HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santa Cruz de la Sierra

$422+ Cheap flights from Madrid, Spain (MAD) to Santa Cruz de la Sierra (VVI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/25. Fares are subject to change and may not be available on all flights or dates of travel.
MAD — VVI
Oct 15 — Oct 221
Wed 10/15
Wed 10/22
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Madrid to Santa Cruz de la Sierra with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheapflights Tip: The best prices from Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl are usually found in May or March, booked 55 days in advance, depart on a Friday or Saturday and return on a Tuesday

Cheap flight deals from Madrid to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Madrid (MAD) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 15, 2025.

Round-trip from

$882
(Avianca)

One-way from

$422
(Avianca)

Popular in

December

Cheapest in

May

Average price

$913
From Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
One-way flight from Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
Highest demand for flights based on searches. 7% potential increase in price ($89 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($37 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in September 2025
Search Deals

Find flight deals from Madrid to Santa Cruz de la Sierra

Cheapest flights from Madrid to Santa Cruz de la Sierra
Explore the most affordable flight options available from Madrid to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 15, 2025.

This Avianca deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/219:40 amMAD - VVI
1 stop22h 10mAvianca
Thu 10/92:50 amVVI - MAD
1 stop26h 20mAvianca
Deal found 9/15$882
This Avianca deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/271:30 amMAD - VVI
1 stop30h 20mAvianca
Sat 10/253:40 amVVI - MAD
1 stop28h 45mAvianca
Deal found 9/15$902
This Avianca deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/246:35 amMAD - VVI
1 stop25h 00mAvianca
Sat 1/243:40 amVVI - MAD
1 stop14h 40mAvianca
Deal found 9/14$941
This Avianca deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/16:35 amMAD - VVI
1 stop25h 00mAvianca
Sat 1/313:40 amVVI - MAD
1 stop19h 55mAvianca
Deal found 9/15$980
This Avianca deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/141:30 amMAD - VVI
1 stop30h 20mAvianca
Tue 10/212:50 amVVI - MAD
1 stop29h 15mAvianca
Deal found 9/15$982
This FlightHub deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1911:35 pmMAD - VVI
Nonstop11h 20mAir Europa
Sat 11/291:30 pmVVI - MAD
Nonstop10h 40mAir Europa
Deal found 9/14$983
This Avianca deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/41:20 amMAD - VVI
1 stop30h 15mAvianca
Tue 11/253:40 amVVI - MAD
1 stop28h 45mAvianca
Deal found 9/15$1,012
This Avianca deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/301:20 amMAD - VVI
1 stop30h 15mAvianca
Mon 11/173:40 amVVI - MAD
1 stop14h 40mAvianca
Deal found 9/14$1,013
This Avianca deal was found by Cheapflights users on 9/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 12/256:35 amMAD - VVI
1 stop25h 00mAvianca
Sat 1/243:40 amVVI - MAD
1 stop28h 45mAvianca
Deal found 9/15$1,015
This Avianca deal was found by Cheapflights users on 9/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 11/2110:50 amMAD - VVI
1 stop20h 45mAvianca
Thu 1/223:40 amVVI - MAD
1 stop14h 40mAvianca
Deal found 9/14$1,021

Cheapflights Fare Finder

 
Customize your flight search to find flights from Madrid to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
Use the filters below to find and compare flights from Madrid to Santa Cruz de la Sierra that are best for you.

Fly from

Madrid

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Mon 2/16

10:50 am-2:35 am

1 stop20h 45m

Santa Cruz de la Sierra Viru Viru Intl

Fri 2/27

3:40 am-4:35 am

1 stop19h 55m

$900

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Sat 9/27

1:30 am-1:50 am

1 stop30h 20m

Santa Cruz de la Sierra Viru Viru Intl

Sat 10/25

3:40 am-1:25 pm

1 stop28h 45m

$902

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Tue 2/10

6:35 am-2:35 am

1 stop25h 00m

Santa Cruz de la Sierra Viru Viru Intl

Mon 3/9

3:40 am-8:50 am

1 stop24h 10m

$902

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Tue 1/20

6:35 am-2:35 am

1 stop25h 00m

Santa Cruz de la Sierra Viru Viru Intl

Fri 2/20

3:40 am-8:50 am

1 stop24h 10m

$941

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Mon 11/24

6:35 am-2:35 am

1 stop25h 00m

Santa Cruz de la Sierra Viru Viru Intl

Wed 1/21

3:40 am-11:20 pm

1 stop14h 40m

$941

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Tue 1/20

6:35 am-2:35 am

1 stop25h 00m

Santa Cruz de la Sierra Viru Viru Intl

Wed 2/18

3:40 am-11:20 pm

1 stop14h 40m

$941

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Mon 11/24

6:35 am-2:35 am

1 stop25h 00m

Santa Cruz de la Sierra Viru Viru Intl

Sat 1/24

3:40 am-11:20 pm

1 stop14h 40m

$941

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Sun 10/12

1:30 am-1:50 am

1 stop30h 20m

Santa Cruz de la Sierra Viru Viru Intl

Sun 10/19

2:50 am-2:05 pm

1 stop29h 15m

$1,015

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Thu 12/25

6:35 am-2:35 am

1 stop25h 00m

Santa Cruz de la Sierra Viru Viru Intl

Sat 1/24

3:40 am-1:25 pm

1 stop28h 45m

$1,015

MadridSanta Cruz de la Sierra

MAD - VVI

MADVVI

Madrid Barajas

Mon 1/5

10:50 am-2:35 am

1 stop20h 45m

Santa Cruz de la Sierra Viru Viru Intl

Wed 2/18

3:40 am-11:20 pm

1 stop14h 40m

$1,021

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/13

Showing 1-10 of 21 results
1
2
3

Best time to book a flight from Madrid to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Madrid with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Madrid to Santa Cruz de la Sierra

How far ahead should I book a flight from Madrid to Santa Cruz de la Sierra?

Use this chart to determine the optimal time to book a round-trip flight from Madrid to Santa Cruz de la Sierra. Price data was last updated on September 12, 2025.

The best time to book flights from Madrid to Santa Cruz de la Sierra is 55 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.

What is the cheapest month to book a flight from Madrid to Santa Cruz de la Sierra?

Currently, October is the cheapest month in which you can book a flight from Madrid to Santa Cruz de la Sierra (average of $597). Flying from Madrid to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

What is the cheapest time of day to fly from MAD to VVI?

Find hourly flight availability from Madrid to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated September 15, 2025.

A simple way to save on the total cost of your ticket is to fly from Madrid to Santa Cruz de la Sierra in the afternoon. If you’re flexible enough to do this you can expect to save up to 21% on your trip compared to booking a flight at noon.

How much does it cost to fly round-trip from Madrid to Santa Cruz de la Sierra?

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated September 15, 2025.
Read through reviews of airlines operating flights from Madrid to Santa Cruz de la Sierra, such as Air Europa, Iberia, and BoA. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Air Europa
7.0
Good
556 reviews

Crew

7.5

Comfort

7.0

Overall

7.0

Entertainment

6.6

Boarding

7.1

Food

6.3

Reviews

1 / 10
8.0
Excellent

Christina,Jun 2025

ALC - MAD

It would be nice to have free messaging wifi on a trans Atlantic flight
Air Europa
7.0
Good
556 reviews
Air Europa
7.0
Good
556 reviews

Crew

7.5

Comfort

7.0

Overall

7.0

Entertainment

6.6

Boarding

7.1

Food

6.3

Reviews

1 / 10
8.0
Excellent

Christina,Jun 2025

ALC - MAD

It would be nice to have free messaging wifi on a trans Atlantic flight
Iberia
7.0
Good
2,924 reviews
Air Europa
7.0
Good
556 reviews

Crew

7.5

Comfort

7.0

Overall

7.0

Entertainment

6.6

Boarding

7.1

Food

6.3

Reviews

1 / 10
8.0
Excellent

Christina,Jun 2025

ALC - MAD

It would be nice to have free messaging wifi on a trans Atlantic flight
BoA
6.8
Okay
136 reviews
Air Europa
7.0
Good
556 reviews

Crew

7.5

Comfort

7.0

Overall

7.0

Entertainment

6.6

Boarding

7.1

Food

6.3

Reviews

1 / 10
8.0
Excellent

Christina,Jun 2025

ALC - MAD

It would be nice to have free messaging wifi on a trans Atlantic flight
Avianca
6.7
Okay
2,435 reviews
Air Europa
7.0
Good
556 reviews

Crew

7.5

Comfort

7.0

Overall

7.0

Entertainment

6.6

Boarding

7.1

Food

6.3

Reviews

1 / 10
8.0
Excellent

Christina,Jun 2025

ALC - MAD

It would be nice to have free messaging wifi on a trans Atlantic flight

Related info for your journey

Find useful and relevant information for your journey from Madrid to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airports do I use to fly from Madrid to Santa Cruz de la Sierra?

    If you wish to fly to Santa Cruz de la Sierra from Madrid, then you need to book flights from Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl. There is 1 flight from Barajas (MAD) to Viru Viru Intl (VVI) per day to choose from. Flights to Santa Cruz de la Sierra from Barajas are available from 4 different airlines, which means you should have some options if you want to compare airfare deals. 11h 15m is how long a nonstop flight from Madrid to Santa Cruz de la Sierra Viru Viru Intl typically takes.

  • How popular is this Madrid to Santa Cruz de la Sierra flight route?

    The Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl flight path was viewed by 1 users in the past month. Keep an eye out for changes in search interest prior to high and low season.

  • How long is the flight from Madrid to Santa Cruz de la Sierra?

    There are many flights that can get you from Madrid to Santa Cruz de la Sierra in 20h 45m. Fly via Avianca to get the fastest option. There are 5537 mi between Madrid and Santa Cruz de la Sierra.

  • What are the cheapest airlines flying from Madrid to Santa Cruz de la Sierra round-trip?

    Avianca, at $720, was found to be the cheapest airline from Madrid to Santa Cruz de la Sierra.Alternate airlines to your destination round-trip include Iberia and Air Europa. Avianca is 30% cheaper than the average price of flights available within the next 90 days to this destination.

  • What are the most reliable airlines from Madrid to Santa Cruz de la Sierra?

    The top 3 most reliable airlines when flying from Madrid to Santa Cruz de la Sierra are Air Europa (56%), BoA (38%) and Iberia (38%).

  • What are the cheapest flights from Madrid to Santa Cruz de la Sierra?

    Looking at all options, your cheapest flight can be booked for $459. While the most popular route (Madrid Barajas - Santa Cruz de la Sierra Viru Viru Intl) can be booked for $982 on average, our data indicates $594 when flying from Madrid to Santa Cruz de la Sierra.

  • Can I find deals for flights from Madrid to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Madrid to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Madrid to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Madrid to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Madrid to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Madrid to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Madrid to Santa Cruz de la Sierra?

    Currently, October is the cheapest month in which you can book a flight from Madrid to Santa Cruz de la Sierra (average of $597). Flying from Madrid to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Madrid to Santa Cruz de la Sierra

See prices for flight routes from nearby airports that may be better suited for you.
Madrid to La Paz flights

Top 4 airlines flying from Madrid to Santa Cruz de la Sierra

Discover the top 4 airlines that operate flights from Madrid to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 15, 2025.
AirlineCheapestAverageFlexibilityOn-time
AviancaCheapest$720Average$900FlexibilityNo cancel feeOn-time71%
IberiaCheapest$799Average$1,175FlexibilityNo cancel feeOn-time77%
Air EuropaCheapest$858Average$965FlexibilityNo cancel feeOn-time83%
BoACheapest$938Average$1,207FlexibilityNo cancel feeOn-timeN/A

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.