To save up to 62% on this flight, we recommend booking at least 31 days prior to travel. The price may fluctuate and will likely increase closer to your departure date. Users on Cheapflights have found tickets from Greenville to Columbia from $294 1-2 weeks out and tickets from $404 for flights departing within the next 72 hours.
Due to multiple factors, expect to potentially pay more when booking in December. For low rates, July can be a great choice for travel to Columbia. Flights to Columbia from Greenville in July are about $244 on average during July, but can be found for as low as $148.