$382+ Cheap flights from Madrid, Spain (MAD) to Santa Cruz de la Sierra (VVI)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 5/22. Fares are subject to change and may not be available on all flights or dates of travel.
MAD — VVI
Jun 6 — Jun 131
Round-trip
1 adult, Economy
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Find cheap flights from Madrid to Santa Cruz de la Sierra with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Madrid Barajas to Santa Cruz de la Sierra Viru Viru Intl are usually found in April or March, booked 56 days in advance, depart on a Thursday or Wednesday and return on a Friday
Cheap flight deals from Madrid to Santa Cruz de la Sierra
Cheapest
Best
Last-minute
One-way
Cheapest flights from Madrid to Santa Cruz de la SierraExplore the most affordable flight options available from Madrid to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 7, 2026.
Explore the most affordable flight options available from Madrid to Santa Cruz de la Sierra. Find the lowest fares from popular airlines and budget airlines, with prices last updated on May 7, 2026.
This Avianca deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/1211:05 am
MAD
- VVI
1 stop21h 25m
Avianca
Tue 10/133:35 am
VVI
- MAD
1 stop14h 45m
Avianca
Deal found 5/6![Avianca logo]()
$784
This Avianca deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/238:10 am
MAD
- VVI
1 stop24h 20m
Avianca
Sun 11/223:40 am
VVI
- MAD
1 stop14h 40m
Avianca
Deal found 5/7![Avianca logo]()
$830
This Iberia deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Iberia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 10/112:45 pm
MAD
- VVI
Nonstop11h 00m
Iberia
Mon 11/307:30 pm
VVI
- MAD
Nonstop11h 45m
Iberia
Deal found 5/7![Iberia logo]()
$842
This Avianca deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/28:10 am
MAD
- VVI
1 stop24h 20m
Avianca
Sat 10/173:35 am
VVI
- MAD
1 stop14h 45m
Avianca
Deal found 5/3![Avianca logo]()
$880
This Avianca deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 11/26:35 am
MAD
- VVI
1 stop25h 00m
Avianca
Thu 11/123:40 am
VVI
- MAD
1 stop14h 40m
Avianca
Deal found 5/5![Avianca logo]()
$881
Best flights from Madrid to Santa Cruz de la SierraDiscover carefully curated flight deals from Madrid to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 7, 2026.
Discover carefully curated flight deals from Madrid to Santa Cruz de la Sierra that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated May 7, 2026.
This Avianca deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/125:20 pm
MAD
- VVI
1 stop15h 10m
Avianca
Tue 10/133:35 am
VVI
- MAD
1 stop14h 45m
Avianca
Deal found 5/5![Avianca logo]()
$785
This United Airlines deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/210:50 am
MAD
- VVI
2 stops41h 54m
United Airlines
Mon 9/2111:47 am
VVI
- MAD
2 stops39h 13m
United Airlines
Deal found 5/7![United Airlines logo]()
$1,420
This Avianca deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/36:35 am
MAD
- VVI
1 stop25h 00m
Avianca
Fri 11/203:40 am
VVI
- MAD
1 stop14h 40m
Avianca
Deal found 5/3![Avianca logo]()
$882
This Avianca deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/2910:50 am
MAD
- VVI
1 stop20h 45m
Avianca
Sun 11/153:40 am
VVI
- MAD
1 stop14h 40m
Avianca
Deal found 5/5![Avianca logo]()
$1,030
This Avianca deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/255:20 pm
MAD
- VVI
1 stop15h 10m
Avianca
Mon 6/83:35 am
VVI
- MAD
1 stop14h 45m
Avianca
Deal found 5/4![Avianca logo]()
$1,205
This Avianca deal was found by Cheapflights users on 5/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/16:35 am
MAD
- VVI
1 stop25h 00m
Avianca
Wed 11/253:40 am
VVI
- MAD
1 stop14h 40m
Avianca
Deal found 5/3![Avianca logo]()
$1,234
This Avianca deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/1311:05 am
MAD
- VVI
1 stop21h 25m
Avianca
Fri 6/263:35 am
VVI
- MAD
2 stops34h 05m
Avianca
Deal found 5/4![Avianca logo]()
$1,360
This Avianca deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/306:40 am
MAD
- VVI
2 stops24h 55m
Avianca
Sun 11/153:40 am
VVI
- MAD
1 stop14h 40m
Avianca
Deal found 5/5![Avianca logo]()
$1,439
Last-minute flights from Madrid to Santa Cruz de la SierraDiscover last-minute flight deals from Madrid to Santa Cruz de la Sierra. Data last updated May 7, 2026 and is based on user searches.
Discover last-minute flight deals from Madrid to Santa Cruz de la Sierra. Data last updated May 7, 2026 and is based on user searches.
This Avianca deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 5/2511:05 am
MAD
- VVI
1 stop21h 25m
Avianca
Mon 6/83:35 am
VVI
- MAD
1 stop14h 45m
Avianca
Deal found 5/6![Avianca logo]()
$1,055
This Avianca deal was found by Cheapflights users on 5/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3111:05 am
MAD
- VVI
1 stop21h 25m
Multiple Airlines
Tue 7/283:35 am
VVI
- MAD
2 stops25h 45m
Multiple Airlines
Deal found 5/7![Multiple Airlines logo]()
$1,132
This Avianca deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 5/3111:05 am
MAD
- VVI
1 stop21h 25m
Avianca
Tue 7/283:35 am
VVI
- MAD
1 stop14h 45m
Avianca
Deal found 5/4![Avianca logo]()
$1,139
This Avianca deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/711:05 am
MAD
- VVI
1 stop21h 25m
Avianca
Fri 7/173:35 am
VVI
- MAD
2 stops62h 35m
Avianca
Deal found 5/6![Avianca logo]()
$910
This Avianca deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/75:20 pm
MAD
- VVI
1 stop15h 10m
Avianca
Wed 7/153:35 am
VVI
- MAD
1 stop14h 45m
Avianca
Deal found 5/6![Avianca logo]()
$1,084
This Avianca deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/711:05 am
MAD
- VVI
1 stop21h 25m
Avianca
Thu 7/163:35 am
VVI
- MAD
2 stops34h 05m
Avianca
Deal found 5/6![Avianca logo]()
$1,138
This Avianca deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/88:10 am
MAD
- VVI
1 stop24h 20m
Avianca
Mon 6/223:35 am
VVI
- MAD
2 stops29h 25m
Avianca
Deal found 5/5![Avianca logo]()
$1,087
This Avianca deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/116:40 am
MAD
- VVI
2 stops25h 50m
Avianca
Fri 7/173:35 am
VVI
- MAD
2 stops62h 35m
Avianca
Deal found 5/6![Avianca logo]()
$1,014
This Avianca deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/1111:05 am
MAD
- VVI
1 stop21h 25m
Avianca
Sat 7/113:35 am
VVI
- MAD
2 stops38h 35m
Avianca
Deal found 5/6![Avianca logo]()
$1,114
This Avianca deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/1311:05 am
MAD
- VVI
1 stop21h 25m
Avianca
Fri 7/173:35 am
VVI
- MAD
2 stops62h 35m
Avianca
Deal found 5/6![Avianca logo]()
$1,059
One-way flights from Madrid to Santa Cruz de la SierraSearch for one-way flight options from Madrid to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated May 7, 2026.
Search for one-way flight options from Madrid to Santa Cruz de la Sierra. Find affordable one-way fares based on user searches. Data last updated May 7, 2026.
This Avianca deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/225:20 pm
MAD
- VVI
1 stop15h 10m
Avianca
Deal found 5/6![Avianca logo]()
$382
This Avianca deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/135:20 pm
MAD
- VVI
1 stop15h 10m
Avianca
Deal found 5/6![Avianca logo]()
$394
This Avianca deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/268:10 am
MAD
- VVI
1 stop24h 20m
Avianca
Deal found 5/5![Avianca logo]()
$406
This Avianca deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 5/222:20 am
MAD
- VVI
1 stop30h 10m
Avianca
Deal found 5/6![Avianca logo]()
$441
This CheapOair deal was found by Cheapflights users on 5/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure CheapOair is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 5/132:40 pm
MAD
- VVI
Nonstop11h 00m
BoA
Deal found 5/6![BoA logo]()
$450
This Orbitz deal was found by Cheapflights users on 5/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 5/191:45 am
MAD
- VVI
1 stop32h 50m
LATAM Airlines
Deal found 5/5![LATAM Airlines logo]()
$458
This Avianca deal was found by Cheapflights users on 5/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Avianca is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/98:10 am
MAD
- VVI
1 stop24h 20m
Avianca
Deal found 5/4![Avianca logo]()
$461
Find flight deals from Madrid to Santa Cruz de la Sierra
Discover tips and strategies to find the most affordable flight options for your journey from Madrid (MAD) to Santa Cruz de la Sierra (VVI). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated May 7, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $784 (Avianca) |
One-way from | $382 (Avianca) |
Popular in | July |
Cheapest in | April |
Average price | $897 |
Cheapflights Fare Finder
Customize your flight search to find flights from Madrid to Santa Cruz de la Sierra that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 7, 2026.
Use the filters below to find and compare flights from Madrid to Santa Cruz de la Sierra that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Sat 9/12
5:20 pm-2:30 am
1 stop15h 10m
Santa Cruz de la Sierra Viru Viru Intl
Tue 10/13
3:35 am-12:20 am
1 stop14h 45m
$785
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Tue 11/3
6:35 am-2:35 am
1 stop25h 00m
Santa Cruz de la Sierra Viru Viru Intl
Fri 11/20
3:40 am-11:20 pm
1 stop14h 40m
$882
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Thu 10/29
10:50 am-2:35 am
1 stop20h 45m
Santa Cruz de la Sierra Viru Viru Intl
Sun 11/15
3:40 am-11:20 pm
1 stop14h 40m
$1,030
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Mon 5/25
5:20 pm-2:30 am
1 stop15h 10m
Santa Cruz de la Sierra Viru Viru Intl
Mon 6/8
3:35 am-12:20 am
1 stop14h 45m
$1,205
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Sun 11/1
6:35 am-2:35 am
1 stop25h 00m
Santa Cruz de la Sierra Viru Viru Intl
Wed 11/25
3:40 am-11:20 pm
1 stop14h 40m
$1,234
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Sat 6/13
11:05 am-2:30 am
1 stop21h 25m
Santa Cruz de la Sierra Viru Viru Intl
Fri 6/26
3:35 am-7:40 pm
2 stops34h 05m
$1,360
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Wed 9/2
10:50 am-10:44 pm
2 stops41h 54m
Santa Cruz de la Sierra Viru Viru Intl
Mon 9/21
11:47 am-9:00 am
2 stops39h 13m
$1,420
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Fri 10/30
6:40 am-2:35 am
2 stops24h 55m
Santa Cruz de la Sierra Viru Viru Intl
Sun 11/15
3:40 am-11:20 pm
1 stop14h 40m
$1,439
Cheapest one-way
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Thu 10/29
6:35 am-2:35 am
1 stop25h 00m
$394
Quickest one-way
MadridSanta Cruz de la Sierra
MAD - VVI
MADVVI
Madrid Barajas
Wed 5/13
2:40 pm-7:40 pm
Nonstop11h 00m
$450
Showing 1-10 of 17 resultsSorted by cheapest first
Compare providers for flights from Madrid to Santa Cruz de la Sierra
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Madrid to Santa Cruz de la Sierra in May.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Madrid-Santa Cruz de la Sierra flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Madrid-Santa Cruz de la Sierra flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Madrid-Santa Cruz de la Sierra flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Madrid-Santa Cruz de la Sierra flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Madrid-Santa Cruz de la Sierra flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Madrid to Santa Cruz de la Sierra
Have a flexible travel schedule? Discover the best time to fly to Santa Cruz de la Sierra from Madrid with our price prediction graph.
MAD-VVI
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Madrid to Santa Cruz de la Sierra
Prices
Delays
How far ahead should I book a flight from Madrid to Santa Cruz de la Sierra?
The best time to book flights from Madrid to Santa Cruz de la Sierra is 55 days before your desired departure date. The cost of your flight will likely increase significantly if you book two weeks in advance of your flight.
What is the cheapest month to book a flight from Madrid to Santa Cruz de la Sierra?
Currently, April is the cheapest month in which you can book a flight from Madrid to Santa Cruz de la Sierra (average of $859). Flying from Madrid to Santa Cruz de la Sierra in July is currently the most expensive (average of $1,441). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
What is the cheapest time of day to fly from MAD to VVI?
Find hourly flight availability from Madrid to Santa Cruz de la Sierra. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated May 7, 2026.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Madrid to Santa Cruz de la Sierra as you normally would.
How often are flights from Madrid to Santa Cruz de la Sierra delayed?
About 43% of weekly flights between Madrid and Santa Cruz de la Sierra have experienced delays in the past year, with the average delay time being 131 minutes.
What is the most punctual flight time for Madrid to Santa Cruz de la Sierra flights?
Historically, flights departing at night are less likely to be delayed, whereas flights leaving in the early afternoon tend to experience delays more often.
What day of the week experiences the fewest flight delays on this route?
Saturday tends to have the lowest number of delays on this route, whereas Wednesday has historically faced a higher average of delays compared to other days of the week.
Which airline has the best punctuality record on Madrid to Santa Cruz de la Sierra flights?
Over the last year, Air Europa have had the lowest number of delays on this route, with just 40% of flights being delayed.
Reviews of airlines servicing Santa Cruz de la Sierra
Get insights into the airlines that provide service to Santa Cruz de la Sierra. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Santa Cruz de la Sierra. Reviews last updated May 7, 2026.
Read through reviews of airlines operating flights from Madrid to Santa Cruz de la Sierra, such as Iberia,Air Europa, andAvianca. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Food
6.3
Overall
7.0
Entertainment
6.6
Boarding
7.2
Comfort
6.7
Crew
7.7
Reviews
1 / 20
10.0
ExcellentSylvie,Dec 2025
MAD - DSS
Food
6.3
Overall
7.0
Entertainment
6.6
Boarding
7.2
Comfort
6.7
Crew
7.7
Reviews
1 / 20
10.0
ExcellentSylvie,Dec 2025
MAD - DSS
Food
6.3
Overall
7.0
Entertainment
6.6
Boarding
7.2
Comfort
6.7
Crew
7.7
Reviews
1 / 20
10.0
ExcellentSylvie,Dec 2025
MAD - DSS
Food
6.3
Overall
7.0
Entertainment
6.6
Boarding
7.2
Comfort
6.7
Crew
7.7
Reviews
1 / 20
10.0
ExcellentSylvie,Dec 2025
MAD - DSS
Related info for your journey
Find useful and relevant information for your journey from Madrid to Santa Cruz de la Sierra. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Complete your trip
Complete your trip to Santa Cruz de la Sierra by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Madrid to Santa Cruz de la Sierra by cabin class
Find flights from Madrid to Santa Cruz de la Sierra, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Madrid and Santa Cruz de la Sierra flights
Browse other Madrid and Santa Cruz de la Sierra flight options. Last updated on May 7, 2026.
Other flights from Madrid
Browse through other flights departing from Madrid. Flights are based on user searches made on Cheapflights and were last updated on May 7, 2026.
Popular flight searches
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Top 3 airlines flying from Madrid to Santa Cruz de la Sierra
Discover the top 3 airlines that operate flights from Madrid to Santa Cruz de la Sierra. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated May 7, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$696 | Average$821 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$831 | Average$842 | FlexibilityNo cancel fee | On-time77% | |
| Cheapest$911 | Average$1,157 | FlexibilityNo cancel fee | On-time83% |