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$456+ Cheap flights from Des Moines (DSM) to the Czech Republic

This is the cheapest one-way flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/20. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — PRG
Jul 9 — Jul 161
Thu 7/9
Thu 7/16
1 adult, Economy
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Cheap flight deals from Des Moines to Czech Republic

Cheapest flights from Des Moines to Czech Republic
Explore the most affordable flight options available from Des Moines to Czech Republic. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 9, 2026.

This United Airlines deal was found by Cheapflights users on 6/4. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 12/71:45 pm
DSM
-
PRG
2 stops16h 20m
United Airlines
Fri 12/117:15 am
PRG
-
DSM
2 stops20h 17m
United Airlines
Deal found 6/4$740
This Air Canada deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/53:20 pm
DSM
-
PRG
2 stops36h 30m
Air Canada
Wed 9/2312:30 pm
PRG
-
DSM
2 stops31h 04m
Air Canada
Deal found 6/6$780
This Air Canada deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:45 am
DSM
-
PRG
2 stops22h 05m
Air Canada
Wed 9/2312:30 pm
PRG
-
DSM
2 stops29h 01m
Air Canada
Deal found 6/6$828
This Air Canada deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Air Canada is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Mon 8/315:21 pm
DSM
-
PRG
2 stops34h 29m
Air Canada
Wed 9/2312:30 pm
PRG
-
DSM
2 stops31h 04m
Air Canada
Deal found 6/6$833
This Scandinavian Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Scandinavian Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 8/3011:28 am
DSM
-
PRG
2 stops39h 12m
Scandinavian Airlines
Fri 9/188:55 pm
PRG
-
DSM
2 stops32h 34m
Scandinavian Airlines
Deal found 6/6$840
This Delta deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/54:11 pm
DSM
-
PRG
2 stops20h 24m
Delta
Fri 9/1811:00 am
PRG
-
DSM
1 stop31h 32m
Delta
Deal found 6/6$842
This Delta deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 9/54:11 pm
DSM
-
PRG
2 stops20h 24m
Delta
Thu 9/246:00 am
PRG
-
DSM
2 stops22h 02m
Delta
Deal found 6/6$844
This Delta deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 9/15:30 pm
DSM
-
PRG
2 stops19h 05m
Delta
Fri 9/1811:00 am
PRG
-
DSM
1 stop31h 32m
Delta
Deal found 6/6$845
This United Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 9/43:20 pm
DSM
-
PRG
2 stops17h 45m
United Airlines
Wed 9/236:10 am
PRG
-
DSM
2 stops22h 17m
United Airlines
Deal found 6/6$847
This Delta deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure Delta is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/145:56 pm
DSM
-
PRG
2 stops20h 49m
Delta
Fri 8/216:00 am
PRG
-
DSM
2 stops21h 58m
Delta
Deal found 6/5$848
This United Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Wed 9/25:21 pm
DSM
-
PRG
2 stops15h 44m
United Airlines
Tue 9/226:10 am
PRG
-
DSM
2 stops15h 10m
United Airlines
Deal found 6/6$850
This United deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Fri 8/146:00 am
DSM
-
PRG
3 stops21h 50m
Multiple Airlines
Fri 8/216:00 am
PRG
-
DSM
2 stops22h 23m
Multiple Airlines
Deal found 6/5$851

Find flight deals from Des Moines to Czech Republic

Keep the following information in mind while searching for Des Moines to Czech Republic flight deals. Data was last updated June 9, 2026.

Round-trip from

$780
(Air Canada)

One-way from

$387
(American Airlines)
From Des Moines to Czech Republic
Search Deals
One-way flight from Des Moines to Czech Republic
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Czech Republic that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 9, 2026.
Use the filters below to find and compare flights from Des Moines to the Czech Republic that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 8/14

5:56 pm-9:45 pm

2 stops20h 49m

Václav Havel Prague

Fri 8/21

6:00 am-8:58 pm

2 stops21h 58m

$848

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 9/2

3:20 pm-4:05 pm

2 stops17h 45m

Václav Havel Prague

Thu 9/24

11:40 am-10:15 pm

2 stops17h 35m

$850

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Fri 8/14

6:00 am-10:50 am

3 stops21h 50m

Václav Havel Prague

Fri 8/21

6:00 am-9:23 pm

2 stops22h 23m

$851

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Wed 9/2

4:11 pm-5:40 pm

2 stops18h 29m

Václav Havel Prague

Mon 9/21

2:30 pm-2:01 pm

2 stops30h 31m

$852

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 8/13

5:21 pm-4:00 pm

2 stops15h 39m

Václav Havel Prague

Sun 8/23

12:30 pm-4:19 pm

2 stops34h 49m

$878

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 8/13

5:41 am-8:15 am

1 stop19h 34m

Václav Havel Prague

Sun 8/23

10:15 am-10:06 pm

1 stop18h 51m

$886

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sun 8/30

8:46 am-10:50 am

2 stops19h 04m

Václav Havel Prague

Thu 9/24

6:00 am-9:02 pm

2 stops22h 02m

$896

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Thu 9/3

3:20 pm-4:05 pm

2 stops17h 45m

Václav Havel Prague

Wed 9/23

1:25 pm-9:27 pm

2 stops15h 02m

$901

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sun 7/26

5:17 pm-9:20 pm

2 stops45h 03m

Václav Havel Prague

Tue 8/4

6:10 am-10:56 pm

2 stops23h 46m

$908
Quickest round-trip

Des MoinesPrague

DSM - PRG

DSMPRG

Des Moines

Sun 8/2

1:04 pm-8:15 am

1 stop12h 11m

Václav Havel Prague

Mon 8/10

7:15 am-6:41 pm

2 stops18h 26m

$958

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/5

Showing 1-10 of 19 resultsSorted by cheapest first
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Best time to book a flight from Des Moines to Czech Republic

Have a flexible travel schedule? Discover the best time to fly to Czech Republic from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to the Czech Republic
No data available for this route at this time. Please check back soon.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Czech Republic. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Czech Republic?

    Most people fly from Des Moines (DSM) if they book a flight from Des Moines to Czech Republic. Des Moines is conveniently located just 3.6 mi from Des Moines’s city center.

  • How long is the flight from Des Moines to Czech Republic?

    For as low as $850, Delta can have you in Czech Republic from Des Moines in 17h 45m. The distance from Des Moines to Czech Republic is about 4753 mi. Both multi-stop and nonstop flights can be found to your destination and back.

  • Can I find deals for flights from Des Moines to Czech Republic that include hotel bookings?

    Yes. In addition to deals on Des Moines to Czech Republic flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Czech Republic?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Czech Republic.

  • Can I find deals for business class flights from Des Moines to Czech Republic?

    Yes. Cheapflights offers flight deals from Des Moines to Czech Republic by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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