$109+ Cheap flights from Des Moines to San Diego (DSM - SAN)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/3. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAN
Jul 12 — Jul 191
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheapflights Tip: The best prices from Des Moines to San Diego are usually found in August or September, booked 43 days in advance, depart on a Monday or Tuesday and return on a Tuesday
Cheap flight deals from Des Moines to San Diego
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to San DiegoExplore the most affordable flight options available from Des Moines to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2026.
Explore the most affordable flight options available from Des Moines to San Diego. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 12, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/1010:06 pm
DSM
- SAN
1 stop18h 02m
Multiple Airlines
Wed 8/199:53 pm
SAN
- DSM
1 stop21h 07m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$179
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1310:01 pm
DSM
- SAN
1 stop18h 07m
Multiple Airlines
Mon 7/204:12 pm
SAN
- DSM
2 stops42h 47m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$233
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1710:01 pm
DSM
- SAN
1 stop24h 05m
Multiple Airlines
Mon 8/34:12 pm
SAN
- DSM
2 stops42h 47m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/212:04 pm
DSM
- SAN
1 stop20h 58m
Multiple Airlines
Thu 9/247:24 pm
SAN
- DSM
1 stop15h 22m
Multiple Airlines
Deal found 6/10![Multiple Airlines logo]()
$239
This Frontier deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/172:19 pm
DSM
- SAN
1 stop11h 32m
Frontier
Wed 8/196:25 am
SAN
- DSM
1 stop5h 06m
Frontier
Deal found 6/9![Frontier logo]()
$251
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/112:30 pm
DSM
- SAN
1 stop4h 55m
Southwest
Tue 9/810:20 am
SAN
- DSM
1 stop5h 25m
Southwest
Deal found 6/11![Southwest logo]()
$252
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2010:01 pm
DSM
- SAN
1 stop18h 07m
Multiple Airlines
Wed 7/223:03 pm
SAN
- DSM
1 stop27h 40m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2710:01 pm
DSM
- SAN
1 stop18h 07m
Multiple Airlines
Mon 8/34:12 pm
SAN
- DSM
2 stops43h 22m
Multiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/112:51 pm
DSM
- SAN
1 stop26h 50m
Frontier
Sun 9/138:32 pm
SAN
- DSM
1 stop15h 24m
Frontier
Deal found 6/9![Frontier logo]()
$256
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/111:33 am
DSM
- SAN
1 stop7h 27m
United Airlines
Tue 9/82:24 pm
SAN
- DSM
2 stops7h 09m
United Airlines
Deal found 6/11![United Airlines logo]()
$258
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/312:08 pm
DSM
- SAN
1 stop27h 24m
Multiple Airlines
Thu 9/39:53 pm
SAN
- DSM
1 stop11h 17m
Multiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$260
Best flights from Des Moines to San DiegoDiscover carefully curated flight deals from Des Moines to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 12, 2026.
Discover carefully curated flight deals from Des Moines to San Diego that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 12, 2026.
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/287:50 pm
DSM
- SAN
1 stop6h 05m
Delta
Sat 10/316:20 am
SAN
- DSM
1 stop5h 51m
Delta
Deal found 6/8![Delta logo]()
$280
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/289:09 am
DSM
- SAN
2 stops10h 20m
United Airlines
Sat 10/3111:20 am
SAN
- DSM
1 stop7h 12m
United Airlines
Deal found 6/11![United Airlines logo]()
$373
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/282:25 pm
DSM
- SAN
2 stops6h 55m
Southwest
Mon 8/3110:30 am
SAN
- DSM
2 stops8h 45m
Southwest
Deal found 6/8![Southwest logo]()
$388
This United Airlines deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/231:35 pm
DSM
- SAN
2 stops9h 10m
United Airlines
Mon 9/282:24 pm
SAN
- DSM
2 stops7h 35m
United Airlines
Deal found 6/11![United Airlines logo]()
$378
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 10/233:30 pm
DSM
- SAN
1 stop6h 55m
Delta
Mon 10/2611:40 am
SAN
- DSM
1 stop7h 44m
Delta
Deal found 6/10![Delta logo]()
$380
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/15:35 am
DSM
- SAN
2 stops11h 45m
Southwest
Sun 10/46:45 am
SAN
- DSM
1 stop7h 15m
Southwest
Deal found 6/10![Southwest logo]()
$408
This Southwest deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/75:35 am
DSM
- SAN
2 stops8h 25m
Southwest
Sun 10/1112:35 pm
SAN
- DSM
2 stops7h 45m
Southwest
Deal found 6/11![Southwest logo]()
$437
This United Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/25:17 pm
DSM
- SAN
1 stop5h 29m
United Airlines
Tue 7/78:45 am
SAN
- DSM
1 stop5h 30m
United Airlines
Deal found 6/7![United Airlines logo]()
$437
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/102:25 pm
DSM
- SAN
2 stops6h 55m
Southwest
Wed 8/1912:20 pm
SAN
- DSM
2 stops6h 40m
Southwest
Deal found 6/7![Southwest logo]()
$447
This Southwest deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 11/151:50 pm
DSM
- SAN
1 stop8h 00m
Southwest
Sun 11/2210:40 pm
SAN
- DSM
1 stop10h 50m
Southwest
Deal found 6/10![Southwest logo]()
$452
Last-minute flights from Des Moines to San DiegoDiscover last-minute flight deals from Des Moines to San Diego. Data last updated June 12, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to San Diego. Data last updated June 12, 2026 and is based on user searches.
This Expedia deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/12:16 pm
DSM
- SAN
1 stop20h 53m
Frontier
Wed 7/86:25 am
SAN
- DSM
1 stop5h 09m
Frontier
Deal found 6/10![Frontier logo]()
$299
This Frontier deal was found by Cheapflights users on 6/12. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/32:16 pm
DSM
- SAN
1 stop11h 37m
Frontier
Fri 7/106:25 am
SAN
- DSM
1 stop5h 09m
Frontier
Deal found 6/12![Frontier logo]()
$310
This Expedia deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/82:19 pm
DSM
- SAN
1 stop11h 32m
Frontier
Wed 7/156:25 am
SAN
- DSM
1 stop5h 09m
Frontier
Deal found 6/10![Frontier logo]()
$288
This Booking.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/82:19 pm
DSM
- SAN
1 stop20h 46m
Frontier
Sun 7/1210:00 am
SAN
- DSM
1 stop25h 34m
Frontier
Deal found 6/8![Frontier logo]()
$301
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/1310:01 pm
DSM
- SAN
1 stop18h 07m
Multiple Airlines
Mon 7/204:12 pm
SAN
- DSM
2 stops42h 47m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$233
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/1710:01 pm
DSM
- SAN
1 stop24h 05m
Multiple Airlines
Mon 8/34:12 pm
SAN
- DSM
2 stops42h 47m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$237
This Kiwi.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2010:01 pm
DSM
- SAN
1 stop18h 07m
Multiple Airlines
Wed 7/223:03 pm
SAN
- DSM
1 stop27h 40m
Multiple Airlines
Deal found 6/9![Multiple Airlines logo]()
$254
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2010:01 pm
DSM
- SAN
1 stop18h 07m
Multiple Airlines
Thu 7/234:12 pm
SAN
- DSM
1 stop20h 50m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$264
This Kiwi.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2710:01 pm
DSM
- SAN
1 stop18h 07m
Multiple Airlines
Mon 8/34:12 pm
SAN
- DSM
2 stops43h 22m
Multiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$255
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2710:01 pm
DSM
- SAN
1 stop18h 07m
Multiple Airlines
Thu 7/3010:00 am
SAN
- DSM
1 stop25h 34m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$290
This Booking.com deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/272:19 pm
DSM
- SAN
1 stop11h 32m
Frontier
Thu 7/3010:00 am
SAN
- DSM
1 stop25h 34m
Frontier
Deal found 6/9![Frontier logo]()
$311
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/3110:01 pm
DSM
- SAN
1 stop24h 05m
Multiple Airlines
Wed 8/53:03 pm
SAN
- DSM
1 stop27h 51m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$312
One-way flights from Des Moines to San DiegoSearch for one-way flight options from Des Moines to San Diego. Find affordable one-way fares based on user searches. Data last updated June 12, 2026.
Search for one-way flight options from Des Moines to San Diego. Find affordable one-way fares based on user searches. Data last updated June 12, 2026.
This Trip.com deal was found by Cheapflights users on 6/11. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Trip.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/310:01 pm
DSM
- SAN
1 stop23h 33m
Multiple Airlines
Deal found 6/11![Multiple Airlines logo]()
$109
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2710:01 pm
DSM
- SAN
1 stop18h 07m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$110
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/610:01 pm
DSM
- SAN
1 stop18h 07m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$125
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:40 pm
DSM
- SAN
1 stop5h 20m
Southwest
Deal found 6/7![Southwest logo]()
$126
This deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 8/262:45 pm
DSM
- SAN
1 stop7h 31m
Delta
Deal found 6/8![Delta logo]()
$129
This Orbitz deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/82:19 pm
DSM
- SAN
1 stop20h 46m
Frontier
Deal found 6/8![Frontier logo]()
$170
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/218:36 pm
DSM
- SAN
1 stop14h 12m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$199
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/2610:57 am
DSM
- SAN
2 stops24h 08m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$222
Find flight deals from Des Moines to San Diego
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Diego (SAN). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 12, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $179 (Kiwi.com) |
One-way from | $109 (Trip.com) |
Popular in | March |
Cheapest in | August |
Average price | $430 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to San Diego that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2026.
Use the filters below to find and compare flights from Des Moines to San Diego that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Wed 10/28
7:50 pm-11:55 pm
1 stop6h 05m
San Diego
Sat 10/31
6:20 am-2:11 pm
1 stop5h 51m
$280
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Wed 10/28
9:09 am-5:29 pm
2 stops10h 20m
San Diego
Sat 10/31
11:20 am-8:32 pm
1 stop7h 12m
$373
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Wed 9/23
1:35 pm-8:45 pm
2 stops9h 10m
San Diego
Mon 9/28
2:24 pm-11:59 pm
2 stops7h 35m
$378
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Fri 10/23
3:30 pm-8:25 pm
1 stop6h 55m
San Diego
Mon 10/26
11:40 am-9:24 pm
1 stop7h 44m
$380
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Fri 8/28
2:25 pm-7:20 pm
2 stops6h 55m
San Diego
Mon 8/31
10:30 am-9:15 pm
2 stops8h 45m
$388
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Thu 10/1
5:35 am-3:20 pm
2 stops11h 45m
San Diego
Sun 10/4
6:45 am-4:00 pm
1 stop7h 15m
$408
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Wed 10/7
5:35 am-12:00 pm
2 stops8h 25m
San Diego
Sun 10/11
12:35 pm-10:20 pm
2 stops7h 45m
$437
Quickest round-trip
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Thu 7/2
5:17 pm-8:46 pm
1 stop5h 29m
San Diego
Tue 7/7
8:45 am-4:15 pm
1 stop5h 30m
$437
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Mon 8/10
2:25 pm-7:20 pm
2 stops6h 55m
San Diego
Wed 8/19
12:20 pm-9:00 pm
2 stops6h 40m
$447
Des MoinesSan Diego
DSM - SAN
DSMSAN
Des Moines
Sun 11/15
1:50 pm-7:50 pm
1 stop8h 00m
San Diego
Sun 11/22
10:40 pm-11:30 am
1 stop10h 50m
$452
Showing 1-10 of 18 resultsSorted by cheapest first
Compare providers for flights from Des Moines to San Diego
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Diego in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy- | Trust Score*1 star |
- Most accurate provider: When it comes to deals on Des Moines-San Diego flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Diego flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Diego flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-San Diego flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Diego flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to San Diego
Have a flexible travel schedule? Discover the best time to fly to San Diego from Des Moines with our price prediction graph.
DSM-SAN
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to San Diego
How far ahead should I book a flight from Des Moines to San Diego?
The price you pay for your flight from Des Moines to San Diego may vary depending on when you book. For the best chance of a lower fare, look to book 42 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Des Moines to San Diego?
Currently, August is the cheapest month in which you can book a flight from Des Moines to San Diego (average of $172). Flying from Des Moines to San Diego in March is currently the most expensive (average of $576). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to San Diego?
Reviews of airlines servicing San Diego
Get insights into the airlines that provide service to San Diego. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Diego. Reviews last updated June 12, 2026.
Read through reviews of airlines operating flights from Des Moines to San Diego, such as Southwest,United Airlines, andAllegiant Air. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Food
7.0
Boarding
8.1
Entertainment
7.5
Overall
7.9
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Food
7.0
Boarding
8.1
Entertainment
7.5
Overall
7.9
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Food
7.0
Boarding
8.1
Entertainment
7.5
Overall
7.9
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Food
7.0
Boarding
8.1
Entertainment
7.5
Overall
7.9
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Food
7.0
Boarding
8.1
Entertainment
7.5
Overall
7.9
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Food
7.0
Boarding
8.1
Entertainment
7.5
Overall
7.9
Comfort
8.0
Crew
8.6
Reviews
1 / 20
10.0
ExcellentWalter,May 2026
LAS - BUR
Related info for your journey
Find useful and relevant information for your journey from Des Moines to San Diego. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Diego?
Book flights to San Diego if you plan to visit one of these locationsEl Cajon
National City
Chula Vista
Poway
Coronado
La Mesa
Santee
Julian
Lemon Grove
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Des Moines and San Diego flights
Browse other Des Moines and San Diego flight options. Last updated on June 12, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on June 12, 2026.
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Top 6 airlines flying from Des Moines to San Diego
Discover the top 6 airlines that operate flights from Des Moines to San Diego. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 12, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$100 | Average$238 | FlexibilityNo cancel fee | On-time62% | |
| Cheapest$102 | Average$154 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$118 | Average$333 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$286 | Average$407 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$296 | Average$476 | FlexibilityNo cancel fee | On-time63% | |
| Cheapest$310 | Average$416 | FlexibilityNo cancel fee | On-time69% |