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$539+ Cheap flights from Buffalo (BUF) to Panama

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 8/17. Fares are subject to change and may not be available on all flights or dates of travel.
BUF — PTY
Jul 9 — Jul 161
Thu 7/9
Thu 7/16
1 adult, Economy
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Cheap flight deals from Buffalo to Panama

Cheapest flights from Buffalo to Panama
Explore the most affordable flight options available from Buffalo to Panama. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 9, 2026.

This oojo deal was found by Cheapflights users on 6/9. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/178:02 pm
BUF
-
PTY
2 stops15h 28m
Multiple Airlines
Sat 8/223:50 pm
PTY
-
BUF
2 stops15h 00m
Multiple Airlines
Deal found 6/9$539
This Expedia deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Expedia is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/154:35 pm
BUF
-
PTY
2 stops18h 55m
Multiple Airlines
Mon 10/193:50 pm
PTY
-
BUF
2 stops15h 34m
Multiple Airlines
Deal found 6/6$570
This Orbitz deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Orbitz is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/48:02 pm
BUF
-
PTY
2 stops15h 28m
Multiple Airlines
Mon 9/143:50 pm
PTY
-
BUF
2 stops21h 36m
Multiple Airlines
Deal found 6/7$588
This oojo deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure oojo is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/208:07 pm
BUF
-
PTY
2 stops15h 23m
Multiple Airlines
Sat 7/43:50 pm
PTY
-
BUF
2 stops15h 10m
Multiple Airlines
Deal found 6/8$639
This Delta deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/256:05 am
BUF
-
PTY
1 stop7h 50m
Delta
Tue 9/12:20 pm
PTY
-
BUF
1 stop8h 39m
Delta
Deal found 6/7$673
This United Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 8/2510:53 am
BUF
-
PTY
1 stop9h 38m
United Airlines
Tue 9/13:30 pm
PTY
-
BUF
2 stops16h 58m
United Airlines
Deal found 6/7$677
This United Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 10/156:30 am
BUF
-
PTY
1 stop14h 01m
United Airlines
Mon 10/199:45 am
PTY
-
BUF
1 stop12h 26m
United Airlines
Deal found 6/6$698
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 7/2310:34 am
BUF
-
PTY
1 stop18h 30m
United Airlines
Thu 7/3010:55 pm
PTY
-
BUF
1 stop23h 04m
United Airlines
Deal found 6/8$700
This United Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 7/2010:34 am
BUF
-
PTY
1 stop18h 30m
United Airlines
Mon 7/2710:55 pm
PTY
-
BUF
1 stop18h 10m
United Airlines
Deal found 6/5$703

Find flight deals from Buffalo to Panama

Keep the following information in mind while searching for Buffalo to Panama flight deals. Data was last updated June 9, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$539
(oojo)
Provider with most accurate pricing for Buffalo-Panama City Tocumen Intl flight deals.
Search Deals
Provider most trusted by Cheapflights users for Buffalo-Panama City Tocumen Intl flights.
Search Deals
From Buffalo to Panama
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Buffalo to Panama that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 9, 2026.
Use the filters below to find and compare flights from Buffalo to Panama that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip
Quickest round-trip

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Tue 8/25

6:05 am-12:55 pm

1 stop7h 50m

Panama City Tocumen Intl

Tue 9/1

2:20 pm-11:59 pm

1 stop8h 39m

$673

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Thu 10/15

6:30 am-7:31 pm

1 stop14h 01m

Panama City Tocumen Intl

Mon 10/19

9:45 am-11:11 pm

1 stop12h 26m

$698

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Thu 7/23

10:34 am-4:04 am

1 stop18h 30m

Panama City Tocumen Intl

Thu 7/30

10:55 pm-10:59 pm

1 stop23h 04m

$700

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Mon 7/20

10:34 am-4:04 am

1 stop18h 30m

Panama City Tocumen Intl

Mon 7/27

10:55 pm-6:05 pm

1 stop18h 10m

$703

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Mon 8/17

6:55 am-6:37 pm

2 stops12h 42m

Panama City Tocumen Intl

Sat 8/22

3:30 pm-9:28 am

2 stops16h 58m

$707

BuffaloPanama City

BUF - PTY

BUFPTY

Buffalo

Sat 6/20

6:00 am-7:31 pm

1 stop14h 31m

Panama City Tocumen Intl

Sat 7/4

10:55 pm-9:53 am

1 stop9h 58m

$739

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/7

Sorted by cheapest first

Best time to book a flight from Buffalo to Panama

Have a flexible travel schedule? Discover the best time to fly to Panama from Buffalo with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Buffalo to Panama
No data available for this route at this time. Please check back soon.

Reviews of airlines servicing Panama

Get insights into the airlines that provide service to Panama. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Panama. Reviews last updated June 9, 2026.
Read through reviews of airlines operating flights from Buffalo to Panama, such as Delta. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
Delta
7.9
Good
8,394 reviews

Entertainment

7.8

Food

7.2

Comfort

7.8

Boarding

8.1

Crew

8.5

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Barney,May 2026

JFK - ATL

Terrible flight. Late, reduced beverage service, lack of headphones, entertainment service didn't work
Delta
7.9
Good
8,394 reviews
Delta
7.9
Good
8,394 reviews

Entertainment

7.8

Food

7.2

Comfort

7.8

Boarding

8.1

Crew

8.5

Overall

7.9

Reviews

1 / 20
2.0
Mediocre

Barney,May 2026

JFK - ATL

Terrible flight. Late, reduced beverage service, lack of headphones, entertainment service didn't work

Related info for your journey

Find useful and relevant information for your journey from Buffalo to Panama. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Buffalo to Panama?

    Buffalo (BUF), located 8.3 mi from the city center, is the airport you fly out of when you book flights from Buffalo to Panama.

  • Can I find deals for flights from Buffalo to Panama that include hotel bookings?

    Yes. In addition to deals on Buffalo to Panama flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Buffalo to Panama?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Buffalo to Panama.

  • Can I find deals for business class flights from Buffalo to Panama?

    Yes. Cheapflights offers flight deals from Buffalo to Panama by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

Browse thousands of different options on Cheapflights for your next trip

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Top airline flying from Buffalo to Panama

Discover the top airline that operate flights from Buffalo to Panama. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 9, 2026.
AirlineCheapestAverageFlexibilityOn-time
DeltaCheapest$517Average$671FlexibilityNo cancel feeOn-timeN/A

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