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Santa Cruz de la Sierra

$635+ Cheap flights from Detroit Metropolitan Wayne County Airport (DTW) to Santa Cruz de la Sierra (VVI)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/8. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — VVI
Mar 18 — Mar 251
Wed 3/18
Wed 3/25
1 adult, Economy
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Cheap flight deals from Detroit to Santa Cruz de la Sierra

Cheapest flights from Detroit to Santa Cruz de la Sierra
Explore the most affordable flight options available from Detroit to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 16, 2026.

This Avianca Connect deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/85:45 am
DTW
-
VVI
2 stops20h 45m
Multiple Airlines
Thu 5/143:35 am
VVI
-
DTW
2 stops20h 02m
Multiple Airlines
Deal found 2/14$635
This Avianca Connect deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/175:45 am
DTW
-
VVI
2 stops20h 45m
Multiple Airlines
Sun 4/263:35 am
VVI
-
DTW
2 stops20h 24m
Multiple Airlines
Deal found 2/15$790
This Avianca Connect deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/167:45 am
DTW
-
VVI
2 stops18h 45m
Multiple Airlines
Sat 4/253:35 am
VVI
-
DTW
2 stops20h 24m
Multiple Airlines
Deal found 2/15$815
This United Airlines deal was found by Cheapflights users on 2/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/176:00 am
DTW
-
VVI
3 stops21h 40m
United Airlines
Mon 4/2711:48 am
VVI
-
DTW
2 stops22h 26m
United Airlines
Deal found 2/15$858
This United Airlines deal was found by Cheapflights users on 2/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/246:05 am
DTW
-
VVI
2 stops39h 45m
United Airlines
Thu 2/2611:44 am
VVI
-
DTW
2 stops26h 46m
United Airlines
Deal found 2/14$1,502

Find flight deals from Detroit to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTW) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 16, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$635
(Avianca Connect)
Provider with most accurate pricing for Detroit Metropolitan Wayne County-Santa Cruz de la Sierra Viru Viru Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Detroit Metropolitan Wayne County-Santa Cruz de la Sierra Viru Viru Intl flights.
Search Deals
From Detroit Metropolitan Wayne County to Santa Cruz de la Sierra Viru Viru Intl
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 16, 2026.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Santa Cruz de la Sierra that are best for you.

Fly from

Detroit

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

DetroitSanta Cruz de la Sierra

DTW - VVI

DTWVVI

Detroit Metropolitan Wayne County

Fri 5/8

5:45 am-2:30 am

2 stops20h 45m

Santa Cruz de la Sierra Viru Viru Intl

Thu 5/14

3:35 am-11:37 pm

2 stops20h 02m

$635

DetroitSanta Cruz de la Sierra

DTW - VVI

DTWVVI

Detroit Metropolitan Wayne County

Fri 4/17

5:45 am-2:30 am

2 stops20h 45m

Santa Cruz de la Sierra Viru Viru Intl

Sun 4/26

3:35 am-11:59 pm

2 stops20h 24m

$790

DetroitSanta Cruz de la Sierra

DTW - VVI

DTWVVI

Detroit Metropolitan Wayne County

Thu 4/16

7:45 am-2:30 am

2 stops18h 45m

Santa Cruz de la Sierra Viru Viru Intl

Sat 4/25

3:35 am-11:59 pm

2 stops20h 24m

$815

DetroitSanta Cruz de la Sierra

DTW - VVI

DTWVVI

Detroit Metropolitan Wayne County

Fri 4/17

6:00 am-3:40 am

3 stops21h 40m

Santa Cruz de la Sierra Viru Viru Intl

Mon 4/27

11:48 am-10:14 am

2 stops22h 26m

$858

DetroitSanta Cruz de la Sierra

DTW - VVI

DTWVVI

Detroit Metropolitan Wayne County

Tue 2/24

6:05 am-10:50 pm

2 stops39h 45m

Santa Cruz de la Sierra Viru Viru Intl

Thu 2/26

11:44 am-1:30 pm

2 stops26h 46m

$1,502

Flights are sorted by cheapest round-trip flights first.

Deals found on 2/14

Compare providers for flights from Detroit to Santa Cruz de la Sierra

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to Santa Cruz de la Sierra in February.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*3 stars
OvagoPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-Santa Cruz de la Sierra flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Detroit Metropolitan Wayne County Airport-Santa Cruz de la Sierra flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Detroit Metropolitan Wayne County Airport-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-Santa Cruz de la Sierra flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit Metropolitan Wayne County Airport-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Detroit to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Detroit to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Detroit Metropolitan Wayne County Airport to Santa Cruz de la Sierra?

    Departing from Detroit Metropolitan Wayne County Airport to Santa Cruz de la Sierra will take you 21h 40m. Airlines will cover a distance of 4330 mi.

  • Can I find deals for flights from Detroit to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Detroit to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Detroit to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Detroit to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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