$413+ Cheap flights from Syracuse to Florence, SC (SYR - FLO)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/10. Fares are subject to change and may not be available on all flights or dates of travel.
SYR — FLO
Jul 4 — Jul 111
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Cheapest
Best
Last-minute
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Cheapest flights from Syracuse to FlorenceExplore the most affordable flight options available from Syracuse to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 4, 2026.
Explore the most affordable flight options available from Syracuse to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 4, 2026.
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/18:00 am
SYR
- FLO
1 stop6h 10m
American Airlines
Wed 7/85:17 am
FLO
- SYR
1 stop5h 59m
American Airlines
Deal found 6/1![American Airlines logo]()
$473
Best flights from Syracuse to FlorenceDiscover carefully curated flight deals from Syracuse to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 4, 2026.
Discover carefully curated flight deals from Syracuse to Florence that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 4, 2026.
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/18:00 am
SYR
- FLO
1 stop6h 10m
American Airlines
Wed 7/85:17 am
FLO
- SYR
1 stop5h 59m
American Airlines
Deal found 6/1![American Airlines logo]()
$473
Last-minute flights from Syracuse to FlorenceDiscover last-minute flight deals from Syracuse to Florence. Data last updated June 4, 2026 and is based on user searches.
Discover last-minute flight deals from Syracuse to Florence. Data last updated June 4, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 6/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/18:00 am
SYR
- FLO
1 stop6h 10m
American Airlines
Wed 7/85:17 am
FLO
- SYR
1 stop5h 59m
American Airlines
Deal found 6/1![American Airlines logo]()
$473
One-way flights from Syracuse to FlorenceSearch for one-way flight options from Syracuse to Florence. Find affordable one-way fares based on user searches. Data last updated June 4, 2026.
Search for one-way flight options from Syracuse to Florence. Find affordable one-way fares based on user searches. Data last updated June 4, 2026.
This American Airlines deal was found by Cheapflights users on 5/31. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/108:00 am
SYR
- FLO
1 stop6h 10m
American Airlines
Deal found 5/31![American Airlines logo]()
$413
This American Airlines deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/215:17 pm
SYR
- FLO
1 stop5h 42m
American Airlines
Deal found 5/30![American Airlines logo]()
$443
This American Airlines deal was found by Cheapflights users on 5/30. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/238:19 pm
SYR
- FLO
2 stops18h 37m
American Airlines
Deal found 5/30![American Airlines logo]()
$462
Find flight deals from Syracuse to Florence
Discover tips and strategies to find the most affordable flight options for your journey from Syracuse (SYR) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 4, 2026.
Most accurate provider | Expedia 1 star |
|---|---|
Most trusted provider | Expedia 3 stars |
Round-trip from | $473 (American Airlines) |
One-way from | $413 (American Airlines) |
Cheapflights Fare Finder
Customize your flight search to find flights from Syracuse to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 4, 2026.
Use the filters below to find and compare flights from Syracuse to Florence that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
SyracuseFlorence
SYR - FLO
SYRFLO
Syracuse Hancock Intl
Wed 7/1
8:00 am-2:10 pm
1 stop6h 10m
Florence
Wed 7/8
5:17 am-11:16 am
1 stop5h 59m
$473
Cheapest one-way
SyracuseFlorence
SYR - FLO
SYRFLO
Syracuse Hancock Intl
Sat 8/22
5:17 pm-10:59 pm
1 stop5h 42m
$413
SyracuseFlorence
SYR - FLO
SYRFLO
Syracuse Hancock Intl
Wed 6/10
8:00 am-2:10 pm
1 stop6h 10m
$413
Quickest one-way
SyracuseFlorence
SYR - FLO
SYRFLO
Syracuse Hancock Intl
Sun 8/23
7:44 pm-11:58 pm
1 stop4h 14m
$443
SyracuseFlorence
SYR - FLO
SYRFLO
Syracuse Hancock Intl
Fri 8/21
5:17 pm-10:59 pm
1 stop5h 42m
$443
Sorted by cheapest first
- Most accurate provider: When it comes to deals on Syracuse-Florence, South Carolina flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Syracuse-Florence, South Carolina flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Syracuse-Florence, South Carolina flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Syracuse-Florence, South Carolina flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Syracuse-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Syracuse to Florence
Have a flexible travel schedule? Discover the best time to fly to Florence from Syracuse with our price prediction graph.
SYR-FLO
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Reviews of airlines servicing Florence
Get insights into the airlines that provide service to Florence. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Florence. Reviews last updated June 4, 2026.
Get a feel of what it's like to fly with American Airlines from Syracuse to Florence by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Entertainment
6.9
Overall
7.1
Crew
7.9
Food
6.4
Boarding
7.5
Comfort
7.2
Reviews
1 / 20
2.0
MediocreAnonymous,Apr 2026
DFW - BDL
Entertainment
6.9
Overall
7.1
Crew
7.9
Food
6.4
Boarding
7.5
Comfort
7.2
Reviews
1 / 20
2.0
MediocreAnonymous,Apr 2026
DFW - BDL
Related info for your journey
Find useful and relevant information for your journey from Syracuse to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near Florence?
Book flights to Florence if you plan to visit one of these locationsSumter
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Other flights to Florence
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Top airline flying from Syracuse to Florence
Discover the top airline that operate flights from Syracuse to Florence. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 4, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$412 | Average$516 | FlexibilityNo cancel fee | On-time71% |