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$316+ Cheap flights from Missouri to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/15. Fares are subject to change and may not be available on all flights or dates of travel.
STL — MAD
Aug 27 — Sep 31
Thu 8/27
Thu 9/3
1 adult, Economy
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Cheap flight deals from Missouri to Spain

Cheapest flights from Missouri to Spain
Explore the most affordable flight options available from Missouri to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on July 28, 2026.

This Gotogate deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/42:40 pm
STL
-
MAD
1 stop11h 10m
Multiple Airlines
Wed 10/141:30 pm
MAD
-
STL
1 stop13h 30m
Multiple Airlines
Deal found 7/24$694
This Gotogate deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/2912:10 pm
STL
-
MAD
1 stop11h 40m
Multiple Airlines
Tue 10/135:55 am
MAD
-
STL
1 stop14h 30m
Multiple Airlines
Deal found 7/27$701
This Gotogate deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Gotogate is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/212:40 pm
STL
-
MAD
1 stop11h 10m
Multiple Airlines
Tue 10/65:55 am
MAD
-
STL
1 stop14h 30m
Multiple Airlines
Deal found 7/27$706
This Expedia deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/196:40 pm
SGF
-
MAD
1 stop12h 45m
Iberia
Thu 10/291:00 pm
MAD
-
SGF
1 stop15h 37m
Iberia
Deal found 7/28$708
This Cheapflightsfares deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/63:14 pm
MCI
-
MAD
2 stops20h 26m
SWISS
Tue 10/2010:05 am
MAD
-
MCI
2 stops18h 59m
SWISS
Deal found 7/24$710
This Expedia deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/107:46 pm
MCI
-
MAD
1 stop29h 34m
Iberia
Tue 10/201:35 pm
MAD
-
MCI
1 stop17h 43m
Iberia
Deal found 7/28$713
This United Airlines deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/412:10 pm
STL
-
MAD
1 stop11h 40m
United Airlines
Wed 10/1412:45 pm
MAD
-
STL
2 stops30h 28m
United Airlines
Deal found 7/27$714
This United Airlines deal was found by Cheapflights users on 7/26. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/211:33 am
MCI
-
MAD
1 stop13h 12m
United Airlines
Wed 11/181:25 pm
MAD
-
MCI
2 stops28h 06m
United Airlines
Deal found 7/26$715
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/288:30 am
STL
-
MAD
1 stop16h 35m
United Airlines
Fri 10/912:45 pm
MAD
-
STL
2 stops33h 58m
United Airlines
Deal found 7/28$715
This United Airlines deal was found by Cheapflights users on 7/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/78:55 am
STL
-
MAD
1 stop17h 40m
United Airlines
Wed 10/2112:45 pm
MAD
-
STL
2 stops30h 28m
United Airlines
Deal found 7/28$719
This United Airlines deal was found by Cheapflights users on 7/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:29 am
MCI
-
MAD
1 stop19h 31m
United Airlines
Tue 10/201:30 pm
MAD
-
MCI
2 stops34h 36m
United Airlines
Deal found 7/24$720
This oojo deal was found by Cheapflights users on 7/27. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/231:08 pm
STL
-
BIO
2 stops15h 32m
Lufthansa
Fri 11/276:45 am
BIO
-
STL
1 stop14h 00m
Lufthansa
Deal found 7/27$722

Find flight deals from Missouri to Spain

Keep the following information in mind while searching for Missouri to Spain flight deals. Data was last updated July 28, 2026.

Round-trip from

$639
(eDestinos)

One-way from

$316
(Kiwi.com)

Popular in

June

Cheapest in

January

Average price

$1,082
From Missouri to Spain
Search Deals
One-way flight from Missouri to Spain
Search Deals
Highest demand for flights based on searches. 22% potential increase in price ($258 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 6% potential price decrease ($52 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in July 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2026.
Use the filters below to find and compare flights from Missouri to Spain that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Mon 11/2

11:33 am-7:45 am

1 stop13h 12m

Madrid Barajas

Wed 11/18

1:25 pm-10:31 am

2 stops28h 06m

$715

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Wed 10/7

8:55 am-9:35 am

1 stop17h 40m

Madrid Barajas

Wed 10/21

12:45 pm-12:13 pm

2 stops30h 28m

$719

St. LouisBilbao

STL - BIO

STLBIO

Lambert-St Louis

Mon 11/23

1:08 pm-11:40 am

2 stops15h 32m

Bilbao

Fri 11/27

6:45 am-1:45 pm

1 stop14h 00m

$722

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Wed 10/21

12:20 pm-9:00 am

1 stop13h 40m

Madrid Barajas

Fri 10/30

6:00 am-2:45 pm

1 stop14h 45m

$724

SpringfieldMadrid

SGF - MAD

SGFMAD

Springfield-Branson

Wed 1/20

5:00 pm-10:55 am

1 stop10h 55m

Madrid Barajas

Wed 2/3

10:00 am-10:32 pm

2 stops19h 32m

$726

SpringfieldMadrid

SGF - MAD

SGFMAD

Springfield-Branson

Wed 1/20

12:45 pm-9:20 am

1 stop13h 35m

Madrid Barajas

Wed 2/3

12:00 pm-7:18 pm

1 stop14h 18m

$726

ColumbiaMadrid

COU - MAD

COUMAD

Columbia Regional

Sun 11/15

3:00 pm-9:15 am

2 stops35h 15m

Madrid Barajas

Thu 11/19

1:25 pm-2:18 pm

2 stops55h 53m

$730

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Tue 10/6

6:29 am-9:00 am

1 stop19h 31m

Madrid Barajas

Tue 10/20

5:55 am-10:35 pm

2 stops23h 40m

$735

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Tue 10/13

12:00 pm-9:55 am

1 stop14h 55m

Madrid Barajas

Tue 10/27

7:00 am-6:33 pm

2 stops17h 33m

$736

SpringfieldMadrid

SGF - MAD

SGFMAD

Springfield-Branson

Mon 10/19

3:05 pm-8:05 am

2 stops34h 00m

Madrid Barajas

Thu 10/29

12:25 pm-10:47 am

2 stops52h 22m

$736

Flights are sorted by cheapest round-trip flights first.

Deals found on 7/25

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from Missouri to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Spain

What is the cheapest month to book a flight from Missouri to Spain?

Currently, February is the cheapest month in which you can book a flight from Missouri to Spain (average of $610). Flying from Missouri to Spain in June is currently the most expensive (average of $1,485). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How far ahead should I book a flight from Missouri to Spain?

Booking 88 days in advance of your planned departure date is, on average, the best time to get cheap flights from Missouri to Spain. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Spain?

    Virgin Atlantic, Iberia, and United Airlines can get you from Missouri to Spain in just under 13h 12m. Your travel time can differ by up to 5h 53m. There are 4589 mi between Missouri and Spain. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Missouri to Spain one-way?

    The cheapest airline one-way is United Airlines, with whom users have recently found tickets for as low as $230. However, be on the lookout for offers from British Airways and Air Canada, as they are both options that can get you from Missouri to Spain for a low price.

  • Can I find deals for flights from Missouri to Spain that include hotel bookings?

    Yes. In addition to deals on Missouri to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Spain.

  • Can I find deals for business class flights from Missouri to Spain?

    Yes. Cheapflights offers flight deals from Missouri to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Spain?

    Currently, February is the cheapest month in which you can book a flight from Missouri to Spain (average of $610). Flying from Missouri to Spain in June is currently the most expensive (average of $1,485). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to Spain

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Heathrow flights
Newark to Heathrow flights
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Boston to Charles de Gaulle flights
John F Kennedy Intl to Malpensa flights
Seattle to Heathrow flights
Los Angeles to Leonardo da Vinci/Fiumicino flights
Boston to Dublin flights
LaGuardia to Gatwick flights
Los Angeles to Charles de Gaulle flights
O'Hare Intl to Leonardo da Vinci/Fiumicino flights
O'Hare Intl to Charles de Gaulle flights
Boston to Leonardo da Vinci/Fiumicino flights
Dallas/Fort Worth to Heathrow flights
Newark to Malpensa flights
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John F Kennedy Intl to Vicenza flights

Top 10 airlines flying from Missouri to Spain

Discover the top 10 airlines that operate flights from Missouri to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated July 28, 2026.
AirlineCheapestAverageFlexibilityOn-time
Virgin AtlanticCheapest$382Average$682FlexibilityNo cancel feeOn-time72%
KLMCheapest$433Average$796FlexibilityNo cancel feeOn-time75%
DeltaCheapest$452Average$828FlexibilityNo cancel feeOn-timeN/A
Air FranceCheapest$457Average$973FlexibilityNo cancel feeOn-time77%
British AirwaysCheapest$461Average$892FlexibilityNo cancel feeOn-time70%
LufthansaCheapest$480Average$1,175FlexibilityNo cancel feeOn-time76%
American AirlinesCheapest$485Average$897FlexibilityNo cancel feeOn-time71%
United AirlinesCheapest$490Average$975FlexibilityNo cancel feeOn-time69%
IberiaCheapest$508Average$829FlexibilityNo cancel feeOn-time77%
Air CanadaCheapest$624Average$1,123FlexibilityNo cancel feeOn-time67%

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