$261+ Cheap flights from Missouri to La Crosse (LSE)
This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 6/20. Fares are subject to change and may not be available on all flights or dates of travel.
MCI — LSE
Jul 9 — Jul 161
Round-trip
1 adult, Economy
We work with more than 300 partners to bring you better travel deals
Find cheap flights from Missouri to La Crosse with Cheapflights
1. Tell us where you want to go
Enter your travel information like dates, passengers, trip type (one-way or round trip), and preferred cabin class then click “Find deals”2. Select your favorite providers
We find the providers serving your travel needs. Choose up to four travel providers to compare side-by-side for flights, hotels, or car rentals.3. Compare prices and book
Review each provider’s pricing and select the best option for you! Book through your favorite provider’s website for a seamless experience.Cheap flight deals from Missouri to La Crosse
Cheapest
Best
Last-minute
One-way
Cheapest flights from Missouri to La CrosseExplore the most affordable flight options available from Missouri to La Crosse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 9, 2026.
Explore the most affordable flight options available from Missouri to La Crosse. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 9, 2026.
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:00 am
MCI
- LSE
1 stop12h 10m
United Airlines
Wed 11/41:41 pm
LSE
- MCI
1 stop8h 08m
United Airlines
Deal found 6/8![United Airlines logo]()
$575
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 6/77:52 pm
MCI
- LSE
1 stop4h 27m
American Airlines
Mon 6/155:25 pm
LSE
- MCI
1 stop7h 23m
American Airlines
Deal found 6/6![American Airlines logo]()
$600
This United Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:50 am
SGF
- LSE
2 stops15h 32m
United Airlines
Sat 10/319:42 am
LSE
- SGF
1 stop25h 52m
United Airlines
Deal found 6/4![United Airlines logo]()
$672
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/1912:19 pm
MCI
- LSE
2 stops12h 00m
American Airlines
Mon 6/2211:52 am
LSE
- MCI
2 stops12h 33m
American Airlines
Deal found 6/8![American Airlines logo]()
$764
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/95:10 am
MCI
- LSE
1 stop6h 12m
American Airlines
Thu 6/1111:52 am
LSE
- MCI
1 stop4h 05m
American Airlines
Deal found 6/7![American Airlines logo]()
$943
This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/27:15 am
SGF
- LSE
1 stop4h 16m
American Airlines
Tue 8/45:57 pm
LSE
- SGF
1 stop4h 40m
American Airlines
Deal found 6/6![American Airlines logo]()
$943
Best flights from Missouri to La CrosseDiscover carefully curated flight deals from Missouri to La Crosse that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 9, 2026.
Discover carefully curated flight deals from Missouri to La Crosse that have cost, travel time, and layovers in mind to ensure you get the best travel experience. Data last updated June 9, 2026.
This United Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 10/316:00 am
MCI
- LSE
1 stop12h 10m
United Airlines
Wed 11/41:41 pm
LSE
- MCI
1 stop8h 08m
United Airlines
Deal found 6/8![United Airlines logo]()
$575
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/1912:19 pm
MCI
- LSE
2 stops12h 00m
American Airlines
Mon 6/2211:52 am
LSE
- MCI
2 stops12h 33m
American Airlines
Deal found 6/8![American Airlines logo]()
$764
This United Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 10/288:50 am
SGF
- LSE
2 stops15h 32m
United Airlines
Sat 10/319:42 am
LSE
- SGF
1 stop25h 52m
United Airlines
Deal found 6/4![United Airlines logo]()
$672
Last-minute flights from Missouri to La CrosseDiscover last-minute flight deals from Missouri to La Crosse. Data last updated June 9, 2026 and is based on user searches.
Discover last-minute flight deals from Missouri to La Crosse. Data last updated June 9, 2026 and is based on user searches.
This American Airlines deal was found by Cheapflights users on 6/7. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/95:10 am
MCI
- LSE
1 stop6h 12m
American Airlines
Thu 6/1111:52 am
LSE
- MCI
1 stop4h 05m
American Airlines
Deal found 6/7![American Airlines logo]()
$943
This American Airlines deal was found by Cheapflights users on 6/8. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 6/197:52 pm
MCI
- LSE
1 stop4h 27m
American Airlines
Mon 6/226:00 am
LSE
- MCI
1 stop7h 18m
American Airlines
Deal found 6/8![American Airlines logo]()
$600
One-way flights from Missouri to La CrosseSearch for one-way flight options from Missouri to La Crosse. Find affordable one-way fares based on user searches. Data last updated June 9, 2026.
Search for one-way flight options from Missouri to La Crosse. Find affordable one-way fares based on user searches. Data last updated June 9, 2026.
This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/206:16 pm
MCI
- LSE
2 stops22h 14m
Multiple Airlines
Deal found 6/4![Multiple Airlines logo]()
$261
This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/51:45 pm
MCI
- LSE
2 stops29h 46m
Multiple Airlines
Deal found 6/4![Multiple Airlines logo]()
$283
This Kiwi.com deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Kiwi.com is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/181:45 pm
MCI
- LSE
2 stops29h 29m
Multiple Airlines
Deal found 6/4![Multiple Airlines logo]()
$358
This American Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/207:36 pm
MCI
- LSE
1 stop4h 43m
American Airlines
Deal found 6/4![American Airlines logo]()
$459
This American Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Thu 6/185:10 am
MCI
- LSE
1 stop6h 12m
American Airlines
Deal found 6/4![American Airlines logo]()
$484
Find flight deals from Missouri to La Crosse
Keep the following information in mind while searching for Missouri to La Crosse flight deals. Data was last updated June 9, 2026.
Most accurate provider | FlightHub 3 stars |
|---|---|
Most trusted provider | FlightHub 3 stars |
Round-trip from | $575 (United Airlines) |
One-way from | $261 (Kiwi.com) |
Cheapflights Fare Finder
Customize your flight search to find flights from Missouri to La Crosse that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 9, 2026.
Use the filters below to find and compare flights from Missouri to La Crosse that are best for you.
Fly from
Fly to
Route
Depart
Return
Cheapest round-trip
Quickest round-trip
Kansas CityLa Crosse
MCI - LSE
MCILSE
Kansas City
Sat 10/31
6:00 am-6:10 pm
1 stop12h 10m
La Crosse
Wed 11/4
1:41 pm-9:49 pm
1 stop8h 08m
$575
SpringfieldLa Crosse
SGF - LSE
SGFLSE
Springfield-Branson
Wed 10/28
8:50 am-12:22 am
2 stops15h 32m
La Crosse
Sat 10/31
9:42 am-11:34 am
1 stop25h 52m
$672
Kansas CityLa Crosse
MCI - LSE
MCILSE
Kansas City
Fri 6/19
12:19 pm-12:19 am
2 stops12h 00m
La Crosse
Mon 6/22
11:52 am-12:25 am
2 stops12h 33m
$764
Cheapest one-way
Kansas CityLa Crosse
MCI - LSE
MCILSE
Kansas City
Sun 7/5
1:45 pm-7:31 pm
3 stops29h 46m
$338
Kansas CityLa Crosse
MCI - LSE
MCILSE
Kansas City
Sat 6/20
6:16 pm-7:14 pm
3 stops48h 58m
$456
Kansas CityLa Crosse
MCI - LSE
MCILSE
Kansas City
Sat 6/20
7:36 pm-12:19 am
1 stop4h 43m
$459
Quickest one-way
Kansas CityLa Crosse
MCI - LSE
MCILSE
Kansas City
Sun 7/5
7:46 pm-11:59 pm
1 stop4h 13m
$484
Kansas CityLa Crosse
MCI - LSE
MCILSE
Kansas City
Thu 6/18
1:45 pm-7:14 pm
3 stops29h 29m
$495
Sorted by cheapest first
Best time to book a flight from Missouri to La Crosse
Have a flexible travel schedule? Discover the best time to fly to La Crosse from Missouri with our price prediction graph.
MCI-LSE
SGF-LSE
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.
Cheapflights Insights
Everything you need to know about your flight from Missouri to La Crosse
USMO-LSE
MCI-LSE
SGF-LSE
No data available for this route at this time. Please check back soon.
Related info for your journey
Find useful and relevant information for your journey from Missouri to La Crosse. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.
Traveling to a place near La Crosse?
Book flights to La Crosse if you plan to visit one of these locationsDecorah
Winona
Browse thousands of different options on Cheapflights for your next trip
Toggle through the tabs below to find thousands of options on Cheapflights for your next trip.
Alternative routes
Complete your trip
Flights by cabin class
La Crosse flight routes
Other flight options
Popular flights
Top destinations
Alternative routes for Missouri to La Crosse
See prices for flight routes from nearby airports that may be better suited for you.
Complete your trip
Complete your trip to La Crosse by adding a car rental and/or hotel reservation to your travel itinerary.
Search flights from Missouri to La Crosse by cabin class
Find flights from Missouri to La Crosse, based on your preferred cabin class, be it economy, premium economy, business, or first class.
Other flights to La Crosse
Explore flights to La Crosse departing from other origins. Flights are based on user searches made on Cheapflights and were last updated on June 9, 2026.
Missouri and La Crosse flights
Browse other Missouri and La Crosse flight options. Last updated on June 9, 2026.
Popular flight searches
Check out other popular destinations found by fellow travelers in 2026
Missouri to La Crosse flights
Consider these flights traveling from Missouri to La Crosse.
Top airline flying from Missouri to La Crosse
Discover the top airline that operate flights from Missouri to La Crosse. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 9, 2026.
| Airline | Cheapest | Average | Flexibility | On-time |
|---|---|---|---|---|
| Cheapest$298 | Average$520 | FlexibilityNo cancel fee | On-time71% |