$133+ Cheap flights from Missouri to Des Moines (DSM)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/22. Fares are subject to change and may not be available on all flights or dates of travel.
MCI — DSM
Jul 10 — Jul 171
Round-trip
1 adult, Economy
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Cheapest flights from Missouri to Des MoinesExplore the most affordable flight options available from Missouri to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 10, 2026.
Explore the most affordable flight options available from Missouri to Des Moines. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 10, 2026.
This Frontier deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/98:08 pm
STL
- DSM
1 stop17h 26m
Frontier
Wed 7/152:19 pm
DSM
- STL
1 stop5h 04m
Frontier
Deal found 6/7![Frontier logo]()
$249
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/286:15 pm
STL
- DSM
1 stop3h 55m
Southwest
Wed 9/306:10 am
DSM
- STL
2 stops8h 20m
Southwest
Deal found 6/9![Southwest logo]()
$254
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/285:36 pm
STL
- DSM
1 stop5h 59m
United Airlines
Thu 10/111:27 am
DSM
- STL
1 stop4h 16m
United Airlines
Deal found 6/9![United Airlines logo]()
$271
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/283:45 pm
STL
- DSM
2 stops6h 25m
Southwest
Thu 10/15:35 am
DSM
- STL
1 stop6h 30m
Southwest
Deal found 6/9![Southwest logo]()
$276
This Booking.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/98:08 pm
STL
- DSM
1 stop17h 26m
Frontier
Mon 7/132:19 pm
DSM
- STL
1 stop5h 04m
Frontier
Deal found 6/7![Frontier logo]()
$280
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/276:00 am
STL
- DSM
1 stop5h 35m
Southwest
Wed 9/302:40 pm
DSM
- STL
1 stop3h 15m
Southwest
Deal found 6/9![Southwest logo]()
$286
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/271:30 pm
STL
- DSM
1 stop7h 02m
United Airlines
Wed 10/2811:30 am
DSM
- STL
1 stop4h 08m
United Airlines
Deal found 6/9![United Airlines logo]()
$297
This Booking.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/78:08 pm
STL
- DSM
1 stop17h 26m
Frontier
Mon 7/132:19 pm
DSM
- STL
1 stop5h 04m
Frontier
Deal found 6/8![Frontier logo]()
$301
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/91:45 pm
MCI
- DSM
1 stop23h 49m
Multiple Airlines
Sun 7/124:57 pm
DSM
- MCI
2 stops24h 13m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$329
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/91:45 pm
MCI
- DSM
2 stops9h 50m
Southwest
Sun 7/125:10 am
DSM
- MCI
2 stops9h 00m
Southwest
Deal found 6/8![Southwest logo]()
$357
This Kiwi.com deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/206:16 pm
MCI
- DSM
2 stops27h 41m
Multiple Airlines
Wed 6/242:16 pm
DSM
- MCI
1 stop22h 44m
Multiple Airlines
Deal found 6/5![Multiple Airlines logo]()
$425
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/205:05 am
MCI
- DSM
1 stop6h 30m
Southwest
Wed 6/245:20 am
DSM
- MCI
1 stop6h 10m
Southwest
Deal found 6/5![Southwest logo]()
$451
Best flights from Missouri to Des MoinesDiscover carefully curated flight deals from Missouri to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 10, 2026.
Discover carefully curated flight deals from Missouri to Des Moines that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 10, 2026.
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/286:15 pm
STL
- DSM
1 stop3h 55m
Southwest
Wed 9/306:10 am
DSM
- STL
2 stops8h 20m
Southwest
Deal found 6/9![Southwest logo]()
$254
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 10/279:13 am
STL
- DSM
1 stop7h 01m
United Airlines
Wed 10/2811:30 am
DSM
- STL
1 stop4h 08m
United Airlines
Deal found 6/8![United Airlines logo]()
$297
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/91:45 pm
MCI
- DSM
1 stop23h 49m
Multiple Airlines
Sun 7/124:57 pm
DSM
- MCI
2 stops24h 13m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$329
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/218:14 pm
STL
- DSM
1 stop4h 21m
American Airlines
Thu 6/257:09 pm
DSM
- STL
1 stop5h 07m
American Airlines
Deal found 6/6![American Airlines logo]()
$355
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 9/283:45 pm
STL
- DSM
2 stops6h 25m
Southwest
Thu 10/15:35 am
DSM
- STL
1 stop6h 30m
Southwest
Deal found 6/9![Southwest logo]()
$276
This Southwest deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 9/273:20 pm
STL
- DSM
2 stops7h 15m
Southwest
Wed 9/306:10 am
DSM
- STL
1 stop5h 10m
Southwest
Deal found 6/9![Southwest logo]()
$291
This United Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/288:50 am
STL
- DSM
1 stop5h 26m
United Airlines
Sun 8/306:00 am
DSM
- STL
1 stop4h 12m
United Airlines
Deal found 6/6![United Airlines logo]()
$345
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/710:15 am
STL
- DSM
2 stops12h 35m
Southwest
Mon 7/135:10 am
DSM
- STL
2 stops8h 40m
Southwest
Deal found 6/8![Southwest logo]()
$340
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/66:30 pm
STL
- DSM
1 stop5h 05m
Southwest
Mon 7/134:40 pm
DSM
- STL
1 stop6h 15m
Southwest
Deal found 6/8![Southwest logo]()
$345
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/94:00 pm
STL
- DSM
1 stop6h 25m
Southwest
Wed 7/155:20 am
DSM
- STL
2 stops9h 25m
Southwest
Deal found 6/7![Southwest logo]()
$354
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/91:45 pm
MCI
- DSM
2 stops9h 50m
Southwest
Sun 7/125:10 am
DSM
- MCI
2 stops9h 00m
Southwest
Deal found 6/8![Southwest logo]()
$357
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/94:25 pm
STL
- DSM
2 stops7h 10m
Southwest
Mon 7/135:10 am
DSM
- STL
2 stops8h 40m
Southwest
Deal found 6/7![Southwest logo]()
$359
This United Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/141:40 pm
MCI
- DSM
1 stop10h 04m
United Airlines
Wed 7/155:50 am
DSM
- MCI
1 stop17h 40m
United Airlines
Deal found 6/9![United Airlines logo]()
$633
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/205:05 am
MCI
- DSM
1 stop6h 30m
Southwest
Wed 6/245:20 am
DSM
- MCI
1 stop6h 10m
Southwest
Deal found 6/5![Southwest logo]()
$451
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 6/227:55 pm
MCI
- DSM
1 stop3h 35m
Southwest
Wed 6/245:20 am
DSM
- MCI
2 stops9h 55m
Southwest
Deal found 6/5![Southwest logo]()
$456
This Southwest deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/217:20 pm
MCI
- DSM
1 stop4h 25m
Southwest
Wed 6/246:25 am
DSM
- MCI
2 stops8h 50m
Southwest
Deal found 6/5![Southwest logo]()
$501
Last-minute flights from Missouri to Des MoinesDiscover last-minute flight deals from Missouri to Des Moines. Data last updated June 10, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to Des Moines. Data last updated June 10, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/218:14 pm
STL
- DSM
1 stop4h 21m
American Airlines
Thu 6/257:09 pm
DSM
- STL
1 stop5h 07m
American Airlines
Deal found 6/6![American Airlines logo]()
$355
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/247:03 am
STL
- DSM
1 stop6h 18m
American Airlines
Wed 6/247:09 pm
DSM
- STL
1 stop5h 07m
American Airlines
Deal found 6/8![American Airlines logo]()
$345
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/62:00 pm
STL
- DSM
2 stops44h 09m
Multiple Airlines
Mon 7/1310:01 pm
DSM
- STL
1 stop20h 04m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$308
This Booking.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/78:08 pm
STL
- DSM
1 stop17h 26m
Frontier
Mon 7/132:19 pm
DSM
- STL
1 stop5h 04m
Frontier
Deal found 6/8![Frontier logo]()
$301
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/77:20 pm
STL
- DSM
2 stops38h 47m
Multiple Airlines
Mon 7/1310:01 pm
DSM
- STL
1 stop20h 04m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$303
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/710:15 am
STL
- DSM
2 stops12h 35m
Southwest
Mon 7/135:10 am
DSM
- STL
2 stops8h 40m
Southwest
Deal found 6/8![Southwest logo]()
$340
This Frontier deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Frontier is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/98:08 pm
STL
- DSM
1 stop17h 26m
Frontier
Wed 7/152:19 pm
DSM
- STL
1 stop5h 04m
Frontier
Deal found 6/7![Frontier logo]()
$249
This Booking.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/98:08 pm
STL
- DSM
1 stop17h 26m
Frontier
Mon 7/132:19 pm
DSM
- STL
1 stop5h 04m
Frontier
Deal found 6/7![Frontier logo]()
$280
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/91:45 pm
MCI
- DSM
1 stop23h 49m
Multiple Airlines
Sun 7/124:57 pm
DSM
- MCI
2 stops24h 13m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$329
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/92:00 pm
STL
- DSM
2 stops26h 40m
Multiple Airlines
Mon 7/1310:01 pm
DSM
- STL
1 stop20h 04m
Multiple Airlines
Deal found 6/7![Multiple Airlines logo]()
$338
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/94:00 pm
STL
- DSM
1 stop6h 25m
Southwest
Wed 7/155:20 am
DSM
- STL
2 stops9h 25m
Southwest
Deal found 6/7![Southwest logo]()
$354
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/91:45 pm
MCI
- DSM
2 stops9h 50m
Southwest
Sun 7/125:10 am
DSM
- MCI
2 stops9h 00m
Southwest
Deal found 6/8![Southwest logo]()
$357
One-way flights from Missouri to Des MoinesSearch for one-way flight options from Missouri to Des Moines. Find affordable one-way fares based on user searches. Data last updated June 10, 2026.
Search for one-way flight options from Missouri to Des Moines. Find affordable one-way fares based on user searches. Data last updated June 10, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/224:57 pm
STL
- DSM
2 stops30h 10m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$133
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/76:21 am
STL
- DSM
1 stop3h 52m
Delta
Deal found 6/8![Delta logo]()
$147
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/224:00 pm
STL
- DSM
1 stop5h 45m
Southwest
Deal found 6/8![Southwest logo]()
$152
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/294:57 pm
STL
- DSM
2 stops28h 30m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$153
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/710:15 am
STL
- DSM
2 stops12h 35m
Southwest
Deal found 6/8![Southwest logo]()
$163
This Booking.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Booking.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/78:08 pm
STL
- DSM
1 stop17h 26m
Frontier
Deal found 6/8![Frontier logo]()
$167
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/241:42 pm
STL
- DSM
1 stop5h 53m
American Airlines
Deal found 6/8![American Airlines logo]()
$173
This Kiwi.com deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/76:34 pm
STL
- DSM
2 stops37h 59m
Multiple Airlines
Deal found 6/8![Multiple Airlines logo]()
$174
This Southwest deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/64:25 pm
STL
- DSM
2 stops7h 10m
Southwest
Deal found 6/8![Southwest logo]()
$178
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/274:25 pm
STL
- DSM
2 stops7h 10m
Southwest
Deal found 6/7![Southwest logo]()
$180
This Kiwi.com deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/231:45 pm
MCI
- DSM
1 stop23h 46m
Frontier
Deal found 6/7![Frontier logo]()
$188
This Southwest deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Southwest is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/2611:45 am
STL
- DSM
2 stops10h 50m
Southwest
Deal found 6/7![Southwest logo]()
$191
Find flight deals from Missouri to Des Moines
Keep the following information in mind while searching for Missouri to Des Moines flight deals. Data was last updated June 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $249 (Frontier) |
One-way from | $133 (Kiwi.com) |
Popular in | January |
Cheapest in | October |
Average price | $364 |
Good one-way deal | $194 or less |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to Des Moines that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 10, 2026.
Use the filters below to find and compare flights from Missouri to Des Moines that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
St. LouisDes Moines
STL - DSM
STLDSM
Lambert-St Louis
Mon 9/28
6:15 pm-10:10 pm
1 stop3h 55m
Des Moines
Wed 9/30
6:10 am-2:30 pm
2 stops8h 20m
$254
St. LouisDes Moines
STL - DSM
STLDSM
Lambert-St Louis
Mon 9/28
3:45 pm-10:10 pm
2 stops6h 25m
Des Moines
Thu 10/1
5:35 am-12:05 pm
1 stop6h 30m
$276
St. LouisDes Moines
STL - DSM
STLDSM
Lambert-St Louis
Sun 9/27
3:20 pm-10:35 pm
2 stops7h 15m
Des Moines
Wed 9/30
6:10 am-11:20 am
1 stop5h 10m
$291
St. LouisDes Moines
STL - DSM
STLDSM
Lambert-St Louis
Tue 10/27
9:13 am-4:14 pm
1 stop7h 01m
Des Moines
Wed 10/28
11:30 am-3:38 pm
1 stop4h 08m
$297
Kansas CityDes Moines
MCI - DSM
MCIDSM
Kansas City
Thu 7/9
1:45 pm-1:34 pm
1 stop23h 49m
Des Moines
Sun 7/12
4:57 pm-5:10 pm
2 stops24h 13m
$329
St. LouisDes Moines
STL - DSM
STLDSM
Lambert-St Louis
Tue 7/7
10:15 am-10:50 pm
2 stops12h 35m
Des Moines
Mon 7/13
5:10 am-1:50 pm
2 stops8h 40m
$340
St. LouisDes Moines
STL - DSM
STLDSM
Lambert-St Louis
Fri 8/28
8:50 am-2:16 pm
1 stop5h 26m
Des Moines
Sun 8/30
6:00 am-10:12 am
1 stop4h 12m
$345
St. LouisDes Moines
STL - DSM
STLDSM
Lambert-St Louis
Mon 7/6
6:30 pm-11:35 pm
1 stop5h 05m
Des Moines
Mon 7/13
4:40 pm-10:55 pm
1 stop6h 15m
$345
St. LouisDes Moines
STL - DSM
STLDSM
Lambert-St Louis
Thu 7/9
4:00 pm-10:25 pm
1 stop6h 25m
Des Moines
Wed 7/15
5:20 am-2:45 pm
2 stops9h 25m
$354
Quickest round-trip
St. LouisDes Moines
STL - DSM
STLDSM
Lambert-St Louis
Sun 6/21
8:14 pm-12:35 am
1 stop4h 21m
Des Moines
Thu 6/25
7:09 pm-12:16 am
1 stop5h 07m
$355
Showing 1-10 of 31 resultsSorted by cheapest first
Best time to book a flight from Missouri to Des Moines
Have a flexible travel schedule? Discover the best time to fly to Des Moines from Missouri with our price prediction graph.
STL-DSM
MCI-DSM
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to Des Moines
USMO-DSM
STL-DSM
MCI-DSM
No data available for this route at this time. Please check back soon.
Related info for your journey
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Traveling to a place near Des Moines?
Book flights to Des Moines if you plan to visit one of these locationsAltoona
Ames
Johnston
Clive
Boone
West Des Moines
Ankeny
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Other flights to Des Moines
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Missouri and Des Moines flights
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Top airline flying from Missouri to Des Moines
Discover the top airline that operate flights from Missouri to Des Moines. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$77 | Average$316 | FlexibilityNo cancel fee | On-time63% |