$751+ Cheap flights from San Francisco (SFO) to La Serena (LSC)
This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 3/2. Fares are subject to change and may not be available on all flights or dates of travel.
SFO — LSC
Jan 3 — Jan 101
1 adult, Economy
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1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
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Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from San Francisco to La Serena
Best flights from San Francisco to La SerenaDiscover carefully curated flight deals from San Francisco to La Serena that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 4, 2025.
Discover carefully curated flight deals from San Francisco to La Serena that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated December 4, 2025.
This LATAM Airlines deal was found by Cheapflights users on 12/1. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 3/28:54 amSFO - LSC
2 stops19h 01mLATAM Airlines
Wed 3/412:46 pmLSC - SFO
2 stops28h 58mLATAM Airlines
Deal found 12/1![LATAM Airlines logo]()
$751
This LATAM Airlines deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure LATAM Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/1711:02 amSFO - LSC
2 stops28h 43mMultiple Airlines
Tue 3/31:38 pmLSC - SFO
3 stops50h 21mMultiple Airlines
Deal found 12/3![Multiple Airlines logo]()
$810
This KAYAK deal was found by Cheapflights users on 12/3. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure KAYAK is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 2/178:54 amSFO - LSC
2 stops21h 25mLATAM Airlines
Tue 3/38:35 pmLSC - SFO
2 stops18h 27mLATAM Airlines
Deal found 12/3![LATAM Airlines logo]()
$796
Find flight deals from San Francisco to La Serena
Discover tips and strategies to find the most affordable flight options for your journey from San Francisco (SFO) to La Serena (LSC). Learn about various techniques such as flexible date searches, comparing prices across and setting up price alerts. Use these methods to find the cheapest flights available for your travel needs. Data last updated December 4, 2025.
Round-trip from | $751 (LATAM Airlines) |
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Cheapflights Fare Finder
Customize your flight search to find flights from San Francisco to La Serena that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated December 4, 2025.
Use the filters below to find and compare flights from San Francisco to La Serena that are best for you.
Fly from
San Francisco
Fly to
La Serena
Route
Depart
Return
Price
San FranciscoLa Serena
SFO - LSC
SFOLSC
San Francisco
Mon 3/2
8:54 am-8:55 am
2 stops19h 01m
La Serena La Florida
Wed 3/4
12:46 pm-12:44 pm
2 stops28h 58m
$751
San FranciscoLa Serena
SFO - LSC
SFOLSC
San Francisco
Tue 2/17
8:54 am-11:19 am
2 stops21h 25m
La Serena La Florida
Tue 3/3
8:35 pm-10:02 am
2 stops18h 27m
$796
San FranciscoLa Serena
SFO - LSC
SFOLSC
San Francisco
Tue 2/17
11:02 am-8:45 pm
2 stops28h 43m
La Serena La Florida
Tue 3/3
1:38 pm-10:59 am
3 stops50h 21m
$810
Best time to book a flight from San Francisco to La Serena
Have a flexible travel schedule? Discover the best time to fly to La Serena from San Francisco with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.