HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Spain

$242+ Cheap flights from Missouri to Spain

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/9. Fares are subject to change and may not be available on all flights or dates of travel.
STL — MAD
Mar 28 — Apr 41
Sat 3/28
Sat 4/4
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Missouri to Spain with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Missouri to Spain

Cheapest flights from Missouri to Spain
Explore the most affordable flight options available from Missouri to Spain. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 26, 2026.

This United Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/218:25 am
STL
-
MAD
1 stop16h 40m
United Airlines
Fri 10/3012:35 pm
MAD
-
STL
2 stops33h 03m
United Airlines
Deal found 2/22$496
This SmartFares deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure SmartFares is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/307:20 am
STL
-
MAD
2 stops16h 00m
Delta
Wed 10/72:35 pm
MAD
-
STL
2 stops16h 04m
Delta
Deal found 2/23$503
This United Airlines deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/236:15 am
STL
-
MAD
2 stops20h 35m
United Airlines
Wed 9/3012:45 pm
MAD
-
STL
2 stops34h 41m
United Airlines
Deal found 2/23$504
This Air Canada deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/212:40 pm
STL
-
MAD
1 stop11h 10m
Air Canada
Wed 9/301:30 pm
MAD
-
STL
2 stops31h 48m
Air Canada
Deal found 2/23$505
This British Airways deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure British Airways is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/79:35 pm
STL
-
MAD
1 stop15h 30m
British Airways
Wed 10/213:55 pm
MAD
-
STL
1 stop15h 17m
British Airways
Deal found 2/24$508
This United Airlines deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/296:40 am
STL
-
MAD
2 stops19h 10m
United Airlines
Fri 10/91:30 pm
MAD
-
STL
2 stops29h 50m
United Airlines
Deal found 2/24$509
This Air Canada deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/266:49 pm
STL
-
MAD
2 stops29h 01m
Air Canada
Tue 9/291:30 pm
MAD
-
STL
2 stops33h 08m
Air Canada
Deal found 2/23$510
This Air Canada deal was found by Cheapflights users on 2/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/226:49 pm
STL
-
MAD
2 stops32h 01m
Air Canada
Tue 9/291:30 pm
MAD
-
STL
2 stops33h 08m
Air Canada
Deal found 2/23$515
This American Airlines deal was found by Cheapflights users on 2/25. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/299:46 am
STL
-
MAD
1 stop15h 34m
American Airlines
Fri 10/93:55 pm
MAD
-
STL
1 stop15h 17m
American Airlines
Deal found 2/25$516
This Delta deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/237:20 am
STL
-
MAD
1 stop18h 55m
Delta
Tue 12/156:00 am
MAD
-
STL
2 stops24h 03m
Delta
Deal found 2/22$518
This Delta deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/253:42 pm
STL
-
MAD
1 stop10h 33m
Delta
Fri 11/61:05 pm
MAD
-
STL
2 stops26h 07m
Delta
Deal found 2/22$519
This KLM deal was found by Cheapflights users on 2/24. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KLM is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/110:35 am
MCI
-
BCN
1 stop15h 05m
KLM
Tue 12/810:15 am
BCN
-
MCI
1 stop15h 54m
KLM
Deal found 2/24$526

Find flight deals from Missouri to Spain

Keep the following information in mind while searching for Missouri to Spain flight deals. Data was last updated February 26, 2026.

Round-trip from

$562
(eDestinos)

One-way from

$242
(oojo)

Popular in

June

Cheapest in

January

Average price

$683
From Missouri to Spain
Search Deals
One-way flight from Missouri to Spain
Search Deals
Highest demand for flights based on searches. 26% potential increase in price ($307 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 4% potential price decrease ($37 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in February 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Missouri to Spain that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 26, 2026.
Use the filters below to find and compare flights from Missouri to Spain that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

St. LouisBarcelona

STL - BCN

STLBCN

Lambert-St Louis

Wed 4/8

11:06 am-1:00 pm

1 stop18h 54m

Barcelona-El Prat

Wed 4/15

3:30 pm-10:16 am

1 stop25h 46m

$577

St. LouisMadrid

STL - MAD

STLMAD

Lambert-St Louis

Mon 4/13

8:30 am-8:05 am

1 stop16h 35m

Madrid Barajas

Wed 4/29

6:20 am-9:47 pm

2 stops22h 27m

$578

St. LouisBarcelona

STL - BCN

STLBCN

Lambert-St Louis

Tue 4/14

4:30 pm-2:15 pm

2 stops14h 45m

Barcelona-El Prat

Tue 4/28

10:30 am-7:33 pm

1 stop16h 03m

$581

St. LouisBarcelona

STL - BCN

STLBCN

Lambert-St Louis

Tue 4/7

6:40 pm-8:00 am

2 stops30h 20m

Barcelona-El Prat

Tue 4/28

12:15 pm-9:08 pm

2 stops39h 53m

$587

St. LouisValencia

STL - VLC

STLVLC

Lambert-St Louis

Wed 4/22

6:15 am-5:30 pm

3 stops28h 15m

Valencia

Wed 4/29

12:55 pm-3:24 pm

2 stops33h 29m

$597

St. LouisValencia

STL - VLC

STLVLC

Lambert-St Louis

Sun 4/19

5:21 pm-7:35 pm

2 stops19h 14m

Valencia

Mon 4/27

8:30 pm-7:30 pm

2 stops30h 00m

$598

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Sat 4/11

12:40 pm-6:50 am

2 stops35h 10m

Madrid Barajas

Mon 4/27

12:45 pm-7:45 pm

3 stops38h 00m

$626

Kansas CityMadrid

MCI - MAD

MCIMAD

Kansas City

Sat 4/11

5:45 pm-8:05 am

1 stop31h 20m

Madrid Barajas

Mon 4/20

12:45 pm-10:27 am

2 stops28h 42m

$628

SpringfieldMadrid

SGF - MAD

SGFMAD

Springfield-Branson

Thu 4/9

6:05 pm-5:30 pm

2 stops16h 25m

Madrid Barajas

Thu 4/16

11:45 am-9:05 pm

1 stop16h 20m

$639

St. LouisValencia

STL - VLC

STLVLC

Lambert-St Louis

Mon 4/20

11:15 am-11:55 am

2 stops17h 40m

Valencia

Sat 5/2

6:05 am-8:05 pm

2 stops21h 00m

$643

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/22

Showing 1-10 of 60 resultsSorted by cheapest first
1
2
3
...
6

Best time to book a flight from Missouri to Spain

Have a flexible travel schedule? Discover the best time to fly to Spain from Missouri with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Missouri to Spain

What is the cheapest month to book a flight from Missouri to Spain?

Currently, February is the cheapest month in which you can book a flight from Missouri to Spain (average of $433). Flying from Missouri to Spain in June is currently the most expensive (average of $764). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

Related info for your journey

Find useful and relevant information for your journey from Missouri to Spain. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Missouri to Spain?

    United Airlines, Air France, and British Airways can get you from Missouri to Spain in just under 14h 45m. Your travel time can differ by up to 1h 50m. There are 4638 mi between Missouri and Spain. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from Missouri to Spain one-way?

    The cheapest airline one-way is United Airlines, with whom users have recently found tickets for as low as $205. However, be on the lookout for offers from Delta and Air Canada, as they are both options that can get you from Missouri to Spain for a low price.

  • Can I find deals for flights from Missouri to Spain that include hotel bookings?

    Yes. In addition to deals on Missouri to Spain flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Missouri to Spain?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Missouri to Spain.

  • Can I find deals for business class flights from Missouri to Spain?

    Yes. Cheapflights offers flight deals from Missouri to Spain by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Missouri to Spain?

    Currently, February is the cheapest month in which you can book a flight from Missouri to Spain (average of $433). Flying from Missouri to Spain in June is currently the most expensive (average of $764). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Missouri to Spain

See prices for flight routes from nearby airports that may be better suited for you.
John F Kennedy Intl to Heathrow flights
Newark to Heathrow flights
John F Kennedy Intl to Charles de Gaulle flights
Newark to Charles de Gaulle flights
John F Kennedy Intl to Leonardo da Vinci/Fiumicino flights
Newark to Leonardo da Vinci/Fiumicino flights
John F Kennedy Intl to Orly flights
Boston to Heathrow flights
LaGuardia to Heathrow flights
Los Angeles to Heathrow flights
Dulles Intl to Heathrow flights
Newark to Athens flights
John F Kennedy Intl to Gatwick flights
John F Kennedy Intl to Lisbon flights
Newark to Orly flights
John F Kennedy Intl to Barcelona-El Prat flights
John F Kennedy Intl to London City flights
Newark to Gatwick flights
John F Kennedy Intl to Madrid flights
Newark to Dublin flights
Newark to Lisbon flights
John F Kennedy Intl to Istanbul flights
John F Kennedy Intl to Dublin flights
Newark to Barcelona-El Prat flights
O'Hare Intl to Heathrow flights
Miami to Madrid flights
San Francisco to Heathrow flights
Newark to Madrid flights
O'Hare Intl to Leonardo da Vinci/Fiumicino flights
John F Kennedy Intl to Malpensa flights
Baltimore to Heathrow flights
John F Kennedy Intl to Athens flights
Boston to Charles de Gaulle flights
Newark to Malpensa flights
Dallas/Fort Worth to Charles de Gaulle flights
Dallas/Fort Worth to Heathrow flights
Boston to Leonardo da Vinci/Fiumicino flights
O'Hare Intl to Charles de Gaulle flights
Los Angeles to Charles de Gaulle flights
John F Kennedy Intl to Frederic Chopin flights
Dulles Intl to Charles de Gaulle flights
Seattle to Heathrow flights
Boston to Dublin flights
LaGuardia to Gatwick flights
Dulles Intl to Leonardo da Vinci/Fiumicino flights
Boston to Gatwick flights

Top 10 airlines flying from Missouri to Spain

Discover the top 10 airlines that operate flights from Missouri to Spain. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 26, 2026.
AirlineCheapestAverageFlexibilityOn-time
KLMCheapest$433Average$758FlexibilityNo cancel feeOn-time75%
Virgin AtlanticCheapest$437Average$756FlexibilityNo cancel feeOn-time72%
British AirwaysCheapest$449Average$796FlexibilityNo cancel feeOn-time70%
Air FranceCheapest$457Average$753FlexibilityNo cancel feeOn-time77%
LufthansaCheapest$480Average$1,213FlexibilityNo cancel feeOn-time76%
American AirlinesCheapest$485Average$1,053FlexibilityNo cancel feeOn-time71%
DeltaCheapest$487Average$857FlexibilityNo cancel feeOn-timeN/A
IberiaCheapest$488Average$972FlexibilityNo cancel feeOn-time77%
United AirlinesCheapest$490Average$842FlexibilityNo cancel feeOn-time69%
Air CanadaCheapest$593Average$1,075FlexibilityNo cancel feeOn-time67%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.