$132+ Cheap flights from Des Moines to San Antonio (DSM - SAT)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 9/1. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — SAT
Jul 10 — Jul 171
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Des Moines to San Antonio with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Des Moines to San Antonio
Cheapest
Best
Last-minute
One-way
Cheapest flights from Des Moines to San AntonioExplore the most affordable flight options available from Des Moines to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 10, 2026.
Explore the most affordable flight options available from Des Moines to San Antonio. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 10, 2026.
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/106:30 pm
DSM
- SAT
1 stop5h 58m
Delta
Wed 11/1810:45 am
SAT
- DSM
1 stop6h 57m
Delta
Deal found 6/8![Delta logo]()
$263
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 11/107:05 am
DSM
- SAT
1 stop6h 55m
Southwest
Wed 11/181:00 pm
SAT
- DSM
2 stops7h 45m
Southwest
Deal found 6/9![Southwest logo]()
$270
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/154:14 pm
DSM
- SAT
1 stop6h 36m
American Airlines
Mon 9/215:41 pm
SAT
- DSM
1 stop5h 32m
American Airlines
Deal found 6/9![American Airlines logo]()
$290
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/62:54 pm
DSM
- SAT
1 stop6h 10m
Delta
Mon 8/102:43 pm
SAT
- DSM
1 stop7h 54m
Delta
Deal found 6/8![Delta logo]()
$317
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/72:25 pm
DSM
- SAT
1 stop7h 00m
Southwest
Tue 8/112:35 pm
SAT
- DSM
1 stop7h 20m
Southwest
Deal found 6/8![Southwest logo]()
$318
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/106:00 am
DSM
- SAT
1 stop6h 06m
United Airlines
Sat 10/175:30 am
SAT
- DSM
2 stops7h 01m
United Airlines
Deal found 6/8![United Airlines logo]()
$322
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/62:25 pm
DSM
- SAT
2 stops9h 00m
Southwest
Mon 8/105:00 am
SAT
- DSM
1 stop6h 25m
Southwest
Deal found 6/8![Southwest logo]()
$323
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/315:17 pm
DSM
- SAT
1 stop6h 38m
United Airlines
Tue 8/45:40 am
SAT
- DSM
1 stop5h 02m
United Airlines
Deal found 6/8![United Airlines logo]()
$335
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/314:40 pm
DSM
- SAT
1 stop7h 30m
Southwest
Tue 8/43:15 pm
SAT
- DSM
2 stops6h 40m
Southwest
Deal found 6/8![Southwest logo]()
$341
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/13:20 pm
DSM
- SAT
1 stop7h 31m
United Airlines
Wed 9/212:55 pm
SAT
- DSM
1 stop8h 28m
United Airlines
Deal found 6/8![United Airlines logo]()
$343
Best flights from Des Moines to San AntonioDiscover carefully curated flight deals from Des Moines to San Antonio that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 10, 2026.
Discover carefully curated flight deals from Des Moines to San Antonio that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 10, 2026.
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/315:17 pm
DSM
- SAT
1 stop6h 38m
United Airlines
Tue 8/45:40 am
SAT
- DSM
1 stop5h 02m
United Airlines
Deal found 6/8![United Airlines logo]()
$335
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/72:25 pm
DSM
- SAT
2 stops9h 00m
Southwest
Tue 8/111:30 pm
SAT
- DSM
2 stops8h 25m
Southwest
Deal found 6/8![Southwest logo]()
$356
This United Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/711:34 am
DSM
- SAT
1 stop5h 21m
United Airlines
Tue 8/119:10 am
SAT
- DSM
1 stop7h 09m
United Airlines
Deal found 6/5![United Airlines logo]()
$381
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:10 am
DSM
- SAT
2 stops7h 00m
Southwest
Fri 7/102:10 pm
SAT
- DSM
1 stop8h 15m
Southwest
Deal found 6/5![Southwest logo]()
$392
This Southwest deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/76:25 am
DSM
- SAT
1 stop4h 55m
Southwest
Tue 7/211:40 pm
SAT
- DSM
1 stop8h 05m
Southwest
Deal found 6/6![Southwest logo]()
$407
This United Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/106:00 am
DSM
- SAT
1 stop6h 12m
United Airlines
Sun 7/125:32 pm
SAT
- DSM
1 stop5h 24m
United Airlines
Deal found 6/7![United Airlines logo]()
$407
This United Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/285:17 pm
DSM
- SAT
1 stop6h 38m
United Airlines
Fri 7/315:40 am
SAT
- DSM
1 stop5h 02m
United Airlines
Deal found 6/7![United Airlines logo]()
$407
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/274:40 pm
DSM
- SAT
1 stop7h 30m
Southwest
Sat 8/12:00 pm
SAT
- DSM
2 stops8h 55m
Southwest
Deal found 6/9![Southwest logo]()
$422
This United Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/16:00 am
DSM
- SAT
2 stops9h 43m
United Airlines
Wed 9/27:35 am
SAT
- DSM
2 stops8h 44m
United Airlines
Deal found 6/4![United Airlines logo]()
$445
Last-minute flights from Des Moines to San AntonioDiscover last-minute flight deals from Des Moines to San Antonio. Data last updated June 10, 2026 and is based on user searches.
Discover last-minute flight deals from Des Moines to San Antonio. Data last updated June 10, 2026 and is based on user searches.
This United Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/49:14 am
DSM
- SAT
1 stop7h 45m
United Airlines
Fri 7/105:32 pm
SAT
- DSM
1 stop5h 24m
United Airlines
Deal found 6/7![United Airlines logo]()
$381
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/48:45 am
DSM
- SAT
2 stops9h 44m
American Airlines
Fri 7/105:01 am
SAT
- DSM
1 stop4h 10m
American Airlines
Deal found 6/7![American Airlines logo]()
$386
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 7/46:10 am
DSM
- SAT
2 stops7h 00m
Southwest
Fri 7/102:10 pm
SAT
- DSM
1 stop8h 15m
Southwest
Deal found 6/5![Southwest logo]()
$392
This United Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/73:24 pm
DSM
- SAT
2 stops7h 18m
United Airlines
Fri 7/105:57 pm
SAT
- DSM
1 stop4h 38m
United Airlines
Deal found 6/5![United Airlines logo]()
$396
This Southwest deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/73:45 pm
DSM
- SAT
1 stop8h 00m
Southwest
Tue 7/216:10 am
SAT
- DSM
2 stops8h 55m
Southwest
Deal found 6/6![Southwest logo]()
$412
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/105:41 am
DSM
- SAT
1 stop7h 57m
Delta
Tue 7/146:40 am
SAT
- DSM
1 stop6h 54m
Delta
Deal found 6/8![Delta logo]()
$407
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/234:48 pm
DSM
- SAT
1 stop4h 15m
American Airlines
Thu 7/305:01 am
SAT
- DSM
1 stop4h 10m
American Airlines
Deal found 6/8![American Airlines logo]()
$403
This American Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/277:13 pm
DSM
- SAT
1 stop4h 45m
American Airlines
Sat 8/85:59 am
SAT
- DSM
1 stop7h 24m
American Airlines
Deal found 6/4![American Airlines logo]()
$402
This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2710:01 pm
DSM
- SAT
1 stop22h 36m
Multiple Airlines
Fri 8/711:30 am
SAT
- DSM
2 stops27h 05m
Multiple Airlines
Deal found 6/4![Multiple Airlines logo]()
$406
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/315:17 pm
DSM
- SAT
1 stop6h 38m
United Airlines
Tue 8/45:40 am
SAT
- DSM
1 stop5h 02m
United Airlines
Deal found 6/8![United Airlines logo]()
$335
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/314:40 pm
DSM
- SAT
1 stop7h 30m
Southwest
Tue 8/43:15 pm
SAT
- DSM
2 stops6h 40m
Southwest
Deal found 6/8![Southwest logo]()
$341
One-way flights from Des Moines to San AntonioSearch for one-way flight options from Des Moines to San Antonio. Find affordable one-way fares based on user searches. Data last updated June 10, 2026.
Search for one-way flight options from Des Moines to San Antonio. Find affordable one-way fares based on user searches. Data last updated June 10, 2026.
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/14:13 pm
DSM
- SAT
1 stop5h 47m
American Airlines
Deal found 6/8![American Airlines logo]()
$132
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/18:00 am
DSM
- SAT
2 stops7h 43m
United Airlines
Deal found 6/8![United Airlines logo]()
$137
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/296:55 am
DSM
- SAT
1 stop4h 54m
Delta
Deal found 6/8![Delta logo]()
$159
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/21:35 pm
DSM
- SAT
2 stops9h 04m
United Airlines
Deal found 6/8![United Airlines logo]()
$177
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/304:48 pm
DSM
- SAT
1 stop7h 11m
American Airlines
Deal found 6/7![American Airlines logo]()
$178
This United Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/303:24 pm
DSM
- SAT
2 stops7h 18m
United Airlines
Deal found 6/7![United Airlines logo]()
$183
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 9/36:00 am
DSM
- SAT
1 stop5h 52m
United Airlines
Deal found 6/8![United Airlines logo]()
$199
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/166:37 pm
DSM
- SAT
1 stop5h 43m
Delta
Deal found 6/8![Delta logo]()
$204
This Southwest deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/43:50 pm
DSM
- SAT
2 stops7h 05m
Southwest
Deal found 6/6![Southwest logo]()
$209
This Kiwi.com deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/139:56 pm
DSM
- SAT
2 stops12h 16m
Multiple Airlines
Deal found 6/6![Multiple Airlines logo]()
$211
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/29:33 pm
DSM
- SAT
1 stop23h 04m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$214
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/137:40 pm
DSM
- SAT
1 stop4h 15m
American Airlines
Deal found 6/6![American Airlines logo]()
$219
Find flight deals from Des Moines to San Antonio
Discover tips and strategies to find the most affordable flight options for your journey from Des Moines (DSM) to San Antonio (SAT). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $263 (Delta) |
One-way from | $132 (American Airlines) |
Popular in | March |
Cheapest in | August |
Average price | $537 |
Cheapflights Fare Finder
Customize your flight search to find flights from Des Moines to San Antonio that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 10, 2026.
Use the filters below to find and compare flights from Des Moines to San Antonio that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Fri 7/31
5:17 pm-11:55 pm
1 stop6h 38m
San Antonio
Tue 8/4
5:40 am-10:42 am
1 stop5h 02m
$335
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Fri 8/7
2:25 pm-11:25 pm
2 stops9h 00m
San Antonio
Tue 8/11
1:30 pm-9:55 pm
2 stops8h 25m
$356
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Fri 8/7
11:34 am-4:55 pm
1 stop5h 21m
San Antonio
Tue 8/11
9:10 am-4:19 pm
1 stop7h 09m
$381
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Sat 7/4
6:10 am-1:10 pm
2 stops7h 00m
San Antonio
Fri 7/10
2:10 pm-10:25 pm
1 stop8h 15m
$392
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Tue 7/7
6:25 am-11:20 am
1 stop4h 55m
San Antonio
Tue 7/21
1:40 pm-9:45 pm
1 stop8h 05m
$407
Quickest round-trip
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Fri 7/10
6:00 am-12:12 pm
1 stop6h 12m
San Antonio
Sun 7/12
5:32 pm-10:56 pm
1 stop5h 24m
$407
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Tue 7/28
5:17 pm-11:55 pm
1 stop6h 38m
San Antonio
Fri 7/31
5:40 am-10:42 am
1 stop5h 02m
$407
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Mon 7/27
4:40 pm-12:10 am
1 stop7h 30m
San Antonio
Sat 8/1
2:00 pm-10:55 pm
2 stops8h 55m
$422
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Tue 9/1
6:00 am-3:43 pm
2 stops9h 43m
San Antonio
Wed 9/2
7:35 am-4:19 pm
2 stops8h 44m
$445
Cheapest one-way
Des MoinesSan Antonio
DSM - SAT
DSMSAT
Des Moines
Sat 8/29
6:55 am-11:49 am
1 stop4h 54m
$159
Showing 1-10 of 21 resultsSorted by cheapest first
Compare providers for flights from Des Moines to San Antonio
Provider information is updated monthly. Please note that these providers often have deals for this flight, but the availability may vary on a day-by-day basis on Cheapflights.
Use the table below to compare price accuracy, trust ratings, and cancellation policies for each provider offering flight deals from Des Moines to San Antonio in June.
| Provider | Price Accuracy | Trust Score* |
|---|---|---|
| Price Accuracy1 star | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy3 stars | Trust Score*3 stars | |
| Price Accuracy1 star | Trust Score*3 stars |
- Most accurate provider: When it comes to deals on Des Moines-San Antonio flights, users find the pricing of FlightHub to be most consistent on Cheapflights vs. FlightHub Users can find the same prices on Des Moines-San Antonio flight deals on Cheapflights vs. FlightHub >95% of the time. Price accuracy is based on data collected from Des Moines-San Antonio flight searches over the past month and is updated monthly.
- Most trusted provider: When it comes to deals on Des Moines-San Antonio flights, Cheapflights users trust FlightHub the most. FlightHub has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Des Moines-San Antonio flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.
Best time to book a flight from Des Moines to San Antonio
Have a flexible travel schedule? Discover the best time to fly to San Antonio from Des Moines with our price prediction graph.
DSM-SAT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Des Moines to San Antonio
How far ahead should I book a flight from Des Moines to San Antonio?
The price you pay for your flight from Des Moines to San Antonio may vary depending on when you book. For the best chance of a lower fare, look to book 62 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
What is the cheapest month to book a flight from Des Moines to San Antonio?
Currently, July is the cheapest month in which you can book a flight from Des Moines to San Antonio (average of $299). Flying from Des Moines to San Antonio in June is currently the most expensive (average of $760). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.
How much does it cost to fly round-trip from Des Moines to San Antonio?
Reviews of airlines servicing San Antonio
Get insights into the airlines that provide service to San Antonio. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to San Antonio. Reviews last updated June 10, 2026.
Read reviews from past customers who have flown Southwest,Delta, andUnited Airlines from Des Moines to San Antonio. Users can see the overall rating for each airline as well as how each is rated in terms of entertainment options, comfort, food, crew/service, and boarding process.
Boarding
8.1
Crew
8.6
Food
7.0
Entertainment
7.5
Overall
7.9
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Crew
8.6
Food
7.0
Entertainment
7.5
Overall
7.9
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Crew
8.6
Food
7.0
Entertainment
7.5
Overall
7.9
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Crew
8.6
Food
7.0
Entertainment
7.5
Overall
7.9
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Boarding
8.1
Crew
8.6
Food
7.0
Entertainment
7.5
Overall
7.9
Comfort
8.0
Reviews
1 / 20
8.0
ExcellentLa Tracimeldamarcos,Jun 2026
LAX - SLC
Related info for your journey
Find useful and relevant information for your journey from Des Moines to San Antonio. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near San Antonio?
Book flights to San Antonio if you plan to visit one of these locationsNew Braunfels
Kerrville
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
Other flight options
Other flights from Des Moines
Popular flights
San Antonio flight routes
Alternative routes for Des Moines to San Antonio
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to San Antonio by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Des Moines to San Antonio by cabin class
Find flights from Des Moines to San Antonio, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Des Moines and San Antonio flights
Browse other Des Moines and San Antonio flight options. Last updated on June 10, 2026.
Other flights from Des Moines
Browse through other flights departing from Des Moines. Flights are based on user searches made on Cheapflights and were last updated on June 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Other flights to San Antonio
Explore flights to San Antonio departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 10, 2026.
Top 4 airlines flying from Des Moines to San Antonio
Discover the top 4 airlines that operate flights from Des Moines to San Antonio. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$213 | Average$406 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$262 | Average$385 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$296 | Average$431 | FlexibilityNo cancel fee | On-time69% | |
| Cheapest$359 | Average$421 | FlexibilityNo cancel fee | On-time63% |