$201+ Cheap flights from Knoxville (TYS) to Biloxi, MS
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/13. Fares are subject to change and may not be available on all flights or dates of travel.
TYS — MSY
Jul 10 — Jul 171
Round-trip
1 adult, Economy
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Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Knoxville to Biloxi
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Best
Last-minute
One-way
Cheapest flights from Knoxville to BiloxiExplore the most affordable flight options available from Knoxville to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 10, 2026.
Explore the most affordable flight options available from Knoxville to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 10, 2026.
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/158:18 am
TYS
- GPT
1 stop5h 54m
American Airlines
Sat 9/195:42 pm
GPT
- TYS
1 stop4h 08m
American Airlines
Deal found 6/9![American Airlines logo]()
$322
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/97:49 pm
TYS
- GPT
1 stop3h 25m
Delta
Tue 7/146:30 am
GPT
- TYS
1 stop5h 46m
Delta
Deal found 6/8![Delta logo]()
$357
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/76:05 pm
TYS
- GPT
1 stop5h 09m
Delta
Tue 7/145:57 pm
GPT
- TYS
1 stop4h 55m
Delta
Deal found 6/9![Delta logo]()
$367
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:40 am
TYS
- GPT
1 stop4h 41m
Delta
Tue 7/75:57 pm
GPT
- TYS
1 stop4h 55m
Delta
Deal found 6/8![Delta logo]()
$372
This United Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/152:21 pm
TYS
- GPT
1 stop6h 17m
United Airlines
Wed 8/192:00 pm
GPT
- TYS
1 stop6h 45m
United Airlines
Deal found 6/7![United Airlines logo]()
$384
This United Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/113:25 pm
TYS
- GPT
1 stop7h 20m
United Airlines
Sat 6/135:24 pm
GPT
- TYS
1 stop4h 48m
United Airlines
Deal found 6/7![United Airlines logo]()
$389
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/85:30 am
TYS
- GPT
1 stop5h 05m
Delta
Sun 9/132:15 pm
GPT
- TYS
1 stop5h 27m
Delta
Deal found 6/8![Delta logo]()
$436
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/38:05 pm
TYS
- GPT
1 stop4h 51m
American Airlines
Fri 7/106:35 pm
GPT
- TYS
1 stop4h 16m
American Airlines
Deal found 6/8![American Airlines logo]()
$446
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/267:46 pm
TYS
- GPT
1 stop3h 31m
Delta
Sun 6/285:57 pm
GPT
- TYS
1 stop4h 57m
Delta
Deal found 6/9![Delta logo]()
$447
Best flights from Knoxville to BiloxiDiscover carefully curated flight deals from Knoxville to Biloxi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 10, 2026.
Discover carefully curated flight deals from Knoxville to Biloxi that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 10, 2026.
This American Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/247:25 pm
TYS
- GPT
1 stop4h 10m
American Airlines
Mon 8/315:45 pm
GPT
- TYS
1 stop4h 13m
American Airlines
Deal found 6/5![American Airlines logo]()
$367
This Delta deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:40 am
TYS
- GPT
1 stop4h 41m
Delta
Tue 7/75:57 pm
GPT
- TYS
1 stop4h 55m
Delta
Deal found 6/7![Delta logo]()
$372
This United Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 8/152:21 pm
TYS
- GPT
1 stop6h 17m
United Airlines
Wed 8/192:00 pm
GPT
- TYS
1 stop6h 45m
United Airlines
Deal found 6/7![United Airlines logo]()
$384
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/267:46 pm
TYS
- GPT
1 stop3h 31m
Delta
Sun 6/285:57 pm
GPT
- TYS
1 stop4h 57m
Delta
Deal found 6/9![Delta logo]()
$447
This American Airlines deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 7/17:59 pm
TYS
- GPT
1 stop5h 00m
American Airlines
Fri 7/310:36 am
GPT
- TYS
1 stop4h 06m
American Airlines
Deal found 6/9![American Airlines logo]()
$514
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/45:40 am
TYS
- GPT
1 stop4h 35m
Delta
Mon 9/76:00 pm
GPT
- TYS
1 stop4h 52m
Delta
Deal found 6/8![Delta logo]()
$503
Last-minute flights from Knoxville to BiloxiDiscover last-minute flight deals from Knoxville to Biloxi. Data last updated June 10, 2026 and is based on user searches.
Discover last-minute flight deals from Knoxville to Biloxi. Data last updated June 10, 2026 and is based on user searches.
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/105:40 am
TYS
- GPT
1 stop4h 41m
Delta
Tue 6/1610:06 am
GPT
- TYS
1 stop3h 43m
Delta
Deal found 6/8![Delta logo]()
$465
This United Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/113:25 pm
TYS
- GPT
1 stop7h 20m
United Airlines
Sat 6/135:24 pm
GPT
- TYS
1 stop4h 48m
United Airlines
Deal found 6/7![United Airlines logo]()
$389
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 6/175:40 am
TYS
- GPT
1 stop4h 41m
Delta
Mon 6/225:56 pm
GPT
- TYS
1 stop4h 58m
Delta
Deal found 6/8![Delta logo]()
$456
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/267:46 pm
TYS
- GPT
1 stop3h 31m
Delta
Sun 6/285:57 pm
GPT
- TYS
1 stop4h 57m
Delta
Deal found 6/9![Delta logo]()
$447
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/305:40 am
TYS
- GPT
1 stop4h 41m
Delta
Tue 7/75:57 pm
GPT
- TYS
1 stop4h 55m
Delta
Deal found 6/8![Delta logo]()
$372
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/38:05 pm
TYS
- GPT
1 stop4h 51m
American Airlines
Fri 7/106:35 pm
GPT
- TYS
1 stop4h 16m
American Airlines
Deal found 6/8![American Airlines logo]()
$446
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/68:05 pm
TYS
- GPT
1 stop4h 51m
American Airlines
Mon 7/136:35 pm
GPT
- TYS
1 stop4h 16m
American Airlines
Deal found 6/8![American Airlines logo]()
$413
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 7/76:05 pm
TYS
- GPT
1 stop5h 09m
Delta
Tue 7/145:57 pm
GPT
- TYS
1 stop4h 55m
Delta
Deal found 6/9![Delta logo]()
$367
This Delta deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/97:49 pm
TYS
- GPT
1 stop3h 25m
Delta
Tue 7/146:30 am
GPT
- TYS
1 stop5h 46m
Delta
Deal found 6/8![Delta logo]()
$357
This Delta deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 7/175:40 am
TYS
- GPT
1 stop4h 39m
Delta
Sun 7/191:51 pm
GPT
- TYS
1 stop3h 53m
Delta
Deal found 6/9![Delta logo]()
$477
One-way flights from Knoxville to BiloxiSearch for one-way flight options from Knoxville to Biloxi. Find affordable one-way fares based on user searches. Data last updated June 10, 2026.
Search for one-way flight options from Knoxville to Biloxi. Find affordable one-way fares based on user searches. Data last updated June 10, 2026.
This Delta deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/136:12 pm
TYS
- GPT
1 stop5h 09m
Delta
Deal found 6/10![Delta logo]()
$201
This United Airlines deal was found by Cheapflights users on 6/10. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 8/135:45 am
TYS
- GPT
2 stops14h 53m
United Airlines
Deal found 6/10![United Airlines logo]()
$488
Find flight deals from Knoxville to Biloxi
Keep the following information in mind while searching for Knoxville to Biloxi flight deals. Data was last updated June 10, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $322 (American Airlines) |
One-way from | $201 (Delta) |
Popular in | March |
Cheapest in | June |
Average price | $308 |
Cheapflights Fare Finder
Customize your flight search to find flights from Knoxville to Biloxi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 10, 2026.
Use the filters below to find and compare flights from Knoxville to Biloxi that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
KnoxvilleGulfport
TYS - GPT
TYSGPT
Knoxville McGhee Tyson
Mon 8/24
7:25 pm-10:35 pm
1 stop4h 10m
Gulfport Biloxi Regional
Mon 8/31
5:45 pm-10:58 pm
1 stop4h 13m
$367
KnoxvilleGulfport
TYS - GPT
TYSGPT
Knoxville McGhee Tyson
Tue 6/30
5:40 am-9:21 am
1 stop4h 41m
Gulfport Biloxi Regional
Tue 7/7
5:57 pm-11:52 pm
1 stop4h 55m
$372
KnoxvilleGulfport
TYS - GPT
TYSGPT
Knoxville McGhee Tyson
Sat 8/15
2:21 pm-7:38 pm
1 stop6h 17m
Gulfport Biloxi Regional
Wed 8/19
2:00 pm-9:45 pm
1 stop6h 45m
$384
KnoxvilleGulfport
TYS - GPT
TYSGPT
Knoxville McGhee Tyson
Fri 6/26
7:46 pm-10:17 pm
1 stop3h 31m
Gulfport Biloxi Regional
Sun 6/28
5:57 pm-11:54 pm
1 stop4h 57m
$447
KnoxvilleGulfport
TYS - GPT
TYSGPT
Knoxville McGhee Tyson
Fri 9/4
5:40 am-9:15 am
1 stop4h 35m
Gulfport Biloxi Regional
Mon 9/7
6:00 pm-11:52 pm
1 stop4h 52m
$503
KnoxvilleGulfport
TYS - GPT
TYSGPT
Knoxville McGhee Tyson
Wed 7/1
7:59 pm-11:59 pm
1 stop5h 00m
Gulfport Biloxi Regional
Fri 7/3
10:36 am-3:42 pm
1 stop4h 06m
$514
Cheapest one-way
Quickest one-way
KnoxvilleGulfport
TYS - GPT
TYSGPT
Knoxville McGhee Tyson
Thu 8/13
6:12 pm-10:21 pm
1 stop5h 09m
$201
KnoxvilleGulfport
TYS - GPT
TYSGPT
Knoxville McGhee Tyson
Thu 8/13
5:45 am-7:38 pm
2 stops14h 53m
$488
Sorted by cheapest first
Best time to book a flight from Knoxville to Biloxi
Have a flexible travel schedule? Discover the best time to fly to Biloxi from Knoxville with our price prediction graph.
TYS-GPT
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Knoxville to Biloxi
TYS-B1L
TYS-GPT
What is the cheapest time of day to fly from TYS to B1L?
Find hourly flight availability from Knoxville to Biloxi. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 10, 2026.
When flying from Knoxville to Biloxi, the time of day you decide to fly out makes little to no difference towards the overall price you’ll pay on tickets.
How much does it cost to fly round-trip from Knoxville to Biloxi?
Reviews of airlines servicing Biloxi
Get insights into the airlines that provide service to Biloxi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Biloxi. Reviews last updated June 10, 2026.
Get a feel of what it's like to fly with Delta and American Airlines from Knoxville to Biloxi by reading reviews from past customers. Users have also rated airlines in terms of entertainment options, comfort, food, crew/service, and boarding process.
Comfort
7.8
Crew
8.5
Overall
7.9
Boarding
8.1
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Crew
8.5
Overall
7.9
Boarding
8.1
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Comfort
7.8
Crew
8.5
Overall
7.9
Boarding
8.1
Entertainment
7.8
Food
7.2
Reviews
1 / 20
10.0
ExcellentAnonymous,May 2026
SEA - KOA
Related info for your journey
Find useful and relevant information for your journey from Knoxville to Biloxi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
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Alternative routes for Knoxville to Biloxi
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Complete your trip
Complete your trip to Biloxi by adding a car rental and/or hotel reservation to your travel itinerary.
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Knoxville and Biloxi flights
Browse other Knoxville and Biloxi flight options. Last updated on June 10, 2026.
Other flights from Knoxville
Browse through other flights departing from Knoxville. Flights are based on user searches made on Cheapflights and were last updated on June 10, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Knoxville to Biloxi flights
Consider these flights traveling from Knoxville to Biloxi.
Top 4 airlines flying from Knoxville to Biloxi
Discover the top 4 airlines that operate flights from Knoxville to Biloxi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 10, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$66 | Average$94 | FlexibilityNo cancel fee | On-time88% | |
| Cheapest$228 | Average$401 | FlexibilityNo cancel fee | On-timeN/A | |
| Cheapest$233 | Average$387 | FlexibilityNo cancel fee | On-time71% | |
| Cheapest$294 | Average$376 | FlexibilityNo cancel fee | On-time63% |