$917+ Cheap flights from Detroit Metropolitan Wayne County Airport (DTW) to Santa Cruz de la Sierra (VVI)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/15. Fares are subject to change and may not be available on all flights or dates of travel.
DTW — VVI
Jun 16 — Jun 231
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Detroit to Santa Cruz de la Sierra with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Detroit to Santa Cruz de la Sierra
Cheapest
Best
Last-minute
Cheapest flights from Detroit to Santa Cruz de la SierraExplore the most affordable flight options available from Detroit to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 17, 2026.
Explore the most affordable flight options available from Detroit to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 17, 2026.
This Ovago deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Ovago is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:15 am
DTW
- VVI
2 stops16h 29m
Multiple Airlines
Thu 9/2412:00 pm
VVI
- DTW
2 stops27h 16m
Multiple Airlines
Deal found 5/14![Multiple Airlines logo]()
$917
This BusinessClass deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure BusinessClass is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:15 am
DTW
- VVI
2 stops16h 29m
Copa Airlines
Tue 9/2211:47 am
VVI
- DTW
2 stops32h 38m
Copa Airlines
Deal found 5/14![Copa Airlines logo]()
$921
This KAYAK deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/1611:00 am
DTW
- VVI
2 stops48h 10m
Multiple Airlines
Tue 9/221:12 am
VVI
- DTW
2 stops19h 13m
Multiple Airlines
Deal found 5/14![Multiple Airlines logo]()
$942
This United Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:00 am
DTW
- VVI
2 stops21h 38m
United Airlines
Mon 9/2111:47 am
VVI
- DTW
2 stops27h 41m
United Airlines
Deal found 5/14![United Airlines logo]()
$953
This United Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/138:50 am
DTW
- VVI
2 stops42h 48m
United Airlines
Tue 9/2211:47 am
VVI
- DTW
2 stops22h 22m
United Airlines
Deal found 5/14![United Airlines logo]()
$960
This United Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:15 am
DTW
- VVI
2 stops16h 29m
United Airlines
Sat 9/2611:47 am
VVI
- DTW
2 stops22h 03m
United Airlines
Deal found 5/14![United Airlines logo]()
$978
This United Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/138:50 am
DTW
- VVI
2 stops42h 48m
United Airlines
Sat 9/2611:47 am
VVI
- DTW
2 stops22h 03m
United Airlines
Deal found 5/14![United Airlines logo]()
$985
This KAYAK deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/166:15 am
DTW
- VVI
2 stops16h 29m
Copa Airlines
Tue 9/2211:47 am
VVI
- DTW
2 stops20h 51m
Copa Airlines
Deal found 5/14![Copa Airlines logo]()
$996
This KAYAK deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/167:47 pm
DTW
- VVI
2 stops39h 23m
Multiple Airlines
Tue 6/2312:05 pm
VVI
- DTW
2 stops30h 33m
Multiple Airlines
Deal found 5/17![Multiple Airlines logo]()
$999
This United Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/189:19 am
DTW
- VVI
2 stops18h 19m
United Airlines
Sat 9/2611:47 am
VVI
- DTW
2 stops22h 03m
United Airlines
Deal found 5/14![United Airlines logo]()
$1,003
This United Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:00 am
DTW
- VVI
2 stops16h 44m
United Airlines
Tue 9/2211:47 am
VVI
- DTW
2 stops22h 22m
United Airlines
Deal found 5/14![United Airlines logo]()
$1,008
This United Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/1811:00 am
DTW
- VVI
2 stops16h 38m
United Airlines
Mon 9/2111:47 am
VVI
- DTW
2 stops27h 41m
United Airlines
Deal found 5/14![United Airlines logo]()
$1,033
Best flights from Detroit to Santa Cruz de la SierraDiscover carefully curated flight deals from Detroit to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 17, 2026.
Discover carefully curated flight deals from Detroit to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 17, 2026.
This United Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:00 am
DTW
- VVI
2 stops21h 38m
United Airlines
Thu 9/2411:47 am
VVI
- DTW
2 stops32h 33m
United Airlines
Deal found 5/14![United Airlines logo]()
$953
This Trip.com deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:30 am
DTW
- VVI
3 stops20h 00m
Multiple Airlines
Mon 6/223:35 am
VVI
- DTW
3 stops21h 09m
Multiple Airlines
Deal found 5/17![Multiple Airlines logo]()
$1,081
This Copa Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/27:45 pm
DTW
- VVI
2 stops31h 46m
Copa Airlines
Thu 6/2511:47 am
VVI
- DTW
2 stops22h 05m
Copa Airlines
Deal found 5/14![Copa Airlines logo]()
$1,195
This Avianca deal was found by Cheapflights users on 5/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/236:00 am
DTW
- VVI
2 stops20h 30m
Avianca
Sat 10/243:40 am
VVI
- DTW
2 stops35h 32m
Avianca
Deal found 5/15![Avianca logo]()
$1,427
This United Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:00 am
DTW
- VVI
2 stops21h 38m
United Airlines
Mon 9/2111:47 am
VVI
- DTW
2 stops27h 41m
United Airlines
Deal found 5/14![United Airlines logo]()
$953
This United Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/156:00 am
DTW
- VVI
2 stops16h 44m
United Airlines
Sat 9/2611:47 am
VVI
- DTW
2 stops22h 03m
United Airlines
Deal found 5/14![United Airlines logo]()
$978
This United Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/146:15 am
DTW
- VVI
2 stops16h 29m
United Airlines
Sat 9/2611:47 am
VVI
- DTW
2 stops22h 03m
United Airlines
Deal found 5/14![United Airlines logo]()
$978
This Trip.com deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:50 am
DTW
- VVI
3 stops19h 40m
Multiple Airlines
Wed 6/243:35 am
VVI
- DTW
3 stops21h 09m
Multiple Airlines
Deal found 5/14![Multiple Airlines logo]()
$1,286
This United Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/196:00 am
DTW
- VVI
2 stops16h 44m
United Airlines
Sat 9/2611:47 am
VVI
- DTW
2 stops27h 29m
United Airlines
Deal found 5/14![United Airlines logo]()
$1,003
This United Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/197:40 pm
DTW
- VVI
2 stops27h 04m
United Airlines
Tue 9/2211:47 am
VVI
- DTW
2 stops22h 00m
United Airlines
Deal found 5/14![United Airlines logo]()
$1,033
This United Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:15 am
DTW
- VVI
2 stops40h 23m
United Airlines
Tue 6/2311:47 am
VVI
- DTW
3 stops36h 10m
United Airlines
Deal found 5/17![United Airlines logo]()
$1,058
Last-minute flights from Detroit to Santa Cruz de la SierraDiscover last-minute flight deals from Detroit to Santa Cruz de la Sierra. Data last updated May 17, 2026 and is based on user searches.
Discover last-minute flight deals from Detroit to Santa Cruz de la Sierra. Data last updated May 17, 2026 and is based on user searches.
This Copa Airlines deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/27:45 pm
DTW
- VVI
2 stops31h 46m
Copa Airlines
Thu 6/2511:47 am
VVI
- DTW
2 stops22h 05m
Copa Airlines
Deal found 5/14![Copa Airlines logo]()
$1,195
This Trip.com deal was found by Cheapflights users on 5/14. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/26:50 am
DTW
- VVI
3 stops19h 40m
Multiple Airlines
Wed 6/243:35 am
VVI
- DTW
3 stops21h 09m
Multiple Airlines
Deal found 5/14![Multiple Airlines logo]()
$1,286
This KAYAK deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/167:47 pm
DTW
- VVI
2 stops39h 23m
Multiple Airlines
Tue 6/2312:05 pm
VVI
- DTW
2 stops30h 33m
Multiple Airlines
Deal found 5/17![Multiple Airlines logo]()
$999
This United Airlines deal was found by Cheapflights users on 5/17. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/166:15 am
DTW
- VVI
2 stops40h 23m
United Airlines
Tue 6/2311:47 am
VVI
- DTW
3 stops36h 10m
United Airlines
Deal found 5/17![United Airlines logo]()
$1,058
This United Airlines deal was found by Cheapflights users on 5/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/276:15 am
DTW
- VVI
2 stops16h 23m
United Airlines
Sat 7/411:47 am
VVI
- DTW
2 stops21h 44m
United Airlines
Deal found 5/12![United Airlines logo]()
$3,628
Find flight deals from Detroit to Santa Cruz de la Sierra
Discover tips and strategies to find the most affordable flight options for your journey from Detroit (DTW) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 17, 2026.
Most accurate provider | Ovago 3 stars |
|---|---|
Most trusted provider | Ovago 3 stars |
Round-trip from | $917 (Ovago) |
Cheapflights Fare Finder
Customize your flight search to find flights from Detroit to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 17, 2026.
Use the filters below to find and compare flights from Detroit Metropolitan Wayne County Airport to Santa Cruz de la Sierra that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
DetroitSanta Cruz de la Sierra
DTW - VVI
DTWVVI
Detroit Metropolitan Wayne County
Mon 9/14
6:00 am-3:38 am
2 stops21h 38m
Santa Cruz de la Sierra Viru Viru Intl
Thu 9/24
11:47 am-8:20 pm
2 stops32h 33m
$953
DetroitSanta Cruz de la Sierra
DTW - VVI
DTWVVI
Detroit Metropolitan Wayne County
Mon 9/14
6:00 am-3:38 am
2 stops21h 38m
Santa Cruz de la Sierra Viru Viru Intl
Mon 9/21
11:47 am-3:28 pm
2 stops27h 41m
$953
DetroitSanta Cruz de la Sierra
DTW - VVI
DTWVVI
Detroit Metropolitan Wayne County
Tue 9/15
6:00 am-10:44 pm
2 stops16h 44m
Santa Cruz de la Sierra Viru Viru Intl
Sat 9/26
11:47 am-9:50 am
2 stops22h 03m
$978
Quickest round-trip
DetroitSanta Cruz de la Sierra
DTW - VVI
DTWVVI
Detroit Metropolitan Wayne County
Mon 9/14
6:15 am-10:44 pm
2 stops16h 29m
Santa Cruz de la Sierra Viru Viru Intl
Sat 9/26
11:47 am-9:50 am
2 stops22h 03m
$978
DetroitSanta Cruz de la Sierra
DTW - VVI
DTWVVI
Detroit Metropolitan Wayne County
Sat 9/19
6:00 am-10:44 pm
2 stops16h 44m
Santa Cruz de la Sierra Viru Viru Intl
Sat 9/26
11:47 am-3:16 pm
2 stops27h 29m
$1,003
DetroitSanta Cruz de la Sierra
DTW - VVI
DTWVVI
Detroit Metropolitan Wayne County
Sat 9/19
7:40 pm-10:44 pm
2 stops27h 04m
Santa Cruz de la Sierra Viru Viru Intl
Tue 9/22
11:47 am-9:47 am
2 stops22h 00m
$1,033
DetroitSanta Cruz de la Sierra
DTW - VVI
DTWVVI
Detroit Metropolitan Wayne County
Tue 6/16
6:15 am-10:38 pm
2 stops40h 23m
Santa Cruz de la Sierra Viru Viru Intl
Tue 6/23
11:47 am-11:57 pm
3 stops36h 10m
$1,058
DetroitSanta Cruz de la Sierra
DTW - VVI
DTWVVI
Detroit Metropolitan Wayne County
Tue 6/16
6:30 am-2:30 am
3 stops20h 00m
Santa Cruz de la Sierra Viru Viru Intl
Mon 6/22
3:35 am-12:44 am
3 stops21h 09m
$1,081
DetroitSanta Cruz de la Sierra
DTW - VVI
DTWVVI
Detroit Metropolitan Wayne County
Tue 6/2
7:45 pm-3:31 am
2 stops31h 46m
Santa Cruz de la Sierra Viru Viru Intl
Thu 6/25
11:47 am-9:52 am
2 stops22h 05m
$1,195
DetroitSanta Cruz de la Sierra
DTW - VVI
DTWVVI
Detroit Metropolitan Wayne County
Tue 6/2
6:50 am-2:30 am
3 stops19h 40m
Santa Cruz de la Sierra Viru Viru Intl
Wed 6/24
3:35 am-12:44 am
3 stops21h 09m
$1,286
Showing 1-10 of 11 resultsSorted by cheapest first
Compare providers for flights from Detroit to Santa Cruz de la Sierra
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Detroit to Santa Cruz de la Sierra in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-Santa Cruz de la Sierra flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on Detroit Metropolitan Wayne County Airport-Santa Cruz de la Sierra flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from Detroit Metropolitan Wayne County Airport-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Detroit Metropolitan Wayne County Airport-Santa Cruz de la Sierra flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Detroit Metropolitan Wayne County Airport-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Detroit to Santa Cruz de la Sierra
Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Detroit with our price prediction graph.
DTW-VVI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Related info for your journey
Find useful and relevant information for your journey from Detroit to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Complete your trip
Flights by cabin class
Other flight options
Other flights from Detroit
Popular flights