To save up to 7% on this flight, we recommend booking at least 52 days prior to travel. The price may fluctuate and will likely increase closer to your departure date. Users on Cheapflights have found tickets from John Wayne/Orange County to Loreto from $327 1-2 weeks out and tickets from $327 for flights departing within the next 72 hours.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from John Wayne/Orange County to Loreto as you normally would.