To save up to 43% on this flight, we recommend booking at least 27 days prior to travel. The price may fluctuate and will likely increase closer to your departure date. Users on Cheapflights have found tickets from Sanford to Houston from $167 1-2 weeks out and tickets from $207 for flights departing within the next 72 hours.
Flights from Sanford to Houston lean towards being more expensive in January. Prices are generally better when you fly from Sanford to Houston in October, with the cheapest ticket starting at $74.