$307+ Cheap flights from Missouri to Spain
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/20. Fares are subject to change and may not be available on all flights or dates of travel.
STL — MAD
May 10 — May 171
Round-trip
1 adult, Economy
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Cheapest flights from Missouri to SpainExplore the most affordable flight options available from Missouri to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 10, 2026.
Explore the most affordable flight options available from Missouri to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 10, 2026.
This Cheapflightsfares deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/213:30 pm
STL
- MAD
1 stop18h 10m
Lufthansa
Fri 10/306:00 am
MAD
- STL
1 stop14h 55m
Lufthansa
Deal found 4/6![Lufthansa logo]()
$701
This Cheapflightsfares deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/284:50 pm
STL
- MAD
1 stop17h 10m
Lufthansa
Wed 11/118:30 am
MAD
- STL
2 stops21h 55m
Lufthansa
Deal found 4/6![Lufthansa logo]()
$710
This oojo deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/79:35 pm
STL
- MAD
1 stop15h 30m
British Airways
Wed 10/213:25 pm
MAD
- STL
1 stop15h 16m
British Airways
Deal found 4/6![British Airways logo]()
$722
This oojo deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/149:35 pm
STL
- MAD
1 stop15h 30m
British Airways
Wed 10/284:40 pm
MAD
- STL
1 stop12h 45m
British Airways
Deal found 4/10![British Airways logo]()
$723
This Cheapflightsfares deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/66:37 pm
MCI
- MAD
2 stops16h 03m
Lufthansa
Tue 10/205:55 am
MAD
- MCI
2 stops22h 39m
Lufthansa
Deal found 4/7![Lufthansa logo]()
$725
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:40 am
STL
- MAD
2 stops18h 25m
United Airlines
Wed 10/211:30 pm
MAD
- STL
2 stops29h 50m
United Airlines
Deal found 4/10![United Airlines logo]()
$725
This oojo deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/173:14 pm
MCI
- AGP
2 stops17h 36m
SWISS
Mon 8/244:50 pm
AGP
- MCI
2 stops35h 50m
SWISS
Deal found 4/5![SWISS logo]()
$726
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/1410:23 am
STL
- MAD
2 stops14h 42m
United Airlines
Wed 10/286:00 am
MAD
- STL
1 stop14h 55m
United Airlines
Deal found 4/10![United Airlines logo]()
$726
This eDestinos deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/205:26 pm
MCI
- MAD
1 stop11h 49m
Virgin Atlantic
Tue 10/69:50 am
MAD
- MCI
1 stop19h 36m
Virgin Atlantic
Deal found 4/5![Virgin Atlantic logo]()
$727
This British Airways deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/299:35 pm
STL
- MAD
1 stop12h 55m
British Airways
Fri 10/93:55 pm
MAD
- STL
1 stop14h 46m
British Airways
Deal found 4/7![British Airways logo]()
$727
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/306:01 am
STL
- MAD
2 stops19h 04m
United Airlines
Wed 10/145:55 am
MAD
- STL
1 stop14h 30m
United Airlines
Deal found 4/10![United Airlines logo]()
$731
This eDestinos deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2512:47 pm
SGF
- MAD
1 stop13h 18m
Iberia
Fri 9/111:35 pm
MAD
- SGF
1 stop13h 50m
Iberia
Deal found 4/9![Iberia logo]()
$738
Best flights from Missouri to SpainDiscover carefully curated flight deals from Missouri to Spain that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 10, 2026.
Discover carefully curated flight deals from Missouri to Spain that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated April 10, 2026.
This oojo deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/173:14 pm
MCI
- AGP
2 stops17h 36m
SWISS
Mon 8/244:50 pm
AGP
- MCI
2 stops35h 50m
SWISS
Deal found 4/5![SWISS logo]()
$726
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/276:05 am
MCI
- AGP
2 stops22h 40m
Delta
Tue 10/65:25 pm
AGP
- MCI
2 stops32h 44m
Delta
Deal found 4/9![Delta logo]()
$742
This Finnair deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/225:20 pm
MCI
- MAD
1 stop14h 05m
Multiple Airlines
Tue 10/611:30 am
MAD
- MCI
1 stop17h 30m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$751
This United Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/76:00 am
MCI
- MAD
2 stops19h 05m
United Airlines
Thu 10/1511:15 am
MAD
- MCI
2 stops17h 19m
United Airlines
Deal found 4/10![United Airlines logo]()
$764
This Justfly.com deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Justfly.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/126:36 pm
MCI
- VLC
2 stops33h 24m
Lufthansa
Sat 12/126:00 am
VLC
- MCI
2 stops17h 19m
Lufthansa
Deal found 4/5![Lufthansa logo]()
$815
This American Airlines deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2511:24 am
SGF
- MAD
1 stop14h 41m
American Airlines
Fri 9/111:35 pm
MAD
- SGF
1 stop13h 50m
American Airlines
Deal found 4/10![American Airlines logo]()
$838
This FlightHub deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/253:18 pm
SGF
- MAD
2 stops15h 57m
British Airways
Fri 9/111:35 pm
MAD
- SGF
1 stop13h 50m
British Airways
Deal found 4/10![British Airways logo]()
$849
This Virgin Atlantic deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Virgin Atlantic is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/2211:42 am
STL
- MAD
2 stops15h 13m
Virgin Atlantic
Tue 5/512:45 pm
MAD
- STL
1 stop17h 51m
Virgin Atlantic
Deal found 4/6![Virgin Atlantic logo]()
$972
This Travelocity deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Travelocity is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 5/301:35 pm
MCI
- VLC
2 stops27h 40m
Iberia
Fri 8/289:40 am
VLC
- MCI
2 stops41h 43m
Iberia
Deal found 4/7![Iberia logo]()
$1,049
This KLM deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/3010:49 am
MCI
- BCN
1 stop19h 01m
KLM
Sat 5/910:55 am
BCN
- MCI
1 stop15h 18m
KLM
Deal found 4/6![KLM logo]()
$1,138
This Finnair deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/209:31 am
MCI
- MAD
1 stop15h 49m
Multiple Airlines
Tue 10/611:30 am
MAD
- MCI
2 stops18h 31m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$751
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1812:10 pm
STL
- MAD
1 stop11h 40m
United Airlines
Tue 10/61:30 pm
MAD
- STL
2 stops33h 56m
United Airlines
Deal found 4/5![United Airlines logo]()
$769
This lastminute.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lastminute.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/87:45 am
MCI
- AGP
2 stops21h 40m
SWISS
Mon 9/141:15 pm
AGP
- MCI
2 stops39h 25m
SWISS
Deal found 4/8![SWISS logo]()
$776
This Delta deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/295:30 pm
STL
- MAD
1 stop11h 45m
Delta
Fri 10/912:45 pm
MAD
- STL
2 stops17h 54m
Delta
Deal found 4/8![Delta logo]()
$790
This KLM deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/61:13 pm
MCI
- MAD
2 stops13h 42m
Multiple Airlines
Tue 10/2012:45 pm
MAD
- MCI
1 stop13h 24m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$764
This United Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/155:32 pm
STL
- MAD
2 stops32h 18m
United Airlines
Sat 9/125:55 am
MAD
- STL
2 stops20h 36m
United Airlines
Deal found 4/5![United Airlines logo]()
$789
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:01 pm
MCI
- VLC
2 stops16h 34m
American Airlines
Tue 5/127:20 am
VLC
- MCI
2 stops19h 01m
American Airlines
Deal found 4/6![American Airlines logo]()
$868
This British Airways deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:05 pm
SGF
- MAD
2 stops16h 25m
British Airways
Tue 5/121:35 pm
MAD
- SGF
1 stop14h 30m
British Airways
Deal found 4/6![British Airways logo]()
$881
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:05 am
MCI
- AGP
2 stops22h 40m
Delta
Fri 10/212:40 pm
AGP
- MCI
2 stops28h 08m
Delta
Deal found 4/9![Delta logo]()
$806
This KAYAK deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/317:45 am
MCI
- AGP
2 stops33h 20m
SWISS
Tue 9/812:20 pm
AGP
- MCI
2 stops36h 14m
SWISS
Deal found 4/5![SWISS logo]()
$827
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:40 am
STL
- MAD
2 stops18h 25m
United Airlines
Fri 10/911:15 am
MAD
- STL
2 stops28h 22m
United Airlines
Deal found 4/9![United Airlines logo]()
$790
This FlightHub deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 4/256:40 pm
MCI
- VLC
2 stops34h 15m
Lufthansa
Sat 5/26:45 pm
VLC
- MCI
2 stops34h 33m
Lufthansa
Deal found 4/6![Lufthansa logo]()
$979
This KLM deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/112:04 pm
MCI
- MAD
1 stop17h 11m
Multiple Airlines
Thu 10/159:50 am
MAD
- MCI
1 stop13h 36m
Multiple Airlines
Deal found 4/5![Multiple Airlines logo]()
$810
This British Airways deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/75:21 pm
STL
- IBZ
2 stops17h 14m
British Airways
Thu 5/149:05 am
IBZ
- STL
2 stops20h 14m
British Airways
Deal found 4/6![British Airways logo]()
$897
This Delta deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/96:05 am
MCI
- AGP
2 stops22h 40m
Delta
Fri 9/185:55 am
AGP
- MCI
2 stops23h 57m
Delta
Deal found 4/9![Delta logo]()
$836
This KAYAK deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/73:16 pm
MCI
- VLC
2 stops15h 54m
SWISS
Mon 8/313:00 pm
VLC
- MCI
2 stops33h 34m
SWISS
Deal found 4/7![SWISS logo]()
$856
This American Airlines deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/127:10 am
SGF
- MAD
1 stop15h 20m
American Airlines
Thu 5/211:35 pm
MAD
- SGF
1 stop16h 05m
American Airlines
Deal found 4/5![American Airlines logo]()
$960
This KLM deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/412:04 pm
MCI
- MAD
2 stops14h 51m
Multiple Airlines
Mon 10/122:35 pm
MAD
- MCI
1 stop35h 11m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$822
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/257:45 am
SGF
- MAD
2 stops17h 20m
United Airlines
Fri 9/111:30 pm
MAD
- SGF
2 stops32h 03m
United Airlines
Deal found 4/9![United Airlines logo]()
$827
This BusinessClass deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 4/229:35 pm
STL
- IBZ
1 stop33h 45m
British Airways
Mon 4/275:15 pm
IBZ
- STL
2 stops30h 26m
British Airways
Deal found 4/8![British Airways logo]()
$926
Last-minute flights from Missouri to SpainDiscover last-minute flight deals from Missouri to Spain. Data last updated April 10, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Spain. Data last updated April 10, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/1211:15 am
STL
- MAD
2 stops13h 50m
United Airlines
Tue 4/285:55 am
MAD
- STL
2 stops25h 02m
United Airlines
Deal found 4/6![United Airlines logo]()
$872
This Finnair deal was found by Cheapflights users on 4/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 4/125:21 pm
STL
- MAD
1 stop13h 09m
Multiple Airlines
Tue 4/2812:20 pm
MAD
- STL
1 stop16h 47m
Multiple Airlines
Deal found 4/10![Multiple Airlines logo]()
$874
This lol.travel deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure lol.travel is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:06 pm
MCI
- MAD
1 stop12h 24m
Finnair
Tue 5/1912:20 pm
MAD
- MCI
1 stop14h 01m
Finnair
Deal found 4/6![Finnair logo]()
$847
This Flighttix deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flighttix is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/45:12 pm
MCI
- MAD
1 stop12h 03m
Virgin Atlantic
Tue 5/1912:45 pm
MAD
- MCI
2 stops18h 04m
Virgin Atlantic
Deal found 4/6![Virgin Atlantic logo]()
$867
This United Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/48:50 am
SGF
- MAD
2 stops17h 10m
United Airlines
Tue 5/1210:50 am
MAD
- SGF
2 stops18h 12m
United Airlines
Deal found 4/6![United Airlines logo]()
$876
This FlightHub deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/68:01 pm
MCI
- VLC
2 stops17h 34m
British Airways
Wed 5/1311:25 am
VLC
- MCI
2 stops19h 51m
British Airways
Deal found 4/8![British Airways logo]()
$847
This American Airlines deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/78:01 pm
MCI
- VLC
2 stops16h 34m
American Airlines
Tue 5/127:20 am
VLC
- MCI
2 stops19h 01m
American Airlines
Deal found 4/6![American Airlines logo]()
$868
This Expedia deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:07 pm
MCI
- VLC
2 stops18h 28m
Multiple Airlines
Tue 5/127:20 am
VLC
- MCI
2 stops18h 59m
Multiple Airlines
Deal found 4/6![Multiple Airlines logo]()
$876
This Expedia deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/76:07 pm
MCI
- AGP
2 stops32h 53m
Iberia
Thu 5/141:25 pm
AGP
- MCI
2 stops17h 42m
Iberia
Deal found 4/7![Iberia logo]()
$879
This Flysmarter deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Flysmarter is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1011:05 am
MCI
- MAD
1 stop15h 30m
Iberia
Tue 5/263:55 pm
MAD
- MCI
1 stop15h 31m
Iberia
Deal found 4/7![Iberia logo]()
$874
This Finnair deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Finnair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/1010:54 am
SGF
- MAD
1 stop20h 31m
Multiple Airlines
Tue 5/193:55 pm
MAD
- SGF
1 stop26h 34m
Multiple Airlines
Deal found 4/8![Multiple Airlines logo]()
$879
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/106:16 pm
MCI
- MAD
1 stop13h 09m
American Airlines
Tue 5/263:55 pm
MAD
- MCI
1 stop15h 31m
American Airlines
Deal found 4/8![American Airlines logo]()
$879
One-way flights from Missouri to SpainSearch for one-way flight options from Missouri to Spain. Find affordable one-way fares based on user searches. Data last updated April 10, 2026.
Search for one-way flight options from Missouri to Spain. Find affordable one-way fares based on user searches. Data last updated April 10, 2026.
This eDestinos deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure eDestinos is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/205:26 pm
MCI
- MAD
1 stop11h 49m
Virgin Atlantic
Deal found 4/6![Virgin Atlantic logo]()
$307
This oojo deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/202:26 pm
MCI
- MAD
2 stops18h 24m
British Airways
Deal found 4/6![British Airways logo]()
$341
This Kiwi.com deal was found by Cheapflights users on 4/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 5/710:35 am
MCI
- AGP
3 stops55h 20m
Multiple Airlines
Deal found 4/7![Multiple Airlines logo]()
$341
This American Airlines deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1012:37 pm
MCI
- MAD
2 stops20h 13m
American Airlines
Deal found 4/8![American Airlines logo]()
$346
This oojo deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/299:39 am
STL
- BCN
2 stops19h 26m
British Airways
Deal found 4/8![British Airways logo]()
$351
This oojo deal was found by Cheapflights users on 4/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/216:05 am
MCI
- MAD
1 stop16h 25m
British Airways
Deal found 4/5![British Airways logo]()
$352
This Orbitz deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/299:35 pm
STL
- BCN
1 stop28h 45m
Iberia
Deal found 4/6![Iberia logo]()
$354
This oojo deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/122:17 pm
MCI
- BCN
2 stops18h 38m
British Airways
Deal found 4/8![British Airways logo]()
$364
This Kiwi.com deal was found by Cheapflights users on 4/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/103:16 pm
MCI
- MAD
2 stops44h 24m
SWISS
Deal found 4/8![SWISS logo]()
$366
This oojo deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/155:11 pm
STL
- BCN
1 stop33h 59m
British Airways
Deal found 4/9![British Airways logo]()
$372
This Cheapflightsfares deal was found by Cheapflights users on 4/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Cheapflightsfares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/126:36 pm
MCI
- BCN
2 stops16h 19m
Lufthansa
Deal found 4/6![Lufthansa logo]()
$374
This United Airlines deal was found by Cheapflights users on 4/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/129:50 am
MCI
- BCN
2 stops15h 30m
United Airlines
Deal found 4/9![United Airlines logo]()
$375
Find flight deals from Missouri to Spain
Keep the following information in mind while searching for Missouri to Spain flight deals. Data was last updated April 10, 2026.
Round-trip from | $722 (oojo) |
|---|---|
One-way from | $307 (eDestinos) |
Popular in | June |
Cheapest in | January |
Average price | $634 |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 10, 2026.
Use the filters below to find and compare flights from Missouri to Spain that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Kansas CityMálaga
MCI - AGP
MCIAGP
Kansas City
Mon 8/17
3:14 pm-3:50 pm
2 stops17h 36m
Malaga
Mon 8/24
4:50 pm-9:40 pm
2 stops35h 50m
$726
Kansas CityMálaga
MCI - AGP
MCIAGP
Kansas City
Sun 9/27
6:05 am-11:45 am
2 stops22h 40m
Malaga
Tue 10/6
5:25 pm-7:09 pm
2 stops32h 44m
$742
Kansas CityMadrid
MCI - MAD
MCIMAD
Kansas City
Tue 9/22
5:20 pm-2:25 pm
1 stop14h 05m
Madrid Barajas
Tue 10/6
11:30 am-10:00 pm
1 stop17h 30m
$751
Kansas CityMadrid
MCI - MAD
MCIMAD
Kansas City
Sun 9/20
9:31 am-8:20 am
1 stop15h 49m
Madrid Barajas
Tue 10/6
11:30 am-11:01 pm
2 stops18h 31m
$751
Kansas CityMadrid
MCI - MAD
MCIMAD
Kansas City
Wed 10/7
6:00 am-8:05 am
2 stops19h 05m
Madrid Barajas
Thu 10/15
11:15 am-9:34 pm
2 stops17h 19m
$764
Quickest round-trip
Kansas CityMadrid
MCI - MAD
MCIMAD
Kansas City
Tue 10/6
1:13 pm-9:55 am
2 stops13h 42m
Madrid Barajas
Tue 10/20
12:45 pm-7:09 pm
1 stop13h 24m
$764
St. LouisMadrid
STL - MAD
STLMAD
Lambert-St Louis
Fri 9/18
12:10 pm-6:50 am
1 stop11h 40m
Madrid Barajas
Tue 10/6
1:30 pm-4:26 pm
2 stops33h 56m
$769
Kansas CityMálaga
MCI - AGP
MCIAGP
Kansas City
Tue 9/8
7:45 am-12:25 pm
2 stops21h 40m
Malaga
Mon 9/14
1:15 pm-9:40 pm
2 stops39h 25m
$776
St. LouisMadrid
STL - MAD
STLMAD
Lambert-St Louis
Sat 8/15
5:32 pm-8:50 am
2 stops32h 18m
Madrid Barajas
Sat 9/12
5:55 am-7:31 pm
2 stops20h 36m
$789
St. LouisMadrid
STL - MAD
STLMAD
Lambert-St Louis
Tue 9/29
5:30 pm-12:15 pm
1 stop11h 45m
Madrid Barajas
Fri 10/9
12:45 pm-11:39 pm
2 stops17h 54m
$790
Showing 1-10 of 60 resultsSorted by cheapest first
Best time to book a flight from Missouri to Spain
Have a flexible travel schedule? Discover the best time to fly to Spain from Missouri with our price prediction graph.
MCI-AGP
MCI-MAD
MCI-BCN
STL-MAD
STL-BCN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Spain
USMO-ES0
MCI-AGP
MCI-MAD
MCI-BCN
STL-MAD
What is the cheapest month to book a flight from Missouri to Spain?
Currently, February is the cheapest month in which you can book a flight from Missouri to Spain (average of $433). Flying from Missouri to Spain in June is currently the most expensive (average of $761). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
Related info for your journey
Find useful and relevant information for your journey from Missouri to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
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Other flight options
Popular flights
Return Flight Options
Top destinations
Top regions
Alternative routes for Missouri to Spain
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to Spain by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to Spain by cabin class
Find flights from Missouri to Spain, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Missouri and Spain flights
Browse other Missouri and Spain flight options. Last updated on April 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Find a return flight route from Spain
Find the right flight back to Missouri after your stay in Spain
Missouri to Spain flights
Consider these flights traveling from Missouri to Spain.
Fly to Spain regions
Consider these flights traveling to Spain regions.
Top 10 airlines flying from Missouri to Spain
Discover the top 10 airlines that operate flights from Missouri to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$433 | Average$747 | FlexibilityNo cancel fee | On-time75% | |
| Cheapest$437 | Average$719 | FlexibilityNo cancel fee | On-time72% | |
| Cheapest$457 | Average$753 | FlexibilityNo cancel fee | On-time77% | |
| Cheapest$461 | Average$785 | FlexibilityNo cancel fee | On-time70% | |
| Cheapest$480 | Average$1,207 | FlexibilityNo cancel fee | On-time76% | |
| Cheapest$485 | Average$859 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$487 | Average$813 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$488 | Average$866 | FlexibilityNo cancel fee | On-time77% | |
| Cheapest$490 | Average$808 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$576 | Average$1,000 | FlexibilityNo cancel fee | On-time67% |