To save up to 43% on this flight, we recommend booking at least 52 days prior to travel. The price may fluctuate and will likely increase closer to your departure date. Users on Cheapflights have found tickets from Mesa to Alaska from $357 1-2 weeks out and tickets from $499 for flights departing within the next 72 hours.
Flights from Mesa to Alaska lean towards being more expensive in May. Prices are generally better when you fly from Mesa to Alaska in August, with the cheapest ticket starting at $169.