HomeSearch by dateVacation packagesHotelsFlight dealsCar rentalTravel tips & news

Cheap flights from Knoxville to St. Louis (TYS - STL) from $64

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/21. Fares are subject to change and may not be available on all flights or dates of travel. Click the price to replicate the search for this deal.
TYS — STL
Jun 16 — Jun 231
From?
To?
Sun 6/16
Sun 6/23
1 adult, Economy
We work with more than 300 partners to bring you better travel deals

The best prices from Knoxville McGhee Tyson to Lambert-St Louis are usually found in April or January, booked 76 days in advance, depart on a Thursday or Wednesday and return on a Saturday

Cheap flight deals from Knoxville to St. Louis

Discover tips and strategies to find the most affordable flight options for your journey from Knoxville (TYS) to St. Louis (STL). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated June 11, 2024.

Popular in

June

Cheapest in

April

Round-trip from

$318

One-way from

$99
High demand for flights, 28% potential price rise
Search Deals
Best time to find cheap flights, 25% potential price drop
Search Deals
From Knoxville McGhee Tyson to Lambert-St Louis
Search Deals
One-way flight from Knoxville McGhee Tyson to Lambert-St Louis
Search Deals

What is the cheapest day to fly round-trip from Knoxville to St. Louis?

Sunday flights are found to be more expensive to fly from Knoxville to St. Louis. This shouldn’t discourage you from searching, as you can still find great deals by being flexible with your options. Use our search form to find deals on tickets to St. Louis.

How far in advance should I book a flight from Knoxville to St. Louis?

Users have found that booking a flight from Knoxville to St. Louis at least 44 days early can save you up to 36% on average compared to booking a flight this week. If booking 44 days before your flight isn’t an option for you, users have found flights from Knoxville to St. Louis for as little as $267 when booking for a departure date within the next two weeks. You can also check prices now. Some users have found airline tickets as low as $464 for flights departing within the next 3 days.

What is the cheapest month to fly from Knoxville to St. Louis?

The best pricing can be found in the month of April. Prices to St. Louis from Knoxville average $341. You can even find prices in April for less than $341, as users have found deals to St. Louis from as low as $214. The month of June appears to be one of the more expensive times to travel to St. Louis from Knoxville. Flying in the targeted month can save you up to 38%.

What is the cheapest time of day to fly from TYS to STL?

A simple way to save on the total cost of your ticket is to fly from Knoxville to St. Louis at noon. If you’re flexible enough to do this you can expect to save up to 31% on your trip compared to booking a flight in the morning.

Cheap Knoxville to St. Louis flights in June & July 2024

Find cheap flight options from Knoxville to St. Louis specifically for the months of June and July 2024. Explore affordable fares based on user searches. Over the last 7 days, Cheapflights users made 3,020,828 searches. Prices were last updated on June 11, 2024.
These are some of the most attractive deals on flights from Knoxville to St. Louis in 2024. Check back in a little while for more flight options.
Thu 7/186:30 amTYS - STL
1 stop11h 59mMultiple Airlines
Tue 7/2310:11 amSTL - TYS
1 stop9h 25mMultiple Airlines
Deal found 6/10$179
Wed 7/107:00 amTYS - STL
1 stop5h 38mDelta
Wed 7/176:00 amSTL - TYS
1 stop4h 16mDelta
Deal found 6/10$198
Tue 7/95:25 amTYS - STL
1 stop4h 37mDelta
Sat 7/135:34 pmSTL - TYS
1 stop3h 40mDelta
Deal found 6/9$213
Tue 7/910:27 pmTYS - STL
1 stop11h 16mFrontier
Thu 7/118:57 pmSTL - TYS
1 stop23h 39mFrontier
Deal found 6/9$216
Thu 7/186:30 amTYS - STL
1 stop11h 59mMultiple Airlines
Tue 7/2310:11 amSTL - TYS
2 stops25h 44mMultiple Airlines
Deal found 6/10$226
Mon 7/85:25 amTYS - STL
1 stop4h 37mDelta
Sat 7/135:34 pmSTL - TYS
1 stop3h 40mDelta
Deal found 6/9$228
Fri 6/286:11 pmTYS - STL
1 stop6h 52mAmerican Airlines
Sun 6/309:23 amSTL - TYS
1 stop3h 50mAmerican Airlines
Deal found 6/8$233
Wed 6/1910:12 amTYS - STL
1 stop5h 45mDelta
Sat 6/225:25 pmSTL - TYS
1 stop5h 28mDelta
Deal found 6/10$246
Thu 6/138:22 amTYS - STL
1 stop5h 50mAmerican Airlines
Thu 6/2712:56 pmSTL - TYS
1 stop6h 44mAmerican Airlines
Deal found 6/9$251

Knoxville to St. Louis 2024 flight deals

Discover exclusive flight deals for travel between Knoxville and St. Louis in 2024. Find excellent offers based on user searches. Over the last 7 days, Cheapflights users made 3,020,828 searches. Data last updated June 11, 2024.
These are some of the most attractive deals on flights from Knoxville to St. Louis in 2024. Check back in a little while for more flight options.
Thu 7/186:30 amTYS - STL
1 stop11h 59mMultiple Airlines
Tue 7/2310:11 amSTL - TYS
1 stop9h 25mMultiple Airlines
Deal found 6/10$179
Wed 7/105:25 amTYS - STL
1 stop4h 37mDelta
Wed 7/102:16 pmSTL - TYS
1 stop6h 09mDelta
Deal found 6/9$198
Tue 7/95:25 amTYS - STL
1 stop4h 37mDelta
Sat 7/135:34 pmSTL - TYS
1 stop3h 40mDelta
Deal found 6/9$213
Tue 7/910:27 pmTYS - STL
1 stop11h 16mFrontier
Thu 7/118:57 pmSTL - TYS
1 stop23h 39mFrontier
Deal found 6/9$216
Thu 8/1512:14 pmTYS - STL
1 stop5h 06mDelta
Thu 8/226:00 amSTL - TYS
1 stop4h 19mDelta
Deal found 6/10$218
Thu 8/85:25 amTYS - STL
1 stop4h 37mDelta
Sun 8/113:49 pmSTL - TYS
1 stop4h 04mDelta
Deal found 6/10$223
Thu 7/186:30 amTYS - STL
1 stop11h 59mMultiple Airlines
Tue 7/2310:11 amSTL - TYS
2 stops25h 44mMultiple Airlines
Deal found 6/10$226
Mon 7/85:25 amTYS - STL
1 stop4h 37mDelta
Sat 7/135:34 pmSTL - TYS
1 stop3h 40mDelta
Deal found 6/9$228
Fri 6/286:11 pmTYS - STL
1 stop6h 52mAmerican Airlines
Sun 6/309:23 amSTL - TYS
1 stop3h 50mAmerican Airlines
Deal found 6/8$233

Knoxville to St. Louis flights leaving soon

Find last-minute flight options from Knoxville to St. Louis for spontaneous travel. Discover available flights and compare prices based on user searches. Secure great deals and offers for spontaneous trips with quick booking options. Over the last 7 days, Cheapflights users made 3,020,828 searches. Data last updated June 11, 2024.
Have a look at some of the flights available from Knoxville to St. Louis departing last-minute. Users should be sure to double check the price, date, and time of their last-minute flight.
Wed 6/1910:12 amTYS - STL
1 stop5h 45mDelta
Sat 6/225:25 pmSTL - TYS
1 stop5h 28mDelta
Deal found 6/10$246
Sat 6/158:22 amTYS - STL
1 stop7h 04mAmerican Airlines
Sun 6/167:00 amSTL - TYS
1 stop4h 14mAmerican Airlines
Deal found 6/10$264
Thu 6/205:12 amTYS - STL
1 stop4h 21mAmerican Airlines
Sun 6/236:00 amSTL - TYS
1 stop4h 14mAmerican Airlines
Deal found 6/10$412
Wed 6/196:45 amTYS - STL
2 stops7h 27mAmerican Airlines
Sat 6/227:00 amSTL - TYS
1 stop6h 13mAmerican Airlines
Deal found 6/10$523
Sat 6/157:10 amTYS - STL
2 stops11h 18mMultiple Airlines
Sun 6/166:55 pmSTL - TYS
1 stop14h 36mMultiple Airlines
Deal found 6/10$562
Thu 6/206:45 amTYS - STL
2 stops8h 41mAmerican Airlines
Sun 6/236:00 amSTL - TYS
2 stops7h 13mAmerican Airlines
Deal found 6/10$643
Sat 6/157:10 amTYS - STL
2 stops11h 18mMultiple Airlines
Sun 6/165:22 pmSTL - TYS
2 stops16h 09mMultiple Airlines
Deal found 6/10$666
Sat 6/157:10 amTYS - STL
2 stops11h 18mMultiple Airlines
Sun 6/1612:15 pmSTL - TYS
3 stops21h 58mMultiple Airlines
Deal found 6/10$690

One-way flights to St. Louis from Knoxville

Search for one-way flight options from Knoxville to St. Louis. Find affordable one-way fares based on user searches. Compare prices and availability to plan your one-way journey according to your preferred dates and budget. Over the last 7 days, Cheapflights users made 3,020,828 searches. Data last updated June 11, 2024.
If you're seeking multiple options on one-way flights from Knoxville to St. Louis, be sure to check out these deals, which are updated often. For those needing a return trip from Knoxville, there is a search form available above.
Fri 6/2110:32 pmTYS - STL
1 stop11h 57mFrontier
Deal found 6/10$64
Sat 9/215:20 amTYS - STL
1 stop4h 46mDelta
Deal found 6/10$99
Wed 6/197:47 pmTYS - STL
1 stop19h 45mFrontier
Deal found 6/9$124
Sat 6/227:30 amTYS - STL
1 stop10h 58mMultiple Airlines
Deal found 6/10$180
Wed 6/199:00 amTYS - STL
3 stops35h 55mMultiple Airlines
Deal found 6/9$243
Fri 6/216:00 amTYS - STL
3 stops29h 34mMultiple Airlines
Deal found 6/10$260
Sat 6/227:10 amTYS - STL
2 stops11h 18mMultiple Airlines
Deal found 6/10$284
Fri 6/2110:15 pmTYS - STL
2 stops22h 46mMultiple Airlines
Deal found 6/10$297
Wed 6/198:10 amTYS - STL
2 stops13h 56mMultiple Airlines
Deal found 6/9$339

Find flights from Knoxville to St. Louis within your budget

Customize your flight search to find flights from Knoxville to St. Louis that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 3,020,828 searches. Data last updated June 11, 2024.

Fly from

Any airport

Fly to

Any airport

Budget

$179 - $396

Route

Depart

Return

Price

Knoxville McGhee TysonLambert-St Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 7/18

1 stop11h 59m

Lambert-St Louis

Tue 7/23

1 stop9h 25m

$179

Knoxville McGhee TysonLambert-St Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Wed 7/10

1 stop5h 38m

Lambert-St Louis

Wed 7/17

1 stop4h 16m

$198

Knoxville McGhee TysonLambert-St Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Tue 7/9

1 stop4h 37m

Lambert-St Louis

Sat 7/13

1 stop3h 40m

$213

Knoxville McGhee TysonLambert-St Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Tue 7/9

1 stop11h 16m

Lambert-St Louis

Thu 7/11

1 stop23h 39m

$216

Knoxville McGhee TysonLambert-St Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 8/15

1 stop5h 06m

Lambert-St Louis

Thu 8/22

1 stop4h 19m

$218

Knoxville McGhee TysonLambert-St Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 7/18

1 stop11h 59m

Lambert-St Louis

Tue 7/23

2 stops25h 44m

$220

Knoxville McGhee TysonLambert-St Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 7/18

1 stop11h 59m

Lambert-St Louis

Tue 7/23

2 stops25h 44m

$226

Knoxville McGhee TysonLambert-St Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 7/11

1 stop4h 20m

Lambert-St Louis

Mon 7/15

1 stop5h 16m

$237

Knoxville McGhee TysonLambert-St Louis

TYS - STL

TYSSTL

Knoxville McGhee Tyson

Thu 8/15

2 stops10h 50m

Lambert-St Louis

Thu 8/22

1 stop5h 15m

$396

Flights are sorted by cheapest first

Deals found on 6/10

How far ahead should I book a flight from Knoxville to St. Louis?

Use this chart to determine the optimal time to book a round-trip flight from Knoxville to St. Louis. Price data was last updated on May 31, 2024.
The price you pay for your flight from Knoxville to St. Louis may vary depending on when you book. For the best chance of a lower fare, look to book 74 days in advance of your trip. Fares are likely to increase a fortnight or so before your departure date.
Search Deals

What is the cheapest day to fly from Knoxville to St. Louis?

Use this chart to determine the cheapest time to fly round-trip from Knoxville to St. Louis. Price data was last updated on June 2, 2024.
Morning
Noon
Afternoon
Evening
All times are departure.
Travelers seeking maximum savings on their Knoxville to St. Louis flight should consider departing on Wednesday afternoons when fares are most often at their lowest. Monday mornings flights should be avoided if possible as fares are typically the most expensive at this time.
Search Deals

Best time to book a flight from Knoxville to St. Louis

Have a flexible travel schedule? Discover the best time to fly to St. Louis from Knoxville with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Temperature and rainfall in St. Louis by month

Plan your trip to St. Louis by taking into account the average temperature and rainfall totals by month.

STL

Temperature

32 - 80.6 °F

If weather is an important factor for your trip to St. Louis, use this chart to help with planning. For those seeking warmer temperatures, July is the ideal time of year to visit, when temperatures reach an average of 80.6 F. Travelers looking to avoid the cold should look outside of January, when temperatures are typically at their lowest (around 32.0 F).

Reviews of airlines servicing St. Louis

Get insights into the airlines that provide service to St. Louis. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to St. Louis. Reviews last updated June 11, 2024.
Peruse reviews from past customers who have flown with Delta, American Airlines and United Airlines from Knoxville to St. Louis to help guide your decision. You can also see how each airline stacks up in terms of entertainment options, comfort, food, crew/service, and boarding process.
Delta
8.0
Very good
10,277 reviews

Comfort

7.9

Entertainment

8.0

Food

7.4

Boarding

8.2

Overall

8.0

Crew

8.6

Reviews

1 / 10

When I was going to board, one of the staff members told me that I could not board with my passport bag because it was tree items and I would need to check a bag. This was so stupid ! The bag was small. So I had to put my things in my pockets, put the funny bag inside the other bag. Then go throw it. Then in the plane put everything back again in my funny bag.

Delta
8.0
Very good
10,277 reviews
Delta
8.0
Very good
10,277 reviews

Comfort

7.9

Entertainment

8.0

Food

7.4

Boarding

8.2

Overall

8.0

Crew

8.6

Reviews

1 / 10

When I was going to board, one of the staff members told me that I could not board with my passport bag because it was tree items and I would need to check a bag. This was so stupid ! The bag was small. So I had to put my things in my pockets, put the funny bag inside the other bag. Then go throw it. Then in the plane put everything back again in my funny bag.

United Airlines
7.4
Good
10,647 reviews
Delta
8.0
Very good
10,277 reviews

Comfort

7.9

Entertainment

8.0

Food

7.4

Boarding

8.2

Overall

8.0

Crew

8.6

Reviews

1 / 10

When I was going to board, one of the staff members told me that I could not board with my passport bag because it was tree items and I would need to check a bag. This was so stupid ! The bag was small. So I had to put my things in my pockets, put the funny bag inside the other bag. Then go throw it. Then in the plane put everything back again in my funny bag.

American Airlines
7.3
Good
14,138 reviews
Delta
8.0
Very good
10,277 reviews

Comfort

7.9

Entertainment

8.0

Food

7.4

Boarding

8.2

Overall

8.0

Crew

8.6

Reviews

1 / 10

When I was going to board, one of the staff members told me that I could not board with my passport bag because it was tree items and I would need to check a bag. This was so stupid ! The bag was small. So I had to put my things in my pockets, put the funny bag inside the other bag. Then go throw it. Then in the plane put everything back again in my funny bag.

Frontier
6.2
Okay
3,962 reviews
Delta
8.0
Very good
10,277 reviews

Comfort

7.9

Entertainment

8.0

Food

7.4

Boarding

8.2

Overall

8.0

Crew

8.6

Reviews

1 / 10

When I was going to board, one of the staff members told me that I could not board with my passport bag because it was tree items and I would need to check a bag. This was so stupid ! The bag was small. So I had to put my things in my pockets, put the funny bag inside the other bag. Then go throw it. Then in the plane put everything back again in my funny bag.

Related info for your journey

Find useful and relevant information for your journey from Knoxville to St. Louis. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • Can I find flights from Knoxville to St. Louis for under $200 on Cheapflights?

    Yes, there are multiple flights from Knoxville to St. Louis for under $200. The cheapest flight booked recently is on Multiple Airlines for just $179, but on average you can expect to pay $261.

  • Are there last-minute flights available from Knoxville to St. Louis for under $300?

    There are currently 8+ open flights from Knoxville to St. Louis within the next 7 days for less than $300.

  • What are the cheapest airlines flying from Knoxville to St. Louis round-trip?

    Cheapflights users have booked flights from Knoxville to St. Louis round-trip from $198. Other airlines that can offer you cheap pricing are Frontier, from $216, and American Airlines, from $237. These flights start at 41% lower than the current average price 3 months from now.

  • What does TYS to STL mean?

    This is defined as Knoxville McGhee Tyson Airport (TYS) and Lambert-St Louis Airport (STL). Codes like Lambert-St Louis Airport are often used to just call airports uniquely.

  • Can I find deals for flights from Knoxville to St. Louis that include extra baggage allowance?

    The amount of baggage you can bring on your Knoxville to St. Louis flight depends on the airline and the type of fare you've chosen. After entering your flight details, you'll be able to view the specific baggage policies for each deal in the search results. Keep in mind that certain deals may offer additional baggage allowance.

  • Can I find deals on flights from Knoxville to St. Louis with specific airlines?

    Yes, Cheapflights allows you to browse and filter Knoxville to St. Louis flight deals by airline. After entering your origin and destination, use the available filters to view flights offered by airlines.

  • Can I find deals for flights from Knoxville to St. Louis that include hotel bookings?

    Yes. In addition to deals on Knoxville to St. Louis flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Knoxville to St. Louis?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Knoxville to St. Louis.

  • Can I find deals for business class flights from Knoxville to St. Louis?

    Yes. Cheapflights offers flight deals from Knoxville to St. Louis by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

  • Can I find deals for flights from Knoxville to St. Louis that allow pets onboard?

    Many airlines flying from Knoxville to St. Louis offer the option to travel with pets. After selecting a flight deal, you can find more information about the airline's pet policy on their official website or by contacting the airline directly. Please note that additional fees and restrictions may apply.

  • Can I find deals on last-minute flights from Knoxville to St. Louis?

    Yes, you can often find last-minute deals on Knoxville to St. Louis flights on Cheapflights. However, these deals can vary and may not always be available. We recommend checking back frequently or signing up for price alerts for the most up-to-date deals.

  • How recently were the Knoxville to St. Louis flight deals updated?

    The Knoxville to St. Louis flight deals you see on this page were last updated on 6/10.

  • What is the cheapest month to book a flight from Knoxville to St. Louis?

    Currently, September is the cheapest month in which you can book a flight from Knoxville to St. Louis (average of $318). Flying from Knoxville to St. Louis in July is currently the most expensive (average of $365). There are several factors that can impact the price of a flight, so comparing airlines, departure airports and flight times can provide users with more options.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.

Alternative routes for Knoxville to St. Louis
See prices for flight routes from nearby airports that may be better suited for you.

Nashville to Kansas City flights
Knoxville to Kansas City flights
Nashville to St. Louis flights
Nashville to Springfield flights
Blountville to Kansas City flights
Memphis to St. Louis flights
Memphis to Kansas City flights
Knoxville to Springfield flights
Chattanooga to Kansas City flights
Chattanooga to St. Louis flights
Jackson to St. Louis flights
Blountville to St. Louis flights
Chattanooga to Springfield flights
Knoxville to Joplin flights
Blountville to Springfield flights
Nashville to Quincy flights

Top 2 airlines flying from Knoxville to St. Louis

Discover the top 2 airlines that operate flights from Knoxville to St. Louis. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 3,020,828 searches. Data last updated June 11, 2024.
AirlineCheapestAverageFlexibilityOn-time
American AirlinesCheapest$206Average$286FlexibilityNo cancel feeOn-time71%
DeltaCheapest$229Average$376FlexibilityNo cancel feeOn-timeN/A
Dallas to San Antonio flights
Chicago to Denver flights
Pittsburgh to Miami flights
Nashville to Chicago flights
Indianapolis to Orlando flights
Los Angeles to Austin flights
Washington, D.C. to Chicago flights
New York to Boston flights
Chicago O'Hare Intl Airport to Los Angeles flights
Buffalo to New York flights
Houston to Orlando flights
Knoxville to Stockholm flights

Search flights from Knoxville to St. Louis by cabin class

Find flights from Knoxville to St. Louis, based on your preferred cabin class, be it economy, premium economy, business, or first class.
First Class
Business Class
Prem Econ Class
Economy Class

Book a flight to one of these trending destinations

User searches for flights to these destinations increased 20% or more in the past 90 days compared to other destinations
Flights to Gaziantep
Flights to Miyakojima Hirara
Flights to Figari-Sud Corse
Flights to Mason City
Flights to Komatsu
Flights to Sendai
Flights to Rhinelander Oneida County
Flights to Constanţa Mihail Kogalniceanu
Flights to Brainerd Crow Wing County
Flights to Reus
Flights to Virac
Flights to Neiva La Marguita
Flights to Pellston Emmet County
Flights to Urumqi
Flights to Bastia Poretta
Flights to Samos
Flights to Hyannis Barnstable
Flights to Provincetown
Flights to Alghero-Fertilia
Flights to Laayoune Hassan I
Flights to Devils Lake
Flights to Vava'u Lupepau'U
Flights to Hakodate
Flights to Edremit/Korfez
100% Free
Cheapflights is completely free to use, so you can start saving the moment you arrive.
Book with Flexibility
Our users can plan ahead with confidence and find flights with no change fees
Travel Smart
Millions of people come to us for their flight needs every year. We help make travel planning easy by providing useful insights and data-driven graphs that can inform your decisions.
View all available airlines