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$427+ Cheap flights from Fort Myers to Florence, SC (RSW - FLO)

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/14. Fares are subject to change and may not be available on all flights or dates of travel.
RSW — FLO
Jul 10 — Jul 171
Fri 7/10
Fri 7/17
1 adult, Economy
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Cheap flight deals from Fort Myers to Florence

Cheapest flights from Fort Myers to Florence
Explore the most affordable flight options available from Fort Myers to Florence. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 10, 2026.

This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/309:59 am
RSW
-
FLO
1 stop4h 11m
American Airlines
Tue 7/75:17 am
FLO
-
RSW
1 stop3h 51m
American Airlines
Deal found 6/8$477
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/243:57 pm
RSW
-
FLO
1 stop6h 03m
American Airlines
Fri 7/32:35 pm
FLO
-
RSW
1 stop4h 16m
American Airlines
Deal found 6/7$591
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/27:41 pm
RSW
-
FLO
1 stop3h 56m
American Airlines
Fri 8/73:22 pm
FLO
-
RSW
1 stop6h 31m
American Airlines
Deal found 6/7$853

Find flight deals from Fort Myers to Florence

Discover tips and strategies to find the most affordable flight options for your journey from Fort Myers (RSW) to Florence (FLO). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 10, 2026.

Most accurate provider

Expedia
1 star

Most trusted provider

Expedia
3 stars

Round-trip from

$477
(American Airlines)

One-way from

$427
(American Airlines)
Provider with most accurate pricing for Fort Myers SW Florida Intl-Florence flight deals.
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Provider most trusted by Cheapflights users for Fort Myers SW Florida Intl-Florence flights.
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From Fort Myers SW Florida Intl to Florence
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One-way flight from Fort Myers SW Florida Intl to Florence
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Cheapflights Fare Finder

 
Customize your flight search to find flights from Fort Myers to Florence that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 10, 2026.
Use the filters below to find and compare flights from Fort Myers to Florence that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

Fort MyersFlorence

RSW - FLO

RSWFLO

Fort Myers SW Florida Intl

Tue 6/30

9:59 am-2:10 pm

1 stop4h 11m

Florence

Tue 7/7

5:17 am-9:08 am

1 stop3h 51m

$477

Fort MyersFlorence

RSW - FLO

RSWFLO

Fort Myers SW Florida Intl

Wed 6/24

7:00 am-10:00 pm

2 stops15h 00m

Florence

Fri 7/3

2:35 pm-8:36 am

2 stops18h 01m

$730

Fort MyersFlorence

RSW - FLO

RSWFLO

Fort Myers SW Florida Intl

Sun 8/2

7:41 pm-11:37 pm

1 stop3h 56m

Florence

Fri 8/7

3:22 pm-9:53 pm

1 stop6h 31m

$853
Cheapest one-way
Quickest one-way

Fort MyersFlorence

RSW - FLO

RSWFLO

Fort Myers SW Florida Intl

Fri 8/14

11:04 am-2:56 pm

1 stop3h 52m

$427

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/8

Sorted by cheapest first
  • Most accurate provider: When it comes to deals on Fort Myers-Florence, South Carolina flights, users find the pricing of Expedia to be most consistent on Cheapflights vs. Expedia Users can find the same prices on Fort Myers-Florence, South Carolina flight deals on Cheapflights vs. Expedia <90% of the time. Price accuracy is based on data collected from Fort Myers-Florence, South Carolina flight searches over the past month and is updated monthly.
  • Most trusted provider: When it comes to deals on Fort Myers-Florence, South Carolina flights, Cheapflights users trust Expedia the most. Expedia has received a user feedback score of 3 out of 3 stars (3 being the best), meaning they have been trusted the most by Cheapflights users looking for Fort Myers-Florence, South Carolina flight deals. Provider user feedback score is based on Cheapflights searches over the past month and is updated monthly.

Best time to book a flight from Fort Myers to Florence

Have a flexible travel schedule? Discover the best time to fly to Florence from Fort Myers with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Related info for your journey

Find useful and relevant information for your journey from Fort Myers to Florence. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • How long is the flight from Fort Myers to Florence, South Carolina?

    A quick flight from Fort Myers to Florence, South Carolina can take about 4h 11m. American Airlines provides one of the quickest options available for as low as $477. The distance from Fort Myers to Florence, South Carolina is about 542 mi.

  • Can I find deals for flights from Fort Myers to Florence that include hotel bookings?

    Yes. In addition to deals on Fort Myers to Florence flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Fort Myers to Florence?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Fort Myers to Florence.

  • Can I find deals for business class flights from Fort Myers to Florence?

    Yes. Cheapflights offers flight deals from Fort Myers to Florence by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Traveling to a place near Florence?

Book flights to Florence if you plan to visit one of these locations
Sumter

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