Flights from Chicago O'Hare Intl Airport to Florence, South Carolina lean towards being more expensive in November. Prices are generally better when you fly from Chicago O'Hare Intl Airport to Florence, South Carolina in October, with the cheapest ticket starting at $189.
Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Chicago O'Hare Intl Airport to Florence, South Carolina as you normally would.