$595+ Cheap flights from Knoxville (TYS) to Grand Cayman
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 10/9. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — GCM
Sep 21 — Sep 281
Round-trip
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Grand Cayman
Cheapest
Best
Last-minute
Cheapest flights from Knoxville to Grand CaymanExplore the most affordable flight options available from Knoxville to Grand Cayman. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 22, 2026.
Explore the most affordable flight options available from Knoxville to Grand Cayman. Find the lowest fares from popular airlines and budget airlines, with prices last updated on August 22, 2026.
This Kiwi.com deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/98:33 am -
1 stop8h 32m
Sun 10/184:45 pm -
2 stops27h 36m
Deal found 8/21![Multiple Airlines logo]()
$595
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/56:00 am -
1 stop14h 00m
Mon 10/128:00 am -
1 stop13h 59m
Deal found 8/21![American Airlines logo]()
$674
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:00 am -
1 stop6h 00m
Sat 11/73:30 pm -
1 stop8h 01m
Deal found 8/18![American Airlines logo]()
$696
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:16 pm -
2 stops18h 11m
Sun 10/112:10 pm -
2 stops8h 45m
Deal found 8/22![American Airlines logo]()
$711
This American Airlines deal was found by Cheapflights users on 8/18. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/26:15 am -
1 stop6h 12m
Fri 10/912:00 pm -
1 stop9h 59m
Deal found 8/18![American Airlines logo]()
$714
This Delta deal was found by Cheapflights users on 8/19. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/27:50 am -
1 stop4h 50m
Sun 10/1112:55 pm -
1 stop10h 04m
Deal found 8/19![Delta logo]()
$731
Best flights from Knoxville to Grand CaymanDiscover carefully curated flight deals from Knoxville to Grand Cayman that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 22, 2026.
Discover carefully curated flight deals from Knoxville to Grand Cayman that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated August 22, 2026.
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 1/126:05 am -
2 stops14h 18m
Sat 1/2312:55 pm -
1 stop5h 51m
Deal found 8/22![American Airlines logo]()
$641
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 10/510:00 am -
2 stops10h 00m
Mon 10/128:00 am -
1 stop13h 59m
Deal found 8/21![American Airlines logo]()
$679
This American Airlines deal was found by Cheapflights users on 8/21. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:00 am -
1 stop6h 00m
Sat 11/73:30 pm -
1 stop8h 01m
Deal found 8/21![American Airlines logo]()
$696
Last-minute flights from Knoxville to Grand CaymanDiscover last-minute flight deals from Knoxville to Grand Cayman. Data last updated August 22, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Grand Cayman. Data last updated August 22, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/37:25 pm -
2 stops16h 35m
Mon 9/712:00 pm -
2 stops20h 43m
Deal found 8/22![American Airlines logo]()
$1,292
This Delta deal was found by Cheapflights users on 8/22. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/35:40 am -
1 stop6h 59m
Mon 9/71:04 pm -
1 stop9h 48m
Deal found 8/22![Delta logo]()
$1,587
Find flight deals from Knoxville to Grand Cayman
Keep the following information in mind while searching for Knoxville to Grand Cayman flight deals. Data was last updated August 22, 2026.
Round-trip from | $595 (Kiwi.com) |
|---|---|
Popular in | May |
Cheapest in | January |
Average price | $650 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Grand Cayman that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 22, 2026.
Use the filters below to find and compare flights from Knoxville to Grand Cayman that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
KnoxvilleGeorge Town
TYS Knoxville McGhee Tyson - GCM George Town Owen Roberts Intl
TYSGCM
Knoxville McGhee Tyson
Tue 1/12
6:05 am-8:23 pm
2 stops14h 18m
George Town Owen Roberts Intl
Sat 1/23
12:55 pm-6:46 pm
1 stop5h 51m
$641
KnoxvilleGeorge Town
TYS Knoxville McGhee Tyson - GCM George Town Owen Roberts Intl
TYSGCM
Knoxville McGhee Tyson
Mon 10/5
10:00 am-7:00 pm
2 stops10h 00m
George Town Owen Roberts Intl
Mon 10/12
8:00 am-10:59 pm
1 stop13h 59m
$679
Quickest round-trip
KnoxvilleGeorge Town
TYS Knoxville McGhee Tyson - GCM George Town Owen Roberts Intl
TYSGCM
Knoxville McGhee Tyson
Sat 10/31
6:00 am-11:00 am
1 stop6h 00m
George Town Owen Roberts Intl
Sat 11/7
3:30 pm-11:31 pm
1 stop8h 01m
$696
Sorted by cheapest first
Best time to book a flight from Knoxville to Grand Cayman
Have a flexible travel schedule? Discover the best time to fly to Grand Cayman from Knoxville with our price prediction graph.
TYS-GCM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Grand Cayman
TYS-zzLAW
TYS-GCM
No data available for this route at this time. Please check back soon.
Reviews of airlines servicing Grand Cayman
Get insights into the airlines that provide service to Grand Cayman. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Grand Cayman. Reviews last updated August 22, 2026.
Get a feel of what it's like to fly with American Airlines from Knoxville to Grand Cayman by reading reviews from past customers. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
6.8
Crew
7.9
Boarding
7.5
Food
6.4
Comfort
7.2
Overall
7.1
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Entertainment
6.8
Crew
7.9
Boarding
7.5
Food
6.4
Comfort
7.2
Overall
7.1
Reviews
1 / 20
10.0
ExcellentLinda,Jul 2026
ROA - CLT
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Grand Cayman. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Knoxville and Grand Cayman flights
Browse other Knoxville and Grand Cayman flight options. Last updated on August 22, 2026.
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Top airline flying from Knoxville to Grand Cayman
Discover the top airline that operate flights from Knoxville to Grand Cayman. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 7,457,451 searches. Data last updated August 22, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$480 | Average$650 | FlexibilityNo cancel fee | On-time71% |