Spain

$242+ Cheap flights from Missouri to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/28. Fares are subject to change and may not be available on all flights or dates of travel.
STL — MAD
Mar 6 — Mar 131
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Cheap flight deals from Missouri to Spain

Cheapest flights from Missouri to Spain
Explore the most affordable flight options available from Missouri to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 4, 2026.

This Flighttix deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/26:16 pm
MCI
-
MAD
2 stops30h 44m
Virgin Atlantic
Mon 3/169:00 am
MAD
-
MCI
2 stops19h 04m
Virgin Atlantic
Deal found 2/2$464
This Kiwi.com deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/21:23 pm
MCI
-
MAD
1 stop12h 52m
KLM
Tue 3/176:00 am
MAD
-
MCI
2 stops16h 55m
KLM
Deal found 2/2$466
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/146:40 pm
MCI
-
BCN
2 stops30h 20m
United Airlines
Tue 4/2112:15 pm
BCN
-
MCI
2 stops35h 33m
United Airlines
Deal found 2/3$470
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 3/39:10 am
MCI
-
MAD
2 stops15h 50m
United Airlines
Tue 3/1012:40 pm
MAD
-
MCI
2 stops31h 40m
United Airlines
Deal found 2/3$475
This oojo deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/85:51 am
MCI
-
BCN
2 stops23h 34m
British Airways
Tue 3/1711:30 am
BCN
-
MCI
1 stop16h 58m
British Airways
Deal found 2/3$475
This Finnair deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/27:05 am
MCI
-
MAD
1 stop18h 05m
Multiple Airlines
Mon 3/1611:30 am
MAD
-
MCI
1 stop16h 34m
Multiple Airlines
Deal found 2/2$478
This Delta deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 3/56:30 am
STL
-
MAD
1 stop18h 30m
Delta
Wed 3/189:00 am
MAD
-
STL
1 stop29h 44m
Delta
Deal found 2/2$478
This United Airlines deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 3/412:15 pm
STL
-
MAD
2 stops21h 25m
United Airlines
Thu 3/1212:40 pm
MAD
-
STL
2 stops35h 20m
United Airlines
Deal found 2/3$480
This oojo deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 4/1411:44 am
STL
-
BCN
2 stops19h 31m
British Airways
Tue 4/285:25 pm
BCN
-
STL
1 stop33h 05m
British Airways
Deal found 2/3$482
This Iberia deal was found by Cheapflights users on 2/2. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/211:02 am
MCI
-
BCN
1 stop14h 48m
Iberia
Tue 3/179:35 am
BCN
-
MCI
1 stop19h 14m
Iberia
Deal found 2/2$483
This oojo deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/132:33 pm
STL
-
BCN
2 stops18h 52m
British Airways
Mon 4/279:20 pm
BCN
-
STL
2 stops26h 21m
British Airways
Deal found 2/3$485
This oojo deal was found by Cheapflights users on 2/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/132:38 pm
MCI
-
BCN
2 stops19h 57m
British Airways
Mon 4/208:35 pm
BCN
-
MCI
2 stops26h 12m
British Airways
Deal found 2/3$485

Find flight deals from Missouri to Spain

Keep the following information in mind while searching for Missouri to Spain flight deals. Data was last updated February 4, 2026.

Round-trip from

$464
(Flighttix)

One-way from

$255
(oojo)

Popular in

June

Cheapest in

January

Average price

$640
From Missouri to Spain
One-way flight from Missouri to Spain
Highest demand for flights based on searches. 26% potential increase in price ($304 potential increase over avg. RT price).
Cheapest flight prices on average. 4% potential price decrease ($36 potential savings vs. average RT price).
Average for round-trip flights in February 2026

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
Use the filters below to find and compare flights from Missouri to Spain that are best for you.

Fly from

Missouri

Fly to

Spain

Route

Depart

Return

Price

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Tue 3/3

9:10 am-8:00 am

2 stops15h 50m

Madrid Barajas

Tue 3/10

12:40 pm-2:20 pm

2 stops31h 40m

$475

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Mon 3/2

7:05 am-8:10 am

1 stop18h 05m

Madrid Barajas

Mon 3/16

11:30 am-10:04 pm

1 stop16h 34m

$478

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Thu 3/5

6:30 am-8:00 am

1 stop18h 30m

Madrid Barajas

Wed 3/18

9:00 am-8:44 am

1 stop29h 44m

$478

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Mon 3/9

5:54 am-8:05 am

1 stop20h 11m

Madrid Barajas

Wed 3/18

10:05 am-9:25 am

1 stop29h 20m

$491

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Wed 3/4

7:05 am-6:20 am

1 stop16h 15m

Madrid Barajas

Thu 3/12

11:30 am-11:58 pm

1 stop18h 28m

$491

Kansas CityBarcelona

MCI - BCN

MCIBCN

Kansas City

Mon 3/2

9:10 am-9:00 am

2 stops16h 50m

Barcelona-El Prat

Mon 3/9

10:30 am-8:41 pm

1 stop16h 11m

$492

SpringfieldMadrid

SGF - MAD

SGFMAD

Springfield-Branson

Wed 4/8

5:19 am-7:55 am

1 stop19h 36m

Madrid Barajas

Thu 4/16

3:55 pm-10:24 am

1 stop25h 29m

$492

SpringfieldBarcelona

SGF - BCN

SGFBCN

Springfield-Branson

Wed 4/15

10:21 am-10:35 am

1 stop17h 14m

Barcelona-El Prat

Mon 4/20

7:20 pm-5:37 pm

2 stops29h 17m

$495

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Mon 3/9

1:15 pm-7:00 am

2 stops35h 45m

Madrid Barajas

Mon 3/16

1:45 pm-12:19 pm

2 stops28h 34m

$495

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Sun 3/8

8:00 am-11:45 am

2 stops21h 45m

Madrid Barajas

Mon 3/16

8:25 am-12:19 pm

2 stops33h 54m

$501

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/3

Showing 1-10 of 60 results
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Best time to book a flight from Missouri to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Spain

What is the cheapest month to book a flight from Missouri to Spain?

Currently, February is the cheapest month in which you can book a flight from Missouri to Spain (average of $433). Flying from Missouri to Spain in June is currently the most expensive (average of $768). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
  • How long is the flight from Missouri to Spain?

    Virgin Atlantic, KLM, and United Airlines can get you from Missouri to Spain in just under 12h 52m. Your travel time can differ by up to 17h 52m. There are 4589 mi between Missouri and Spain. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Missouri to Spain one-way?

    The cheapest airline one-way is Delta, with whom users have recently found tickets for as low as $293. However, be on the lookout for offers from Air Canada and United Airlines, as they are both options that can get you from Missouri to Spain for a low price.

  • Can I find deals for flights from Missouri to Spain that include hotel bookings?

    Yes. In addition to deals on Missouri to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Spain.

  • Can I find deals for business class flights from Missouri to Spain?

    Yes. Cheapflights offers flight deals from Missouri to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Spain?

    Currently, February is the cheapest month in which you can book a flight from Missouri to Spain (average of $433). Flying from Missouri to Spain in June is currently the most expensive (average of $768). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Alternative routes for Missouri to Spain

See prices for flight routes from nearby airports that may be better suited for you.

Top 10 airlines flying from Missouri to Spain

Discover the top 10 airlines that operate flights from Missouri to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 4, 2026.
AirlineCheapestAverageFlexibilityOn-time
KLMCheapest$433Average$746FlexibilityNo cancel feeOn-time75%
Virgin AtlanticCheapest$437Average$756FlexibilityNo cancel feeOn-time72%
British AirwaysCheapest$449Average$827FlexibilityNo cancel feeOn-time70%
Air FranceCheapest$457Average$753FlexibilityNo cancel feeOn-time77%
LufthansaCheapest$482Average$1,164FlexibilityNo cancel feeOn-time76%
American AirlinesCheapest$485Average$1,059FlexibilityNo cancel feeOn-time71%
DeltaCheapest$487Average$864FlexibilityNo cancel feeOn-timeN/A
IberiaCheapest$488Average$995FlexibilityNo cancel feeOn-time77%
United AirlinesCheapest$490Average$866FlexibilityNo cancel feeOn-time69%
Air CanadaCheapest$593Average$1,066FlexibilityNo cancel feeOn-time67%

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