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Santa Cruz de la Sierra

$749+ Cheap flights from Detroit Metropolitan Wayne County Airport (DTW) to Santa Cruz de la Sierra (VVI)

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/29. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — VVI
Oct 17 — Oct 241
Fri 10/17
Fri 10/24
1 adult, Economy
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Cheap flight deals from Detroit to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTW) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated September 17, 2025.

Round-trip from

$749
(Avianca Connect)
From Detroit Metropolitan Wayne County to Santa Cruz de la Sierra Viru Viru Intl
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Find flight deals from Detroit to Santa Cruz de la Sierra

Cheapest flights from Detroit to Santa Cruz de la Sierra
Explore the most affordable flight options available from Detroit to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on September 17, 2025.

This Avianca Connect deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca Connect is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/216:41 amDTW - VVI
2 stops19h 09mMultiple Airlines
Mon 9/222:50 amVVI - DTW
2 stops20h 53mMultiple Airlines
Deal found 9/17$782
This Copa Airlines deal was found by Cheapflights users on 9/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/216:00 amDTW - VVI
2 stops16h 25mCopa Airlines
Tue 9/2312:15 pmVVI - DTW
2 stops21h 42mCopa Airlines
Deal found 9/17$931

Cheapflights Fare Finder

 
Customize your flight search to find flights from Detroit to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated September 17, 2025.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Santa Cruz de la Sierra that are best for you.

Fly from

Detroit

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

DetroitSanta Cruz de la Sierra

DTW - VVI

DTWVVI

Detroit Metropolitan Wayne County

Thu 1/29

6:11 am-2:35 am

2 stops19h 24m

Santa Cruz de la Sierra Viru Viru Intl

Mon 2/2

3:40 am-9:23 pm

2 stops18h 43m

$749

DetroitSanta Cruz de la Sierra

DTW - VVI

DTWVVI

Detroit Metropolitan Wayne County

Thu 1/29

7:44 pm-10:50 pm

2 stops26h 06m

Santa Cruz de la Sierra Viru Viru Intl

Tue 2/3

11:44 am-10:06 am

2 stops23h 22m

$941

Flights are sorted by cheapest round-trip flights first.

Deals found on 9/17

Best time to book a flight from Detroit to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Detroit with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Detroit to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Detroit Metropolitan Wayne County Airport to Santa Cruz de la Sierra?

    Departing from Detroit Metropolitan Wayne County Airport to Santa Cruz de la Sierra will take you 26h 06m. Airlines will cover a distance of 4330 mi.

  • Can I find deals for flights from Detroit to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Detroit to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Detroit to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Detroit to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Detroit to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Detroit to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from Detroit Metropolitan Wayne County Airport to Santa Cruz de la Sierra?

    Currently, October is the cheapest month in which you can book a flight from Detroit Metropolitan Wayne County Airport to Santa Cruz de la Sierra (average of $597). Flying from Detroit Metropolitan Wayne County Airport to Santa Cruz de la Sierra in December is currently the most expensive (average of $822). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

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