$348+ Cheap flights from Denver (DEN) to Santa Cruz de la Sierra (VVI)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 11/15. Fares are subject to change and may not be available on all flights or dates of travel.
DEN — VVI
Nov 19 — Nov 261
Round-trip
1 adult, Economy
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Find cheap flights from Denver to Santa Cruz de la Sierra with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Denver to Santa Cruz de la Sierra
Cheapest
Best
Last-minute
One-way
Cheapest flights from Denver to Santa Cruz de la SierraExplore the most affordable flight options available from Denver to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 20, 2026.
Explore the most affordable flight options available from Denver to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on October 20, 2026.
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:00 am -
2 stops15h 44m
Tue 11/311:41 am -
2 stops24h 21m
Deal found 10/18![United Airlines logo]()
$753
This oojo deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/149:49 pm -
1 stop21h 49m
Sat 11/2111:41 am -
1 stop32h 21m
Deal found 10/15![Copa Airlines logo]()
$871
This United deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/143:46 pm -
2 stops27h 52m
Sat 11/2111:41 am -
1 stop32h 21m
Deal found 10/15![Multiple Airlines logo]()
$1,243
This Avianca deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:40 am -
2 stops17h 00m
Mon 11/23:45 am -
2 stops17h 32m
Deal found 10/16![Avianca logo]()
$2,266
Best flights from Denver to Santa Cruz de la SierraDiscover carefully curated flight deals from Denver to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 20, 2026.
Discover carefully curated flight deals from Denver to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated October 20, 2026.
This United Airlines deal was found by Cheapflights users on 10/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:00 am -
2 stops15h 44m
Tue 11/311:41 am -
2 stops24h 21m
Deal found 10/19![United Airlines logo]()
$753
This oojo deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals ”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/149:49 pm -
1 stop21h 49m
Sat 11/2111:41 am -
1 stop32h 21m
Deal found 10/15![Copa Airlines logo]()
$871
This United deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/143:46 pm -
2 stops27h 52m
Sat 11/2111:41 am -
1 stop32h 21m
Deal found 10/15![Multiple Airlines logo]()
$1,243
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/145:55 pm -
2 stops25h 43m
Sat 11/2111:41 am -
2 stops23h 36m
Deal found 10/15![United Airlines logo]()
$753
This KAYAK deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/137:45 am -
2 stops16h 59m
Wed 1/2011:53 am -
2 stops14h 37m
Deal found 10/20![Copa Airlines logo]()
$972
This Kiwi.com deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/67:08 pm -
1 stop29h 42m
Wed 1/1311:35 pm -
2 stops39h 24m
Deal found 10/20![Multiple Airlines logo]()
$1,532
This Mytrip deal was found by Cheapflights users on 10/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 1/1312:18 pm -
3 stops35h 22m
Tue 1/193:45 am -
3 stops34h 46m
Deal found 10/20![Multiple Airlines logo]()
$1,539
Last-minute flights from Denver to Santa Cruz de la SierraDiscover last-minute flight deals from Denver to Santa Cruz de la Sierra. Data last updated October 20, 2026 and is based on user searches.
Discover last-minute flight deals from Denver to Santa Cruz de la Sierra. Data last updated October 20, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 10/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/305:00 am -
2 stops15h 44m
Tue 11/311:41 am -
2 stops24h 21m
Deal found 10/18![United Airlines logo]()
$753
This Avianca deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/307:40 am -
2 stops17h 00m
Mon 11/23:45 am -
2 stops17h 32m
Deal found 10/16![Avianca logo]()
$2,266
This oojo deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/149:49 pm -
1 stop21h 49m
Sat 11/2111:41 am -
1 stop32h 21m
Deal found 10/15![Copa Airlines logo]()
$871
This United deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/143:46 pm -
2 stops27h 52m
Sat 11/2111:41 am -
1 stop32h 21m
Deal found 10/15![Multiple Airlines logo]()
$1,243
One-way flights from Denver to Santa Cruz de la SierraSearch for one-way flight options from Denver to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated October 20, 2026.
Search for one-way flight options from Denver to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated October 20, 2026.
This Copa Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/159:49 pm -
1 stop26h 48m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/15![Copa Airlines logo]()
$348
This United Airlines deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/155:00 am -
2 stops38h 38m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/15![United Airlines logo]()
$363
This Kiwi.com deal was found by Cheapflights users on 10/15. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/1510:41 am -
3 stops37h 56m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/15![Multiple Airlines logo]()
$449
This Kiwi.com deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/1810:41 am -
3 stops56h 57m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Multiple Airlines logo]()
$483
This Copa Airlines deal was found by Cheapflights users on 10/16. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 11/189:49 pm -
1 stop21h 49m
Wed 12/3112:00 am -
Nonstop0h 00m
Deal found 10/16![Copa Airlines logo]()
$568
Find flight deals from Denver to Santa Cruz de la Sierra
Discover tips and strategies to find the most affordable flight options for your journey from Denver (DEN) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated October 20, 2026.
Most accurate provider | Ovago 3 stars |
|---|---|
Most trusted provider | Ovago 3 stars |
Round-trip from | $753 (United Airlines) |
One-way from | $348 (Copa Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Denver to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 20, 2026.
Use the filters below to find and compare flights from Denver to Santa Cruz de la Sierra that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
DenverSanta Cruz de la Sierra
DEN Denver Intl - VVI Santa Cruz de la Sierra Viru Viru Intl
DENVVI
Denver Intl
Sun 11/15
9:49 pm-3:37 am
1 stop26h 48m
Santa Cruz de la Sierra Viru Viru Intl
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$348
DenverSanta Cruz de la Sierra
DEN Denver Intl - VVI Santa Cruz de la Sierra Viru Viru Intl
DENVVI
Denver Intl
Sun 11/15
5:00 am-10:38 pm
2 stops38h 38m
Santa Cruz de la Sierra Viru Viru Intl
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$363
Quickest round-trip
DenverSanta Cruz de la Sierra
DEN Denver Intl - VVI Santa Cruz de la Sierra Viru Viru Intl
DENVVI
Denver Intl
Wed 11/18
9:49 pm-10:38 pm
1 stop21h 49m
Santa Cruz de la Sierra Viru Viru Intl
Wed 12/31
12:00 am-9:00 pm
Nonstop0h 00m
$568
DenverSanta Cruz de la Sierra
DEN Denver Intl - VVI Santa Cruz de la Sierra Viru Viru Intl
DENVVI
Denver Intl
Fri 10/30
5:00 am-10:44 pm
2 stops15h 44m
Santa Cruz de la Sierra Viru Viru Intl
Tue 11/3
11:41 am-9:02 am
2 stops24h 21m
$753
DenverSanta Cruz de la Sierra
DEN Denver Intl - VVI Santa Cruz de la Sierra Viru Viru Intl
DENVVI
Denver Intl
Sat 11/14
5:55 pm-10:38 pm
2 stops25h 43m
Santa Cruz de la Sierra Viru Viru Intl
Sat 11/21
11:41 am-8:17 am
2 stops23h 36m
$753
DenverSanta Cruz de la Sierra
DEN Denver Intl - VVI Santa Cruz de la Sierra Viru Viru Intl
DENVVI
Denver Intl
Sat 11/14
9:49 pm-10:38 pm
1 stop21h 49m
Santa Cruz de la Sierra Viru Viru Intl
Sat 11/21
11:41 am-5:02 pm
1 stop32h 21m
$871
DenverSanta Cruz de la Sierra
DEN Denver Intl - VVI Santa Cruz de la Sierra Viru Viru Intl
DENVVI
Denver Intl
Wed 1/13
7:45 am-3:44 am
2 stops16h 59m
Santa Cruz de la Sierra Viru Viru Intl
Wed 1/20
11:53 am-11:30 pm
2 stops14h 37m
$972
DenverSanta Cruz de la Sierra
DEN Denver Intl - VVI Santa Cruz de la Sierra Viru Viru Intl
DENVVI
Denver Intl
Sat 11/14
3:46 pm-10:38 pm
2 stops27h 52m
Santa Cruz de la Sierra Viru Viru Intl
Sat 11/21
11:41 am-5:02 pm
1 stop32h 21m
$1,243
DenverSanta Cruz de la Sierra
DEN Denver Intl - VVI Santa Cruz de la Sierra Viru Viru Intl
DENVVI
Denver Intl
Wed 1/6
7:08 pm-3:50 am
1 stop29h 42m
Santa Cruz de la Sierra Viru Viru Intl
Wed 1/13
11:35 pm-11:59 am
2 stops39h 24m
$1,532
DenverSanta Cruz de la Sierra
DEN Denver Intl - VVI Santa Cruz de la Sierra Viru Viru Intl
DENVVI
Denver Intl
Wed 1/13
12:18 pm-2:40 am
3 stops35h 22m
Santa Cruz de la Sierra Viru Viru Intl
Tue 1/19
3:45 am-11:31 am
3 stops34h 46m
$1,539
Sorted by cheapest first
Compare providers for flights from Denver to Santa Cruz de la Sierra
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Denver to Santa Cruz de la Sierra in October.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Denver-Santa Cruz de la Sierra flights, users find the pricing of Ovago to be most consistent on Cheapflights vs. Ovago Users can find the same prices on Denver-Santa Cruz de la Sierra flight deals on Cheapflights vs. Ovago >95% of the time. Price accuracy is based on data collected from Denver-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Denver-Santa Cruz de la Sierra flights, Cheapflights users trust Ovago the most. Ovago has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Denver-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Denver to Santa Cruz de la Sierra
Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Denver with our price prediction graph.
DEN-VVI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Santa Cruz de la Sierra
Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated October 20, 2026.
Read through reviews of airlines operating flights from Denver to Santa Cruz de la Sierra, such as Copa Airlines and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Boarding
7.8
Entertainment
6.9
Crew
8.1
Comfort
7.5
Food
7.0
Overall
7.6
Reviews
1 / 20
2.0
MediocreAnonymous,Oct 2026
BOS - PTY
Boarding
7.8
Entertainment
6.9
Crew
8.1
Comfort
7.5
Food
7.0
Overall
7.6
Reviews
1 / 20
2.0
MediocreAnonymous,Oct 2026
BOS - PTY
Boarding
7.8
Entertainment
6.9
Crew
8.1
Comfort
7.5
Food
7.0
Overall
7.6
Reviews
1 / 20
2.0
MediocreAnonymous,Oct 2026
BOS - PTY
Related info for your journey
Find useful and relevant information for your journey from Denver to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Denver to Santa Cruz de la Sierra, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Denver and Santa Cruz de la Sierra flights
Browse other Denver and Santa Cruz de la Sierra flight options. Last updated on October 20, 2026.
Other flights from Denver
Browse through other flights departing from Denver. Flights are based on user searches made on Cheapflights and were last updated on October 20, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Denver to Santa Cruz de la Sierra
Discover the top 2 airlines that operate flights from Denver to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated October 20, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$317 | Average$667 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$606 | Average$795 | FlexibilityNo cancel fee | On-time70% |