To save on the cost of your flight from St Louis to Santa Clara, book at least 61 days before your planned departure. Booking around this time can save you about 17% on the cost of this flight compared to booking a flight leaving this week. We have found prices from $517 if you need a flight within two weeks. For flights within the next 72 hours, you can find tickets from as low as $526.
Flights from St Louis to Santa Clara lean towards being more expensive in December. Prices are generally better when you fly from St Louis to Santa Clara in September, with the cheapest ticket starting at $190.