$282+ Cheap flights from Denver (DEN) to Santa Cruz de la Sierra (VVI)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 4/23. Fares are subject to change and may not be available on all flights or dates of travel.
DEN — VVI
Mar 24 — Mar 311
1 adult, Economy
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Find cheap flights from Denver to Santa Cruz de la Sierra with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Denver to Santa Cruz de la Sierra
Cheapest
Best
Last-minute
One-way
Cheapest flights from Denver to Santa Cruz de la SierraExplore the most affordable flight options available from Denver to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 22, 2026.
Explore the most affordable flight options available from Denver to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on February 22, 2026.
This United Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/89:06 pm
DEN
- VVI
2 stops28h 25m
United Airlines
Thu 3/1211:54 am
VVI
- DEN
2 stops22h 48m
United Airlines
Deal found 2/19![United Airlines logo]()
$653
This KAYAK deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 12/1111:40 pm
DEN
- VVI
2 stops44h 10m
Multiple Airlines
Mon 12/143:40 am
VVI
- DEN
2 stops15h 44m
Multiple Airlines
Deal found 2/19![Multiple Airlines logo]()
$768
This United Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/297:35 pm
DEN
- VVI
2 stops25h 03m
United Airlines
Thu 6/1111:47 am
VVI
- DEN
2 stops36h 28m
United Airlines
Deal found 2/22![United Airlines logo]()
$882
This KAYAK deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/298:28 pm
DEN
- VVI
2 stops24h 10m
Copa Airlines
Thu 6/1111:47 am
VVI
- DEN
2 stops36h 28m
Copa Airlines
Deal found 2/22![Copa Airlines logo]()
$894
This KAYAK deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/85:00 am
DEN
- VVI
2 stops15h 40m
Copa Airlines
Tue 7/141:12 am
VVI
- DEN
2 stops24h 16m
Copa Airlines
Deal found 2/21![Copa Airlines logo]()
$1,139
This Mytrip deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/291:53 pm
DEN
- VVI
2 stops34h 37m
Multiple Airlines
Thu 6/115:25 am
VVI
- DEN
3 stops32h 54m
Multiple Airlines
Deal found 2/22![Multiple Airlines logo]()
$1,208
This Mytrip deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/81:53 pm
DEN
- VVI
3 stops34h 37m
Multiple Airlines
Tue 7/143:35 am
VVI
- DEN
2 stops18h 37m
Multiple Airlines
Deal found 2/21![Multiple Airlines logo]()
$1,547
Best flights from Denver to Santa Cruz de la SierraDiscover carefully curated flight deals from Denver to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 22, 2026.
Discover carefully curated flight deals from Denver to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated February 22, 2026.
This United Airlines deal was found by Cheapflights users on 2/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/89:06 pm
DEN
- VVI
2 stops28h 25m
United Airlines
Thu 3/1211:54 am
VVI
- DEN
2 stops22h 48m
United Airlines
Deal found 2/19![United Airlines logo]()
$653
This Mytrip deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/291:53 pm
DEN
- VVI
2 stops34h 37m
Multiple Airlines
Thu 6/115:25 am
VVI
- DEN
3 stops32h 54m
Multiple Airlines
Deal found 2/22![Multiple Airlines logo]()
$1,208
This Copa Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/2910:51 pm
DEN
- VVI
1 stop21h 47m
Copa Airlines
Wed 6/101:12 am
VVI
- DEN
1 stop19h 13m
Copa Airlines
Deal found 2/22![Copa Airlines logo]()
$1,304
This United Airlines deal was found by Cheapflights users on 2/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/297:35 pm
DEN
- VVI
2 stops25h 03m
United Airlines
Thu 6/1111:47 am
VVI
- DEN
2 stops36h 28m
United Airlines
Deal found 2/22![United Airlines logo]()
$882
This Mytrip deal was found by Cheapflights users on 2/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Mytrip is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/81:53 pm
DEN
- VVI
3 stops34h 37m
Multiple Airlines
Tue 7/143:35 am
VVI
- DEN
2 stops18h 37m
Multiple Airlines
Deal found 2/21![Multiple Airlines logo]()
$1,547
Last-minute flights from Denver to Santa Cruz de la SierraDiscover last-minute flight deals from Denver to Santa Cruz de la Sierra. Data last updated February 22, 2026 and is based on user searches.
Discover last-minute flight deals from Denver to Santa Cruz de la Sierra. Data last updated February 22, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 2/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 3/89:06 pm
DEN
- VVI
2 stops28h 25m
United Airlines
Thu 3/1211:54 am
VVI
- DEN
2 stops23h 47m
United Airlines
Deal found 2/18![United Airlines logo]()
$653
One-way flights from Denver to Santa Cruz de la SierraSearch for one-way flight options from Denver to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated February 22, 2026.
Search for one-way flight options from Denver to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated February 22, 2026.
This Trip.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/239:00 pm
DEN
- VVI
2 stops27h 30m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$282
This Trip.com deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 4/246:00 am
DEN
- VVI
2 stops18h 30m
Multiple Airlines
Deal found 2/20![Multiple Airlines logo]()
$283
This Copa Airlines deal was found by Cheapflights users on 2/20. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Copa Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 4/2310:51 pm
DEN
- VVI
1 stop21h 51m
Copa Airlines
Deal found 2/20![Copa Airlines logo]()
$315
Find flight deals from Denver to Santa Cruz de la Sierra
Discover tips and strategies to find the most affordable flight options for your journey from Denver (DEN) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated February 22, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $653 (United Airlines) |
One-way from | $282 (Trip.com) |
Popular in | December |
Cheapest in | October |
Average price | $606 |
Cheapflights Fare Finder
Customize your flight search to find flights from Denver to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 22, 2026.
Use the filters below to find and compare flights from Denver to Santa Cruz de la Sierra that are best for you.
Fly from
Denver
Fly to
Santa Cruz de la Sierra
Route
Depart
Return
Price
DenverSanta Cruz de la Sierra
DEN - VVI
DENVVI
Denver Intl
Sun 3/8
9:06 pm-3:31 am
2 stops28h 25m
Santa Cruz de la Sierra Viru Viru Intl
Thu 3/12
11:54 am-8:42 am
2 stops22h 48m
$653
DenverSanta Cruz de la Sierra
DEN - VVI
DENVVI
Denver Intl
Fri 5/29
7:35 pm-10:38 pm
2 stops25h 03m
Santa Cruz de la Sierra Viru Viru Intl
Thu 6/11
11:47 am-10:15 pm
2 stops36h 28m
$882
DenverSanta Cruz de la Sierra
DEN - VVI
DENVVI
Denver Intl
Fri 5/29
1:53 pm-2:30 am
2 stops34h 37m
Santa Cruz de la Sierra Viru Viru Intl
Thu 6/11
5:25 am-12:19 pm
3 stops32h 54m
$1,208
DenverSanta Cruz de la Sierra
DEN - VVI
DENVVI
Denver Intl
Fri 5/29
10:51 pm-10:38 pm
1 stop21h 47m
Santa Cruz de la Sierra Viru Viru Intl
Wed 6/10
1:12 am-6:25 pm
1 stop19h 13m
$1,304
DenverSanta Cruz de la Sierra
DEN - VVI
DENVVI
Denver Intl
Wed 7/8
1:53 pm-2:30 am
3 stops34h 37m
Santa Cruz de la Sierra Viru Viru Intl
Tue 7/14
3:35 am-8:12 pm
2 stops18h 37m
$1,547
DenverSanta Cruz de la Sierra
DEN - VVI
DENVVI
Denver Intl
Fri 4/24
6:00 am-2:30 am
2 stops18h 30m
$283
DenverSanta Cruz de la Sierra
DEN - VVI
DENVVI
Denver Intl
Thu 4/23
10:51 pm-10:42 pm
1 stop21h 51m
$315
DenverSanta Cruz de la Sierra
DEN - VVI
DENVVI
Denver Intl
Thu 4/23
6:00 am-10:42 pm
3 stops38h 42m
$396
Compare providers for flights from Denver to Santa Cruz de la Sierra
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Denver to Santa Cruz de la Sierra in February.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy2 stars | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Denver-Santa Cruz de la Sierra flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Denver-Santa Cruz de la Sierra flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Denver-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Denver-Santa Cruz de la Sierra flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Denver-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Denver to Santa Cruz de la Sierra
Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Denver with our price prediction graph.
DEN-VVI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Santa Cruz de la Sierra
Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated February 22, 2026.
Read through reviews of airlines operating flights from Denver to Santa Cruz de la Sierra, such as Copa Airlines and United Airlines. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Food
6.8
Boarding
7.8
Comfort
7.4
Overall
7.5
Crew
8.1
Entertainment
6.8
Reviews
1 / 20
6.0
GoodMaria,Dec 2025
MIA - PTY
Food
6.8
Boarding
7.8
Comfort
7.4
Overall
7.5
Crew
8.1
Entertainment
6.8
Reviews
1 / 20
6.0
GoodMaria,Dec 2025
MIA - PTY
Food
6.8
Boarding
7.8
Comfort
7.4
Overall
7.5
Crew
8.1
Entertainment
6.8
Reviews
1 / 20
6.0
GoodMaria,Dec 2025
MIA - PTY
Related info for your journey
Find useful and relevant information for your journey from Denver to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
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Find flights from Denver to Santa Cruz de la Sierra, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Denver and Santa Cruz de la Sierra flights
Browse other Denver and Santa Cruz de la Sierra flight options. Last updated on February 22, 2026.
Other flights from Denver
Browse through other flights departing from Denver. Flights are based on user searches made on Cheapflights and were last updated on February 22, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Top 2 airlines flying from Denver to Santa Cruz de la Sierra
Discover the top 2 airlines that operate flights from Denver to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated February 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$581 | Average$667 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$606 | Average$781 | FlexibilityNo cancel fee | On-time70% |