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Santa Cruz de la Sierra

$1,018+ Cheap flights from Detroit Metropolitan Wayne County Airport (DTW) to Santa Cruz de la Sierra (VVI)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/4. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — VVI
May 4 — May 111
Mon 5/4
Mon 5/11
1 adult, Economy
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Cheap flight deals from Detroit to Santa Cruz de la Sierra

Cheapest flights from Detroit to Santa Cruz de la Sierra
Explore the most affordable flight options available from Detroit to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on April 4, 2026.

This United Airlines deal was found by Cheapflights users on 3/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/49:00 am
DTW
-
VVI
2 stops18h 31m
United Airlines
Mon 5/1111:47 am
VVI
-
DTW
2 stops36h 00m
United Airlines
Deal found 3/31$1,018
This Copa Airlines deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/49:00 am
DTW
-
VVI
2 stops37h 38m
Copa Airlines
Mon 5/1111:47 am
VVI
-
DTW
2 stops31h 13m
Copa Airlines
Deal found 4/3$1,019
This BusinessClass deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/258:50 am
DTW
-
VVI
2 stops17h 54m
Copa Airlines
Sat 11/281:15 am
VVI
-
DTW
2 stops20h 05m
Copa Airlines
Deal found 4/4$1,065
This United Airlines deal was found by Cheapflights users on 3/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/93:29 pm
DTW
-
VVI
2 stops36h 11m
United Airlines
Mon 4/1311:48 am
VVI
-
DTW
2 stops36h 09m
United Airlines
Deal found 3/30$1,243
This Avianca deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 4/207:47 pm
DTW
-
VVI
2 stops30h 43m
Avianca
Thu 4/233:35 am
VVI
-
DTW
2 stops39h 16m
Avianca
Deal found 4/3$1,648
This FlightHub deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:50 pm
DTW
-
VVI
3 stops63h 39m
LATAM Airlines
Mon 5/115:25 am
VVI
-
DTW
2 stops28h 01m
LATAM Airlines
Deal found 4/3$2,038
This Mytrip deal was found by Cheapflights users on 4/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/256:15 pm
DTW
-
VVI
2 stops31h 20m
Multiple Airlines
Sat 11/283:40 am
VVI
-
DTW
3 stops29h 00m
Multiple Airlines
Deal found 4/4$2,100
This FlightHub deal was found by Cheapflights users on 4/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure FlightHub is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/46:50 pm
DTW
-
VVI
3 stops63h 39m
LATAM Airlines
Fri 5/155:25 am
VVI
-
DTW
2 stops33h 41m
LATAM Airlines
Deal found 4/3$2,230

Find flight deals from Detroit to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTW) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated April 4, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$1,018
(United Airlines)
Provider with most accurate pricing for Detroit Metropolitan Wayne County-Santa Cruz de la Sierra Viru Viru Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Detroit Metropolitan Wayne County-Santa Cruz de la Sierra Viru Viru Intl flights.
Search Deals
From Detroit Metropolitan Wayne County to Santa Cruz de la Sierra Viru Viru Intl
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated April 4, 2026.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Santa Cruz de la Sierra that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

DetroitSanta Cruz de la Sierra

DTW - VVI

DTWVVI

Detroit Metropolitan Wayne County

Mon 5/4

9:00 am-3:31 am

2 stops18h 31m

Santa Cruz de la Sierra Viru Viru Intl

Mon 5/11

11:47 am-11:47 pm

2 stops36h 00m

$1,018

DetroitSanta Cruz de la Sierra

DTW - VVI

DTWVVI

Detroit Metropolitan Wayne County

Mon 5/4

9:00 am-10:38 pm

2 stops37h 38m

Santa Cruz de la Sierra Viru Viru Intl

Thu 5/14

1:12 am-8:28 am

2 stops31h 16m

$1,019

DetroitSanta Cruz de la Sierra

DTW - VVI

DTWVVI

Detroit Metropolitan Wayne County

Mon 5/4

9:00 am-10:38 pm

2 stops37h 38m

Santa Cruz de la Sierra Viru Viru Intl

Mon 5/11

11:47 am-7:00 pm

2 stops31h 13m

$1,019

DetroitSanta Cruz de la Sierra

DTW - VVI

DTWVVI

Detroit Metropolitan Wayne County

Mon 4/20

7:47 pm-2:30 am

2 stops30h 43m

Santa Cruz de la Sierra Viru Viru Intl

Thu 4/23

3:35 am-6:51 pm

2 stops39h 16m

$1,648

DetroitSanta Cruz de la Sierra

DTW - VVI

DTWVVI

Detroit Metropolitan Wayne County

Mon 5/4

6:50 pm-10:29 am

3 stops63h 39m

Santa Cruz de la Sierra Viru Viru Intl

Mon 5/11

5:25 am-9:26 am

2 stops28h 01m

$2,038

Flights are sorted by cheapest round-trip flights first.

Deals found on 3/31

Sorted by cheapest first

Compare providers for flights from Detroit to Santa Cruz de la Sierra

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to Santa Cruz de la Sierra in April.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
OvagoPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-Santa Cruz de la Sierra flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Detroit Metropolitan Wayne County Airport-Santa Cruz de la Sierra flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Detroit Metropolitan Wayne County Airport-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-Santa Cruz de la Sierra flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit Metropolitan Wayne County Airport-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Detroit to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Detroit to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Detroit Metropolitan Wayne County Airport to Santa Cruz de la Sierra?

    Departing from Detroit Metropolitan Wayne County Airport to Santa Cruz de la Sierra will take you 18h 31m. Airlines will cover a distance of 4330 mi. This flight may include one or multiple stops.

  • Can I find deals for flights from Detroit to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Detroit to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Detroit to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Detroit to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
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