HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news
Santa Cruz de la Sierra

$264+ Cheap flights from Denver (DEN) to Santa Cruz de la Sierra (VVI)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 1/28. Fares are subject to change and may not be available on all flights or dates of travel.
DEN — VVI
Dec 26 — Jan 21
Fri 12/26
Fri 1/2
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

Find cheap flights from Denver to Santa Cruz de la Sierra with Cheapflights

1. Tell us where you want to go

Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”

2. Select your favorite providers

We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.

3. Compare prices and book

Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.

Cheap flight deals from Denver to Santa Cruz de la Sierra

Discover tips and strategies to find the most affordable flight options for your journey from Denver (DEN) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated November 26, 2025.

Most accurate provider

eDreams
3 stars

Most trusted provider

eDreams
3 stars

Round-trip from

$582
(United Airlines)

One-way from

$264
(United Airlines)

Popular in

December

Cheapest in

January
Provider with most accurate pricing for Denver Intl-Santa Cruz de la Sierra Viru Viru Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Denver Intl-Santa Cruz de la Sierra Viru Viru Intl flights.
Search Deals
From Denver Intl to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
One-way flight from Denver Intl to Santa Cruz de la Sierra Viru Viru Intl
Search Deals
Highest demand for flights based on searches. 1% potential increase in price ($9 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 3% potential price decrease ($33 potential savings vs. average RT price).
Search Deals

Find flight deals from Denver to Santa Cruz de la Sierra

Cheapest flights from Denver to Santa Cruz de la Sierra
Explore the most affordable flight options available from Denver to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on November 26, 2025.

This United Airlines deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/245:56 pmDEN - VVI
2 stops25h 50mUnited Airlines
Mon 12/111:40 amVVI - DEN
2 stops27h 47mUnited Airlines
Deal found 11/23$582
This Copa Airlines deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/249:38 pmDEN - VVI
1 stop22h 08mCopa Airlines
Sun 11/301:09 amVVI - DEN
1 stop19h 08mCopa Airlines
Deal found 11/23$1,096
This Kiwi.com deal was found by Cheapflights users on 11/23. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/241:10 pmDEN - VVI
2 stops36h 25mMultiple Airlines
Mon 12/18:35 amVVI - DEN
1 stop27h 33mMultiple Airlines
Deal found 11/23$1,154

Cheapflights Fare Finder

 
Customize your flight search to find flights from Denver to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 26, 2025.
Use the filters below to find and compare flights from Denver to Santa Cruz de la Sierra that are best for you.

Fly from

Denver

Fly to

Santa Cruz de la Sierra

Route

Depart

Return

Price

DenverSanta Cruz de la Sierra

DEN - VVI

DENVVI

Denver Intl

Mon 2/23

5:00 am-3:44 am

2 stops19h 44m

Santa Cruz de la Sierra Viru Viru Intl

Thu 2/26

11:44 am-8:26 am

2 stops23h 42m

$582

DenverSanta Cruz de la Sierra

DEN - VVI

DENVVI

Denver Intl

Fri 5/22

12:57 am-10:50 pm

2 stops43h 53m

Santa Cruz de la Sierra Viru Viru Intl

Mon 6/22

11:44 am-8:20 am

2 stops46h 36m

$712

DenverSanta Cruz de la Sierra

DEN - VVI

DENVVI

Denver Intl

Mon 2/23

9:38 pm-10:50 pm

1 stop22h 12m

Santa Cruz de la Sierra Viru Viru Intl

Wed 2/25

1:15 am-5:16 pm

1 stop19h 01m

$729

DenverSanta Cruz de la Sierra

DEN - VVI

DENVVI

Denver Intl

Mon 2/23

12:29 pm-2:35 am

2 stops35h 06m

Santa Cruz de la Sierra Viru Viru Intl

Wed 2/25

3:40 am-7:35 am

3 stops30h 55m

$1,087

DenverSanta Cruz de la Sierra

DEN - VVI

DENVVI

Denver Intl

Wed 1/28

7:47 am-10:50 pm

3 stops36h 03m

$264

DenverSanta Cruz de la Sierra

DEN - VVI

DENVVI

Denver Intl

Tue 1/27

1:52 pm-3:44 am

2 stops34h 52m

$264

DenverSanta Cruz de la Sierra

DEN - VVI

DENVVI

Denver Intl

Wed 1/28

9:38 pm-10:50 pm

1 stop22h 12m

$358

DenverSanta Cruz de la Sierra

DEN - VVI

DENVVI

Denver Intl

Tue 1/27

9:38 pm-10:50 pm

1 stop22h 12m

$358

DenverSanta Cruz de la Sierra

DEN - VVI

DENVVI

Denver Intl

Tue 1/27

12:30 am-4:35 am

3 stops25h 05m

$472

Flights are sorted by cheapest round-trip flights first.

Deals found on 11/26

Compare providers for flights from Denver to Santa Cruz de la Sierra

Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Denver to Santa Cruz de la Sierra in November.
ProviderPrice AccuracyTrust Score*
FlightHubPrice Accuracy3 starsTrust Score*1 star
eDreamsPrice Accuracy3 starsTrust Score*3 stars
AranGrantPrice Accuracy2 starsTrust Score*3 stars

*The Trust Score is based on feedback from users after their booking experience. It measures overall satisfaction, helping us identify issues like hidden fees, problems during the ticketing process, and the quality of customer service. This score is our best indicator of the provider's quality and reliability.

  • Most accurate provider: When it comes to deals on Denver-Santa Cruz de la Sierra flights, users find the pricing of eDreams to be most consistent on Cheapflights vs. eDreams Users can find the same prices on Denver-Santa Cruz de la Sierra flight deals on Cheapflights vs. eDreams >95% of the time. Price accuracy is based on data collected from Denver-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Denver-Santa Cruz de la Sierra flights, Cheapflights users trust eDreams the most. eDreams has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Denver-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Denver to Santa Cruz de la Sierra

Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Denver with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Reviews of airlines servicing Santa Cruz de la Sierra

Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated November 26, 2025.
Read through reviews of airlines operating flights from Denver to Santa Cruz de la Sierra, such as Copa Airlines and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Copa Airlines
7.6
Good
1,569 reviews

Crew

8.1

Entertainment

6.8

Overall

7.6

Food

6.8

Boarding

7.8

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
Copa Airlines
7.6
Good
1,569 reviews
Copa Airlines
7.6
Good
1,569 reviews

Crew

8.1

Entertainment

6.8

Overall

7.6

Food

6.8

Boarding

7.8

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip
United Airlines
7.4
Good
9,047 reviews
Copa Airlines
7.6
Good
1,569 reviews

Crew

8.1

Entertainment

6.8

Overall

7.6

Food

6.8

Boarding

7.8

Comfort

7.4

Reviews

1 / 20
4.0
Okay

Juan Pablo,Sep 2025

PTY - VVI

not a good expirience, the plane was packed, the seats wear very unconftrable, coudent conect with the entratainmente service on the plane, the onboarding was in charge of a very angry lady i really had a unplesent trip

Related info for your journey

Find useful and relevant information for your journey from Denver to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Denver to Santa Cruz de la Sierra?

    Airlines like United Airlines fly from Denver to Santa Cruz de la Sierra in about 19h 44m. The time it takes to get you to your destination can typically vary by up to . There are 4786 mi between Denver and Santa Cruz de la Sierra.

  • What are the cheapest airlines flying from Denver to Santa Cruz de la Sierra round-trip?

    Flying on Copa Airlines is currently your cheapest option to Santa Cruz de la Sierra, with prices starting at $595. Another option worth looking into is United Airlines, starting at $596 round trip. Copa Airlines is priced at 31% lower than the current average price of a flight leaving 3 months from now.

  • Can I find deals for flights from Denver to Santa Cruz de la Sierra that include hotel bookings?

    Yes. In addition to deals on Denver to Santa Cruz de la Sierra flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Denver to Santa Cruz de la Sierra?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Denver to Santa Cruz de la Sierra.

  • Can I find deals for business class flights from Denver to Santa Cruz de la Sierra?

    Yes. Cheapflights offers flight deals from Denver to Santa Cruz de la Sierra by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Denver to Santa Cruz de la Sierra

See prices for flight routes from nearby airports that may be better suited for you.
Denver to La Paz flights

Top 2 airlines flying from Denver to Santa Cruz de la Sierra

Discover the top 2 airlines that operate flights from Denver to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated November 26, 2025.
AirlineCheapestAverageFlexibilityOn-time
Copa AirlinesCheapest$595Average$776FlexibilityNo cancel feeOn-time70%
United AirlinesCheapest$596Average$995FlexibilityNo cancel feeOn-time69%

100% Free

Cheapflights is completely free to use, so you can start saving the moment you arrive.

Book with Flexibility

Our users can plan ahead with confidence and find flights with no change fees

Travel Smart

Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.