2 stops16h 55mBritish Airways
Mon 10/209:15 pmMAD - MCI
2 stops28h 34mBritish Airways
Deal found 4/30$568
This Expedia deal was found by Cheapflights users on 4/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/168:01 pmSTL - BCN
1 stop31h 29mBritish Airways
Mon 9/229:10 pmBCN - STL
2 stops28h 58mBritish Airways
Deal found 4/30$572

Cheapflights Fare Finder

Customize your flight search to find flights from Missouri to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
Use the filters below to find and compare flights from Missouri to Spain that are best for you.

Fly from

Missouri

Fly to

Spain

Route

Depart

Return

Price

St. LouisBarcelona

STL - BCN

STLBCN

Lambert-St Louis

Mon 10/27

9:00 am-7:00 am

1 stop16h 00m

Barcelona-El Prat

Wed 11/12

10:15 am-8:50 pm

1 stop17h 35m

$542

SpringfieldMadrid

SGF - MAD

SGFMAD

Springfield-Branson

Tue 10/21

5:41 pm-1:25 pm

1 stop12h 44m

Madrid Barajas

Tue 11/18

11:35 am-8:32 pm

1 stop15h 57m

$546

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Sun 10/12

11:46 am-5:40 am

1 stop10h 54m

Madrid Barajas

Wed 10/22

11:35 am-8:23 pm

1 stop15h 48m

$546

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Sun 10/12

8:01 pm-5:35 pm

2 stops14h 34m

Madrid Barajas

Wed 10/22

1:45 pm-8:19 pm

1 stop13h 34m

$550

SpringfieldMadrid

SGF - MAD

SGFMAD

Springfield-Branson

Wed 10/22

3:30 pm-9:35 am

1 stop11h 05m

Madrid Barajas

Wed 11/19

10:00 am-10:32 pm

2 stops19h 32m

$551

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Mon 10/6

3:30 pm-9:35 am

1 stop11h 05m

Madrid Barajas

Tue 10/21

12:40 pm-8:10 am

2 stops26h 30m

$551

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Sun 10/12

12:28 pm-6:40 am

2 stops35h 12m

Madrid Barajas

Wed 10/22

12:45 pm-3:38 pm

2 stops33h 53m

$563

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Sun 10/12

4:05 pm-6:40 am

2 stops31h 35m

Madrid Barajas

Wed 10/22

12:45 pm-2:19 pm

2 stops32h 34m

$565

St. LouisBilbao

STL - BIO

STLBIO

Lambert-St Louis

Sun 10/5

4:17 pm-9:55 pm

2 stops22h 38m

Bilbao

Wed 10/15

6:45 am-11:49 pm

2 stops24h 04m

$568

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Tue 10/14

8:00 pm-7:55 pm

2 stops16h 55m

Madrid Barajas

Mon 10/20

9:15 pm-6:49 pm

2 stops28h 34m

$568

Flights are sorted by cheapest round-trip flights first.

Deals found on 4/30

Showing 1-10 of 60 results
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Best time to book a flight from Missouri to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Spain

What is the cheapest month to book a flight from Missouri to Spain?

Currently, November is the cheapest month in which you can book a flight from Missouri to Spain (average of $543). Flying from Missouri to Spain in June is currently the most expensive (average of $1,086). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MO to ES?

Find hourly flight availability from Missouri to Spain. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 1, 2025.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Missouri to Spain as you normally would.

Rainfall in Spain by month

Plan your trip to Spain by taking into account the average rainfall totals by month.

In terms of precipitation, rainfall in Spain ranges from 0.8 - 3.6 inches per month. October is typically the wettest month, when rainfall can reach 3.6 in. July is typically the driest time to visit Spain when rainfall is around 0.8 in.

Temperature in Spain by month

Plan your trip to Spain by taking into account the average temperature totals by month.

If weather is an important factor for your trip to Spain, use this chart to help with planning. For those seeking warmer temperatures, August is the ideal time of year to visit, when temperatures reach an average of 75.2 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 48.2 F).

Reviews of airlines servicing Spain

Get insights into the airlines that provide service to Spain. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Spain. Reviews last updated May 1, 2025.
Peruse reviews from past customers who have flown with Delta, KLM and Finnair from Missouri to Spain to help guide your decision. You can also see how each airline compares in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Delta
8.0
Very good
7,934 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
KLM
7.8
Good
1,334 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Finnair
7.6
Good
1,275 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
SWISS
7.5
Good
1,588 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.
Air France
7.4
Good
1,446 reviews
Delta
8.0
Very good
7,934 reviews

Boarding

8.2

Overall

8.0

Entertainment

7.9

Crew

8.5

Comfort

7.9

Food

7.3

Reviews

1 / 20
10.0
Excellent

Aaron,Oct 2024

LAX - LHR

This was a flight operated by Virgin Atlantic in their Upper Class cabin. Overall, an outstanding experience.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What are the cheapest airlines to fly from Missouri to Spain one-way?

    The cheapest airline one-way is Aer Lingus, with whom users have recently found tickets for as low as $401. However, be on the lookout for offers from British Airways and KLM, as they are both options that can get you from Missouri to Spain for a low price.

  • Can I find deals for flights from Missouri to Spain that include hotel bookings?

    Yes. In addition to deals on Missouri to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Spain.

  • Can I find deals for business class flights from Missouri to Spain?

    Yes. Cheapflights offers flight deals from Missouri to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Spain?

    Currently, November is the cheapest month in which you can book a flight from Missouri to Spain (average of $543). Flying from Missouri to Spain in June is currently the most expensive (average of $1,086). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Spain

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Heathrow flights
John F Kennedy Intl to Charles de Gaulle flights
Newark to Heathrow flights
John F Kennedy Intl to Leonardo da Vinci/Fiumicino flights
Newark to Charles de Gaulle flights
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Newark to Athens flights
John F Kennedy Intl to Lisbon flights
LaGuardia to Heathrow flights
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John F Kennedy Intl to Athens flights
John F Kennedy Intl to Orly flights
Boston to Heathrow flights
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San Francisco to Heathrow flights
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LaGuardia to Charles de Gaulle flights
John F Kennedy Intl to Madrid flights
John F Kennedy Intl to Malpensa flights
O'Hare Intl to Heathrow flights
Dallas/Fort Worth to Heathrow flights
Seattle to Heathrow flights
O'Hare Intl to Leonardo da Vinci/Fiumicino flights
Newark to Dublin flights
John F Kennedy Intl to Dublin flights
Dulles Intl to Charles de Gaulle flights
Newark to Madrid flights
O'Hare Intl to Charles de Gaulle flights
Boston to Leonardo da Vinci/Fiumicino flights
O'Hare Intl to Athens flights
Baltimore to Heathrow flights
Dallas/Fort Worth to Charles de Gaulle flights
Boston to Charles de Gaulle flights
LaGuardia to Gatwick flights
LaGuardia to Leonardo da Vinci/Fiumicino flights
Dulles Intl to Leonardo da Vinci/Fiumicino flights
Newark to Malpensa flights
LaGuardia to Athens flights
Boston to Gatwick flights
Atlanta to Heathrow flights
San Francisco to Charles de Gaulle flights
Newark to Frankfurt flights

Top 9 airlines flying from Missouri to Spain

Discover the top 9 airlines that operate flights from Missouri to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 1, 2025.
AirlineCheapestAverageFlexibilityOn-time
LufthansaCheapest$527Average$1,126FlexibilityNo cancel feeOn-time76%
KLMCheapest$540Average$751FlexibilityNo cancel feeOn-time75%
United AirlinesCheapest$542Average$1,090FlexibilityNo cancel feeOn-time69%
DeltaCheapest$544Average$1,079FlexibilityNo cancel feeOn-timeN/A
British AirwaysCheapest$545Average$965FlexibilityNo cancel feeOn-time70%
American AirlinesCheapest$550Average$1,058FlexibilityNo cancel feeOn-time71%
IberiaCheapest$553Average$1,097FlexibilityNo cancel feeOn-time77%
Air FranceCheapest$650Average$1,064FlexibilityNo cancel feeOn-time77%
Air CanadaCheapest$670Average$1,068FlexibilityNo cancel feeOn-time67%

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