$314+ Cheap flights from Detroit Metropolitan Wayne County Airport (DTW) to Santa Cruz de la Sierra (VVI)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/5. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — VVI
Nov 29 — Dec 61
1 adult, Economy
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Find cheap flights from Detroit to Santa Cruz de la Sierra with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Find flight deals from Detroit to Santa Cruz de la Sierra
Cheapest flights from Detroit to Santa Cruz de la SierraExplore the most affordable flight options available from Detroit to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.
Explore the most affordable flight options available from Detroit to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 30, 2025.
This Avianca Connect deal was found by Cheapflights users on 10/29. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 11/277:10 amDTW - VVI
2 stops18h 25mMultiple Airlines
Thu 12/43:40 amVVI - DTW
2 stops18h 24mMultiple Airlines
Deal found 10/29![Multiple Airlines logo]()
$662
This Mytrip deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/87:42 pmDTW - VVI
3 stops29h 53mMultiple Airlines
Mon 12/155:25 amVVI - DTW
3 stops29h 43mMultiple Airlines
Deal found 10/28![Multiple Airlines logo]()
$841
This Kiwi.com deal was found by Cheapflights users on 10/28. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/37:10 amDTW - VVI
1 stop20h 40mMultiple Airlines
Wed 11/123:40 amVVI - DTW
2 stops21h 14mMultiple Airlines
Deal found 10/28![Multiple Airlines logo]()
$890
Cheap flight deals from Detroit to Santa Cruz de la Sierra
Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTW) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 30, 2025.
Most accurate provider | eDreams 3 stars |
|---|---|
Most trusted provider | eDreams 3 stars |
Round-trip from | $662 (Avianca Connect) |
One-way from | $314 (Avianca Connect) |
Cheapflights Fare Finder
Customize your flight search to find flights from Detroit to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated October 30, 2025.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Santa Cruz de la Sierra that are best for you.
Fly from
Detroit
Fly to
Santa Cruz de la Sierra
Route
Depart
Return
Price
DetroitSanta Cruz de la Sierra
DTW - VVI
DTWVVI
Detroit Metropolitan Wayne County
Thu 11/27
7:10 am-2:35 am
2 stops18h 25m
Santa Cruz de la Sierra Viru Viru Intl
Thu 12/4
3:40 am-9:04 pm
2 stops18h 24m
$662
DetroitSanta Cruz de la Sierra
DTW - VVI
DTWVVI
Detroit Metropolitan Wayne County
Mon 12/8
4:39 pm-2:35 am
2 stops32h 56m
Santa Cruz de la Sierra Viru Viru Intl
Mon 12/15
5:25 am-10:08 am
3 stops29h 43m
$842
DetroitSanta Cruz de la Sierra
DTW - VVI
DTWVVI
Detroit Metropolitan Wayne County
Sat 4/4
9:26 am-10:50 pm
2 stops37h 24m
Santa Cruz de la Sierra Viru Viru Intl
Tue 4/7
11:44 am-8:20 pm
2 stops32h 36m
$862
DetroitSanta Cruz de la Sierra
DTW - VVI
DTWVVI
Detroit Metropolitan Wayne County
Wed 11/5
6:10 am-2:35 am
2 stops19h 25m
$314
Compare providers for flights from Detroit to Santa Cruz de la Sierra
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to Santa Cruz de la Sierra in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*1 star | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-Santa Cruz de la Sierra flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Detroit Metropolitan Wayne County Airport-Santa Cruz de la Sierra flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Detroit Metropolitan Wayne County Airport-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-Santa Cruz de la Sierra flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit Metropolitan Wayne County Airport-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Detroit to Santa Cruz de la Sierra
Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.