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$238+ Cheap flights from Missouri to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/10. Fares are subject to change and may not be available on all flights or dates of travel.
STL — MAD
Mar 14 — Mar 211
Sat 3/14
Sat 3/21
1 adult, Economy
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Cheap flight deals from Missouri to Spain

Cheapest flights from Missouri to Spain
Explore the most affordable flight options available from Missouri to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 12, 2026.

This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/153:21 pm
MCI
-
BCN
1 stop14h 54m
United Airlines
Thu 4/2312:15 pm
BCN
-
MCI
2 stops38h 30m
United Airlines
Deal found 2/10$467
This oojo deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/192:12 pm
STL
-
VLC
2 stops22h 23m
British Airways
Tue 4/288:30 pm
VLC
-
STL
1 stop30h 00m
British Airways
Deal found 2/9$471
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/159:55 am
MCI
-
BCN
1 stop20h 20m
United Airlines
Wed 4/221:15 pm
BCN
-
MCI
2 stops28h 12m
United Airlines
Deal found 2/10$472
This oojo deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/142:33 pm
STL
-
BCN
2 stops16h 42m
British Airways
Tue 4/289:30 pm
BCN
-
STL
1 stop29h 00m
British Airways
Deal found 2/9$481
This Cheapflightsfares deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/2111:30 am
MCI
-
MAD
2 stops23h 10m
Lufthansa
Tue 4/285:55 am
MAD
-
MCI
2 stops23h 35m
Lufthansa
Deal found 2/9$481
This United Airlines deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/223:21 pm
MCI
-
BCN
2 stops15h 44m
United Airlines
Wed 4/291:15 pm
BCN
-
MCI
2 stops40h 46m
United Airlines
Deal found 2/10$481
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/138:30 am
STL
-
MAD
1 stop16h 35m
United Airlines
Wed 4/225:55 am
MAD
-
STL
1 stop14h 30m
United Airlines
Deal found 2/9$482
This oojo deal was found by Cheapflights users on 2/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/144:17 pm
MCI
-
MAD
2 stops18h 13m
British Airways
Tue 4/289:00 pm
MAD
-
MCI
2 stops26h 17m
British Airways
Deal found 2/11$484
This oojo deal was found by Cheapflights users on 2/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/136:06 pm
MCI
-
BCN
2 stops16h 29m
British Airways
Mon 4/208:35 pm
BCN
-
MCI
2 stops27h 57m
British Airways
Deal found 2/10$484
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/149:10 am
STL
-
BCN
2 stops16h 50m
United Airlines
Wed 4/226:40 am
BCN
-
STL
1 stop13h 45m
United Airlines
Deal found 2/9$485
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/127:45 am
STL
-
BCN
1 stop22h 30m
United Airlines
Wed 4/226:40 am
BCN
-
STL
1 stop13h 45m
United Airlines
Deal found 2/9$486
This United Airlines deal was found by Cheapflights users on 2/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/127:45 am
STL
-
MAD
2 stops17h 20m
United Airlines
Wed 4/225:55 am
MAD
-
STL
1 stop14h 30m
United Airlines
Deal found 2/9$486

Find flight deals from Missouri to Spain

Keep the following information in mind while searching for Missouri to Spain flight deals. Data was last updated February 12, 2026.

Round-trip from

$467
(United Airlines)

One-way from

$238
(Trip.com)

Popular in

June

Cheapest in

January

Average price

$683
From Missouri to Spain
Search Deals
One-way flight from Missouri to Spain
Search Deals
Highest demand for flights based on searches. 26% potential increase in price ($308 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($37 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
Use the filters below to find and compare flights from Missouri to Spain that are best for you.

Fly from

Missouri

Fly to

Spain

Route

Depart

Return

Price

St. LouisValencia

STL - VLC

STLVLC

Lambert-St Louis

Sun 4/19

2:12 pm-7:35 pm

2 stops22h 23m

Valencia

Tue 4/28

8:30 pm-7:30 pm

1 stop30h 00m

$471

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Tue 4/21

4:17 pm-3:50 pm

2 stops16h 33m

Madrid Barajas

Tue 4/28

9:00 pm-4:17 pm

2 stops26h 17m

$484

St. LouisBarcelona

STL - BCN

STLBCN

Lambert-St Louis

Tue 4/14

12:25 pm-2:15 pm

2 stops18h 50m

Barcelona-El Prat

Tue 4/28

9:30 pm-4:00 pm

2 stops25h 30m

$485

Kansas CityBarcelona

MCI - BCN

MCIBCN

Kansas City

Mon 4/13

6:06 pm-4:25 pm

2 stops15h 19m

Barcelona-El Prat

Mon 4/20

9:20 pm-5:32 pm

2 stops27h 12m

$485

St. LouisBarcelona

STL - BCN

STLBCN

Lambert-St Louis

Sun 4/12

7:45 am-1:15 pm

1 stop22h 30m

Barcelona-El Prat

Wed 4/22

6:40 am-1:25 pm

1 stop13h 45m

$486

St. LouisBarcelona

STL - BCN

STLBCN

Lambert-St Louis

Tue 4/14

10:19 am-8:45 am

1 stop15h 26m

Barcelona-El Prat

Tue 4/21

11:00 am-5:44 pm

1 stop13h 44m

$487

Kansas CityBarcelona

MCI - BCN

MCIBCN

Kansas City

Wed 4/22

3:03 pm-12:50 pm

1 stop14h 47m

Barcelona-El Prat

Wed 4/29

11:00 am-10:11 pm

1 stop18h 11m

$487

St. LouisBarcelona

STL - BCN

STLBCN

Lambert-St Louis

Sun 4/12

7:45 am-1:15 pm

1 stop22h 30m

Barcelona-El Prat

Tue 4/21

3:15 pm-9:08 pm

1 stop12h 53m

$487

St. LouisBarcelona

STL - BCN

STLBCN

Lambert-St Louis

Mon 4/13

6:25 am-8:45 am

1 stop19h 20m

Barcelona-El Prat

Tue 4/21

11:00 am-11:34 pm

1 stop19h 34m

$487

St. LouisBarcelona

STL - BCN

STLBCN

Lambert-St Louis

Wed 4/15

7:45 am-1:15 pm

1 stop22h 30m

Barcelona-El Prat

Tue 4/21

3:15 pm-9:08 pm

1 stop12h 53m

$487

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/9

Showing 1-10 of 60 results
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Best time to book a flight from Missouri to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Spain

What is the cheapest month to book a flight from Missouri to Spain?

Currently, February is the cheapest month in which you can book a flight from Missouri to Spain (average of $433). Flying from Missouri to Spain in June is currently the most expensive (average of $761). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Spain?

    United Airlines, British Airways, and Delta can get you from Missouri to Spain in just under 14h 54m. Your travel time can differ by up to 7h 29m. There are 4803 mi between Missouri and Spain. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Missouri to Spain one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $288. However, be on the lookout for offers from Air Canada and United Airlines, as they are both options that can get you from Missouri to Spain for a low price.

  • Can I find deals for flights from Missouri to Spain that include hotel bookings?

    Yes. In addition to deals on Missouri to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Spain.

  • Can I find deals for business class flights from Missouri to Spain?

    Yes. Cheapflights offers flight deals from Missouri to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Spain?

    Currently, February is the cheapest month in which you can book a flight from Missouri to Spain (average of $433). Flying from Missouri to Spain in June is currently the most expensive (average of $761). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

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Alternative routes for Missouri to Spain

See prices for flight routes from nearby airports that may be better suited for you.
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O'Hare Intl to Heathrow flights
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LaGuardia to Charles de Gaulle flights
O'Hare Intl to Leonardo da Vinci/Fiumicino flights
John F Kennedy Intl to Stansted flights
San Francisco to Heathrow flights
Boston to Charles de Gaulle flights
Dallas/Fort Worth to Heathrow flights
O'Hare Intl to Charles de Gaulle flights
Baltimore to Heathrow flights
Boston to Leonardo da Vinci/Fiumicino flights
John F Kennedy Intl to Amsterdam flights
LaGuardia to Leonardo da Vinci/Fiumicino flights
Dulles Intl to Charles de Gaulle flights
Los Angeles to Charles de Gaulle flights
Seattle to Heathrow flights
San Francisco to Charles de Gaulle flights
Dallas/Fort Worth to Leonardo da Vinci/Fiumicino flights
John F Kennedy Intl to Frederic Chopin flights
Boston to Dublin flights
Dulles Intl to Leonardo da Vinci/Fiumicino flights
LaGuardia to Gatwick flights

Top 10 airlines flying from Missouri to Spain

Discover the top 10 airlines that operate flights from Missouri to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 12, 2026.
AirlineCheapestAverageFlexibilityOn-time
KLMCheapest$433Average$755FlexibilityNo cancel feeOn-time75%
Virgin AtlanticCheapest$437Average$756FlexibilityNo cancel feeOn-time72%
British AirwaysCheapest$449Average$794FlexibilityNo cancel feeOn-time70%
Air FranceCheapest$457Average$753FlexibilityNo cancel feeOn-time77%
LufthansaCheapest$482Average$1,134FlexibilityNo cancel feeOn-time76%
American AirlinesCheapest$485Average$1,053FlexibilityNo cancel feeOn-time71%
DeltaCheapest$487Average$857FlexibilityNo cancel feeOn-timeN/A
IberiaCheapest$488Average$991FlexibilityNo cancel feeOn-time77%
United AirlinesCheapest$490Average$863FlexibilityNo cancel feeOn-time69%
Air CanadaCheapest$593Average$1,077FlexibilityNo cancel feeOn-time67%

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