To save on the cost of your flight from Mesa to Sanford, book at least 61 days before your planned departure. Booking around this time can save you about 25% on the cost of this flight compared to booking a flight leaving this week. We have found prices from $242 if you need a flight within two weeks. For flights within the next 72 hours, you can find tickets from as low as $283.
Due to multiple factors, expect to potentially pay more when booking in December. For low rates, September can be a great choice for travel to Sanford. Flights to Sanford from Mesa in September are about $230 on average during September, but can be found for as low as $147.