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Biloxi

$319+ Cheap flights from Des Moines (DSM) to Biloxi, MS

This is the cheapest round-trip flight price found by a Cheapflights user in the last 72 hours by searching for a flight departing on 7/5. Fares are subject to change and may not be available on all flights or dates of travel.
DSM — MSY
Jul 7 — Jul 141
Tue 7/7
Tue 7/14
1 adult, Economy
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Cheap flight deals from Des Moines to Biloxi

Cheapest flights from Des Moines to Biloxi
Explore the most affordable flight options available from Des Moines to Biloxi. Find the lowest fares from popular airlines and budget airlines, with prices last updated on June 7, 2026.

This American Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sun 7/55:12 am
DSM
-
GPT
1 stop5h 43m
American Airlines
Sat 7/116:35 pm
GPT
-
DSM
1 stop5h 34m
American Airlines
Deal found 6/6$319
This American Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/234:48 pm
DSM
-
GPT
1 stop6h 13m
American Airlines
Wed 9/306:22 pm
GPT
-
DSM
1 stop4h 51m
American Airlines
Deal found 6/5$324
This American Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 6/204:48 pm
DSM
-
GPT
1 stop6h 13m
American Airlines
Wed 6/246:38 pm
GPT
-
DSM
1 stop5h 34m
American Airlines
Deal found 6/5$339
This United Airlines deal was found by Cheapflights users on 6/6. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure United Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Sat 11/148:00 am
DSM
-
GPT
1 stop8h 02m
United Airlines
Tue 11/175:15 pm
GPT
-
DSM
1 stop5h 15m
United Airlines
Deal found 6/6$399
This American Airlines deal was found by Cheapflights users on 6/5. Clicking the “Pick Dates” button in this card will allow you to select your dates and further customize your flight criteria. From there, click “Find deals”, make sure American Airlines is selected, and click “Compare selected” under the list of providers to see comparable flight deals.
Tue 6/94:48 pm
DSM
-
GPT
1 stop6h 13m
American Airlines
Tue 6/166:38 pm
GPT
-
DSM
1 stop5h 34m
American Airlines
Deal found 6/5$414

Find flight deals from Des Moines to Biloxi

Keep the following information in mind while searching for Des Moines to Biloxi flight deals. Data was last updated June 7, 2026.

Most accurate provider

FlightHub
3 stars

Most trusted provider

FlightHub
3 stars

Round-trip from

$319
(American Airlines)

Popular in

March

Cheapest in

July

Average price

$373
Provider with most accurate pricing for Des Moines-Gulfport Biloxi Regional flight deals.
Search Deals
Provider most trusted by Cheapflights users for Des Moines-Gulfport Biloxi Regional flights.
Search Deals
From Des Moines to Biloxi
Search Deals
Highest demand for flights based on searches. 26% potential increase in price ($132 potential increase over avg. RT price).
Search Deals
Cheapest flight prices on average. 8% potential price decrease ($28 potential savings vs. average RT price).
Search Deals
Average for round-trip flights in June 2026
Search Deals

Cheapflights Fare Finder

 
Customize your flight search to find flights from Des Moines to Biloxi that fit within your specific budget. Explore options based on user searches and filter the results based on your desired price range. Find flights that match your budget for a cost-effective journey. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 7, 2026.
Use the filters below to find and compare flights from Des Moines to Biloxi that are best for you.

Fly from

Fly to

Route

Depart

Return

Price

Cheapest round-trip

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Sun 7/5

5:12 am-10:55 am

1 stop5h 43m

Gulfport Biloxi Regional

Sat 7/11

6:35 pm-12:09 am

1 stop5h 34m

$319

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Sat 11/14

8:00 am-4:02 pm

1 stop8h 02m

Gulfport Biloxi Regional

Tue 11/17

5:15 pm-10:30 pm

1 stop5h 15m

$399

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Tue 7/7

11:30 am-5:12 pm

1 stop5h 42m

Gulfport Biloxi Regional

Fri 7/10

5:57 pm-10:29 pm

1 stop4h 32m

$484
Quickest round-trip

Des MoinesGulfport

DSM - GPT

DSMGPT

Des Moines

Sat 8/29

3:02 pm-7:38 pm

1 stop4h 36m

Gulfport Biloxi Regional

Tue 9/1

4:59 pm-10:30 pm

1 stop5h 31m

$544

Flights are sorted by cheapest round-trip flights first.

Deals found on 6/6

Sorted by cheapest first

Best time to book a flight from Des Moines to Biloxi

Have a flexible travel schedule? Discover the best time to fly to Biloxi from Des Moines with our price prediction graph.
Estimated round-trip price
Rates are based on past data. Find the cheapest month and day to book your flight based on your travel requirements, then search for cheap deals.

Cheapflights Insights

Everything you need to know about your flight from Des Moines to Biloxi

What is the cheapest time of day to fly from DSM to B1L?

Find hourly flight availability from Des Moines to Biloxi. Discover flight options and departure times throughout the day, allowing you to choose a departure time that suits your schedule. Data last updated June 7, 2026.

Regardless of the time of day you decide to fly, the ticket price will remain around the same. Book flights from Des Moines to Biloxi as you normally would.

How much does it cost to fly round-trip from Des Moines to Biloxi?

Reviews of airlines servicing Biloxi

Get insights into the airlines that provide service to Biloxi. Read reviews, discover amenities, and learn about the overall travel experience offered by airlines. Use this information to make informed decisions when choosing an airline for your flight to Biloxi. Reviews last updated June 7, 2026.
Read reviews from past customers who have flown United Airlines and American Airlines from Des Moines to Biloxi. Reviews also offer insight into each airline's entertainment options, comfort, food, crew/service, and boarding process.
United Airlines
7.4
Good
9,777 reviews

Crew

8.1

Food

6.6

Entertainment

7.1

Overall

7.4

Boarding

7.7

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Dynasty,May 2026

LAX - EWR

The food wasn’t nice - Hosts were not that kind.
United Airlines
7.4
Good
9,777 reviews
United Airlines
7.4
Good
9,777 reviews

Crew

8.1

Food

6.6

Entertainment

7.1

Overall

7.4

Boarding

7.7

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Dynasty,May 2026

LAX - EWR

The food wasn’t nice - Hosts were not that kind.
American Airlines
7.1
Good
11,649 reviews
United Airlines
7.4
Good
9,777 reviews

Crew

8.1

Food

6.6

Entertainment

7.1

Overall

7.4

Boarding

7.7

Comfort

7.3

Reviews

1 / 20
4.0
Okay

Dynasty,May 2026

LAX - EWR

The food wasn’t nice - Hosts were not that kind.

Related info for your journey

Find useful and relevant information for your journey from Des Moines to Biloxi. Access travel guides, tips, and recommendations to enhance your travel experience. Get information about local attractions, weather, transportation options, and more.

  • What airport do you fly from for flights from Des Moines to Biloxi?

    Located just 3.6 mi from the city center, Des Moines is the airport most travelers will use when flying to Biloxi from Des Moines. Booking flights from Des Moines (DSM) to Biloxi should be relatively easy as there are 0 daily outbound flights to Biloxi from 5 different airlines.

  • How long is the flight from Des Moines to Biloxi?

    American Airlines and United Airlines can get you from Des Moines to Biloxi in just under 5h 43m. Your travel time can differ by up to 2h 19m. Des Moines and Biloxi are separated by a distance of 810 mi. When browsing for deals, the options you’ll see will be for both nonstop flights and flights with stops.

  • Can I find deals for flights from Des Moines to Biloxi that include hotel bookings?

    Yes. In addition to deals on Des Moines to Biloxi flights, Cheapflights offers vacation packages that include both flights and hotel.

  • How can I find direct flights from Des Moines to Biloxi?

    After entering your origin and destination, apply the non-stop filter on the search result page to find direct flights from Des Moines to Biloxi.

  • Can I find deals for business class flights from Des Moines to Biloxi?

    Yes. Cheapflights offers flight deals from Des Moines to Biloxi by cabin class. In addition to browsing deals, you can also filter by cabin class on the search results page after making a search.

See more FAQs

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Top 5 airlines flying from Des Moines to Biloxi

Discover the top 5 airlines that operate flights from Des Moines to Biloxi. Compare their services, reliability, and customer satisfaction ratings to choose the airline that best suits your travel preferences and needs. Over the last 7 days, Cheapflights users made 2,558,603 searches. Data last updated June 7, 2026.
AirlineCheapestAverageFlexibilityOn-time
Allegiant AirCheapest$132Average$218FlexibilityNo cancel feeOn-time88%
American AirlinesCheapest$216Average$384FlexibilityNo cancel feeOn-time71%
DeltaCheapest$236Average$437FlexibilityNo cancel feeOn-timeN/A
United AirlinesCheapest$258Average$367FlexibilityNo cancel feeOn-time69%
SouthwestCheapest$270Average$387FlexibilityNo cancel feeOn-time63%

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