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San Diego

$105+ Cheap flights from South Carolina to San Diego (SAN)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/19. Fares are subject to change and may not be available on all flights or dates of travel.
CHS — SAN
Jul 12 — Jul 191
Sun 7/12
Sun 7/19
1 adult, Economy
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Cheap flight deals from South Carolina to San Diego

Cheapest flights from South Carolina to San Diego
Explore the most affordable flight options available from South Carolina to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2026.

This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/301:25 pm
CHS
-
SAN
1 stop9h 10m
Southwest
Wed 10/77:15 am
SAN
-
CHS
1 stop11h 35m
Southwest
Deal found 6/8$215
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/221:20 pm
CHS
-
SAN
1 stop8h 05m
Southwest
Sat 8/296:20 am
SAN
-
CHS
1 stop6h 35m
Southwest
Deal found 6/11$249
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/187:00 am
GSP
-
SAN
1 stop6h 10m
Southwest
Tue 8/2510:40 pm
SAN
-
GSP
1 stop8h 35m
Southwest
Deal found 6/8$261
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/144:30 pm
CHS
-
SAN
1 stop8h 57m
United Airlines
Tue 8/189:45 pm
SAN
-
CHS
1 stop9h 18m
United Airlines
Deal found 6/10$269
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/104:05 pm
CHS
-
SAN
1 stop8h 55m
Southwest
Wed 8/1210:40 pm
SAN
-
CHS
1 stop13h 45m
Southwest
Deal found 6/10$271
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/296:50 pm
CHS
-
SAN
1 stop7h 40m
Southwest
Wed 8/1210:40 pm
SAN
-
CHS
1 stop13h 45m
Southwest
Deal found 6/11$274
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/176:30 pm
CHS
-
SAN
1 stop7h 25m
Southwest
Sat 9/196:20 am
SAN
-
CHS
1 stop6h 35m
Southwest
Deal found 6/8$285
This American Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/113:32 pm
GSP
-
SAN
1 stop6h 45m
American Airlines
Tue 9/1512:08 pm
SAN
-
GSP
1 stop7h 03m
American Airlines
Deal found 6/10$291
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/115:50 am
GSP
-
SAN
1 stop8h 35m
United Airlines
Tue 9/159:45 pm
SAN
-
GSP
2 stops9h 50m
United Airlines
Deal found 6/10$296
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/125:46 am
GSP
-
SAN
1 stop6h 40m
Delta
Tue 8/186:15 am
SAN
-
GSP
1 stop9h 00m
Delta
Deal found 6/8$297
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/285:31 am
MYR
-
SAN
1 stop6h 36m
American Airlines
Wed 11/46:15 am
SAN
-
MYR
1 stop7h 26m
American Airlines
Deal found 6/9$299
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 12/86:45 am
CLT
-
SAN
2 stops8h 05m
Southwest
Tue 12/156:45 am
SAN
-
CLT
2 stops8h 20m
Southwest
Deal found 6/7$303

Find flight deals from South Carolina to San Diego

Keep the following information in mind while searching for South Carolina to San Diego flight deals. Data was last updated June 12, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$215
(Southwest)

One-way from

$105
(Southwest)

Popular in

December

Cheapest in

September

Average price

$576
Provider with most accurate pricing for Myrtle Beach Intl-San Diego flight deals.
Search Deals
Provider most trusted by Cheapflights users for Myrtle Beach Intl-San Diego flights.
Search Deals
From South Carolina to San Diego
Search Deals
One-way flight from South Carolina to San Diego
Search Deals
Highest demand for flights based on searches. 12% potential increase in price ($73 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 2% potential price decrease ($12 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from South Carolina to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2026.
Use the filters below to find and compare flights from South Carolina to San Diego that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

CharlestonSan Diego

CHS - SAN

CHSSAN

Charleston

Wed 9/30

1:25 pm-8:30 pm

2 stops10h 05m

San Diego

Wed 10/7

7:15 am-9:50 pm

1 stop11h 35m

$220

CharlestonSan Diego

CHS - SAN

CHSSAN

Charleston

Tue 9/1

7:35 am-12:15 pm

1 stop7h 40m

San Diego

Sun 9/6

10:40 pm-11:25 am

1 stop9h 45m

$302

CharlestonSan Diego

CHS - SAN

CHSSAN

Charleston

Sat 8/22

11:00 am-4:15 pm

2 stops8h 15m

San Diego

Sat 8/29

6:20 am-6:45 pm

2 stops9h 25m

$310

GreenvilleSan Diego

GSP - SAN

GSPSAN

Greenville

Mon 9/21

6:25 pm-10:55 pm

1 stop7h 30m

San Diego

Sat 10/3

10:30 pm-9:14 am

1 stop7h 44m

$313

SavannahSan Diego

SAV - SAN

SAVSAN

Savannah/Hilton Head

Thu 8/13

5:35 pm-10:45 pm

1 stop8h 10m

San Diego

Mon 8/17

6:40 am-6:45 pm

1 stop9h 05m

$335

AugustaSan Diego

AGS - SAN

AGSSAN

Augusta Bush Field

Tue 8/11

7:15 pm-11:00 pm

1 stop6h 45m

San Diego

Tue 9/1

10:25 pm-9:26 am

1 stop8h 01m

$349

CharlestonSan Diego

CHS - SAN

CHSSAN

Charleston

Thu 7/30

5:55 pm-11:30 pm

1 stop8h 35m

San Diego

Mon 8/3

8:00 am-8:40 pm

2 stops9h 40m

$356

CharlestonSan Diego

CHS - SAN

CHSSAN

Charleston

Wed 7/22

4:15 pm-10:45 pm

2 stops9h 30m

San Diego

Mon 7/27

10:40 pm-1:10 pm

1 stop11h 30m

$362

Myrtle BeachSan Diego

MYR - SAN

MYRSAN

Myrtle Beach Intl

Mon 9/21

6:40 am-12:00 pm

1 stop8h 20m

San Diego

Thu 9/24

6:45 am-5:35 pm

1 stop7h 50m

$363

SavannahSan Diego

SAV - SAN

SAVSAN

Savannah/Hilton Head

Thu 7/23

4:15 pm-10:25 pm

1 stop9h 10m

San Diego

Mon 7/27

10:25 pm-10:23 am

1 stop8h 58m

$367

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/11

Showing 1-10 of 60 resultsSorted by cheapest first
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Best time to book a flight from South Carolina to San Diego

Have a flexible travel schedule? Discover the best time to fly to San Diego from South Carolina with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from South Carolina to San Diego

What is the cheapest month to book a flight from South Carolina to San Diego?

Currently, December is the cheapest month in which you can book a flight from South Carolina to San Diego (average of $137). Flying from South Carolina to San Diego in June is currently the most expensive (average of $384). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

How much does it cost to fly round-trip from South Carolina to San Diego?

How far ahead should I book a flight from South Carolina to San Diego?

Booking 84 days in advance of your planned departure date is, on average, the best time to get cheap flights from South Carolina to San Diego. The general trend is that the closer you book to the departure date, the more expensive your flight will be.

Related info for your journey

Find useful and relevant information for your journey from South Carolina to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly into for flights to San Diego from South Carolina?

    San Diego (SAN) is the airport you will fly into if you book a flight from South Carolina to San Diego. It is only a 2.6 mi journey from San Diego (SAN) to San Diego’s city center.

  • How long is the flight from South Carolina to San Diego?

    A quick flight from South Carolina to San Diego can take about 7h 30m. Southwest provides one of the quickest options available for as low as $313. South Carolina and San Diego are separated by a distance of 2002 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • What are the cheapest airlines to fly from South Carolina to San Diego one-way?

    To fly one-way, consider booking your trip with United Airlines, which is currently one of the cheapest options available, starting at $153. Alaska Airlines flights start at $160 while deals on Delta start at $169 one-way.

  • What are the most popular routes from South Carolina to San Diego?

    The most popular flight routes from South Carolina to San Diego are Charlotte Douglas - San Diego, Charleston - San Diego and Greenville - San Diego.

  • Can I find deals for flights from South Carolina to San Diego that include hotel bookings?

    Yes. In addition to deals on South Carolina to San Diego flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from South Carolina to San Diego?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from South Carolina to San Diego.

  • Can I find deals for business class flights from South Carolina to San Diego?

    Yes. Cheapflights offers flight deals from South Carolina to San Diego by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • What is the cheapest month to book a flight from South Carolina to San Diego?

    Currently, December is the cheapest month in which you can book a flight from South Carolina to San Diego (average of $137). Flying from South Carolina to San Diego in June is currently the most expensive (average of $384). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Traveling to a place near San Diego?

Book flights to San Diego if you plan to visit one of these locations
El Cajon
National City
Chula Vista
Poway
Coronado
La Mesa
Santee
Julian
Lemon Grove

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Alternative routes for South Carolina to San Diego

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Top 4 airlines flying from South Carolina to San Diego

Discover the top 4 airlines that operate flights from South Carolina to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2026.
AirlineCheapestAverageFlexibilityOn-time
United AirlinesCheapest$279Average$471FlexibilityNo cancel feeOn-time69%
American AirlinesCheapest$281Average$483FlexibilityNo cancel feeOn-time71%
DeltaCheapest$296Average$494FlexibilityNo cancel feeOn-timeN/A
SouthwestCheapest$305Average$486FlexibilityNo cancel feeOn-time63%

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